Lipase

Lipase refers to a class of enzymes that catalyze the hydrolysis of fats. Some lipases display a broad substrate scope including esters of cholesterol, phospholipids, and of lipid-soluble vitamins, and sphingomyelinases; however, these are usually treated separately from "conventional" lipases. Unlike esterases, which function in water, lipases "are activated only when adsorbed to an oil-water interface". Lipases perform essential roles in the digestion, transport and processing of dietary lipids in most organisms.

Cat. No.	Product Name	CAS No.	Purity
T4052	KML29 化合物KML29	1380424-42-9	98%
KML29 是一种口服具有活性的、高度选择性的不可逆 MAGL 抑制剂，其对小鼠、大鼠和人的 IC50值分别为15 nM、43 nM 和 5.9 nM。它对 FAAH 在内的其他中心和外周丝氨酸水解酶的交叉反应极小。
T5353	ABX-1431 化合物ABX-1431	1446817-84-0	98%
ABX-1431 (Elcubragistat) 是口服具有活力的、选择性CNS-渗透性单酰基甘油脂肪酶抑制剂，IC50=14 nM。
T11724	JNJ-42226314 化合物 JNJ-42226314	1252765-13-1	98%
JNJ-42226314 是一种具有高选择性的非共价单酰基甘油脂肪酶 (MAGL) 抑制剂，具有抗伤害作用。JNJ-42226314 通过内源性大麻素-2-丙烯酰甘油（2-AG）在神经病理性疼痛和炎症性疼痛模型中显示出疗效。
T9687	MAGL-IN-4 化合物His121 ARG57	2135785-20-3	98%
MAGL-IN-4 (His121 ARG57) 是选择性的、口服有效的、可透过血脑屏障的、可逆的单酰基甘油脂肪酶抑制剂，IC50=6.2 nM。它主要通过大脑中选择性抑制 MAGL 增加 2-花生四烯酰甘油水平来增强内源性大麻素信号。
T1846	Y-320 化合物Y320	288250-47-5	98%
Y-320 是一种免疫调节剂，能阻碍IL-15刺激CD4 T 细胞后的IL-17的产生，IC50=20~60 nM。

Cat. No.

Product Name

CAS No.

Purity

Chemical Structure

T4052

KML29

化合物KML29

1380424-42-9

98%