nojirimycin

Nojirimycin is the parent compound of a class of antibiotics and glycosidase inhibitors obtained from a class of Streptomyces species.

Nojirimycin 1-sulfonic acid 一种在生化反应中使用的试剂。

1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖，预防糖尿病。

Homonojirimycin is an alpha-glucosidase inhibitor.

1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂，具有降血糖、减肥和抗病毒的作用，可抑制餐后血糖，预防糖尿病。

1-Deoxymannojirimycin hydrochloride 是一种选择性的 α1,2-甘露糖苷酶抑制剂，IC50值为 20 μM。它还抑制 HIV-1 毒株，抗病毒活性较差。

AMP-Deoxynojirimycin (AMP-DNM) 是一种有效的神经酰胺葡萄糖基转移酶和 GCase 2 抑制剂。AMP-Deoxynojirimycin 是一种有效的 GlcCer 生物合成抑制剂，可用于研究帕金森和糖尿病。

Deoxynojirimycin (dNM) tetrabenzyl ether is an intermediate for the synthesis of glucosylceramide synthase inhibitors such as 1-dNM, a glucose analog that potently inhibits α-glucosidase I and II.

The effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin (ppDNM) on the lectin binding to HIV-1 glycoprotein was analyzed by using biotinylated lectins of various sugar specificities as probes. ppDNM potentially inhibited HIV-1-induced syncytium formation and viral infectivity of HIV-1 without cytotoxicity. The lectin binding assay showed that ppDNM treatment reduced Con A binding to gp120 of HIV-1.

Deoxyfuconojirimycin hydrochloride 是人肝 α-L-岩藻糖苷酶的特异性竞争性抑制剂。

1-Deoxynojirimycin, a potent glucose analog, inhibits α-glucosidase I and II effectively. Its derivative, N-5-Carboxypentyl-1-deoxynojirimycin, serves as a ligand for glucosidase I and II purification, utilizing carboxypentyl groups for affinity chromatography resin linkage. Furthermore, N-5-Carboxypentyl-1-deoxynojirimycin demonstrates comparable or superior inhibition of glucosidase compared to 1-deoxynojirimycin, with inhibition constants (Ki) of 0.45 µM and 2.1 µM, respectively, for pig liver glucosidase I.

N-Nonyldeoxynojirimycin (NN-DNJ) is an inhibitor of acid α-glucosidase and α-1,6-glucosidase with IC50 values of 0.42 μM and 8.4 μM, respectively.

Deoxymannojirimycin hydrochloride 一种在生化反应中使用的试剂。

N-5-Carboxypentyl-deoxymannojirimycin 是用于糖生物学研究的生化试剂。糖生物学侧重于糖的结构、合成、功能和进化，涉及碳水化合物化学、聚糖合成和分解的酶学、蛋白质与聚糖的识别，以及聚糖在生物系统中的功能。该领域与基础研究、生物医学及生物技术紧密相连。

N-Ethyldeoxynojirimycin (hydrochloride) 是一种在生化反应中使用的试剂。

Miglustat (NB-DNJ) 是一种葡萄糖神经酰胺合成酶抑制剂，可用于I 型戈谢病。

Lucerastat（NBDGJ，芦舍司他）是一种口服的葡萄糖神经酰胺合酶（Glucosylceramide Synthase, GCS）的抑制剂，具有治疗法布里病的潜力。 ​GCS是鞘糖脂合成的关键酶，抑制其活性可减少有害底物的积累。

UR-MK299 is a NPY Y1 receptor antagonist.

Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.

Famiraprinium is a competitive antagonist at the GABA receptor site.