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DNA/RNA Synthesis

DNA/RNA Synthesis

RNA synthesis, which is also called DNA transcription, is a highly selective process. Transcription by RNA polymerase II extends beyond RNA synthesis, towards a more active role in mRNA maturation, surveillance and export to the cytoplasm. Single-strand breaks are repaired by DNA ligase using the complementary strand of the double helix as a template, with DNA ligase creating the final phosphodiester bond to fully repair the DNA.DNA ligases discriminate against substrates containing RNA strands or mismatched base pairs at positions near the ends of the nickedDNA. Bleomycin (BLM) exerts its genotoxicity by generating free radicals, whichattack C-4′ in the deoxyribose backbone of DNA, leading to opening of the ribose ring and strand breakage; it is an S-independentradiomimetic agent that causes double-strand breaks in DNA.
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN4913 Riddelline
化合物 TN4913
23246-96-0 98%
Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
TN3691 Communic acid
化合物 TN3691
2761-77-5 98%
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN4227 Horminone
化合物 TN4227
21887-01-4 98%
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
T17071 Thiarabine
化合物 T17071
26599-17-7 98%
Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
TN1374 α-​Chaconine
阿尔法卡茄碱
20562-03-2 98%
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Al...
TN5011 Shizukaol B
化合物 TN5011
142279-40-1 98%
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN2529 1-Decarboxy-3-oxo-ceanothic acid
化合物 TN2529
214150-74-0 98%
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in par...
T13479 2-Keto-D-galactose
D-半乳糖酮
54142-77-7 98%
2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.
TN4437 Licorisoflavan A
化合物 TN4437
129314-37-0 98%
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
T15094 Dehydroaltenusin
脱氢阿霉素
31186-13-7 98%
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits ma...
T73367 Zn(BQTC)
化合物 Zn(BQTC)
2785342-54-1 98%
Zn(BQTC)为高效线粒体DNA(mtDNA)及核DNA(nDNA)抑制剂,能对二者造成严重损伤,进而影响线粒体与核功能。该化合物激活DNA损伤诱导的细胞凋亡信号通路并对A549R细胞显示出选择性抗增殖效果,适用于抗癌研究领域。
T74630 RNA polymerase II-IN-1
化合物 RNA polymerase II-IN-1
2891451-07-1 98%
RNA polymerase II-IN-1(compound 19iv)是一款鹅膏毒素类化合物,能够抑制RNA聚合酶II(Pol II),其半抑制浓度IC50为36.66 nM。该化合物相较于α-Amanitin,对癌细胞展现出更高的细胞毒性,而对正常细胞的毒性较低。
T36667 2'-Deoxyadenosine-5'-triphosphate
2'-脱氧腺苷 5'-三磷酸酯
1927-31-7 98%
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸,在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-D...
TQ0016 NKP-1339
化合物NKP-1339
197723-00-5 98%
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
T16749 Rifalazil
利福拉齐
129791-92-0 98%
Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymeras...
TMA0291 Dehydroglyasperin D
化合物 TMA0291
517885-72-2 98%
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN2507 1,6,7-Trihydroxyxanthone
化合物 TN2507
25577-04-2 98%
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gro...
T23384 SR 11302
化合物SR 11302
160162-42-5 98%
SR 11302 是一种类视黄醇,是一种激活蛋白-1 转录因子抑制剂,能够特异性抑制 AP-1 活性,而不会激活视黄酸反应元件 (RARE) 的转录。
TN1660 Ganoderic acid C1
灵芝酸C1
95311-97-0 98%
Ganoderic acid C1 是分离自 G. lucidum 中的天然产物,能够抑制小鼠巨噬细胞TNF-α 的生成。
TN5153 Torilin
窃衣素
13018-10-5 98%
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF...
Riddelline
TN4913
Riddelline is a potent genotoxic agent in vitro and induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver.
Communic acid
TN3691
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
Horminone
TN4227
Horminone has antimicrobial activity, it can inhibit the protein synthesis in several types of bacteria; it can inhibit the in vitro growth of Trypanosoma cruzi,...
Thiarabine
T17071
Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
α-​Chaconine
TN1374
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Al...
Shizukaol B
TN5011
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
1-Decarboxy-3-oxo-ceanothic acid
TN2529
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in par...
2-Keto-D-galactose
T13479
2-Keto-D-galactose inhibits DNA synthesis and inhibits the proliferation of in vitro grown Ehrlich ascites tumor cells.
Licorisoflavan A
TN4437
Licorisoflavan A shows weak scavenging activity against superoxide anion radical, it and licoricidin have potential for the development of novel host-modulating ...
Dehydroaltenusin
T15094
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits ma...
Zn(BQTC)
T73367
Zn(BQTC)为高效线粒体DNA(mtDNA)及核DNA(nDNA)抑制剂,能对二者造成严重损伤,进而影响线粒体与核功能。该化合物激活DNA损伤诱导的细胞凋亡信号通路并对A549R细胞显示出选择性抗增殖效果,适用于抗癌研究领域。
RNA polymerase II-IN-1
T74630
RNA polymerase II-IN-1(compound 19iv)是一款鹅膏毒素类化合物,能够抑制RNA聚合酶II(Pol II),其半抑制浓度IC50为36.66 nM。该化合物相较于α-Amanitin,对癌细胞展现出更高的细胞毒性,而对正常细胞的毒性较低。
2'-Deoxyadenosine-5'-triphosphate
T36667
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸,在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-D...
NKP-1339
TQ0016
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway.
Rifalazil
T16749
Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymeras...
Dehydroglyasperin D
TMA0291
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
1,6,7-Trihydroxyxanthone
TN2507
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell gro...
SR 11302
T23384
SR 11302 是一种类视黄醇,是一种激活蛋白-1 转录因子抑制剂,能够特异性抑制 AP-1 活性,而不会激活视黄酸反应元件 (RARE) 的转录。
Ganoderic acid C1
TN1660
Ganoderic acid C1 是分离自 G. lucidum 中的天然产物,能够抑制小鼠巨噬细胞TNF-α 的生成。
Torilin
TN5153
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF...
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