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Tissue Factor Protein, Human, Recombinant (aa 1-295, His)

产品编号 TMPY-05083

别名: coagulation factor 3, TF, TFA, coagulation factor III, coagulation factor III (thromboplastin, tissue factor), CD142

Tissue Factor Protein, Human, Recombinant (aa 1-295, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P13726-1.

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Tissue Factor Protein, Human, Recombinant (aa 1-295, His)

规格	价格/CNY		货期	数量
50 μg	￥ 5,750		5日内发货

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生物活性	Testing in progress
产品描述	Tissue Factor Protein, Human, Recombinant (aa 1-295, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 31 kDa and the accession number is P13726-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	P13726-1
别名	coagulation factor 3, TF, TFA, coagulation factor III, coagulation factor III (thromboplastin, tissue factor), CD142
蛋白构建	The Human F3 (NP_001984.1) (Met1-Ser295) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	31 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions.

参考文献

1. Morrissey JH. (2004) Tissue factor: a key molecule in hemostatic and nonhemostatic systems. Int J Hematol. 79(2): 103-8. 2. Milsom C,et al.(2008) Tissue factor and cancer. Pathophysiol Haemost Thromb. 36(3-4): 160-76. 3. Kasthuri RS,et al.(2009) Role of tissue factor in cancer. J Clin Oncol. 27(29): 4834-8.

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Keywords

Tissue Factor Protein, Human, Recombinant (aa 1-295, His) coagulation factor 3 TF thromboplastin, tissue factor CD 142 TFA coagulation factor III CD-142 coagulation factor III (thromboplastin, tissue factor) CD142 recombinant recombinant-proteins proteins protein

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