TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product Name	CAS No.	Purity
TN5912	Macluraxanthone 桑橙酮	5848-14-6	98%
TN5912	Macluraxanthone (3-Hydroxyblancoxanthone) 具有许多生物活性，包括抗胆碱酯酶、抗氧化、抗癌、抗疟疾、抗炎和免疫调节作用。Macluraxanthone 通过增加表达CD86的巨噬细胞的百分比，同时减少其CD14、CD11b 和CD80的表达，来促进M1类促炎症巨噬细胞的极化。Mac...
TN2588	11-Hydroxytephrosin 化合物 TN2588	72458-85-6	98%
TN2588	11-Hydroxytephrosin inhibits NF-kappaB activity.
TN1212	2-Hydroxyeupatolide 2ALPHA-羟基泽兰内酯	72229-33-5	98%
TN1212	2-Hydroxyeupatolide has anti-inflammatory activity,it may suppress the inflammatory response through inhibiting the activation of NF-κB signaling pathways, and m...
TN3495	Benzyl ferulate 化合物 TN3495	132335-97-8	98%
TN3495	Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE...
TN4064	Flavoglaucin 化合物 TN4064	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TMA1409	Cis-Mulberroside A 化合物 TMA1409	166734-06-1	98%
TMA1409	cis-Mulberroside A shows high analgesic and anti-inflammatory activities, it can protect mice against ethanol-induced hepatic damage.
TN5238	Viscidulin II 化合物 TN5238	92519-93-2	98%
TN5238	Viscidulin II can be potential therapeutic agents against P. acnes-induced skin inflammation, it can significantly suppress P. acnes-induced IL-8 and IL-1β produ...
TN4303	Isokaempferide 化合物 TN4303	1592-70-7	98%
TN4303	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
TN3453	Arteannuin N 化合物 TN3453	207446-92-2	98%
TN3453	Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 5-羟基-7,8-二甲氧基黄烷酮	113981-49-0	98%
TN3119	5-Hydroxy-7,8-dimethoxyflavanone 是从穿心莲叶和根中分离出来的，具有抗炎活性。
TN1232	5,7-Dimethoxyflavanone (2R)-5,7-二甲氧基二氢黄酮	1277188-85-8	98%
TN1232	5,7-Dimethoxyflavanone has anti-inflammatory activity.
TN1793	Isorhamnetin 3-O-galactoside 异鼠李素-3-O-半乳糖苷	6743-92-6	98%
TN1793	Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN4561	N-Decyl-4-methoxyaniline 化合物 TN4561	733-40-4	98%
TN4561	Methylnissolin is a natural product from A. membranaceus.
TN4489	Manassantin A 化合物 TN4489	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol 化合物 TN3325	166322-14-1	98%
TN3325	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cyt...
TN3741	Cyclocurcumin 化合物 TN3741	153127-42-5	98%
TN3741	Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
T19250	CRIPGBM 化合物 T19250	2361988-76-1	98%
T19250	cRIPGBM 是RIPGBM 的促凋亡衍生物。cRIPGBM 通过与受体相互作用蛋白激酶2(RIPK2)结合，从而选择性诱导 GBM 肿瘤干细胞凋亡，对 GBM-1 细胞的EC50值为 68 nM。
TN3537	Braylin 化合物 TN3537	6054-10-0	98%
TN3537	Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition ...
TN3839	Desoxo-narchinol A 化合物 TN3839	53859-06-6	98%
TN3839	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN4243	Hyuganin D 化合物 TN4243	77331-76-1	98%
TN4243	Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages.