DHAP

2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1 2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。

3',4'-Dihydroxyacetophenone (Qingxintong) 是一种血管活性物质和抗氧化剂，可从Picea Schrenkiana 中分离得到，能抑制酪氨酸酶，其IC50=10 μM。

Dihydroxyacetone phosphate hemimagnesium salt hydrate 也称为磷酸二羟基丙酮或 3-羟基-2-氧代丙基磷酸。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 存在于从细菌到人类的所有生物中。在人类体内， Dihydroxyacetone phosphate hemimagnesium salt hydrate参与许多酶促反应。 Dihydroxyacetone phosphate hemimagnesium salt hydrate 已被研究用于治疗淋巴瘤、大细胞淋巴瘤、弥漫性淋巴瘤。

DHAPC (1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine) 可作为前列腺癌PET显像剂的氟-18放射性标记。

LDHA PDKs-IN-1 (compound 20e) is a highly effective dual inhibitor of PDKs and LDHA, displaying IC50 values of 0.8 μM and 0.15 μM, respectively. It significantly suppresses A549 cell proliferation (EC50 = 13.2 μM), reduces lactate formation, and enhances oxygen consumption. This compound holds great promise for cancer research [1].

LDHA PDKs-IN-2 (compound 20k) 是有效的 LDHA 和 PDKs 的双重抑制剂，IC50 值分别为 0.7 和 1.6 μM。LDHA PDKs-IN-2 会增加耗氧量并且减少乳酸的形成。LDHA PDKs-IN-2 显示了癌症研究的潜力，它可以减少 A549 细胞的增殖，EC50值为 15.7 μM。

DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer.

Glycerol-3-phosphate dehydrogenase, Saccharomyces cerevisiae 是一种在酵母Saccharomyces cerevisiae中发挥关键作用的酶，主要参与甘油代谢及能量产生过程。它催化Glycerol-3-phosphate (G3P)氧化成磷酸二羟丙酮 (DHAP)，并作为该菌种生物合成甘油的限速酶，调节甘油的生成与积累，有利于Saccharomyces cerevisiae应对高渗透压环境。此外，该酶亦可用于代谢工程领域的研究。

3,5-Dihydroxyacetophenone is an endogenous metabolite.

Dihydroxyacetone phosphate (DHAP) is a crucial intermediate in lipid biosynthesis and glycolysis, participating in numerous metabolic pathways, including the Calvin cycle and glycolysis in plants.