IκB/IKK

The IκB kinase (IKK) is an enzyme complex that is involved in propagating the cellular response to inflammation.The IκB kinase enzyme complex is part of the upstream NF-κB signal transduction cascade. The IκBα (inhibitor of nuclear factor kappa B) protein inactivates the NF-κB transcription factor by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. Specifically, IKK phosphorylates the inhibitory IκBα protein. This phosphorylation results in the dissociation of IκBα from NF-κB. NF-κB, which is now free, migrates into the nucleus and activates the expression of at least 150 genes; some of which are anti-apoptotic.

Cat. No.	Product Name	CAS No.	Purity
TN3726	Cudraflavone B 化合物 TN3726	19275-49-1	98%
TN3726	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
T12659	(Rac)-BAY-985 化合物 T12659	2101925-20-4	98%
T12659	(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.
TN3517	Bisacurone 化合物 TN3517	120681-81-4	98%
TN3517	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN5153	Torilin 窃衣素	13018-10-5	98%
TN5153	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF...
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3486	Bakkenolide IIIa 化合物 TN3486	915289-60-0	98%
TN3486	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB...
TN3806	Dehydroglyasperin C 化合物 TN3806	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN4635	Neoechinulin A 化合物 TN4635	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
TD0099	Malachite green oxalate 孔雀石绿草酸盐	2437-29-8	N/A
TD0099	Malachite green oxalate 是一种三苯基甲烷染料，可用于检测酶促反应中磷酸盐的释放。它也是一种选择性IKBKE 抑制剂，在体内外均表现出抗肿瘤活性。
T7951	TBK1/IKKε-IN-5 化合物TBK1/IKKε-IN-5	1893397-65-3	99.93%
T7951	TBK1/IKKε-IN-5 是一种 TBK1 (IC50:1 nM) 和 IKKε (IC50:5.6 nM) 的双抑制剂。
T8542	BMS-345541 hydrochloride 化合物BMS-345541 hydrochloride	547757-23-3	99.92%
T8542	BMS-345541 hydrochloride 是选择性的 IKK 催化亚基 IKK-1 和 IKK-2 抑制剂，抑制 IKK-2 (IC50=0.3 nM) 和 IKK-1 (IC50=4 nM)。它与 IKK 的变构位点结合。
T1558	Resveratrol 白藜芦醇	501-36-0	99.9%
T1558	Resveratrol (SRT 501) 属于多酚类天然产物，是一种植物抗毒素，具有抗氧化和化学预防活性。Resveratrol 的靶点广泛，包括 COX、SIRT、LOC 等。Resveratrol 可以诱导细胞自噬和凋亡。
T2118	SC-514 化合物SC-514	354812-17-2	99.88%
T2118	SC-514 (GK 01140) 是 IKK-2 的选择性抑制剂 (IC50=11.2 μM)，不抑制其他 IKK 亚型或其他丝氨酸-苏氨酸和酪氨酸激酶。
T2833	Dehydrocostus Lactone 去氢木香烃内酯	477-43-0	99.86%
T2833	Dehydrocostus Lactone ((-)-Dehydrocostus lactone) 是一种倍半萜内酯，从云木香中分离得到。
T2106	WS6 化合物WS6	1421227-53-3	99.83%
T2106	WS6 是一种具有促beta 细胞增生作用的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。
T5540	GSK8612 化合物GSK8612	2361659-62-1	99.8%
T5540	GSK8612 是一种具有高度选择性的TBK1强效抑制剂，其 pIC50=6.8。
T0097	MRT67307 化合物MRT67307	1190378-57-4	99.79%
T0097	MRT67307 是一种IKKε和TBK-1的双抑制剂，IC50分别为 160 和 19 nM。它抑制细胞自噬，也可抑制ULK1和ULK2，IC50分别为 45 和 38 nM。
T15564	IMD-0560 化合物IMD-0560	439144-66-8	99.78%
T15564	IMD-0560 是新型 IκB kinase β抑制剂。
T3736	Olivetol 橄榄醇	500-66-3	99.74%
T3736	Olivetol (5-n-Amylresorcinol) 是天然多酚类化合物，存在于地衣中，或由一些昆虫产生。它竞争性地抑制大麻素受体CB1和CB2，抑制 CYP2C19 (IC50=15.3 μM;Ki=7.21 μM) 和 CYP2D6 (IC50=2.71 μM;Ki=2.87 μM) 的活性。
T25465	GS143 化合物GS-143	916232-21-8	99.72%
T25465	GS-143 是选择性的IκBα泛素化抑制剂，抑制 SCFβTrCP1介导的IκBα泛素化作用，IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录，并且不抑制蛋白酶体的特性，并具有抗哮喘作用。