95
58
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36816 |
S-trityl-L-Cysteine
STLC |
Kinesin | Cytoskeletal Signaling |
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。 | |||
T21685 |
CCT 031374 hydrobromide
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
CCT 031374 hydrobromide 是一种 TCF/β-catenin 抑制剂,具有抗肿瘤活性。 | |||
T19668 |
Tiomolibdate diammonium
Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa |
Others | Others |
Tiomolibdate diammonium (NSC-286644) 是超氧化物歧化酶 1 (SOD1) 的抑制剂,具有抗血管生成和抗肿瘤活性。 Tiomolibdate diammonium 抑制铜酶的活性,包括 SOD1 和 COX。 | |||
T9940 |
Protein kinase G inhibitor-2
|
Others | Others |
Protein kinase G inhibitor-2 具有抗菌、抗病毒和抗肿瘤活性。 | |||
T9991 |
WAY-620645
|
cholecystokinin | GPCR/G Protein |
WAY-620645 是一种 CCK 拮抗剂,具有抗肿瘤和镇痛活性。 | |||
T9399 |
Menin-MLL inhibitor 20
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
Menin-MLL inhibitor 20 是一种不可逆的menin-MLL 相互作用抑制剂,具有抗肿瘤活性。 | |||
T7470 |
6-Chloropurine
6-氯嘌呤,6-Chloro-9H-purine |
Others | Others |
6-Chloropurine (6-Chloro-9H-purine) 是一种制备9-烷基嘌呤和6-巯基嘌呤的中间体,是化学合成的砌块,具有抗肿瘤作用。 | |||
T1898 |
RKI-1447
RKI1447 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
RKI-1447 是一种高效的ROCK1和ROCK2的小分子抑制剂,IC50值分别为14.5和6.2 nM。 | |||
T0876 |
Clioquinol
Chinoform,Iodochlorhydroxyquin,氯碘羟喹 |
Mitophagy; Antibiotic; Autophagy; Antifungal | Autophagy; Microbiology/Virology |
Clioquinol (Iodochlorhydroxyquin) 是一种局部抗真菌药,具有抗肿瘤活性。它作为口服抗菌剂,可研究腹泻和皮肤感染。 | |||
T9999 |
Sirtuin modulator 2
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide |
Others; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) 具有抗糖尿病、抗炎和抗肿瘤活性。 | |||
T0707 |
Cyclophosphamide hydrate
环磷酰胺一水物,Cyclophosphamide monohydrate,环磷酰胺水合物 |
DNA Alkylator/Crosslinker; DNA; MRP | DNA Damage/DNA Repair; Immunology/Inflammation |
Cyclophosphamide hydrate 是一种 DNA 烷化剂,一种 DNA 合成抑制剂。Cyclophosphamide hydrate 具有抗肿瘤活性、免疫抑制活性等。 | |||
T50022 |
4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one
|
Others | Others |
4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one 是一种噻唑-2-酮类化合物,被发现具有抗炎、抗细菌、抗真菌和抗肿瘤等活性。 | |||
TN6963 |
Hentriacontane
|
NF-κB | NF-κB |
Hentriacontane 是一种天然产物,具有多种药理作用,包括抗炎、抗肿瘤和抗菌活性。 | |||
T72043 |
SCFSkp2-IN-2
|
Apoptosis; E1/E2/E3 Enzyme | Apoptosis; Ubiquitination |
SCFSkp2-IN-2 是一种 Skp2抑制剂,其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis),显示出抗肿瘤活性。 | |||
T0251 |
Gemcitabine
吉西他滨,NSC 613327,LY188011 |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gemcitabine (LY188011) 是一种人工合成的胞嘧啶核苷衍生物,一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。 | |||
T0638 |
2-Methyl-4-nitroimidazole
|
Others | Others |
2-Methyl-4-nitroimidazole(2-MNI)是一种杂环化合物,具有抗菌、抗炎和抗肿瘤活性。2-MNI 已被用于多种领域,包括生物化学、药理学和生物技术。 | |||
T1485 |
Methotrexate
NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。 | |||
T6069 |
Gemcitabine hydrochloride
