TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product Name	CAS No.	Purity
TN4581	Moracin D 化合物 TN4581	69120-07-6	98%
TN4581	Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization o...
TN1960	Mussaenoside 化合物Mussaenoside	64421-27-8	98%
TN1960	Mussaenoside has anti-inflammatory action, the mechanism associated with downregulation of nuclear factor-κB.
TN4648	Nepetoidin B 化合物Nepetoidin B	55486-06-1	98%
TN4648	Nepetoidin B 具有抗真菌、抗细菌和抗炎作用，它可以抑制 LPS 刺激的 NO 生成，可能是通过调节 RAW 264.7 细胞中由 MKP-5/NF-ÎºB 通路介导的 iNOS 。
TMA0627	Taxiresinol 化合物 TMA0627	40951-69-7	98%
TMA0627	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic c...
T5768	Bruceine B 鸦胆子素B	25514-29-8	98%
T5768	Bruceine B 是一种有效的白细胞-内皮细胞粘附抑制剂，可抑制蛋白质和核酸合成。
TN3245	7-O-Methylmorroniside 化合物 TN3245	119943-46-3	98%
TN3245	7-O-Methylmorroniside exhibits anti-inflammatory activity.
T14312	Apratastat 化合物 T14312	287405-51-0	98%
T14312	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) an...
T16755	RIPK-IN-4 化合物 T16755	2141969-56-2	98%
T16755	RIPK-IN-4 is an effective and selective inhibitor of RIPK2. It also has excellent oral bioavailability (IC50: 3 nM).
TN5264	Xanthoxyletin 化合物 TN5264	84-99-1	98%
TN5264	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN1242	3,3'-Di-O-methylellagic acid 3,3'-O-二甲基鞣花酸	2239-88-5	98%
TN1242	3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a ...
TN1660	Ganoderic acid C1 灵芝酸C1	95311-97-0	98%
TN1660	Ganoderic acid C1 是分离自 G. lucidum 中的天然产物，能够抑制小鼠巨噬细胞TNF-α 的生成。
TN1359	Aflatoxin G1 黄曲霉毒素G1	1165-39-5	98%
TN1359	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce l...
TN2224	Soyasapogenol A 大豆甾醇A	508-01-0	98%
TN2224	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma T...
TN3517	Bisacurone 化合物 TN3517	120681-81-4	98%
TN3517	Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN1407	Artocarpin 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮	7608-44-8	98%
TN1407	Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN4409	Lansiumarin C 化合物 TN4409	205115-75-9	98%
TN4409	Lansiumarin C can decrease nitric oxide (NO) and tumor necrosis factor-α (TNF-α) production in lipopolysaccharide (LPS)-induced macrophages.
T12202	Nec-4 化合物 T12202	1041644-43-2	98%
T12202	Nec-4 is a potent inhibitor of receptor interacting protein 1 (RIP1)(IC50 of 2.6 μM),and is a tricyclic derivative.
TN5138	Teuclatriol 化合物 TN5138	152110-17-3	98%
TN5138	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
TN1227	25R-Inokosterone 25R-牛膝甾酮	19682-38-3	98%
TN1227	25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2...
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...