Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product Name	CAS No.	Purity
TN3614	Cearoin 化合物 TN3614	52811-37-7	98%
TN3614	Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN2895	3,5-Dicaffeoyl-epi-quinic acid 化合物 TN2895	879305-14-3	98%
TN2895	3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases.
T13764	Lycopodine 化合物 T13764	466-61-5	98%
T13764	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis...
TMA0153	Safflor Yellow A 化合物 TMA0153	85532-77-0	98%
TMA0153	Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
TN4107	Ganoderic acid X 化合物 TN4107	86377-53-9	98%
TN4107	Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN3681	Clerosterol 化合物 TN3681	2364-23-0	98%
TN3681	Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cy...
TN3621	Centrolobol 化合物 TN3621	30359-01-4	98%
TN3621	(-)-Centrolobol has antifibrotic activity, it can significantly inhibit the proliferation of HSC-T6 cells in a dose-dependent manner. Centrolobol exhibits strong...
TN4903	Regiolone 化合物 TN4903	137494-04-3	98%
TN4903	Regiolone demonstrates phytotoxicity. Regiolone also has anti-proliferative and apoptotic activities, it can induce apoptosis in MCF-7 cells through the caspase-...
T15180	Duocarmycin A 化合物 T15180	118292-34-5	98%
T15180	Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as ...
T4S2012	Dihydrosanguinarine 二氢血根碱	3606-45-9	99.99%
T4S2012	Dihydrosanguinarine 是榕树叶片提取出的一种天然产物，具有抗真菌和抗癌活性。
T8652	CASP3 Activator 1541 化合物CASP3 Activator 1541	1100353-03-4	99.98%
T8652	CASP3 Activator 1541 是 caspase-3 酶原形式的激活剂，可诱导细胞死亡。
T6191	Tasisulam 他司磺胺	519055-62-0	99.97%
T6191	Tasisulam (LY573636) 是一种小分子抗肿瘤药物，通过内在途径诱导细胞凋亡，导致细胞色素 c 释放和 caspase 依赖性细胞死亡。它抑制有丝分裂进程并诱导血管正常化。
TN1854	Lasiodin 毛栲利素	28957-08-6	99.90%
TN1854	Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物，可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性，可诱导细胞周期组长和凋亡，诱导细胞迁移和侵袭，可用于研究鼻咽癌
TN1807	Isoverticine 泪杉醇	23496-43-7	99.88%
TN1807	Isoverticine 是一种具有生物活性的等甾体生物碱，从 Fritillaria pallidiflora 球茎中分离得到，具有显著的细胞毒性。
T10990	Dehydrocorydaline chloride 盐酸脱氢紫堇碱	10605-03-5	99.88%
T10990	Dehydrocorydaline chloride (13-Methylpalmatine chloride) 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。它具...
TN1677	Gartanin 化合物Gartanin	33390-42-0	99.85%
TN1677	Gartanin 是山竹果中的一种天然黄酮，具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬，抑制其迁移。
T4085	Paris saponin VII 重楼皂苷 VII	68124-04-9	99.83%
T4085	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T7019	Z-IETD-FMK 化合物Z-IETD-FMK	210344-98-2	99.81%
T7019	Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) 是一种选择性 caspase 8 抑制剂，具有细胞渗透性。它也是颗粒酶 B 抑制剂。
T4S1335	Daphnoretin 西瑞香素	2034-69-7	99.80%
T4S1335	Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物，具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 黄腐酚	569-83-5	99.79%
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) 是一种从蛇麻草中提纯的具有多种生物功能的天然产物。黄腐酚对 HIV-1 有效，可能是一种有趣的先导化合物...