Gemcitabine HCl,吉西他滨盐酸盐,Gemzar,LY188011,盐酸吉西他滨,LY 188011 hydrochloride |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gemcitabine hydrochloride (LY 188011 hydrochloride) 是一种人工合成的胞嘧啶核苷衍生物,一种 DNA 合成抑制剂。Gemcitabine 具有抗肿瘤活性和抗代谢活性。Gemcitabine 可以引起细胞自噬和凋亡。 | |||
T50068 |
2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide
|
Others | Others |
2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide 是一种用作分子结构单元的化合物,为环状二肽。它可以诱导细胞凋亡、抑制细胞增殖和调节免疫反应,具有广泛的生物活性,包括抗肿瘤、抗真菌、抗细菌、抗病毒和免疫条件活性等。 | |||
T73549 |
RSH-7
|
Apoptosis; FLT; BTK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
RSH-7 是一种高效的 BTK 和 FLT3 双重抑制剂,IC50 分别为 47、12 nM。RSH-7 具有抗增殖活性和抗肿瘤活性,可诱导细胞凋亡 (apoptosis) ,抑制 BTK 和 FLT3 信号转导。 | |||
T11961 |
MBM-55S
|
GSK-3; MAPK; Akt; Bcr-Abl; CDK; S6 Kinase; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
MBM-55S 是一种有效的 Nek2 抑制剂,IC50 为 1 nM。 MBM-55S 抑制细胞周期停滞和凋亡,从而抑制癌细胞的增殖。 MBM-55S 表现出抗肿瘤作用。 | |||
T60688 |
MKI-1
MASTL Kinase Inhibitor-1 |
Others | Others |
MKI-1 (MASTL Kinase Inhibitor-1) 是微管相关丝氨酸/苏氨酸样激酶 (MASTL) 抑制剂 (IC50= 9.9 μM)。MKI-1 通过激活乳腺癌中的PP2A 发挥放射增敏和抗肿瘤活性。 | |||
T8541 |
Lenvatinib mesylate
仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼 |
VEGFR; FGFR; c-RET; PDGFR; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Lenvatinib mesylate (E7080 (mesylate)) 是一种口服具有活力的,多靶点酪氨酸激酶抑制剂,能够抑制血管内皮生长因子受体(VEGFR1-3),成纤维细胞生长因子受体(FGFR1-4),干细胞因子受体(KIT),血小板衍生生长因子受体(PDGFR),转染期间重排(RET),具有效抗癌作用。 | |||
T11090L1 |
Aldoxorubicin hydrochloride
Aldoxorubicin hydrochloride (1361644-26-9 Free base) |
Topoisomerase | DNA Damage/DNA Repair |
Aldoxorubicin hydrochloride 是 Doxorubicin (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前药。Aldoxorubicin hydrochloride 在酸性条件下从白蛋白中释放出来。 Aldoxorubicin hydrochloride 显示出有效的抗肿瘤活性。 | |||
T15044 |
D609
|
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
D609 (Tricyclodecan-9-yl-Xanthogenate) 具有广泛的生物活性,包括抗氧化、抗凋亡、抗胆碱能、抗肿瘤、抗炎、抗病毒、抗增殖和神经保护活性。D609 通过引起磷脂酰胆碱 (PC) 特异性磷脂酶 C (PC-PLC) 和鞘磷脂合酶 (SMS) 的竞争性抑制来发挥作用。 | |||
T21593 |
AAL-993
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
AAL-993 是口服有效的VEGFR 选择性抑制剂,抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM,对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。 | |||
T36113 |
Cobaltic Protoporphyrin IX chloride
Protoporphyrin IX cobaltic chloride |
Autophagy | Autophagy |
Cobaltic Protoporphyrin IX chloride (CoPP)是一种有效的血红素加氧酶 1(HO-1)诱导剂,具有抗病毒活性,通过诱导 I 型 IFN 反应来抑制甲型流感病毒(IAV)感染。 | |||
T14348 |
Auristatin E
|
Microtubule Associated | Cytoskeletal Signaling |
Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂,具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物,是抗体-药物偶联物中的细胞毒素。 | |||
T11154L |
EG01377 2HCl
EG01377 2HCl(2227996-00-9 Free base) |
Complement System | Immunology/Inflammation |
EG01377 2HCl 是一种有效的、可生物利用的和选择性的neuropilin-1(NRP1)抑制剂,Kd 值为1.32μM,EG01377 2HCl 对NRP1-a1和NRP1-b1的IC50值均为609nM。EG01377具有抗血管生成,抗迁移及抗肿瘤等活性。 | |||
T6230 |
Imatinib
伊马替尼,STI571,CGP057148B,ST-1571 |
SARS-CoV; Bcr-Abl; PDGFR; c-Kit; Autophagy | Angiogenesis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Imatinib (STI571) 是一种多靶点受体酪氨酸激酶抑制剂,可选择性抑制 BCR/ABL、v-Abl、PDGFR、c-kit 等激酶活性,具有口服活性。Imatinib 具有抗肿瘤活性,可用于治疗慢性粒细胞白血病。 | |||
T21497 |
9-cis-Retinoic Acid
Alitretinoin |
Apoptosis | Apoptosis |
9-cis-Retinoic Acid (Alitretinoin) 是一种维生素 A 的衍生物,是一种 RAR/RXR 激动剂,具有抗癌、抗肿瘤活性、抗炎和神经保护活性,可诱导细胞凋亡 (apoptosis),调节细胞周期,可用于研究晚期肿瘤。 | |||
T10883L |
CRA-026440 hydrochloride
CRA-026440 hydrochloride(847460-34-8 Free base) |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
CRA-026440 hydrochloride 是有效的、广谱的 HDAC 抑制剂。CRA-026440 hydrochloride 作用于 HDAC1,HDAC2,HDAC3,HDAC6,HDAC8 和 HDAC10, Ki 值分别为 4 nM,14 nM,11 nM,15 nM,7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗血管生成和抗肿瘤活性。 | |||
T35557 |
CK2 inhibitor 2
|
Casein Kinase | Metabolism; Stem Cells |
CK2 inhibitor 2 是一种有效的,选择性和口服CK2抑制剂,IC50值为 0.66 nM。CK2 inhibitor 2 对 Clk2 (IC50=32.69 nM)/CK2 显示出高选择性。 CK2 inhibitor 2 表现出良好的抗增殖和抗肿瘤活性。 | |||
T9017 |
HPK1-IN-2
Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2 |
Others; FLT; Src | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) 是一种有效且具有口服活性的造血祖细胞激酶-1 抑制剂(HPK1;IC50<0.05 µM)。它还抑制 Lck (0.05 µM<IC50<0.5 µM) 和 Flt3 (IC50<0.05 µM) 激酶活性,具有抗肿瘤活性。 | |||
T50069 |
1-pentyl-1H-indole-3-carboxylic acid
|
Others | Others |
1-pentyl-1H-indole-3-carboxylic acid 是一种天然存在的吲哚生物碱类化合物,具有多种生物活性,包括抗炎、镇痛、抗氧化和抗真菌、抗肿瘤活性等;它通过结合体内的各种受体和酶发挥作用,包括血清素受体、大麻素受体、PPARγ受体和PDE4酶。 | |||
T36953 |
Naphthofluorescein
Naphthafluorescein |
HIF | Angiogenesis; Chromatin/Epigenetic |
Naphthofluorescein (Naphthafluorescein)是一种 Mint3 抑制剂,具有潜在的抗肿瘤和抗炎活性,抑制 HIF-1 和 Mint3 之间的相互作用,抑制 Mint3 依赖性 HIF-1 活性,抑制癌细胞和巨噬细胞的糖酵解活动,同时未显示出明显的体外细胞毒性和体内副作用。Naphthofluorescein 也是一种荧光 pH 敏感探针,可用于功能性切伦科夫成像。 | |||
T35900 |
JAK2-IN-7
JAK2-IN-7 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-7 是一种选择性 JAK2抑制剂,对 JAK2,SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3,FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期,并诱导肿瘤细胞凋亡 (apoptosis),具有抗肿瘤活性。 | |||
T124358 |
Deferoxamine
Deferoxamine B,Desferrioxamine B |
Apoptosis; Antioxidant; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; oxidation-reduction |
Deferoxamine(Desferrioxamine B) 是一种铁螯合剂 (结合 Fe(III) 和许多其他金属阳离子),可抑制神经元病变,可用于改减少铁在组织中的积累和沉积,可通过抑制创伤性脑损伤后的铁死亡和神经炎症来改善神经功能障碍。Desferrioxamin-B 具有抗氧化、抗增殖、抗肿瘤活性,可诱导 HIF-1α 产生,诱导癌细胞凋亡和自噬。Desferrioxamin-B 可用于治疗急性铁中毒和与 COVID-19 相关疾病。 | |||
T25620 |
Lankacidinol
Antibiotic T 2636F,T2636 F,T-2636 F,T 2636 F |
||
Lankacidinol is an antibiotic that has antitumor and immunosuppressive activities. | |||
T26121 |
Rooperol
|
||
Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, antibacterial, anticonvulsant, and antioxidant activities. It is a novel p38α inhibitor. | |||
