Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.

Cat. No.	Product Name	CAS No.	Purity
T72722	Physachenolide C 化合物 Physachenolide C	791117-61-8	98%
T72722	Physachenolide C 是一种选择性BET抑制剂，具有诱导细胞凋亡(apoptosis)和引起细胞周期在G0-G1期停滞的抗肿瘤活性。
T15484	HJB97 化合物HJB97	2093391-24-1	98%
T15484	HJB97 可用于开发设计 PROTAC BET 的降解剂，具有抗肿瘤活性。HJB97 是高亲和力的 BET 抑制剂，Ki 值分别为 0.9 nM (BRD2 BD1)，0.27 nM (BRD2 BD2)，0.18 nM (BRD3 BD1)，0.21 nM (BRD3 BD2)，0.5 nM (BRD4 BD1)，1...
T13715L	GSK9311 化合物 T13715L	1923851-49-3	98%
T13715L	GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively). GSK9311 is a less active analog of GSK6853. It can be used as a negativ...
T13086	I-BET762 carboxylic acid 化合物 T13086	1300019-38-8	98%
T13086	I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T13190	TP-472 化合物 T13190	2079895-62-6	98%
T13190	TP-472 is a selective inhibitor of BRD9 (Kd: 33 nM).
T17147	TPOP146 化合物 T17147	2018300-62-2	98%
T17147	TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T12798	(S)-GNE-987 化合物 T12798	T12798	98%
T12798	(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
T11887	LT052 化合物 T11887	2543545-44-2	98%
T11887	LT052 是一种高活性和选择性BET BD1抑制剂，其IC50为 87.7 nM。LT052 表现出纳摩尔级别的 BRD4 BD1 的抑制活性，选择性是 BRD4 BD2 的 138 倍 (IC50=12.130 μM)。LT052 具有抗炎活性，可用于治疗急性痛风性关节炎。
T13834	PROTAC BRD4 Degrader-2 化合物 T13834	2185795-53-1	98%
T13834	PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
T13786	MZP-55 化合物 T13786	2010159-48-3	98%
T13786	MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
T12113	MS645 化合物MS645	2250091-96-2	98%
T12113	MS645 是一种含溴结构域蛋白 4 (BRD4) 的抑制剂，对 BRD4-BD1/BD2 的 Ki 值为 18.4 nM。
T13915	PROTAC BRD9-binding moiety 1 化合物 T13915	2097512-23-5	98%
T13915	PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
TP2149L	NP213 化合物 TP2149L	942577-31-3	98%
TP2149L	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal...
T12660	(Rac)-BAY1238097 化合物 T12660	1564268-19-4	98%
T12660	(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
T10522	BET-IN-6 化合物 T10522	2570470-39-0	98%
T10522	BET-IN-6 是一种有效且高亲和力的BRD2/BRD4抑制剂。BET-IN-6 是靶蛋白 BRD2/4 的配体，可用于合成 PROTAC BRD2/BRD4 degrader-1 。
T13105	TD-428 化合物 T13105	T13105	98%
T13105	TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD...
T13833	PROTAC BRD4 Degrader-1 化合物 T13833	2133360-00-4	98%
T13833	PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).
T16139	MRS2698 化合物 T16139	934014-05-8	98%
T16139	MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recepto...
T13715	GSK9311 hydrochloride 化合物 T13715	2253733-09-2	98%
T13715	GSK9311 hydrochloride, a less active analog of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain (pIC50s: 6.0 and 4.3 f...
T10702	CBP/p300-IN-2 化合物 T10702	2158265-96-2	98%
T10702	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).