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P450

P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
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Cat. No. Product Name CAS No. Purity Chemical Structure
TN4435 Licopyranocoumarin
化合物 TN4435
117038-80-9 98%
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
TN1526 Corydalmine
紫堇达明碱
30413-84-4 98%
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
TQ0276 Methysticin
麻醉椒苦素
20697-20-5 98%
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
TN3875 Dipterocarpol
化合物 TN3875
471-69-2 98%
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
TN1210 2-Hydroxy-1-Methoxyaporphine
2-羟基-1-甲氧基阿朴啡
33770-27-3 98%
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
T10535L BI 653048 phosphate
化合物 T10535L
1198784-97-2 98%
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
TN1748 Humantenirine
4-脱甲基-11-甲氧基胡蔓藤碱乙
82375-30-2 98%
Humantenirine是一种天然产物,属于马钱科断肠草属,其产品编号为 TN1748,CAS号为 82375-30-2。Humantenirine可用作对照参考。
TN3627 Chalepensin
化合物 TN3627
13164-03-9 98%
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
TN3147 6',7'-Dihydroxybergamottin
化合物 TN3147
264234-05-1 98%
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
TN3574 Canadine
化合物 TN3574
5096-57-1 98%
Canadine has antioxidant activity with low-toxic effect.
T10688 Casopitant mesylate
化合物 T10688
414910-30-8 98%
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
TN4130 Germacrone 4,5-epoxide
化合物 TN4130
92691-35-5 98%
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
T14678 BMS-819881
化合物 T14678
1197420-05-5 98%
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
T5S0669 Bergamottin
佛手柑素
7380-40-7 99.99%
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。
T2088 APD668
化合物APD 668
832714-46-2 99.97%
APD668 是选择性的,口服有效的GPR119激动剂,对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
T1149 Fenofibrate
非诺贝特
49562-28-9 99.97%
Fenofibrate (Lipanthyl) 是一种选择性PPARα激动剂,EC50为 30 μM。它是一种合成的苯氧基异丁酸衍生物和前药,具有抗高血脂活性。它抑制细胞色素 P450 亚型, 对CYP2C19、CYP2B6、CYP2C9、CYP2C8和CYP3A4的IC50分别为 0.2、0.7、9.7、4.8 和 1...
T10953 Dafadine-A
化合物Dafadine-A
1065506-69-5 99.96%
Dafadine-A 是dafadine 的类似物,是C. elegans DAF-9 细胞色素P450抑制剂,同时对哺乳动物的CYP27A1具有抑制作用。
T8937 Soticlestat
化合物Soticlestat
1429505-03-2 99.95%
Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。
T0920 Ambroxol
氨溴索
18683-91-5 99.95%
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。
T3158L Harman hydrochloride
哈尔满盐酸盐
21655-84-5 99.95%
Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达,可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。
Licopyranocoumarin
TN4435
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
Corydalmine
TN1526
Corydalmine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus strains.1-Corydalmine significantly inhibits spor...
Methysticin
TQ0276
Methysticin, a major kavalactone extracted from kava, can induce CYP1A1.
Dipterocarpol
TN3875
Dipterocarpol is a dammarane-type triterpenoid, as are the major bioactive compounds of ginseng. Dipterocarpol A shows moderate acetylcholinesterase inhibitory a...
2-Hydroxy-1-Methoxyaporphine
TN1210
2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
BI 653048 phosphate
T10535L
BI 653048 phosphate is a selective and orally active agonist of nonsteroidal glucocorticoid (GC)(IC50 : 55 nM).
Humantenirine
TN1748
Humantenirine是一种天然产物,属于马钱科断肠草属,其产品编号为 TN1748,CAS号为 82375-30-2。Humantenirine可用作对照参考。
Chalepensin
TN3627
Chalepensin behaves as an energy transfer inhibitor at low concentration, it inhibits multiple P450s and that epoxidation activity is crucial for the potential d...
6',7'-Dihydroxybergamottin
TN3147
6',7'-Dihydroxybergamottin(DHB), a well-known inhibitor of CYP3A4, the inhibition of CYP3A4 activity by DHB includes the inhibition of POR activity, DHB can inhi...
Canadine
TN3574
Canadine has antioxidant activity with low-toxic effect.
Casopitant mesylate
T10688
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of anti...
Germacrone 4,5-epoxide
TN4130
(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
BMS-819881
T14678
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A...
Bergamottin
T5S0669
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。
APD668
T2088
APD668 是选择性的,口服有效的GPR119激动剂,对hGPR119和rGPR119的EC50分别为 2.7 nM 和 33 nM。它对除CYP2C9(Ki=0.1 μM) 以外的五种主要 CYP 亚型均无明显抑制作用。它可用于脂肪性肝炎和糖尿病的研究。
Fenofibrate
T1149
Fenofibrate (Lipanthyl) 是一种选择性PPARα激动剂,EC50为 30 μM。它是一种合成的苯氧基异丁酸衍生物和前药,具有抗高血脂活性。它抑制细胞色素 P450 亚型, 对CYP2C19、CYP2B6、CYP2C9、CYP2C8和CYP3A4的IC50分别为 0.2、0.7、9.7、4.8 和 1...
Dafadine-A
T10953
Dafadine-A 是dafadine 的类似物,是C. elegans DAF-9 细胞色素P450抑制剂,同时对哺乳动物的CYP27A1具有抑制作用。
Soticlestat
T8937
Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。
Ambroxol
T0920
Ambroxol (NA-872) 是前药溴己辛的活性代谢产物,是一种分泌溶解剂,具有强效祛痰作用,用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬,有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣,可增加葡糖脑苷脂酶的活性。
Harman hydrochloride
T3158L
Harman hydrochloride 可以以 AhR 依赖性方式直接诱导 CYP1A1 基因表达,可能代表了harman 促进致突变性、共致突变性和致癌性的新机制。
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