T12590 |
Pyrindamycin A
|
Others | Others |
Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia. | |||
T26355 |
ZYJ-34c
ZYJ 34c,ZYJ34c |
||
ZYJ-34c is a potent oral antitumor activities histone deacetylase inhibitor (HDACi). | |||
T26354 |
ZYJ-25e
ZYJ 25e |
||
ZYJ-25e is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities. | |||
T26356 |
ZYJ-34v
|
||
ZYJ-34v is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities. | |||
T27223 |
DW10075
DW-10075,DW 10075 |
||
DW10075, a novel potent and highly selective inhibitor of VEGFR, exhibits antitumor activities both in vitro and in vivo. | |||
T26043 |
Ravidomycin
AY 25545,AY25545,AY-25545 |
||
Ravidomycin is an antitumor antibiotic. It shows effective anticancer activities against various cancer cell lines in the presence of visible light. | |||
T26185 |
Septacidin
NSC-65104,NSC65104,NSC 65104 |
||
Septacidin represents a group of l-eptopyranoses including nucleoside antibiotics with antitumor, antifungal, and pain-relief activities. | |||
T24553 |
NSC-639829
NSC 639829 |
||
NSC-639829 is a tubulin polymerization inhibitor that acts by demonstrating potent antitumor activities against several cancer cell lines. | |||
T11795 | L-4-Oxalysine hydrochloride | Others | Others |
L-4-Oxalysine hydrochloride has shown antitumor activities, is a natural product isolated from the culture media of Streptomyces roseovirdofuscus in China. | |||
T33281 |
Melflufen
Prodrug J-1, Melflufen, Melphalan flufenamide,Melphalan flufenamide,J 1,J1,J-1 |
||
Melphalen fluoroaniline, also known as melphalen, J-1, or prodrug J-1, is a prodrug of melphalen, in which the alkylating agent melphalen is combined with fluoroaniline and has potential antitumor and antiangiogenic activities. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11363 |
Ganoderic acid F
|
Others | Others |
Ganoderic acid F 是一种灵芝酸。它具有抗肿瘤和抗转移的活性,与抑制血管生成和涉及细胞增殖和细胞死亡,致癌作用,氧化应激,钙信号传导和内质网应激的蛋白质改变等机制相关。 | |||
T3819 |
Ursolic acid acetate
熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid |
AChE | Neuroscience |
Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中,对 KB 细胞显示细胞毒性(IC50:8.4 μM)。 | |||
T6473 |
Dioscin
山药,CCRIS 4123,Collettiside III,Saponin |
Apoptosis; Autophagy | Apoptosis; Autophagy |
Dioscin (Collettiside III) 是一种来源植物的天然甾体皂苷,针对多种癌细胞有较好的抗癌活性。 | |||
T2997 |
Rhein
Rheinic Acid,Monorhein,大黄酸,NSC 38629,Rheic Acid,Rhubarb yellow |
Reactive Oxygen Species; Antibacterial; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Rhein (NSC 38629) 从蓼科大黄中提取的一种蒽醌类化合物,有抗炎、抗氧化、抗癌等作用。 | |||
T2863 |
p-Coumaric acid
para-Coumaric Acid,4-Hydroxycinnamic acid,trans-4-Hydroxycinnamic acid,对香豆酸,Trans-p-Coumaric acid,4-Coumaric acid,P-Hydroxycinnamic acid |
Endogenous Metabolite; Antibiotic | Metabolism; Microbiology/Virology |
p-Coumaric acid (para-Coumaric Acid) 是肉桂酸的丰富异构体,具有抗诱变和抗肿瘤特性。 | |||
