PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product Name	CAS No.	Purity
T14352	Autotaxin-IN-1 化合物 T14352	1619971-30-0	98%
T14352	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treat...
T10481L	BAY 73-6691 化合物 T10481L	794568-92-6	98%
T10481L	BAY 73-6691 is an inhibitor of brain penetrant PDE9A.
T13232	TyK2-IN-2 化合物 T13232	2098466-94-3	98%
T13232	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
T38108	Fulvic Acid 黄腐酸	479-66-3	98%
T38108	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系...
T15766	Lirimilast 化合物 T15766	329306-27-6	98%
T15766	Lirimilast is an effective, selective, and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 49 nM). Lirimilast has potently anti-inflammatory properties...
TN1843	Kushenol K 苦参醇K	101236-49-1	98%
TN1843	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K s...
T16976	TAK-915 化合物 T16976	1476727-50-0	98%
T16976	TAK-915 is a potent, selective, and brain-penetrant phosphodiesterase 2A (PDE2A) inhibitor (IC50: 0.61 nM). TAK-915 is >4100-fold more selectivity for PDE2A than...
T10416	Autotaxin-IN-4 化合物 T10416	2156655-86-4	98%
T10416	Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T10417	Autotaxin-IN-5 化合物 T10417	2156655-99-9	98%
T10417	Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T15640	K134 化合物 T15640	189362-06-9	98%
T15640	K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.
T16272	Naproxen etemesil 化合物 T16272	385800-16-8	98%
T16272	Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naprox...
T10994L2	Deltasonamide 2 (TFA) 化合物 T10994L2	2235358-74-2	98%
T10994L2	Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
T10350	Apremilast-d5 化合物 T10350	1258597-47-5	98%
T10350	Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α rele...
T9805	BAY 2666605 化合物BAY 2666605	2275774-60-0	99.98%
T9805	BAY 2666605 是一种具有口服活性的 PDE3A 和 PDE3B 抑制剂，IC50 分别为 87 nM 和 50 nM。 BAY 2666605 具有抗癌作用。
TN2159	Robustine 大叶桉亭	2255-50-7	99.97%
TN2159	Robustine 是一种从 Dictamnus albus 获得的呋喃喹啉生物碱，在体外对人磷酸二酯酶 5 (hPDE5A) 具有抑制作用。
T0080	Trapidil 唑嘧胺	15421-84-8	99.96%
T0080	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T2205	Acefylline 茶碱乙酸	652-37-9	99.95%
T2205	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
T1681	Aminophylline 氨茶碱	317-34-0	99.94%
T1681	Aminophylline (Phyllocontin) 是一种竞争性非选择性磷酸二酯酶抑制剂，具有支气管扩张作用。它是竞争性的腺苷受体拮抗剂，有用于哮喘研究的潜力。
T1096	Milrinone 米力农	78415-72-2	99.93%
T1096	Milrinone (Win 47203) 是一种 PDE3抑制剂，也是一种强心药、血管舒张药。
TN6120	Nauclefine 牛蒡子苷	57103-51-2	99.92%
TN6120	Nauclefine (Parvine) 是一种植物吲哚生物碱天然产物，可通过 PDE3A-SLFN12 依赖性死亡途径诱导多种癌细胞的凋亡。 Nauclefine 结合 PDE3A 但不抑制 PDE3A 的磷酸二酯酶活性。