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29

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72306	Mycobacterial Zmp1-IN-1
	Mycobacterial Zmp1-IN-1 是一种分枝杆菌锌金属蛋白酶-1(Zmp1)抑制剂。Mycobacterial Zmp1-IN-1 对 MtbH37Ra 具有剂量依赖性抑制的抗分枝杆菌活性。Mycobacterial Zmp1-IN-1 可用于结核病 (TB) 的研究。
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T60073	Antimycobacterial agent-4 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide	Antibacterial	Microbiology/Virology
	Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) 对结核分枝杆菌具有抗菌活性。
T63420	Antimycobacterial agent-2
	Antimycobacterial agent-2 是有效的抗分枝杆菌剂，对结核分枝杆菌 (M.tb) H37Rv 的MIC99为 0.8 μM。Antimycobacterial agent-2 具有出细胞毒作用，能够作用于 CHO 细胞 (IC50: 48.1 μM)。
T63865	Antimycobacterial agent-3
	Antimycobacterial agent-3 是一种抗分枝杆菌 (antimycobacterial) 剂，细胞毒性较低。Antimycobacterial agent-3 能够有效作用于药敏的 MTB 菌株 H37Rv 和耐药的临床分离株 (MIC< 0.029-0.110 μM)。
T61853	Antimycobacterial agent-1
	Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg/ml. Notably, antimycobacterial agent-1 exhibits low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg/ml in Vero cells [1].
T79281	Antimycobacterial agent-6
	Antimycobacterial agent-6 (compound 25) 是抗结核药物，针对野生型及氟喹诺酮耐药的结核分枝杆菌 (Mtb) 株有效。此化合物对 Mtb DprE1-C387S 突变具有抑制作用，其最小抑菌浓度（MIC90）对 H37Rv 和 MoxR 株均为 0.9 μM，对 DprE1-P116S 株为 0.5 μM。
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T78748	MtUng-IN-1	Antibacterial	Microbiology/Virology
	MtUng-IN-1（Compound 18a）可抑制分枝杆菌尿嘧啶DNA糖基化酶（MtUng），IC50值为300 μM。MtUng-IN-1适用于癌症和传染病研究领域。
T8411	C-215	Others	Others
	C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性，对哺乳动物细胞的非特异性毒性较低，对结核分枝杆菌的IC90=16 μM，并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。
T12231	NITD-349	Others; Antibacterial	Microbiology/Virology; Others
	NITD-349 是MmpL3的抑制剂，它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性，MIC50 为 23 nM。
T0377	Clofazimine NSC-141046,氯法齐明,氯苯吩嗪	DNA; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Clofazimine (NSC-141046) 是一种具有显著的抗炎效果的亚氨基酚嗪类染料，与其它抗分支杆菌药物联用来治疗AIDS 和克罗恩病。
T29249	(+)-Xylariamide A Xylariamide-A,ent Xylariamide A,ent-Xylariamide A,Xylariamide A
	(+)-Xylariamide A is a probe used for mycobacterial and fungal carbonic anhydrase.
T61676	4-Piperidinecarboxamide
	4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1].
T61149	Antibacterial agent 121
	Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications in Tuberculosis (TB) research [1].
T10563L2	BM635 mesylate (1493762-74-5 free base) BM635 mesylate	Others	Others
	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T61772	PknB-IN-1
	PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growth of M. tuberculosis H37Rv strain, with a minimum inhibitory concentration (MIC) of 6.2 μg/mL [1].
T10887	CRS400393	Antibacterial	Microbiology/Virology
	CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.
T36357	Dimethyldioctadecylammonium (bromide)
	Dimethyldioctadecylammonium (DDA) is a cationic amphipathic lipid. DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at an intramuscular or subcutaneous injection site in mice, increasing immune cell exposure to the antigen. In a guinea pig model of M. tuberculosis infection, spleen bacterial load is reduced and lung and spleen lesion numbers are decreased when the mycobacterial lipid antigens Ac2SGL and PIM2 are administered in liposomes comprised of DDA and a synthetic...
T60690	Antibacterial agent 122
	Antibacterial agent 122 (compound 15) 是一种硫脲衍生物，可用于研究结核病。Antibacterial agent 122 表现出低细胞毒性，并且具有抗分枝杆菌活性。
T10563L	BM635 hydrochloride (1493762-74-5 free base) BM635 hydrochloride	Others	Others
	BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10563	BM635	Others	Others
	BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T61665	Antibacterial agent 118
	Antibacterial agent 118 (also known as compound 20) is a potent antimycobacterial compound with activity against various mycobacterial strains, including Mtb H37Ra, M. aurum, M. smegmatis, Mtb H37Rv, and M. avium. The minimum inhibitory concentration (MIC) values for Antibacterial agent 118 against these strains are 40.7 μM, 10.2 μM, 163.0 μM, 62.5 μM, and 62.5 μM, respectively. This compound holds potential for tuberculosis research [1].
T10992	Delamanid D4 OPC-67683 D4	Others	Others
	Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.
T63786	WX-081
	WX-081 是抗结核剂 (anti-tuberculosis)，对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果，并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml)，对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。
T61143	Antitubercular agent-18
	Antitubercular agent-18 (Compound 9a) 为抗结核剂，对M. tuberculosisH37Rv、Spec. 192、Spec 210 及 Spec. 800 的最小抑制浓度(MIC)值依次为2、2、2 及128 μg/ml，展现出对分支杆菌的高选择性抗菌活性。
T61303	MmpL3-IN-1
	MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].
T73986	ONX-0914 TFA
	ONX-0914 (PR-957) TFA 为针对免疫蛋白酶体中的LMP7（低分子量多肽-7）的选择性抑制剂，LMP7为类糜蛋白酶亚单位。该化合物通过抑制细胞因子产生，减缓实验性关节炎进展，并已证实为分枝杆菌蛋白酶体的非竞争性不可逆抑制剂（Ki=5.2 μM）。此外，ONX-0914 TFA 能通过HSF-1介导的p-TEFb活化，激活潜伏的HIV-1。
T79441	DprE1-IN-6
	DprE1-IN-6（Compound 56）是DprE1的一种抑制剂，对Mtb H37Rv菌株表现出抗结核活性（MIC: 4 μM），同时也对耐药分枝杆菌株有抗菌效果。该化合物具有较强的微粒体稳定性以及中等的清除速率。