TN1190 |
14,15 β-Dihydroxyklaineanone
14,15beta-Dihydroxyklaineanone |
Parasite | Microbiology/Virology |
14,15 β-Dihydroxyklaineanone(14,15beta-Dihydroxyklaineanone)从 Eurycoma longifolia 中分离得到的苦味素类化合物,具有抗肿瘤促进、抗血吸虫和杀疟原虫活性。 | |||
TN6097 |
Girinimbine
Girinimbin |
Apoptosis; Antioxidant; Antibacterial | Apoptosis; Microbiology/Virology; oxidation-reduction |
Girinimbine (Girinimbin) 是一种来自植物九里香、 M. koenigii和Murraya koenigii中分离出的咔唑类生物碱。Girinimbine 具有多种生物学作用,可诱导细胞凋亡 (apoptosis),具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。 | |||
T3013 |
Catharanthine tartrate
Catharanthine hemitartrate,酒石酸长春质碱 |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱,可抑制电压门控 L 型钙离子通道,具有抗肿瘤和降血压活性。 | |||
TN1490 |
Chrysoeriol
|
ERK; p38 MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Chrysoeriol 是一种天然黄酮,可从热带植物Coronopus didymus 中提取获得,具有强大的抗氧化功能,能够抑制脂质的过氧化。 | |||
T2853 |
Curcumol
莪术醇,(-)-Curcumol,姜黄醇 |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Curcumol ((-)-Curcumol) 是一种倍半萜,具有抗癌,抗微生物,抗真菌,抗病毒和抗炎活性。它通过靶向关键信号通路,在许多癌细胞中有效地诱导凋亡。 | |||
T5771 |
Hypocrellin A
|
Antibacterial; PKC; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology |
Hypocrellin A 是一种天然的PKC 抑制剂,具有光诱导的抗肿瘤、抗真菌和抗病毒活性,还对 MHC 限制性抗原呈递发挥免疫调节作用。 | |||
T2177 |
Kaempferol
Kempferol,山柰酚,山奈酚,Robigenin |
Apoptosis; Estrogen Receptor/ERR; Mitophagy; Estrogen/progestogen Receptor; HIV Protease; Endogenous Metabolite; Parasite; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Kaempferol (Robigenin) 属于天然类黄酮,是一种 ERRα 和 ERRγ 的反向激动剂。Kaempferol 具有抗肿瘤、抗炎、抗氧化、抗菌和抗病毒等多种活性。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
TN1079 |
Deoxyelephantopin
|
NF-κB | NF-κB |
Deoxyelephantopin 是来自Elephantopus scaber 的,具有生物活性的天然倍半萜烯内酯,能够抑制NF-κB,MAPK,PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。 | |||
T1062 |
Capsaicin
Qutenza,8-Methyl-N-vanillyl-trans-6-nonenamide,天然辣椒素,Vanilloid,辣椒素,(E)-Capsaicin,Zostrix |
Apoptosis; TRP/TRPV Channel; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel |
Capsaicin ((E)-Capsaicin) 属于天然产物,提取自辣椒,是一种 TRPV1 激动剂 (EC50=0.29 μM)。Capsaicin 具有抗肿瘤、抗炎、抗氧化、神经保护等活性。 | |||
TN1130 |
Yadanziolide A
鸦胆子素 H,鸦胆子内酯A |
Antiviral | Immunology/Inflammation |
Yadanziolide A 来源于 Brucea javanica 干燥的种子。它具有强的抗病毒作用,能够抗烟草花叶病毒(IC50:5.5 μM)。它具有抗肿瘤活性。 | |||
T1125 |
Shikonin
NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid |
TNF; NF-κB; Chloride channel; HIV Protease; PKM | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Shikonin (Anchusa acid) 属于天然产物,是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。 | |||
T8189 |
Dihydroberberine
|
Potassium Channel; HSP; HER | Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors |
Dihydroberberine 可抑制人类 ether-a-go-go 相关基因 (hERG) 通道并显着降低 Hsp90 表达及其与 hERG 的相互作用,具有抗动脉粥样硬化、抗炎、降血脂和抗肿瘤活性。 | |||
TN6675 |
Cyclo(Pro-Val)
Cyclo(prolylvalyl) |
