CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product Name	CAS No.	Purity
T14990	CDK12-IN-3 化合物 T14990	2220184-50-7	98%
T14990	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).
T10546	Bio-THZ1 化合物 T10546	1604811-14-4	98%
T10546	bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).
T13153	THZ1-R 化合物 T13153	1621523-07-6	98%
T13153	THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).
T12355	Palbociclib-d8 化合物 T12355	1628752-83-9	98%
T12355	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively)....
T10382	AS2863619 free base 化合物 T10382	2241300-50-3	98%
T10382	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 ...
T13202L	Trilaciclib 化合物 T13202L	1374743-00-6	98%
T13202L	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
TL0017	Aristolactam AIIIa 化合物 TL0017	97399-91-2	98%
TL0017	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
T10464	Atuveciclib 化合物 T10464	2923012-24-0	98%
T10464	Atuveciclib (BAY-1143572) 是一种有效且高度选择性的口服 PTEFb/CDK9抑制剂。Atuveciclib (BAY-1143572) 抑制 CDK9/CycT1，IC50为 13 nM。
TN1728	Hellebrigenin 蟾蜍它里定	465-90-7	98%
TN1728	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
T15731	Ribociclib succinate hydrate 化合物 T15731	1374639-79-8	98%
T15731	Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyc...
TN3673	Clausine Z 化合物 TN3673	866111-14-0	98%
TN3673	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
T11655	Indomethacin-D4 吲哚美辛-D4	87377-08-0	98%
T11655	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for huma...
T10465	Atuveciclib S-Enantiomer 化合物 T10465	2250279-81-1	98%
T10465	Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) 是 BAY-1143572的 S-对映异构体，是一种有效的选择性 CDK9抑制剂，抑制 CDK9/CycT1，IC50为 16 nM。
T10836	CLK1-IN-1 化合物 T10836	2123491-32-5	98%
T10836	CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
T14915	CDK12-IN-E9 化合物 T14915	2020052-55-3	98%
T14915	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak bind...
T10096	(2S,3R)-Voruciclib 化合物 T10096	1253731-24-6	98%
T10096	(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.
T13696	FN-1501-propionic acid 化合物 T13696	2408642-48-6	98%
T13696	FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
T22440	TP-353 化合物TP-353	1253799-29-9	99.98%
T22440	TP-353 (EOS-61973) 是一种 CDK7 抑制剂。
T11960	MBM-55 化合物MBM-55	2083622-09-5	99.98%
T11960	MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂，IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T6162	BS-181 hydrochloride 化合物BS-181 HCl	1397219-81-6	99.97%
T6162	BS-181 hydrochloride (BS-181 HCl) 是一种高度选择性的CDK7抑制剂，IC50值为 21 nM。它对 CDK7 的选择性是对 CDK1、2、4、5、6 和 9 的 40 倍以上。