dag kinase a

QNN33358 is an alkylacylglycerol acts as a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist.

JH-131e-153, 作为一种二酰基甘油(DAG)内酯，具有激活 Munc13-1 的功能，靶向其 C1 结构域。JH-131e-153 对 Munc13-1 激活效率表现为 WT>I590≈R592A≈W588A。值得注意的是，Munc13-1 的 C1 结构域与蛋白激酶 C (PKC) 在序列和结构上具有同源性。对于 Munc13-1 和 PKC 的激活效率，JH-131e-153 的效果排序为 PKCα>Munc13-1>PKCε。该化合物通过调节 Munc13-1，对神经元过程产生影响，因此可用于神经退行性疾病的相关研究。

Diacylglycerols (DAG) are generated through the hydrolysis of membrane phospholipids and function as lipid second messengers by activating protein kinase C (PKC) and modulating cell growth and apoptosis. Additionally, they act as precursors for DAG kinases in the synthesis of phosphatidic acid, a crucial lipid messenger. The compound 1-NBD-decanoyl-2-decanoyl-sn-glycerol incorporates a nitrobenzoxadiazole (NBD) fluorophore at the ω-end of its terminal decanoyl chain, using the structure of 1,2-didecanoyl-sn-glycerol as a model for diacylglycerol. This molecule is expected to exhibit excitation and emission peaks at roughly 470/541 nm, paralleling those of various NBD-labeled phospholipids. Fluorescently labeled lipids, such as this, are instrumental in exploring their interactions with proteins, their uptake by cells and liposomes, and in developing assays for lipid metabolism research.