纤维生长因子受体 (Fibroblast Growth Factor Receptors, FGFRs) 是与纤维生长因子 (Fibroblast Growth Factor ,FGF) 蛋白家族成员结合的受体。FGFR 由一个由三个免疫球蛋白样结构域组成的细胞外配体结构域、一个跨膜螺旋结构域和一个具有酪氨酸激酶活性的细胞内结构域组成。FGF/FGFR信号通路与多种癌症有关。目前有作用于所有 FGFR1-4 和其他蛋白质的非选择性 FGFR 抑制剂,以及作用于部分/全部 FGFR1-4 的一些选择性 FGFR 抑制剂,例如AZD4547、BGJ398、JNJ42756493和PD173074。
Cat. No. | Product Name / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00388 | FGFR2IIIc Protein, Human, Recombinant (hFc)
FGFR2IIIc Protein, Human, Recombinant (hFc)
|
Human | Human Cells |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and througho... | |||
TMPJ-00389 | FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc)
FGFR2 alpha (IIIc) Protein, Human, Recombinant (hFc)
|
Human | Human Cells |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and througho... | |||
TMPJ-00390 | FGFR2IIIb Protein, Human, Recombinant (hFc)
FGFR2IIIb Protein, Human, Recombinant (hFc)
|
Human | Human Cells |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and througho... | |||
TMPJ-00391 | FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
|
Human | Human Cells |
FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and througho... | |||
TMPJ-01224 | FGFRL1 Protein, Human, Recombinant (His)
FGFRL1 Protein, Human, Recombinant (His)
|
Human | Human Cells |
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consi... | |||
TMPK-00378 | FGFR4 beta Protein, Human, Recombinant (His & Avi)
FGFR4 beta Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that ... | |||
TMPK-00379 | FGFR4 Protein, Human, Recombinant (His & Avi)
FGFR4 Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that ... | |||
TMPK-00380 | FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that ... | |||
TMPK-00381 | FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase.Tyrosine-protein kinase that ... | |||
TMPK-00384 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00385 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00386 | FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR3 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00387 | FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00388 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi)
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00389 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi)
FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00390 | FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR3 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00391 | FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR3 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, thr... | |||
TMPK-00392 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabo... | |||
TMPK-00393 | FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 |
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and patho... | |||
TMPK-00394 | FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabo... |