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Search Results for " pct "

Targets Recommended: CFTR Autophagy

6

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2451	GlyH-101 GlyH 101	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂，Ki 为1.4 uM。
T37302	PCTR3
	Protein conjugates in tissue regeneration 3 (PCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 and PCTR3 via peptidases. PCTR3 is found in infected mouse spleens and resolving exudate as well as isolated human spleen and septic plasma. It is also found in both M1 and M2 macrophages differentiated from isolated human monocytes.
T37300	PCTR1 PCTR1
	Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase. PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice. PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It als...
T37301	PCTR2
	Protein conjugates in tissue regeneration 2 (PCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid . DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to PCTR1 by glutathione S-transferase and to PCTR2 via γ-glutamyl transpeptidase. PCTR2 is found in resolving mouse exudate and in both M1 and M2 macrophages differentiated from isolated human monocytes.
T36297	Btk inhibitor 1 hydrochloride
	Btk inhibitor 1 Hcl is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.IC50 value:Target: BtkFrom PCT Int. Appl. (2012), WO 2012158843 A2 20121122. [1]. PCT Int. Appl. (2012), WO 2012158843 A2 20121122.
T69678	WUN40378
	WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of Ro 24-7429. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

化合物

Cat.No: T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

Cat.No: T37302

Cat.No: T37300

Synonym: PCTR1

Cat.No: T37301

Btk inhibitor 1 hydrochloride

Cat.No: T36297

Cat.No: T69678

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00678	CALCA/CGRP Protein, Mouse, Recombinant (hFc) CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,...	Mouse	HEK293 Cells
	Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca.
TMPY-00066	Procalcitonin/CALCA Protein, Human, Recombinant (His) KC,CGRP,CALC1,Procalcitonin,CT,calcitonin-related polypeptid...	Human	HEK293 Cells
	Procalcitonin/CALCA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.2 kDa and the accession number is P01258-1.
TMPY-04120	Procalcitonin/CALCA Protein, Human, Recombinant (mFc) Procalcitonin,CGRP,CGRP-I,calcitonin-related polypeptide α,C...	Human	HEK293 Cells
	Procalcitonin/CALCA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 39.2 kDa and the accession number is P01258-1.
TMPH-01395	QPCTL Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Responsible for the biosynthesis of pyroglutamyl peptides. QPCTL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.5 kDa and the accession number is Q9NXS2.
TMPY-04776	PCTAIRE1 Protein, Human, Recombinant (GST) cyclin-dependent kinase 16,PCTAIRE,PCTK1,<...	Human	Baculovirus Insect Cells
	PCTAIRE1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 82 kDa and the accession number is Q00536-1.
TMPH-02679	QPCT Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. QPCT Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 39.6 kDa and the accession number is Q9CYK2.
TMPH-02680	QPCT Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. QPCT Protein, Mouse, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 41.6 kDa and the accession number is Q9CYK2.
TMPY-03260	QPCT Protein, Human, Recombinant (His) QC,GCT,glutaminyl-peptide cyclotransferase,sQC	Human	Baculovirus Insect Cells
	Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and...

重组蛋白

CALCA/CGRP Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00678

Species: Mouse

Expression System: HEK293 Cells

Procalcitonin/CALCA Protein, Human, Recombinant (His)

Cat.No: TMPY-00066

Species: Human

Expression System: HEK293 Cells

Procalcitonin/CALCA Protein, Human, Recombinant (mFc)

Cat.No: TMPY-04120

Species: Human

Expression System: HEK293 Cells

QPCTL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01395

Species: Human

Expression System: E. coli

PCTAIRE1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04776

Species: Human

Expression System: Baculovirus Insect Cells

QPCT Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02679

Species: Mouse

Expression System: P. pastoris (Yeast)

QPCT Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02680

Species: Mouse

Expression System: HEK293 Cells

QPCT Protein, Human, Recombinant (His)

Cat.No: TMPY-03260

Species: Human

Expression System: Baculovirus Insect Cells

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