NMDAR

The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane. The NMDA receptor is very important for controlling synaptic plasticity and memory function.The NMDAR is a specific type of ionotropic glutamate receptor. The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. While the opening and closing of the ion channel is primarily gated by ligand binding, the current flow through the ion channel is voltage dependent. Extracellular magnesium (Mg2+) and zinc (Zn2+) ions can bind to specific sites on the receptor, blocking the passage of other cations through the open ion channel. Depolarization of the cell dislodges and repels the Mg2+ and Zn2+ ions from the pore, thus allowing a voltage-dependent flow of sodium (Na+) and small amounts of calcium (Ca2+) ions into the cell and potassium (K+) out of the cell.

Cat. No.	Product Name	CAS No.	Purity
T22748	DQP 1105 化合物DQP 1105	380560-89-4	98.77%
T22748	DQP 1105 是一种高效非竞争性NMDA 受体拮抗剂。DQP-1105 抑制含有 GluN2C (IC50:7.0 Μm) 和 GluN2D (IC50:2.7 Μm) 的受体。 IC50值至少比重组 GluN2B-、GluN2A-、GluA1- 或 GluK2 受体低 50 倍。
T28367L1	BDBM50597431 化合物BDBM50597431	1629853-49-1	98.64%
T28367L1	BDBM50597431 是一种 NMDA 受体调节剂，可能具有可用于研究阿尔滋海默症和帕金森综合征。
T23048	N20C hydrochloride 盐酸N20C	1177583-87-7	98.58%
T23048	N20C hydrochloride (2-((3,3-diphenylpropyl)amino)acetamide hydrochloride) 是一种非竞争性 NMDA 受体开放通道阻滞剂。
T22900	L-701252 化合物L-701252	151057-13-5	98.53%
T22900	L-701252 是一种有效的甘氨酸位点 NMDA 受体拮抗剂，IC50 值为 420 nM。L-701252 对全脑缺血提供小范围的神经保护。
T22674	Co 101244 hydrochloride Co 101244盐酸盐	193356-17-1	98.44%
T22674	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) 是一种含有 NR2B 的 NMDA 受体拮抗剂。
T24918	UBP710 化合物UBP710	1333111-40-2	98.39%
T24918	UBP710 是一种有效的选择性 NMDA 受体调节剂。
T9133	Caroverine hydrochloride 化合物Caroverine HCL	55750-05-5	98.37%
T9133	Caroverine hydrochloride (Caroverine HCL) 是竞争性可逆的NMDA 和AMPA 谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。
T13248	UK-240455 化合物UK-240455	178908-09-3	98.34%
T13248	UK-240455是一种有效的且具有选择性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸受体拮抗剂，具有神经保护作用和改善帕金森病模型的运动的功能，是治疗帕金森病的潜在候选化合物。
T26686	AV-101 (S)-4-氯犬尿氨酸	153152-32-0	98.27%
T26686	AV-101 (4-Cl-KYN) 是 NMDA 受体甘氨酸位点的前药拮抗剂，具有抗抑郁活性，可减少 MPTP 猴子中左旋多巴诱导的运动障碍。
T27606	Indantadol HCl Indantadol盐酸盐	202914-18-9	98.24%
T27606	Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。
T62839	Dalzanemdor 化合物Dalzanemdor	1629853-48-0	98.20%
T62839	Dalzanemdor (SAGE-718) 是 NMDA 受体阳性变构调节剂，可用于研究亨廷顿舞蹈病、阿尔茨海默病和认知功能障碍。
T26645	Aptiganel 阿替加奈	137159-92-3	98.19%
T26645	Aptiganel (CNS-1102) 是一种非竞争性 NMDA 拮抗剂，是一种多肽，可用于研究急性缺血性卒中。
T27143	Delucemine Hydrochloride 德芦西明盐酸盐	186495-99-8	98.14%
T27143	Delucemine Hydrochloride (Delucemine) 是一种多胺NMDA受体拮抗剂，可用于研究抑郁症和阿尔茨海默症等神经系统疾病。
T12110	MRZ 2-514 化合物MRZ 2-514	202808-11-5	98.13%
T12110	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) 是 NMDA receptor(glycineB) 的拮抗剂，Ki=33 μM。
T9626	Cycloleucine 环亮氨酸	52-52-8	98.13%
T9626	Cycloleucine 是 NMDA 受体相关甘氨酸受体的拮抗剂，Ki 为 600 μM。Cycloleucine 也是 S-腺苷甲硫氨酸介导的甲基化的竞争性抑制剂，具有抗焦虑和细胞抑制作用。
T1909	L-701324 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉	142326-59-8	98%
T1909	L-701324 是一种 NMDA 受体，对甘氨酸位点具有高亲和力和选择性，用作口服活性和长效抗惊厥药。
T0802	Procaine hydrochloride 盐酸普鲁卡因	51-05-8	98%
T0802	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T7778	Glypromate 甘氨酰-脯氨酰-谷氨酸	32302-76-4	98%
T7778	Glypromate (Gly-Pro-Glu) 是一种神经保护剂，是一种弱 NMDA 受体激动剂。
TN1432	Bacopasaponin C 假马齿苋皂苷C	178064-13-6	97.85%
TN1432	Bacopasaponin C 是一种分离自Bacopa monniera 中的天然糖苷，具有抗肿瘤和抗利什曼原虫作用。
T12234	NMDA-IN-1 化合物NMDA-IN-1	700878-19-9	97.01%
T12234	NMDA-IN-1是一种 NR2B 选择性 NMDA 拮抗剂，对NMDA 的Ki 值为 0.85 nM，对NR2B Ca2+ influx 的IC50值为 9.7 nM。