(±)-Bambuterol

BaMbuterol-d9 Hydrochloride 是 BaMbuterol Hydrochloride 的氘代化合物。

Bambuterol is a prodrug of β2-agonist commonly used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) with the advantage of once daily dosing and favorable side effect profile. Administration of a single-dose of R-bambuterol resulted in dose-dependent reductions in the levels of plasma LDL-C, high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) at Tmax. R-bambuterol can lower the plasma levels of LDL-C, and marginally raise the ratio of ApoA1 ApoB (indicator of HDL-C LDL-C) with both a single dose and multiple doses. R-bambuterol was more potent in LDL-C lowering than rac-bambutero

long acting beta-adrenoceptor agonist

Bambuterol hydrochloride (KWD-2183 hydrochloride) 是 Terbutaline 的前体药物，是一种肾上腺素受体长效激动剂。

Terbutaline 是 bambuterol 的活性代谢物，也是β2肾上腺素能受体的短效激动剂，可预防早产及用作支气管扩张剂。