化合物

Mycobacterial Zmp1-IN-1

Cat.No: T72306

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

Antimycobacterial agent-4

Cat.No: T60073

Synonym: 4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide

Target: Antibacterial

Antimycobacterial agent-2

Cat.No: T63420

Antimycobacterial agent-3

Cat.No: T63865

Antimycobacterial agent-1

Cat.No: T61853

Antimycobacterial agent-6

Cat.No: T79281

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

Cat.No: T78748

Target: Antibacterial

Cat.No: T8411

Target: Others

Cat.No: T12231

Target: Others, Antibacterial

Cat.No: T0377

Synonym: NSC-141046,氯法齐明,氯苯吩嗪

Target: DNA, Antibacterial, Antibiotic

(+)-Xylariamide A

Cat.No: T29249

Synonym: Xylariamide-A,ent Xylariamide A,ent-Xylariamide A,Xylariamide A

4-Piperidinecarboxamide

Cat.No: T61676

Antibacterial agent 121

Cat.No: T61149

BM635 mesylate (1493762-74-5 free base)

Cat.No: T10563L2

Synonym: BM635 mesylate

Target: Others

Cat.No: T61772

Cat.No: T10887

Target: Antibacterial

Dimethyldioctadecylammonium (bromide)

Cat.No: T36357

Antibacterial agent 122

Cat.No: T60690

BM635 hydrochloride (1493762-74-5 free base)

Cat.No: T10563L

Synonym: BM635 hydrochloride

Target: Others

Cat.No: T10563

Target: Others

Antibacterial agent 118

Cat.No: T61665

Cat.No: T10992

Synonym: OPC-67683 D4

Target: Others

Cat.No: T63786

Antitubercular agent-18

Cat.No: T61143

Cat.No: T61303

Cat.No: T73986

Cat.No: T79441

Cat. No.	Product Name	Target	Signaling Pathways
TN1040	Skullcapflavone II	COX; Antibacterial; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells
	Skullcapflavone II 是从黄芩中提取的黄酮，具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。
T10662L	Calcimycin Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187	Apoptosis; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Microbiology/Virology
	Calcimycin (A-23187) 是抗生素和二价阳离子离子载体。它抑制革兰氏阳性细菌和一些真菌生长，也抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化。它通过增加细胞内钙浓度诱导 Ca2+依赖性细胞死亡。
T8229	5,7,3',4'-Tetramethoxyflavone 木犀草素四甲醚,3,4,5,7-四甲氧基黄酮	Antibacterial; Parasite; Antifungal	Microbiology/Virology
	5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflammatory properties. Moreover, TMF specifically targets β-catenin signaling to exhibit chondroprotective activity.
T4S1545	Licarin B (-)-Licarin B,Licarine B,(-)-利卡灵B	transporter; Antibacterial; PPAR	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Licarin B (Licarine B) 是来源于肉豆蔻种子的一种天然产物，是 NO 生成抑制剂，可通过激活 IRS-1/PI3K/AKT 通路中的PPARγ和GLUT4 改善胰岛素敏感性。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
TN1556	Decarine	Antifection	Microbiology/Virology
	Decarine has high antibacterial activity against mycobacterial, gram-positive and gram-negative bacteria, and low cytotoxicity towards human macrophages.Decarine inhibits fMLP/CB-induced elastase release with IC(50) values < or = 5.53 microg/mL.
TN3691	Communic acid	MMP; MAPK; Akt; PI3K; DNA/RNA Synthesis; Antifection	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
T72742	(-)-Pinocembrin (-)-乔松素
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。

天然产物

Skullcapflavone II

Cat.No: TN1040

Target: COX, Antibacterial, TGF-beta/Smad

Cat.No: T10662L

Synonym: Antibiotic A-23187,离子载体(钙镁盐混合物),A-23187

Target: Apoptosis, Antibacterial, Antibiotic, Autophagy, Antifungal

5,7,3',4'-Tetramethoxyflavone

Cat.No: T8229

Synonym: 木犀草素四甲醚,3,4,5,7-四甲氧基黄酮

Target: Antibacterial, Parasite, Antifungal

Cat.No: T4S1545

Synonym: (-)-Licarin B,Licarine B,(-)-利卡灵B

Target: transporter, Antibacterial, PPAR

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Cat.No: TN1556

Target: Antifection

Cat.No: TN3691

Target: MMP, MAPK, Akt, PI3K, DNA/RNA Synthesis, Antifection

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

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