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EGFR

EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T73128 EGFR-IN-61
化合物 EGFR-IN-61
2890261-81-9 98%
EGFR-IN-61(化合物22a)为一种高效EGFR激酶抑制剂,其对L858R/T790M、L858R/T790M/C797S和WT的IC50值分别为42 nM、137 nM和743 nM。此外,EGFR-IN-61对A549和H1975细胞株展现抗增殖效应,其IC50值依次为2.14 μM和1.82 μM。
T73165 EGFR-IN-73
化合物 EGFR-IN-73
2857033-34-0 98%
EGFR-IN-73 (Compound 3f) 对EGFR突变EGFRDel19显示出高效抑制,其IC50值为119 nM。
T73995 EGFR/CSC-IN-1
化合物 EGFR/CSC-IN-1
2820447-02-5 98%
EGFR/CSC-IN-1为针对三阴性乳腺癌研究的潜在EGFR(IC50为10.52 nM)及肿瘤干细胞(CSC)双重抑制剂。
T10556 BKI-1369
化合物 T10556
1951431-22-3 98%
BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
T9923 Nimotuzumab
尼妥珠单抗
828933-51-3 98%
Nimotuzumab 是一种针对表皮生长因子受体 EGFR 的人源化治疗性单克隆抗体。
T10433 Osimertinib dimesylate
奥希替尼二甲磺酸盐
2070014-82-1 98%
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).
T11213L Epertinib
化合物 T11213L
908305-13-5 98%
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
TN3711 Corylifol C
化合物 TN3711
775351-91-2 98%
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
T16362 Nuvenzepine
化合物 T16362
96487-37-5 98%
Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
TN5100 Taspine
化合物 TN5100
602-07-3 98%
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN4213 Hirsutenone
化合物 TN4213
41137-87-5 98%
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T12131 Mutated EGFR-IN-3
化合物 T12131
2375107-27-8 98%
Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM a...
T13743 JH-XI-10-02
化合物 T13743
2209085-22-1 98%
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
TN1912 Marinobufogenin
南美蟾毒精
470-42-8 98%
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
T9922 Matuzumab
马妥珠单抗
339186-68-4 98%
Matuzumab
Matuzumab 是一种用于癌症治疗的人源化单克隆抗体。它对 EGFR 具有高亲和力,通常与恶性肿瘤中血管的生长有关,从而促进肿瘤的生长和存活。
TN2504 1,5-Dihydroxyxanthone
化合物 TN2504
14686-65-8 98%
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have ant...
T12130 Mutated EGFR-IN-2
化合物 T12130
2050906-97-1 98%
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
T11159 EGFR-IN-2
化合物 T11159
1643497-70-4 98%
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
T8525 EGFR-IN-16
化合物AG473
133550-22-8 98%
EGFR-IN-16 (AG473) 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。
TN4638 Neolinine
化合物 TN4638
112515-37-4 98%
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
EGFR-IN-61
T73128
EGFR-IN-61(化合物22a)为一种高效EGFR激酶抑制剂,其对L858R/T790M、L858R/T790M/C797S和WT的IC50值分别为42 nM、137 nM和743 nM。此外,EGFR-IN-61对A549和H1975细胞株展现抗增殖效应,其IC50值依次为2.14 μM和1.82 μM。
EGFR-IN-73
T73165
EGFR-IN-73 (Compound 3f) 对EGFR突变EGFRDel19显示出高效抑制,其IC50值为119 nM。
EGFR/CSC-IN-1
T73995
EGFR/CSC-IN-1为针对三阴性乳腺癌研究的潜在EGFR(IC50为10.52 nM)及肿瘤干细胞(CSC)双重抑制剂。
BKI-1369
T10556
BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
Nimotuzumab
T9923
Nimotuzumab 是一种针对表皮生长因子受体 EGFR 的人源化治疗性单克隆抗体。
Osimertinib dimesylate
T10433
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M).
Epertinib
T11213L
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
Corylifol C
TN3711
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
Nuvenzepine
T16362
Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
Taspine
TN5100
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
Hirsutenone
TN4213
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
Mutated EGFR-IN-3
T12131
Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM a...
JH-XI-10-02
T13743
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
Marinobufogenin
TN1912
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure.
Matuzumab
T9922
Matuzumab 是一种用于癌症治疗的人源化单克隆抗体。它对 EGFR 具有高亲和力,通常与恶性肿瘤中血管的生长有关,从而促进肿瘤的生长和存活。
1,5-Dihydroxyxanthone
TN2504
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have ant...
Mutated EGFR-IN-2
T12130
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR.
EGFR-IN-2
T11159
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor.
EGFR-IN-16
T8525
EGFR-IN-16 (AG473) 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。
Neolinine
TN4638
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
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