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GPR

GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TQ0241 TUG-770
化合物TUG-770
1402601-82-4 98%
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
T10507 GPR40 Agonist 2
化合物 T10507
1147729-48-3 98%
GPR40 Agonist 2 is a GPR40 agonist extracted from patent WO2009054479A1. It can be used in the research of diabetes.
T4689 Palosuran hydrochloride 540769-28-6(free base)
化合物Palosuran hydrochloride
T4689 98%
Palosuran hydrochloride 540769-28-6(free base) (ACT-058362 hydrochloride) 是一种新型强效特异性人 UT 受体拮抗剂,IC50 为 3.6±0.2 nM。
T15283 Firuglipel
化合物 T15283
1371591-51-3 98%
Firuglipel is an orally available and selective agonist of GPR119.
T14200 AM-1638
化合物 T14200
1142214-62-7 98%
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
T14202 AM-4668
化合物 T14202
1011531-27-3 98%
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respec...
T37264 15(R)-15-methyl Prostaglandin D2
化合物 T37264
210978-26-0 98%
15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) 是一种 PGD2 合成类似物,也是一种具有选择性和强效性的 CRTH2/DP2 受体激动剂,可调节嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化。
T62858 HGPR91 antagonist 3
hGPR91拮抗剂3
1314796-31-0 98%
hGPR91 antagonist 3 是一种具有口服活性、有效性和选择性的 hGPR91 拮抗剂。hGPR91 antagonist 3 可用于研究高血压、自身免疫性疾病和视网膜血管生成方面的疾病。
T15448 GW-1100
化合物 T15448
306974-70-9 98%
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
T2351L TAK-875 Hemihydrate
化合物TAK-875 Hemihydrate
1374598-80-7 98%
TAK-875 Hemihydrate (Fasiglifam) 是一种选择性 GPR40 激动剂,EC50 为 14 nM,比油酸强 400 倍。
T11452 GPR120 Agonist 1
化合物 T11452
1628448-77-0 98%
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GP...
T11460 GPR4 antagonist 1
化合物 T11460
1197879-16-5 98%
GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).
TP2166 Urotensin II, mouse TFA (9047-55-6 free base)
化合物 TP2166
TP2166 98%
Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
T12778L RTI-13951-33
化合物 T12778L
2244884-08-8 98%
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
TQ0051 MK-7246
化合物MK-7246
1218918-62-7 98%
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
T11462 GPR84 antagonist 8
化合物 T11462
1445846-30-9 98%
GPR84 antagonist 8 is a selective GPR84 antagonist.
T21623 AS1269574
化合物AS 1269574
330981-72-1 99.98%
AS1269574 是口服有效的GPR119激动剂,在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道,刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
T2088 APD668
化合物APD 668
832714-46-2 99.97%
APD668 是选择性的,口服有效的GPR119激动剂,对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
T2396 Ramatroban
雷马曲班
116649-85-5 99.96%
Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂,IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2,IC50为113 nM。它用于治疗过敏性鼻炎,可用于治疗哮喘的研究。
T11461 NE 52-QQ57
化合物NE 52-QQ57
1401728-56-0 99.93%
NE 52-QQ57 是一种具有口服活性、选择性的 GPR4拮抗剂(IC50:70 nM),具有抗炎作用。
TUG-770
TQ0241
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
GPR40 Agonist 2
T10507
GPR40 Agonist 2 is a GPR40 agonist extracted from patent WO2009054479A1. It can be used in the research of diabetes.
Palosuran hydrochloride 540769-28-6(free base)
T4689
Palosuran hydrochloride 540769-28-6(free base) (ACT-058362 hydrochloride) 是一种新型强效特异性人 UT 受体拮抗剂,IC50 为 3.6±0.2 nM。
Firuglipel
T15283
Firuglipel is an orally available and selective agonist of GPR119.
AM-1638
T14200
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
AM-4668
T14202
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respec...
15(R)-15-methyl Prostaglandin D2
T37264
15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) 是一种 PGD2 合成类似物,也是一种具有选择性和强效性的 CRTH2/DP2 受体激动剂,可调节嗜酸性粒细胞 CD11b 表达、肌动蛋白聚合和趋化。
hGPR91 antagonist 3
T62858
hGPR91 antagonist 3 是一种具有口服活性、有效性和选择性的 hGPR91 拮抗剂。hGPR91 antagonist 3 可用于研究高血压、自身免疫性疾病和视网膜血管生成方面的疾病。
GW-1100
T15448
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
TAK-875 Hemihydrate
T2351L
TAK-875 Hemihydrate (Fasiglifam) 是一种选择性 GPR40 激动剂,EC50 为 14 nM,比油酸强 400 倍。
GPR120 Agonist 1
T11452
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GP...
GPR4 antagonist 1
T11460
GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).
Urotensin II, mouse TFA (9047-55-6 free base)
TP2166
Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
RTI-13951-33
T12778L
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
MK-7246
TQ0051
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
GPR84 antagonist 8
T11462
GPR84 antagonist 8 is a selective GPR84 antagonist.
AS1269574
T21623
AS1269574 是口服有效的GPR119激动剂,在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道,刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。
APD668
T2088
APD668 是选择性的,口服有效的GPR119激动剂,对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
Ramatroban
T2396
Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂,IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2,IC50为113 nM。它用于治疗过敏性鼻炎,可用于治疗哮喘的研究。
NE 52-QQ57
T11461
NE 52-QQ57 是一种具有口服活性、选择性的 GPR4拮抗剂(IC50:70 nM),具有抗炎作用。
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