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20

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0099	Tolterodine tartrate Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定	AChR	Neuroscience
	Tolterodine tartrate (PNU-200583E) 是毒蕈碱受体的有效拮抗剂。它在体内显示出对膀胱和唾液腺的选择性。
T8832	Eledoisin trifluoroacetate (69-25-0 free base) Eledoisin trifluoroacetate	Others	Others
	Eledoisin trifluoroacetate (69-25-0 free base) 是从某些小章鱼（Eledone spp.，Mollusca）的后唾液腺中提取或合成获得的肽。它的作用类似于 P 物质的作用；它是一种有效的血管扩张剂，可增加毛细血管的通透性。
T1006	Propantheline bromide Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl	AChR	Neuroscience
	Propantheline bromide (Pro-Banthine) 是一种抗毒蕈碱剂，用于研究多汗症，遗尿，胃肠和膀胱痉挛。
T20131	Cevimeline hydrochloride 盐酸西维美林,Cevimeline HCl,Evoxac
	Cevimeline HCl is an agonist of cholinergic that binds to muscarinic receptors. Muscarinic agonists in sufficient dosage can enhance the secretion of exocrine glands, such as salivary and sweat glands.
T30610	Bufotoxin Vulgarobufotoxin
	Bufotoxin, a toxic steroid lactone, exists in the parotoid glands, skin, and poison of many toads and other amphibians, and in some plants and mushrooms.
TP1764	Adrenomedullin (1-50), rat
	Adrenomedullin (1-50), rat is a 50 amino acid peptide, which induces a selective arterial vasodilation via activation of CGRP1 receptor. Adrenomedullin (1-50) is a peptide hormone with RNA expressed in rat adrenal glands, lung, kidney, heart, and spleen,
TP1824	Cerebellin
	Cerebellin is a 16-amino acid peptide, originally isolated from rat cerebellum, whose presence has been recently demonstrated in the human adrenal glands and especially in medullary chromaffin cells.
TP1839	Dermaseptin
	Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.
TP1694	Thymus peptide C
	Thymus peptide C, a hormonal drug derived from the thymus glands of young calves, acts as a substitute for the physiological functions of the thymus.
T80122	Dermcidin-1L (human)	Antibiotic	Microbiology/Virology
	Dermcidin-1L (human) 是由汗腺分泌的抗菌肽，具备抗菌活性，适用于研究炎症性皮肤疾病。
T31383	D-Epinephrine L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799
	D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear
TP2283	parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]	Others	Others
	parathyroid hormone (7-34) [Homo sapiens] [Macaca fascicularis] is a peptide with the sequence H2N-LMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 3474.03. Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid glands as a polypeptide containing
T69151	Adrenaline sulfate
	Adrenaline sulfate 是一种由肾上腺髓质分泌的口服活性激素。Adrenaline sulfate 是一种 α-adrenergic 和 β-adrenergic 受体激动剂。Adrenaline sulfate 可用于治疗过敏反应。Adrenaline sulfate 具有心脏骤停研究潜力[4]。
T71102	CFG920
	CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential antiandrogen and antineoplastic activities. Upon oral administration, CYP17 inhibitor CFG920 inhibits the enzymatic activity of CYP17A1 in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells.
T82216	Helospectin II
	Helospectin II，一种属于血管活性肠肽（VIP）家族的神经肽，具备血管扩张作用及抗高血压活性，能够降低血压。该化合物最初从蜥蜴Heloderma suspectum的唾液腺毒液中分离得到。
T16547	PK14105	Others	Others
	PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilaterally lesioned striata, PK14105 was observed to quickly cross the blood-brain barrier, displaying significant radioactivity retention in the lesioned striatum, in contrast to the unlesioned striatum or cerebellar vermis. Additionally, PK14105 has the capability to inhibit recepto...
T75894	Sauvagine TFA
	Sauvagine TFA，是一种来自青蛙皮肤的 40 个氨基酸的神经肽，是哺乳动物 CRF 激动剂。Sauvagine TFA 可有效从大鼠垂体细胞释放 ACTH。Sauvagine TFA 在利尿，心血管系统和内分泌腺体方面具有许多药理作用。
T73692	Parathyroid hormone
	Parathyroid hormone (PTH) 是一种含84个氨基酸的循环激素，由甲状旁腺分泌。它主要针对骨骼和肾脏工作，功能是维持细胞外钙浓度在正常水平。此外，Parathyroid hormone 在骨质疏松症的研究中有重要应用。
T36731	Cholesteryl Heptadecanoate
	Cholesteryl heptadecanoate is a cholesterol ester (CE) formed by the condensation of cholesterol with heptadecanoic acid, a C-17 saturated fatty acid that does not occur in any natural animal or vegetable fat at high concentrations. As such, it is commonly used as an internal standard for the quantification of cholesterol esters by GC- or LC-mass spectrometry. CEs are major constituents of lipoprotein particles carried in blood and accumulate in the fatty acid lesions of atherosclerotic plaques....
T75849	Lys-γ3-MSH(human) TFA
	Lys-γ3-MSH(human) TFA是源自POMC片段C端的黑素皮质素肽，具备增强大鼠肾上腺对促肾上腺皮质激素(ACTH)的类固醇生成反应的能力。该化合物作为一种有效的脂解激活剂，其表观EC50值为3.56 nM，能够激活激素敏感脂肪酶(HSL)和紫苏脂素A，进而促进脂解。