Antibacterial; Antifungal | Microbiology/Virology |
Cyclo(Pro-Val) (Cyclo(prolylvalyl)) 是从海洋真菌中获得的,具有中等的抗真菌活性和较弱的抗肿瘤活性。 Cyclo(Pro-Val) 抑制枯草芽孢杆菌的生长,MIC 为 0.8 g/L。 | |||
T1737 |
Genistein
NPI 031L,三叶草,染料木素,金雀异黄酮 |
Apoptosis; EGFR; Endogenous Metabolite; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors |
Genistein (NPI 031L) 是一种大豆异黄酮,是一种多重的酪氨酸激酶抑制剂,通过改变细胞凋亡,细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。 | |||
TN1600 |
Eclalbasaponin I
|
Others | Others |
Eclalbasaponin I 分离自鳢肠中,具有抗肿瘤作用,能够抑制肝癌细胞 smmc-7721 的增殖(IC50:111.1703 μg/ml)。 | |||
T1516 |
Curcumin
Diferuloylmethane,Natural Yellow 3,姜黄素,Indian Saffron,Turmeric yellow |
Mitophagy; Epigenetic Reader Domain; Ferroptosis; Influenza Virus; Nrf2; Histone Acetyltransferase; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology |
Curcumin (Natural Yellow 3) 属于酚类天然产物,是一种组蛋白乙酰化转移酶 p300/CREB 的抑制剂 (IC50=25 μM),具有特异性。Curcumin 具有抗肿瘤、抗炎和抗氧化等多种药理活性。 | |||
T1027 |
Luteolin
木犀草素,Luteolol,Flacitran,Digitoflavone,Luteoline |
Apoptosis; Nrf2; Endogenous Metabolite; PDE; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism |
Luteolin (Luteolol) 属于黄酮类天然产物,是一种 Nrf2 抑制剂、PDE 抑制剂。Luteolin 具有多种生物活性,包括抗肿瘤、抗氧化、抗炎、抗菌、抗病毒、抗过敏和促凝血等。 | |||
TN1087 |
Deoxypodophyllotoxin
脱氧鬼臼毒素,去氧鬼臼毒素 |
Apoptosis; Microtubule Associated; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling |
Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素,是鬼臼毒素衍生物,具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂,作为靶向微管药物,在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加,诱导细胞自噬和凋亡。 | |||
TN1120 |
Osthenol
|
MAO; Monoamine Oxidase | Metabolism; Neuroscience |
Osthenol 是一种前酰化香豆素,从独活干根中分离得到。它对重组 hMAO-A 具有潜在的选择性抑制作用,IC50=0.74 µM,对 hMAO-A 和 hMAO-B 表现出较高的选择性指数。它是一种可逆的,选择性的竞争性人单胺氧化酶-A(hMAO-A)抑制剂 (Ki=0.26 µM)。 | |||
T2S0886 |
Terrestrosin D
|
Apoptosis; Others | Apoptosis; Others |
Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷,可诱导细胞周期阻滞和癌细胞凋亡,具有抗血管生成的活性。 | |||
T5S1058 |
Triptonide
雷公藤内酯酮,PG 492,NSC 165677 |
Apoptosis; Wnt/beta-catenin; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells |
Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物,是一种 Wnt 信号抑制剂,其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。 | |||
TN1854 |
Lasiodin
毛栲利素,Lasiokaurin |
P450; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物,可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性,可诱导细胞周期组长和凋亡,诱导细胞迁移和侵袭,可用于研究鼻咽癌 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
TN2063 |
Physalin B
NSC-287088 |
Apoptosis; NF-κB; Akt; PI3K; Nrf2; NOD | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Physalin B 是茄科植物的主要活性化合物之一,具有广泛的生物活性,可用于治疗炎症湿疹和疱疹等疾病。Physalin B 通过激活 PI3K/Akt 通路抑制 NF-κB 和 NLRP3,从而改善脂多糖诱导的急性肺损伤造成的炎症反应。Physalin B 通过激活 Nrf2 通路抑制 PDGF-BB 诱导的 VSMC 增殖、迁移和表型转化。Physalin B 通过抑制 LAP2α-HDAC1 介导的胶质瘤相关癌基因 1 的去乙酰化和肝星状细胞活化来发挥抗肿瘤活性。 | |||
TN4923 |
Rubicordifolin
|
