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HDAC

HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T14947 CHDI-390576
化合物 T14947
1629729-98-1 98%
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T14936 Ivaltinostat
化合物 T14936
936221-33-9 98%
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T11542 HDAC-IN-4
化合物 T11542
1252003-13-6 98%
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T10602 BRD 4354 ditrifluoroacetate
化合物 T10602
T10602 98%
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T2S0606 Bakkenolide A
蜂斗菜内酯A
19906-72-0 98%
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T11543 HDAC-IN-5
化合物 T11543
1314890-51-1 98%
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T11544 HDACs/mTOR Inhibitor 1
化合物 T11544
2271413-06-8 98%
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
T72872 HDAC/BET-IN-1
化合物 HDAC/BET-IN-1
2757573-68-3 98%
HDAC/BET-IN-1表现出对HDAC1 (IC50= 0.163 μM) 和HDAC6 (IC50= 0.067 μM) 的亚微摩尔级别抑制作用,以及对BRD4 (Ki= 0.076 μM) 的抑制活性,同时也显示出显著的抗白血病活性。
T73454 SAHA-OH
化合物 SAHA-OH
2857098-30-5 98%
SAHA-OH为HDAC6选择性抑制剂(IC50=23 nM),对HDAC6具有10至47倍选择性,相较于HDAC1、2、3及8。该化合物展现抗炎活性,能够降低巨噬细胞凋亡。
T74617 HDAC6-IN-8
化合物 HDAC6-IN-8
2796282-49-8 98%
Compound 12c has been synthesized with modifications to the Cap group and exhibits broad-spectrum enzyme inhibitory activity as evidenced by enzyme inhibition as...
T74783 HDAC-IN-53
化合物 HDAC-IN-53
2921948-27-6 98%
HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂,其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9;IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长,同时抑制携带...
T9959 Suprastat
化合物Suprastat
90093-40-6 98%
Suprastat 是一种 HDAC6 抑制剂,可用于计算机模拟。
T6637 Resminostat
马西替坦
864814-88-0 98%
Resminostat (4SC-201) 是一种可口服的HDAC1、HDAC3和HDAC6抑制剂,IC50值分别为 42.5、50.1和71.8 nM,具有潜在抗肿瘤活性。
T16805 RTS-V5
化合物 T16805
2285346-31-6 98%
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
T16415 Oxamflatin
化合物 T16415
151720-43-3 98%
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
T2205 Acefylline
茶碱乙酸
652-37-9 99.95%
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
T2157 M344
化合物Histone Deacetylase Inhibitor III
251456-60-7 99.95%
M344 (Histone Deacetylase Inhibitor III) 是一种组蛋白去乙酰化酶抑制剂,IC50为 100 nM。
T1583 Vorinostat
伏立诺他
149647-78-9 99.93%
Vorinostat (suberoylanilide hydroxamic acid) 是一种具有抗肿瘤活性的组蛋白脱乙酰酶泛抑制剂,IC50值约为 10 nM。
T1852 Rac-Belinostat
化合物Belinostat
414864-00-9 99.93%
Rac-Belinostat (PX-105684) 是一种具有抗肿瘤活性的新型异羟肟酸型组蛋白脱乙酰酶 (HDAC) 抑制剂。 Belinostat 靶向 HDAC 酶,从而抑制肿瘤细胞增殖、诱导细胞凋亡、促进细胞分化和抑制血管生成。这种药物可以使耐药肿瘤细胞对其他抗肿瘤药物敏感,可能是通过一种涉及胸苷酸合酶下调的机制...
T1535 Sodium 4-phenylbutyrate
苯丁酸钠
1716-12-7 99.92%
Sodium 4-phenylbutyrate (TriButyrate) 是一种组蛋白去乙酰化酶和内质网应激抑制剂,可研究癌症和感染等疾病。
CHDI-390576
T14947
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
Ivaltinostat
T14936
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
HDAC-IN-4
T11542
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
BRD 4354 ditrifluoroacetate
T10602
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
HDAC-IN-5
T11543
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
HDACs/mTOR Inhibitor 1
T11544
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
HDAC/BET-IN-1
T72872
HDAC/BET-IN-1表现出对HDAC1 (IC50= 0.163 μM) 和HDAC6 (IC50= 0.067 μM) 的亚微摩尔级别抑制作用,以及对BRD4 (Ki= 0.076 μM) 的抑制活性,同时也显示出显著的抗白血病活性。
SAHA-OH
T73454
SAHA-OH为HDAC6选择性抑制剂(IC50=23 nM),对HDAC6具有10至47倍选择性,相较于HDAC1、2、3及8。该化合物展现抗炎活性,能够降低巨噬细胞凋亡。
HDAC6-IN-8
T74617
Compound 12c has been synthesized with modifications to the Cap group and exhibits broad-spectrum enzyme inhibitory activity as evidenced by enzyme inhibition as...
HDAC-IN-53
T74783
HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂,其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9;IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长,同时抑制携带...
Suprastat
T9959
Suprastat 是一种 HDAC6 抑制剂,可用于计算机模拟。
Resminostat
T6637
Resminostat (4SC-201) 是一种可口服的HDAC1、HDAC3和HDAC6抑制剂,IC50值分别为 42.5、50.1和71.8 nM,具有潜在抗肿瘤活性。
RTS-V5
T16805
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
Oxamflatin
T16415
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
Acefylline
T2205
Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物,是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂,也是一种支气管扩张剂,可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
M344
T2157
M344 (Histone Deacetylase Inhibitor III) 是一种组蛋白去乙酰化酶抑制剂,IC50为 100 nM。
Vorinostat
T1583
Vorinostat (suberoylanilide hydroxamic acid) 是一种具有抗肿瘤活性的组蛋白脱乙酰酶泛抑制剂,IC50值约为 10 nM。
Rac-Belinostat
T1852
Rac-Belinostat (PX-105684) 是一种具有抗肿瘤活性的新型异羟肟酸型组蛋白脱乙酰酶 (HDAC) 抑制剂。 Belinostat 靶向 HDAC 酶,从而抑制肿瘤细胞增殖、诱导细胞凋亡、促进细胞分化和抑制血管生成。这种药物可以使耐药肿瘤细胞对其他抗肿瘤药物敏感,可能是通过一种涉及胸苷酸合酶下调的机制...
Sodium 4-phenylbutyrate
T1535
Sodium 4-phenylbutyrate (TriButyrate) 是一种组蛋白去乙酰化酶和内质网应激抑制剂,可研究癌症和感染等疾病。
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