HCV Protease

NS2-3 protease (of hepatitis C virus, HCV) is an enzyme responsible for proteolytic cleavage between NS2 and NS3, which are non-structural proteins that form part of the HCV virus particle. NS3 protease of hepatitis C virus, on the other hand, is responsible for the cleavage of non-structural protein downstream. Both of these proteases are directly involved in HCV genome replication, that is, during the viral life-cycle that leads to virus multiplication in the host that has been infected by the virus.

Cat. No.	Product Name	CAS No.	Purity
TN1033	Sennidin A 番泻苷元A	641-12-3	100%
TN1033	Sennidin A 是从狭叶番泻分离得到的一种天然产物，能够抑制 HCV NS3 解旋酶，其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化，刺激葡萄糖掺入。
TN1138	γ-Fagarine γ-崖椒碱	524-15-2
TN1138	gamma-Fagarine possesses moderate levels of anti-HCV activities with IC50 values being 20.4 ± 0.4 ug/ml, respectively. It has sister chromatid exchanges (SCEs)-i...
TN1034	Sennidin B 番泻苷元B	517-44-2
TN1034	Sennidin B 是从Cassia angustifolia 分离得到的Sennidin A 异构体，它刺激葡萄糖掺入，诱导Akt 和葡萄糖转运蛋白4 的磷酸化。
T5539	GS-443902 瑞德西韦代谢物	1355149-45-9
T5539	Remdesivir triphosphate 是一种有效的病毒 RNA 依赖的 RNA 聚合酶抑制剂，对RSVRdRp 和 HCVRdRp 的IC50分别为 1.1 µM 和 5 µM。它是 Remdesivir 的活性三磷酸代谢物。
TN3809	Dehydrojuncusol 化合物 TN3809	117824-04-1	98%
TN3809	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is acti...
T12966	Sofosbuvir impurity K 索非布韦杂质 K	1496552-51-2	98%
T12966	Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12969	Sofosbuvir impurity N 索非布韦杂质 N	1394157-34-6	98%
T12969	Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12033	Micrococcin P1 微球菌素 P1	67401-56-3	98%
T12033	Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor(EC50 range of 0.1-0.5 μM)
T12965	Sofosbuvir impurity J 索非布韦杂质 J	1334513-10-8	98%
T12965	Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12963	Sofosbuvir impurity H 化合物 T12963	T12963	98%
T12963	Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an...
T10067	2',5-Difluoro-2'-deoxycytidine 化合物 T10067	581772-30-7	98%
T10067	2',5-Difluoro-2'-deoxycytidine has potent anti-HCV activity and toxicity to rRNA.
T12967	Sofosbuvir impurity L 化合物 T12967	T12967	98%
T12967	Sofosbuvir impurity L is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T12968	Sofosbuvir impurity M 索非布韦杂质 M	2095551-10-1	98%
T12968	Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.
T73223	NS5A-IN-3 化合物 NS5A-IN-3	2764786-56-1	98%
T73223	NS5A-IN-3 (Compound 15) 为高效NS5A抑制剂，对HCV基因型1b显示出高效力，并对基因型3a (GT 3a) 活性提升以及展现出良好的代谢稳定性。NS5A-IN-3相较于daclatasvir，对基因型1b具有更高的耐药门槛。
T73834	NS5A-IN-2 化合物 NS5A-IN-2	2764786-74-3	98%
T73834	NS5A-IN-2 (Compound 33)为一种高效的NS5A抑制剂，对HCV基因型1b展现出极高效力，并对基因型3a (GT 3a) 亦具备增强活性与良好的代谢稳定性。
T16675	PSI-352938 化合物 T16675	1231747-17-3	98%
T16675	PSI-352938 is an inhibitor of hepatitis C virus nucleotide.
TN3438	Arborinine 化合物 TN3438	5489-57-6	98%
TN3438	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0....
TN5079	Sulochrin 化合物 TN5079	519-57-3	98%
TN5079	Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotox...
T13281	Valopicitabine 化合物 T13281	640281-90-9	98%
T13281	Valopicitabine is an effective prodrug of the effective anti-HCV drug 2'-C-methylcytidine and can be used as a promising antiviral drug for the study of chronic ...
TQ0122	VCH-916 化合物VCH-916	1200133-34-1	98%
TQ0122	VCH-916 是一种新型非核苷类 HCV NS5B 聚合酶抑制剂。