Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TASIN-1 Hydrochloride (TASIN-1 HCl) 是一种截短型 APC 的选择性抑制剂,通过降低细胞胆固醇水平和通过结肠癌细胞中的 ER 应激/ROS/JNK 信号传导诱导凋亡细胞死亡来选择性杀死表达截短型 APC 的结肠直肠癌细胞。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 997 | 现货 | ||
5 mg | ¥ 1,990 | 现货 | ||
10 mg | ¥ 3,210 | 现货 | ||
25 mg | ¥ 4,990 | 现货 | ||
50 mg | ¥ 6,960 | 现货 | ||
100 mg | ¥ 9,580 | 现货 | ||
500 mg | ¥ 18,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,990 | 现货 |
产品描述 | TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells. |
靶点活性 | APC:70 nM(DLD1 cells) |
体内活性 | In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1]. |
别名 | 塔辛-1盐酸盐, TASIN-1 HCl, TASIN 1 HCl, TASIN1 HCl |
分子量 | 388.95 |
分子式 | C18H29ClN2O3S |
CAS No. | 1678515-13-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (141.41 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.571 mL | 12.8551 mL | 25.7102 mL | 64.2756 mL |
5 mM | 0.5142 mL | 2.571 mL | 5.142 mL | 12.8551 mL | |
10 mM | 0.2571 mL | 1.2855 mL | 2.571 mL | 6.4276 mL | |
20 mM | 0.1286 mL | 0.6428 mL | 1.2855 mL | 3.2138 mL | |
50 mM | 0.0514 mL | 0.2571 mL | 0.5142 mL | 1.2855 mL | |
100 mM | 0.0257 mL | 0.1286 mL | 0.2571 mL | 0.6428 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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