Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
TN4435 | Licopyranocoumarin
化合物 TN4435
|
117038-80-9 | 98% |
|
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane... | ||||
TN1526 | Corydalmine
紫堇达明碱
|
30413-84-4 | 98% |
|
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor... | ||||
TQ0276 | Methysticin
麻醉椒苦素
|
20697-20-5 | 98% |
|
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1. | ||||
TN3875 | Dipterocarpol
化合物 TN3875
|
471-69-2 | 98% |
|
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a... | ||||
TN1210 | 2-Hydroxy-1-Methoxyaporphine
2-羟基-1-甲氧基阿朴啡
|
33770-27-3 | 98% |
|
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone. | ||||
T10535L | BI 653048 phosphate
化合物 T10535L
|
1198784-97-2 | 98% |
|
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM). | ||||
TN1748 | Humantenirine
4-脱甲基-11-甲氧基胡蔓藤碱乙
|
82375-30-2 | 98% |
|
Humantenirine是一种天然产物,属于马钱科断肠草属,其产品编号为 TN1748,CAS号为 82375-30-2。Humantenirine可用作对照参考。 | ||||
TN3627 | Chalepensin
化合物 TN3627
|
13164-03-9 | 98% |
|
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d... | ||||
TN3147 | 6',7'-Dihydroxybergamottin
化合物 TN3147
|
264234-05-1 | 98% |
|
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi... | ||||
TN3574 | Canadine
化合物 TN3574
|
5096-57-1 | 98% |
|
Canadine has antioxidant activity with low-toxic effect. | ||||
T10688 | Casopitant mesylate
化合物 T10688
|
414910-30-8 | 98% |
|
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti... | ||||
TN4130 | Germacrone 4,5-epoxide
化合物 TN4130
|
92691-35-5 | 98% |
|
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP). | ||||
T14678 | BMS-819881
化合物 T14678
|
1197420-05-5 | 98% |
|
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A... | ||||
T5S0669 | Bergamottin
佛手柑素
|
7380-40-7 | 99.99% |
|
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。 | ||||
T2088 | APD668
化合物APD 668
|
832714-46-2 | 99.97% |
|
APD668 是选择性的,口服有效的GPR119激动剂,对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。 | ||||
T1149 | Fenofibrate
非诺贝特
|
49562-28-9 | 99.97% |
|
Fenofibrate (Lipanthyl) 是一种选择性PPARα激动剂,EC50为 30 μM。它是一种合成的苯氧基异丁酸衍生物和前药,具有抗高血脂活性。它抑制细胞色素 P450 亚型, 对CYP2C19、CYP2B6、CYP2C9、CYP2C8和CYP3A4的IC50分别为 0.2、0.7、9.7、4.8 和 1... | ||||
T10953 | Dafadine-A
化合物Dafadine-A
|
1065506-69-5 | 99.96% |
|
Dafadine-A 是dafadine 的类似物,是C. elegans DAF-9 细胞色素P450抑制剂,同时对哺乳动物的CYP27A1具有抑制作用。 | ||||
T8937 | Soticlestat
化合物Soticlestat
|
1429505-03-2 | 99.95% |
|
Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。 | ||||
T0920 | Ambroxol
氨溴索
|
18683-91-5 | 99.95% |
|
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。 | ||||
T3158L | Harman hydrochloride
哈尔满盐酸盐
|
21655-84-5 | 99.95% |
|
Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达,可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。 |