Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product Name	CAS No.	Purity
T2S0606	Bakkenolide A 蜂斗菜内酯A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TN4999	Serratenediol 化合物 TN4999	2239-24-9	98%
TN4999	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
T13922	Thevetiaflavone 黄花夹竹桃黄酮	29376-68-9	98%
T13922	Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮，可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。
TN4603	Myricanol 化合物 TN4603	33606-81-4	98%
TN4603	Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly decelerate tumor growth in vivo by inducing apoptosis.
TN3619	Cedrusin 化合物 TN3619	75775-36-9	98%
TN3619	Cedrusin shows a cytotoxic effect on A375 and HeLa cells.
TN2191	Scutebarbatine A 半枝莲碱	176520-13-1	98%
TN2191	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
TN1875	Liriodenine 化合物Liriodenine	475-75-2	98%
TN1875	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
TN4637	Neogrifolin 化合物 TN4637	23665-96-5	98%
TN4637	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
TN1211	2-Hydroxy-3-methylanthraquinone 化合物2-Hydroxy-3-methylanthraquinone	17241-40-6	98%
TN1211	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
TN4166	Griffipavixanthone 化合物 TN4166	219649-95-3	98%
TN4166	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
T11701	J22352 化合物 T11701	2252395-44-9	98%
T11701	J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblas...
TN5201	Uncarinic acid E 化合物 TN5201	277751-61-8	98%
TN5201	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN1814	Juncusol 6-甲基灯心草二酚	62023-90-9	98%
TN1814	Juncusol shows anxiolytic and sedative activities, it shows anxiolytic activity at dosages of 10 mg/kg; it can induce caspase-3-mediated cytotoxicity in HT22 cel...
TN2945	3-Hydroxybakuchiol 化合物 TN2945	178765-54-3	98%
TN2945	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondri...
TN4087	Furowanin A 化合物 TN4087	911004-72-3	98%
TN4087	Furowanin A shows significant cytotoxicity against HL-60 cells, it induces that Caspase-9 and caspase-3 inhibitors suppresses apoptosis.
TN2106	Protodeltonin 化合物 TN2106	94992-08-2	98%
TN2106	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
TL0014	Pinusolide 化合物 TL0014	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one 化合物Ergosta-4,6,8(14),22-tetraen-3-one	19254-69-4	98%
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN3618	Cedrin 化合物 TN3618	75513-81-4	98%
TN3618	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4341	IVHD-valtrate 化合物 TN4341	28325-56-6	98%
TN4341	VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...