BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product Name	CAS No.	Purity
TN3152	6-Acetonyldihydrochelerythrine 化合物 TN3152	22864-92-2	98%
TN3152	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TN4490	Manassantin B 化合物 TN4490	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
T14499	Bax activator-1 化合物 T14499	1638526-94-9	98%
T14499	Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
TN1139	Dehydrocavidine 岩黄连碱	83218-34-2	98%
TN1139	Dehydrocavidine (Dehydrocorydaline) 具有抗肿瘤活性，它通过诱导调节 Bax/Bcl-2 介导的细胞凋亡、激活半胱天冬酶以及切割 PARP 来抑制 MCF-7 细胞增殖。
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 化合物 TN3931	57719-81-0	98%
TN3931	Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN3653	Cimidahurinine 化合物 TN3653	142542-89-0	98%
TN3653	Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
T10485	PROTAC Bcl2 degrader-1 化合物 T10485	2378801-85-3	98%
T10485	PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
TN2040	Panaxynol 人参炔醇	81203-57-8	98%
TN2040	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TN4307	Isolimonexic acid 化合物 TN4307	73904-93-5	98%
TN4307	Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
T5526	Glycoborinine 化合物 T5526	233279-39-5	98%
T5526	Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
T13337	WEHI-539 hydrochloride 化合物 T13337	2070018-33-4	98%
T13337	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
T13337L	WEHI-539 化合物WEHI-539	1431866-33-9	98%
T13337L	WEHI-539是一种选择性的 Bcl-XL 抑制剂（IC50：1.1 nM）。
TN4271	Isochamaejasmine 异狼毒素	93859-63-3	98%
TN4271	Isochamaejasmine 分离自 S. chamaejasme L. 中分离出来，可抑制 NF-κB 活化。 Isochamaejasmine 通过抑制 Bcl-2 家族蛋白的活性诱导白血病细胞凋亡，可用于抗癌研究。
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN2308	Wilfortrine 雷公藤春碱	37239-48-8	98%
TN2308	Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic ...
TMA0153	Safflor Yellow A 化合物 TMA0153	85532-77-0	98%
TMA0153	Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
T11973	Mcl1-IN-11 化合物 T11973	2042211-13-0	98%
T11973	Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
T10577	BM 957 化合物 T10577	1391107-54-2	98%
T10577	BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
T16043	Metaproterenol 化合物 T16043	586-06-1	98%
T16043	Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM).
TN3486	Bakkenolide IIIa 化合物 TN3486	915289-60-0	98%
TN3486	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB...