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Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.

Cat. No.	Product Name	CAS No.	Purity
T2947	Indole-3-carbinol 3-吲哚甲醇	700-06-1	100%
T2947	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
T2148	Carbidopa monohydrate 卡比多巴水合物	38821-49-7
T2148	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T4644	Tapinarof 苯烯莫德	79338-84-4
T4644	Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。
T4607	CAY 10465 化合物CAY10465	688348-33-6
T4607	CAY 10465 是一种选择性和高亲和力的芳香烃受体(AhR)激动剂，Ki 值为 0.2 nM。
T6795	Carbidopa 卡比多巴	28860-95-9
T6795	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T13276	VAF347 4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺	574759-62-9	98%
T13276	VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂，可诱导AhR 信号传导，具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。
T4608	PDM2 化合物PDM2	688348-25-6	98%
T4608	PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂，Ki 为 1.2±0.4 nM。