Hydroxylase

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound. In biochemistry, hydroxylation reactions are often facilitated by enzymes called hydroxylases. Hydroxylation is the first step in the oxidative degradation of organic compounds in air. It is extremely important in detoxification since hydroxylation converts lipophilic compounds into water-soluble (hydrophilic) products that are more readily removed by the kidneys or liver and excreted. Some drugs (for example, steroids) are activated or deactivated by hydroxylation.

Cat. No.	Product Name	CAS No.	Purity
T15778	LP-533401 化合物 T15778	945976-43-2	98%
T15778	LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.
T16779	Rodatristat ethyl 化合物	1673571-51-1	98%
T16779	Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂，低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH)，
T6356	(R)-Nepicastat HCl 盐酸内匹司他	195881-94-8	98%
T6356	(R)-Nepicastat HCl (RS-25560-198 HCl) 是 Nepicastat HCl 的 R-对映异构体，是一种有效的选择性抑制剂，对牛和人多巴胺-β-羟化酶的 IC50 分别为 25.1 nM 和 18.3 nM，对其他 12 种酶和 13 种神经递质受体的亲和力可忽略不计.
T15786	LPA2 antagonist 1 化合物 T15786	1017606-66-4	98%
T15786	LPA2 antagonist 1 is an LPA2 antagonist (IC50: 17 nM).
T15426	GSK180 化合物 T15426	1799725-26-0	98%
T15426	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.
T11470	GSK 366 化合物 T11470	1953157-39-5	98%
T11470	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
T7117	Sapropterin dihydrochloride 盐酸沙丙蝶呤	69056-38-8	99.88%
T7117	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。
T6004	Tetrahydropapaverine hydrochloride 四氢罂粟碱盐酸盐	6429-04-5	99.83%
T6004	Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) 是一种四氢异喹啉类药物。它对多巴胺神经元有神经毒性作用。
T6604	Nepicastat hydrochloride 内匹司他盐酸盐	170151-24-3	99.81%
T6604	Nepicastat hydrochloride (RS-25560-197 hydrochloride) 是一种选择性的，有效的，口服活性的多巴胺 β 羟化酶(dopamine-beta-hydroxylase)抑制剂，对牛和人多巴胺 β 羟化酶的IC50分别为IC50=8.5 nM 和IC50=9 nM。Nepica...
T0679	Ketoconazole 酮康唑	65277-42-1	99.62%
T0679	Ketoconazole (R-41400) 是一种咪唑类抗真菌剂，也是一种 CYP3A4 抑制剂。
T41274	P-Fluoro-L-phenylalanine 化合物p-Fluoro-L-phenylalanine	1132-68-9	99.53%
T41274	p-Fluoro-L-phenylalanine 是酪氨酸羟化酶的一种底物。它可以与大肠杆菌的 L-亮氨酸特异性受体结合，KD 为0.26 μM。
T21506	Telotristat 化合物Telotristat	1033805-28-5	99.49%
T21506	Telotristat 是色氨酸羟化酶 (tryptophan hydroxylase) 抑制剂，在体内的IC50值为0.028 μM。
T14119	ACT-678689 化合物ACT-678689	1783256-96-1	99.45%
T14119	ACT-678689 (Compound Example 1.53.4) 是一种色氨酸羟化酶 (TPH) 抑制剂，IC50=8 nM。
T6044	Telotristat Etiprate 特罗司他马尿酸盐	1137608-69-5	99.21%
T6044	Telotristat Etiprate (LX 1606 Hippurate) 是一种色氨酸羟化酶抑制剂，可抑制血清素的产生。
T4277	Osilodrostat 化合物Osilodrostat	928134-65-0	99.10%
T4277	Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂，IC50分别值为2.5 和0.7nM。
T41143	PCPA methyl ester hydrochloride 4-氯-DL-苯基丙氨酸甲酯盐酸盐	14173-40-1	99.08%
T41143	pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢...
T15124	Diethyl-pythiDC 化合物Diethyl-pythiDC	1821370-70-0	98.87%
T15124	Diethyl-pythiDC 是一种胶原蛋白脯氨酰 4-羟化酶抑制剂。
T1896	Ro 61-8048 化合物Ro 61-8048	199666-03-0	98.86%
T1896	Ro 61-8048 是一种选择性的、口服有效的犬尿氨酸 3-羟化酶抑制剂(IC50:37 nM)。它能够导致细胞喹啉酸浓度的显著增加。
T1447	Fenclonine 芬克洛宁	7424-00-2	98.81%
T1447	Fenclonine (CP-10188) 是一种有效的色氨酸羟化酶(Trp)的不可逆抑制剂。其中色氨酸羟化酶是 5-羟色胺生物合成的限速酶。
T11897	Telotristat ethyl 化合物Telotristat ethyl	1033805-22-9	98.11%
T11897	Telotristat ethyl (LX1606) 是一种口服具有活力的色氨酸羟化酶抑制剂，可抑制血清素的产生。