化合物

Tolterodine tartrate

Cat.No: T0099

Synonym: Detrol LA,PNU-200583E,Kabi-2234,酒石酸托特罗定

Target: AChR

Eledoisin trifluoroacetate (69-25-0 free base)

Cat.No: T8832

Synonym: Eledoisin trifluoroacetate

Target: Others

Propantheline bromide

Cat.No: T1006

Synonym: Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl

Target: AChR

Cevimeline hydrochloride

Cat.No: T20131

Synonym: 盐酸西维美林,Cevimeline HCl,Evoxac

Cat.No: T30610

Synonym: Vulgarobufotoxin

Adrenomedullin (1-50), rat

Cat.No: TP1764

Cat.No: TP1824

Cat.No: TP1839

Thymus peptide C

Cat.No: TP1694

Dermcidin-1L (human)

Cat.No: T80122

Target: Antibiotic

Cat.No: T31383

Synonym: L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799

parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]

Cat.No: TP2283

Target: Others

Adrenaline sulfate

Cat.No: T69151

Cat.No: T71102

Cat.No: T82216

Cat.No: T16547

Target: Others

Cat.No: T75894

Parathyroid hormone

Cat.No: T73692

Cholesteryl Heptadecanoate

Cat.No: T36731

Lys-γ3-MSH(human) TFA

Cat.No: T75849

Cat. No.	Product Name	Target	Signaling Pathways
T0478	Progesterone 孕酮,Pregn-4-ene-3,20-dione	Estrogen/progestogen Receptor; Progesterone Receptor; Opioid Receptor; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience; Others
	Progesterone (Pregn-4-ene-3,20-dione) 是类固醇激素，能够调节月经周期。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
TN7037	(Z)-9-nonadecene 9-Nonadecene	Others	Others
	(Z)-9-nonadecene (9-Nonadecene) 首次在 T. melanocephalum 中被发现。它是下颌腺中的主要成分，而虹膜在尾腺中产生。
T83514	(Z,Z)-3,13-Octadecadienyl acetate
	(Chemical name)为从雌性(S.bicingulata scientific name)的信息素腺提取物中分离的化合物，对吸引该物种雄性个体至关重要，且常用作诱捕雄蛾的诱饵。

天然产物

Cat.No: T0478

Synonym: 孕酮,Pregn-4-ene-3,20-dione

Target: Estrogen/progestogen Receptor, Progesterone Receptor, Opioid Receptor, Endogenous Metabolite

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

(Z)-9-nonadecene

Cat.No: TN7037

Synonym: 9-Nonadecene

Target: Others

(Z,Z)-3,13-Octadecadienyl acetate

Cat.No: T83514

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