BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product Name	CAS No.	Purity
TN2191	Scutebarbatine A 半枝莲碱	176520-13-1	98%
TN2191	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
TN2116	Pteropodine 钩藤碱 C	5629-60-7	98%
TN2116	Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
TN1875	Liriodenine 化合物Liriodenine	475-75-2	98%
TN1875	Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
T16042	Metaldehyde 四聚乙醛	108-62-3	98%
T16042	Metaldehyde is used for snails and other gastropods pesticide against.
T11974	Mcl1-IN-12 化合物 T11974	2042211-12-9	98%
T11974	Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
TN5201	Uncarinic acid E 化合物 TN5201	277751-61-8	98%
TN5201	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN2149	Reynosin 喘诺木烯内酯	28254-53-7	98%
TN2149	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
T14213	Tapotoclax 化合物 T14213	1883727-34-1	98%
T14213	AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
TN2106	Protodeltonin 化合物 TN2106	94992-08-2	98%
TN2106	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one 化合物Ergosta-4,6,8(14),22-tetraen-3-one	19254-69-4	98%
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN3618	Cedrin 化合物 TN3618	75513-81-4	98%
TN3618	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4341	IVHD-valtrate 化合物 TN4341	28325-56-6	98%
TN4341	VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
TN5100	Taspine 化合物 TN5100	602-07-3	98%
TN5100	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
T11975	PROTAC Mcl1 degrader-1 化合物 T11975	2163793-38-0	98%
T11975	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide t...
TN2002	Obovatol 和厚朴新酚	83864-78-2	98%
TN2002	Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...
TN2691	2',3'-Dehydrosalannol 化合物 TN2691	97411-50-2	98%
TN2691	2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
TN1093	Ginsenoside F4 人参皂苷F4	181225-33-2	98%
TN1093	Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
TN1532	Crenulatin 大花红天素	63026-02-8	98%
TN1532	Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L ...
TN2775	2-Methoxystypandrone 化合物 TN2775	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN4604	Myricanone 化合物 TN4604	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...