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3

抑制剂 & 化合物

5

天然产物

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Cat. No. Product Name Target Signaling Pathways
T74893 EGCG-4″-sulfate

EGCG-4″-sulfate,作为绿茶中的主要多酚成分,具有抑制细胞增殖和诱导细胞凋亡的功能。它通过抑制谷氨酸脱氢酶1/2(GDH1/2, GLUD1/2)活性,发挥作用。此外,EGCG-4″-sulfate在对抗结直肠癌、髓性白血病、甲状腺癌等多种癌症中显示出显著的抗癌、抗氧化和抗炎效果[2]。
T41290 MST-312

Telomerase Inhibitor IX

Telomerase DNA Damage/DNA Repair
MST-312 (Telomerase Inhibitor IX) 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的衍生物。MST-312 是 telomerase 抑制剂,可用于肿瘤的研究,如多发性骨髓瘤 (MM)。
T21854 Proteasome inhibitor IX

PS-IX,AM114

Proteasome Proteases/Proteasome; Ubiquitination
Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物,对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用,IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长,IC50为 1.49 μM,显示出有效的抗癌活性。

化合物

EGCG-4″-sulfate
Cat.No: T74893
Synonym:
Target:
MST-312
Cat.No: T41290
Synonym: Telomerase Inhibitor IX
Target: Telomerase
Proteasome inhibitor IX
Cat.No: T21854
Synonym: PS-IX,AM114
Target: Proteasome
Cat. No. Product Name Target Signaling Pathways
T8160 EGCG Octaacetate

乙酰化表没食子儿茶素没食子酸酯,乙酰化EGCG

Others; Antibacterial Microbiology/Virology; Others
EGCG Octaacetate 是表没食子儿茶素没食子酸酯的前药,对革兰氏阳性菌和革兰氏阴性菌有潜在抗菌可能。它可下调 PI3K/Akt/NFκB 磷酸化和 p65 乙酰化来降低促炎介质水平,减少小鼠结肠炎引起的结肠癌。
TN1608 (-)-Epigallocatechin-3-(3''-O-methyl) gallate

(-)-EGCG-3''-O-ME

Antioxidant; Antibacterial Microbiology/Virology; oxidation-reduction
(-)-Epigallocatechin-3-(3''-O-methyl) gallate ((-)-EGCG-3''-O-ME) 是从茶叶中分离出的一种天然产物,具有很强的抗氧化、细胞毒性和抗菌活性,可增强蚀刻漂洗粘合剂与牙本质的粘合稳定性。
T2988 (-)-Epigallocatechin Gallate

Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG

Ferroptosis; Reactive Oxygen Species; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite; Autophagy Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
(-)-Epigallocatechin Gallate (EGCG) 是茶类黄酮,具有强大的抗氧化,抗炎和抗癌作用。它可抑制EGFR 信号传导,有抗癌作用。它是谷氨酸脱氢酶 1/2 抑制剂。它通过激活细胞色素c 氧化酶来诱导氧化磷酸化。
TN6613 Delphinidin-3-O-galactoside chloride

Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity. D3G is capable of masking the EGCG-induced cytotoxicity and ER stress, presumably
TN2977 3-O-trans-p-Coumaroyltormentic acid

Caspase; Antifection Apoptosis; Microbiology/Virology; Proteases/Proteasome
3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

EGCG Octaacetate
Cat.No: T8160
Synonym: 乙酰化表没食子儿茶素没食子酸酯,乙酰化EGCG
Target: Others, Antibacterial
(-)-Epigallocatechin-3-(3''-O-methyl) gallate
Cat.No: TN1608
Synonym: (-)-EGCG-3''-O-ME
Target: Antioxidant, Antibacterial
(-)-Epigallocatechin Gallate
Cat.No: T2988
Synonym: Epigallocatechol Gallate,(-)-表没食子儿茶素没食子酸酯,EGCG
Target: Ferroptosis, Reactive Oxygen Species, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite, Autophagy
Delphinidin-3-O-galactoside chloride
Cat.No: TN6613
Synonym:
Target:
3-O-trans-p-Coumaroyltormentic acid
Cat.No: TN2977
Synonym:
Target: Caspase, Antifection
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