Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Cat. No.	Product Name	CAS No.	Purity
T7660	IDO inhibitor 1 化合物IDO inhibitor 1	1204669-37-3	99.16%
T7660	IDO inhibitor 1 是一种有效的吲哚胺-2,3 双加氧酶 (IDO) 抑制剂 (IC50 <100 nM)。具有潜在的免疫调节和抗肿瘤活性。
T39476	NLG802 化合物NLG802	2071683-99-1	99.08%
T39476	NLG802 是 indoximod 的前药，indoximod 是一种口服活性的吲哚胺2,3-双加氧酶（IDO）抑制剂。
T5S0056	Coptisine chloride 盐酸黄连碱	6020-18-4	98.85%
T5S0056	Coptisine chloride (NSC-119754) 是从黄连中分离到的一种生物碱，是一种非竞争性 IDO 抑制剂，Ki 值为 5.8 μM，IC50值为 6.3 μM。它是一种 H1N1 神经氨酸酶抑制剂，可用于甲型流感病毒感染，IC50为 104.6 μg/mL。
T3548	Epacadostat 艾卡哚司他	1204669-58-8	98.56%
T3548	Epacadostat (INCB 024360) 是选择性的IDO1抑制剂，IC50=71.8 nM。
T9164	BMS-986242 化合物BMS-986242	1923844-48-7	98.25%
T9164	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T7181	IDO-IN-1 化合物IDO-IN-1	914638-30-5	98%
T7181	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T4S0051	Coptisine sulfate 硫酸黄连碱	1198398-71-8	98%
T4S0051	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T11901	IDO1-IN-5 化合物IDO1-IN-5	2166616-75-5	96.7%
T11901	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T3S1967	(S)-Indoximod 相思子碱	21339-55-9	95.39%
T3S1967	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T2647	IDO5L 化合物INCB024360 analogue	914471-09-3	100%
T2647	IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。