P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).

Cat. No.	Product Name	CAS No.	Purity
TN1526	Corydalmine 紫堇达明碱	30413-84-4	98%
TN1526	Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
TQ0276	Methysticin 麻醉椒苦素	20697-20-5	98%
TQ0276	Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN3875	Dipterocarpol 化合物 TN3875	471-69-2	98%
TN3875	Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN1210	2-Hydroxy-1-Methoxyaporphine 2-羟基-1-甲氧基阿朴啡	33770-27-3	98%
TN1210	2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
T10535L	BI 653048 phosphate 化合物 T10535L	1198784-97-2	98%
T10535L	BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
TN1748	Humantenirine 4-脱甲基-11-甲氧基胡蔓藤碱乙	82375-30-2	98%
TN1748	Humantenirine是一种天然产物，属于马钱科断肠草属，其产品编号为 TN1748，CAS号为 82375-30-2。Humantenirine可用作对照参考。
TN3627	Chalepensin 化合物 TN3627	13164-03-9	98%
TN3627	Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
TN3147	6',7'-Dihydroxybergamottin 化合物 TN3147	264234-05-1	98%
TN3147	6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN3574	Canadine 化合物 TN3574	5096-57-1	98%
TN3574	Canadine has antioxidant activity with low-toxic effect.
T10688	Casopitant mesylate 化合物 T10688	414910-30-8	98%
T10688	Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TN4130	Germacrone 4,5-epoxide 化合物 TN4130	92691-35-5	98%
TN4130	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T14678	BMS-819881 化合物 T14678	1197420-05-5	98%
T14678	BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
T5S0669	Bergamottin 佛手柑素	7380-40-7	99.99%
T5S0669	Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。
T2088	APD668 化合物APD 668	832714-46-2	99.97%
T2088	APD668 是选择性的，口服有效的GPR119激动剂，对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
T1149	Fenofibrate 非诺贝特	49562-28-9	99.97%
T1149	Fenofibrate (Lipanthyl) 是一种选择性PPARα激动剂，EC50为 30 μM。它是一种合成的苯氧基异丁酸衍生物和前药，具有抗高血脂活性。它抑制细胞色素 P450 亚型, 对CYP2C19、CYP2B6、CYP2C9、CYP2C8和CYP3A4的IC50分别为 0.2、0.7、9.7、4.8 和 1...
T10953	Dafadine-A 化合物Dafadine-A	1065506-69-5	99.96%
T10953	Dafadine-A 是dafadine 的类似物，是C. elegans DAF-9 细胞色素P450抑制剂，同时对哺乳动物的CYP27A1具有抑制作用。
T8937	Soticlestat 化合物Soticlestat	1429505-03-2	99.95%
T8937	Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。
T0920	Ambroxol 氨溴索	18683-91-5	99.95%
T0920	Ambroxol (NA-872) 是前药溴己辛的活性代谢产物，是一种分泌溶解剂，具有强效祛痰作用，用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬，有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣，可增加葡糖脑苷脂酶的活性。
T3158L	Harman hydrochloride 哈尔满盐酸盐	21655-84-5	99.95%
T3158L	Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达，可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。
T3941	Choline Fenofibrate 非诺贝特胆碱	856676-23-8	99.95%
T3941	Choline Fenofibrate (Trilipix) 是 Fenofibric acid 的胆碱盐，在胃肠道中释放游离的 Fenofibric acid。Fenofibric acid 是一种合成的苯氧基异丁酸衍生物和具有抗高血脂活性的前药。