er in mcf-7 cells

ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrade

ER degrader 9 (compound 1) 作为一种双功能分子，展现出强效的雌激素受体 (ER) 降解活性，具体表现为在 MCF-7 细胞中的 DC50 值不大于10 nM。该化合物主要应用于乳腺癌相关的科学研究。