target/BTK/2

PROTAC BTK Degrader-13 (Compound 25) 是一种专门靶向BTK的PROTAC降解剂，具有DC50为0.27 μM的活性。该化合物对BTK的抑制作用IC50值为0.44 μM，并对IL-2诱导的T细胞激酶（ITK）显示IC50为2.16 μM的抑制活性。同时，PROTAC BTK Degrader-13 能抑制p38 MAPK信号通路，阻止BCR（B细胞受体）信号通路被激活。(Pink: ligand for target protein BTK ligand 15; Black: linker; Blue: ligand for E3 ligase cereblon)

The Immuno-Oncology Screening Library consists of 2 plates and contains more than 90 cancer and immunology-associated compounds in a 96-well Matrix tube rack format as 10 mM stock solutions in DMSO. This library includes a variety of immuno-oncology target modulators, including but not limited to, adenosine, CCR, CXCR, and TLR agonists and antagonists, BTK, PI3K, VEGFR, and BRAF inhibitors, PD-1/PDL-1 interaction inhibitors, and HDAC inhibitors. Please review the product insert for a full list of targets. Stability data is not available for the compounds as supplied in the screening library.