Topoisomerase | DNA Damage/DNA Repair |
Rubicordifolin exhibits potent cytotoxic and antitumor activities. | |||
TN6446 |
Cyclo(Ile-Val)
|
||
Cyclo(Ile-Val) shows moderate antifungal and weak antitumor activities in vitro. | |||
T13126 |
Tephrosin
Deguelinol I,灰叶草素,Hydroxydeguelin |
Others | Others |
Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors, has potent antitumor activities. | |||
T16407 |
Osajin
NSC 21565,CID 95168 |
Others | Others |
Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities. | |||
TN5270 |
Yadanzioside P
|
Others | Others |
Yadanzioside P has antileukemic and antitumor activities. | |||
T81196 |
Schiarisanrin C
|
||
Schiarisanrin C为具抗肿瘤活性的木脂素化合物。 | |||
TN1572 |
Desacetylcinobufotalin
|
Others | Others |
Desacetylcinobufotalin has significant antitumor activity through induction apoptosis via mitochondria pathway, it also shows potent cytotoxic activities against HL-60 cell lines. | |||
T40641 |
Crocin-4
|
||
Crocin-4, a carotenoid compound found in saffron, possesses potent antioxidant properties and can penetrate the brain. It effectively inhibits the aggregation and deposition of Aβ fibrils, making it useful for Alzheimer's Disease research. Additionally, Crocin-4 demonstrates antitumor and anti-inflammatory activities. | |||
TN4387 | Khellactone | Antifection | Microbiology/Virology |
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -sensitive strains of with IC(50) values from 1.5 and 2.4 microM. | |||
T74050 |
Allyl methyl trisulfide
|
||
Allyl methyl trisulfide 是一种来自大蒜(Allium sativum L.)精油的挥发性有机化合物,具备抗菌、抗氧化和抗肿瘤活性。 | |||
T81193 |
Schineolignin C
|
||
Schisandroligin C, 一个从五味子(Schisandra chinensis)果实中分离得到的木酚素, 拥有抗肝炎、抗肿瘤及抗HIV-1的活性。 | |||
T8290 |
3,5-DIHYDROXY-4-METHOXYBENZOIC ACID
|
Others | Others |
3,5-DIHYDROXY-4-METHOXYBENZOIC ACID 是一种天然存在的酚类化合物,存在于各种植物和动物中,具有抗氧化、抗炎、抗菌和抗肿瘤的活性。 | |||
TN6528 |
Butyrospermol
|
Others | Others |
Butyrospermol 是一种从乳木果(大戟属植物)中提取的protolimonoid,是首次从天然产物中发现的长链脂肪酸酯,具有拒食和抗肿瘤活性。 | |||
T76129 | Hemocyanin | ||
Hemocyanin是一种含铜的大分子呼吸蛋白,扮演着重要的非特异性先天免疫防御分子角色,具备酚氧化酶、抗病毒、抗菌、溶血及抗肿瘤活性。 | |||
T73874 | Kievitone | ||
Kievitone 是一种异黄酮,是可以从Rhizoctonia solani Kühn 感染Phaseolus vulgaris L.的下胚轴中分离出来。Kievitone 具有抗真菌活性和抗肿瘤活性。 | |||
TN4652 | Niazimicin | NF-κB; PI3K; AChR; Antifection | Microbiology/Virology; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling |
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as ini | |||
T8291 |
2-Carene
|
Others | Others |
2-Carene 是一种天然存在的双环单萜,存在于许多精油中,如松树、雪松和柏树。它被发现具有抗炎、抗真菌和抗菌活性,以及抗氧化、抗肿瘤和抗过敏活性,还有神经保护、心脏保护和肝脏保护作用。 | |||
T5157 |
9,13-Epidioxy-8(14)-abieten-18-oic acid
|
Others | Others |
9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory... | |||
TN4263 |
Isoangustone A
|
MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals. | |||
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