Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation. They are named caspases due to their specific cysteine protease activity – a cysteine in its active site nucleophilically attacks and cleaves a target protein only after an aspartic acid residue.

Cat. No.	Product Name	CAS No.	Purity
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone 化合物 Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	1926163-65-6	98%
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone 是一种细胞渗透性且无毒的抑制剂，它能与活化的caspase-3在凋亡细胞内不可逆结合。该抑制剂的荧光强度可通过流式细胞仪、微孔板读数器或荧光显微镜检测。
T82774	Caspase-3 activator 3 化合物 Caspase-3 activator 3		98%
T82774	Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis，表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM，对K562细胞的IC50值为33.61 μM。
T82775	Caspase-3 activator 2 化合物 Caspase-3 activator 2		98%
T82775	Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂，适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性，IC50 值分别为 33.52 μM 和 76.90 μM。
T83205	Ac-DNLD-CHO 化合物 Ac-DNLD-CHO	775289-20-8	98%
T83205	Ac-DNLD-CHO（Ac-Asp-Asn-Leu-Asp-CHO）是一种有效的Caspase-3/7抑制剂，具有较低的IC50（分别为9.89, 245 nM）和Kiapp（分别为0.68、55.7 nM）。该化合物在研究caspase介导的细胞凋亡过程中具有重要应用价值，适用于神经退行性疾病和病毒感染疾病的相关研究...
T78586L	Ac-IETD-CHO TFA Ac-IETD-CHO 三氟乙酸盐		98%
T78586L	Ac-IETD-CHO TFA 是一种 granzyme B 和 caspase-8 抑制剂，通过阻断 caspase3 前体裂解抑制 caspase8 活性。Ac-IETD-CHO TFA 抑制 Fas 介导的细胞凋亡(Apoptosis)。
T21523	β-Tocotrienol 化合物 T21523	490-23-3	98%
T21523	Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG ...
TN1642	Ferruginol 化合物Ferruginol	514-62-5	98%
TN1642	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
TN4496	Marginatoxin 化合物 TN4496	1422536-56-8	98%
TN4496	Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in v...
TN4877	Quercetin 3,4'-dimethyl ether 化合物 TN4877	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN5033	Skullcapflavone I 化合物 TN5033	41060-16-6	98%
TN5033	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and...
TN2835	28-Deoxonimbolide 化合物 TN2835	126005-94-5	98%
TN2835	28-Deoxonimbolide exhibits potent cytotoxic activity against HL60 leukemia cells.
TN2977	3-O-trans-p-Coumaroyltormentic acid 化合物 TN2977	121064-78-6	98%
TN2977	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in ...
T10548	Biotin-VAD-FMK 化合物 T10548	1135688-15-1	98%
T10548	Biotin-VAD-FMK is a cell-permeable, irreversible biotin-labeled inhibitor of caspase. It is used to identify active caspases in cell lysates.
T4366	Quinovic acid 化合物 T4366	465-74-7	98%
T4366	Quinovic acid shows some anti-tumour activities, quinovic acid glycosides have a potent inhibitory effect on the growth of human bladder cancer cell lines by ind...
T13797	Nivalenol 雪腐镰刀菌烯醇	23282-20-4	98%
T13797	Nivalenol 是一种由禾谷镰刀菌产生的真菌代谢物。 Nivalenol 通过 caspase 和内在凋亡途径诱导细胞死亡，从而影响免疫系统并引起呕吐、生长迟缓和生殖障碍。
TN3525	Boehmenan 化合物 TN3525	57296-22-7	98%
TN3525	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN2511	Britannilactone diacetate 化合物 TN2511	1286694-67-4	98%
TN2511	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN3708	Coronarin D 化合物 TN3708	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T14003	15-Acetoxyscirpenol 15-乙酰蛇形菌素	2623-22-5	98%
T14003	15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-de...
T2S0606	Bakkenolide A 蜂斗菜内酯A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...