P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.

Cat. No.	Product Name	CAS No.	Purity
TCS2336	Evodine 吴茱萸内酯	6989-38-4
TCS2336	Evodine 是吴茱萸中的主要柠檬苦素，是P-gp 有效抑制剂，可通过保留抗氧化剂防御系统，针对谷氨酸诱导的毒性具有保护作用。
TN2257	Tanshinone IIB 化合物Tanshinone IIB	17397-93-2	98%
TN2257	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4410	Lappaol C 化合物 TN4410	64855-00-1	98%
TN4410	Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also ...
TN2726	Jatrophane 5 化合物 TN2726	210108-89-7	98%
TN2726	Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-Tx...
TQ0043	Dofequidar 化合物Dofequidar	129716-58-1	98%
TQ0043	Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
TN5124	Taxuspine X 化合物 TN5124	194782-02-0	98%
TN5124	Taxuspine X may have p-glycoprotein inhibitory activity.
TN5114	Taxinine 化合物 TN5114	3835-52-7	98%
TN5114	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN4819	(-)-Praeruptorin A 化合物 TN4819	14017-71-1	98%
TN4819	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depen...
TN4749	Pepluanin A 化合物 TN4749	670257-89-3	98%
TN4749	Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated dauno...
TN4411	Lappaol F 化合物 TN4411	69394-17-8	98%
TN4411	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. 2. Lap...
TN1099	Dihydroevocarpine 二氢吴茱萸卡品碱	15266-35-0	98%
TN1099	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
TN3937	Ent-16alpha,17-Dihydroxyatisan-3-one 化合物 TN3937	112523-91-8	98%
TN3937	ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymp...
TN2263	Tenacigenin B 通光藤甙元乙	80508-42-5	98%
TN2263	Tenacigenin B是一种天然产物，属于萝藦科牛奶菜属，其产品编号为 TN2263，CAS号为 80508-42-5。Tenacigenin B可用作对照参考。
TN2727	Jatrophane 2 化合物 TN2727	210108-86-4	98%
TN2727	2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fee...
TN1072	Lappaol A 牛蒡酚A	62333-08-8	98%
TN1072	Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
T16561	Polyoxyethylene stearate 聚氧乙烯硬脂酸酯	9004-99-3	polymer
T16561	Polyoxyethylene stearate (POES) 是一种非离子乳化剂。
T8426	Encequidar 化合物Encequidar	849675-66-7	99.93%
T8426	Encequidar (HM30181A) 是一种选择性 P-糖蛋白抑制剂。
T72055	FM04 化合物FM04	1807320-40-6	99.84%
T72055	FM04 是一种具有口服活性和高效性的 P-糖蛋白 (P-gp) 抑制剂，EC50 值为 83 nM。FM04 可以与人P-gp核苷酸结合域2（NBD2）中的Q1193和I1115相互作用。从而破坏 R262-Q1081-Q1118 相互作用口袋并解偶联 ICL2-NBD2 相互作用，从而抑制 P-gp。FM04 可用...
T1010	Verapamil hydrochloride 盐酸维拉帕米	152-11-4	99.79%
T1010	Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。
T0100L	Atazanavir 阿扎那韦	198904-31-3	99.76%
T0100L	Atazanavir (BMS-232632) 是一种高选择性的HIV-1蛋白酶抑制剂，可研究艾滋病毒感染。它也是SARS-CoV 3CLpro 的抑制剂，IC50为 3.49 μM。它是CYP3A4的底物和抑制剂，也是P-糖蛋白的抑制剂和诱导剂。