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高通量筛选天然产物库

高通量筛选天然产物库

产品编号 L6000 Natural Product Library for HTS
  库化合物信息   Excel SDF

天然产物是由自然界中的生物体产生的化合物,它们的结构和功能在大自然漫长的进化过程中得以被选择和优化,并通过氧化态升降、骨架重排、阳离子环化、缩合反应以及周环反应等不同过程,产生了具有高度多样性的结构。这些独特的化学结构赋予了天然产物与靶点专一性结合的能力和良好的生物活性,成为发现治疗重大疾病药物的重要源泉,在现代药物研究中具有轰动效应的药物出现时,大都伴随着一种新类型天然产物的发现,这同时也推动了药物化学和生命科学的发展。

TargetMol 高通量筛选天然产物库精心挑选收录了4533 种天然产物单体,这些天然产物单体来源丰富,结构多样,具有很强的代表性。它们存在于三千余种中草药植物、动物以及微生物中提取纯化的天然来源中,涵盖了五百余种不同骨架结构和千余种靶点受体,大部分成分都达到对照品纯度。不仅如此,库中还包含了众多单价极高的稀有天然产物,性价比极高,是您在药物开发、药理研究、干细胞分化、指纹图谱研究、质量研究等领域的有力工具。

TargetMol的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。
TargetMol Compound Library
规格
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)
如果上述化合物库无法满足您的需求,您可发送邮件至tech@targetmol.com咨询我们的技术专员,为您量身定制专属化合物库!
咨询化合物库
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产品描述

  • 4533种天然产物的独特集合,是药物开发、药理研究、干细胞分化、指纹图谱研究、质量研究等领域的有力工具,可用于HTS和HCS;
  • 提供产品的生物学信息和药物学信息,为筛选提供理论方向和研究基础;
  • 来源清晰:精选来自动物、植物、微生物的已知活性天然产物;更具体到植物种属,并标注准确英文名与拉丁名,方便您的后期研究确证。
  • 结构多样性好:4533种天然产物,含黄酮类、生物碱类在内的多种化合物类型,拥有详细的分类信息。
  • 信息全面:从化合物结构到溶解度,从信号通路、作用靶点到生物活性信息均有详细描述。
  • 可根据天然产物来源、天然产物类别、研究领域、药物市场状态等方面自由组合,高度定制。TargetMol天然产物库让高通量筛选更贴合您的研究方向!

化合物库定制

TargetMol的化合物可以高度定制! 了解更多

包装和存储

  • 干粉或者DMSO溶液置于带二维码的储存管中,或排列于96孔板/384孔板;
  • 蓝冰运输
获取筛选库化合物信息 (L6000)
点击图片重新获取验证码

TargetMol Library Books客户使用化合物库发表的文献

1. Nature Biotechnology. 2021, 39(11): 1444-1452. 2. Immunity. 2023. 3. Nature Microbiology. 2023, 8(1): 121-134. 4. Nature Communications. 2022, 13(1): 1-15.. 5. Blood. 2021, 137(11): 1478-1490. 6. Nature Communications. 2019 Apr 23;10(1):1914. 7. Nature Communications. 2020, 11(1): 1-12. 8. Acta Pharmaceutica Sinica B. 2022. 9. Protein & Cell. 2017 Aug;8(8):618-622.
10. Engineering. 2023. 11. Bone Research. 2023, 11(1): 54. 12. Cancer Immunology Research. 2023: CIR-22-0483. 13. Redox Biology. 2022: 102229. 14. Journal of Cell Biology. 2022, 221(5): e202112024. 15. Clinical Cancer Research. 2020, 26(13): 3408-3419. 16. Chemical Science. 2022. 17. Cell & Bioscience. 2021, 11(1): 1-14. 18. Cell Reports. 2023, 42(12). 19. Journal of Translational Medicine. 2022, 20(1): 1-11.. 20. Biomedicine & Pharmacotherapy. 2024, 171: 116176. 21. Acta Pharmacologica Sinica. 2022: 1-15. 22. Cell Proliferation. 2022: e13214. 23. Cell Death & Disease,. 2020, 11(9): 1-12. 24. The American Journal of Chinese Medicine. 2020: 1-20. 25. International Journal of Molecular Sciences. 2021, 22(21): 12037. 26. Journal of Agricultural and Food Chemistry. 2023. 27. Viruses. 2023, 15(4): 891. 28. Acta Pharmaceutica Sinica B. 2020. 29. Journal of Chemical Information and Modeling. 2023. 30. Frontiers in chemistry. 2022, 10. 31. Food & Function. 2018, 9(11): 5536-5546. 32. Journal of Agricultural and Food Chemistry. 2021. 33. Cell Death Discovery. 2021, 7(1): 1-10. 34. Pharmaceuticals. 2023, 16(5): 767. 35. Bioorganic Chemistry. 114 (2021): 105043. 36. European Journal of Pharmaceutical Sciences. 2023: 106672.. 37. Plants-Basel. 2024, 13(2): 318.. 38. Cancer Science. 2021, 112(11): 4722. 39. Frontiers in Pharmacology. 2020, 11. 40. Journal of Cheminformatics. 2020, 12(1): 1-51. 41. Journal of Natural Products. 2022. 42. Neoplasia. 2020, 22(4): 179-191. 43. Journal of Chemical Information and Modeling. 2018 Aug 27;58(8):1518-1532. 44. Plos one. 2023, 18(4): e0281834. 45. Virology. 2022. 46. ChemMedChem. 2022: e202100719. 47. Veterinary Microbiology. 2021 Apr;255:109016. 48. Molecules. 2020, 25(4): 938. 49. Biomolecules. 2019 Jan 24;9(2). 50. Experimental and Therapeutic Medicine. 2021, 22(2): 1-13. 51. Pharmacology. 2020: 1-7. 52. Interdisciplinary Sciences, Computational Life Sciences. 2020, 12: 368-376. 53. Springer. 2020: 1-27. 54. bioRxiv. 2023: 2023.08. 31.555687.. 55. SSRN. 2023. 56. Preprints. 2019. 57. bioRxiv. 2021. 58. STAR Protocols. 2022: 101794. 59. bioRxiv. 2022. 60. Molecular Immunology. 2022, 147: 1-9. 62. Physical Sciences Reviews. 2019, 4(6). 63. Cell Stem Cell. 2022 Apr 29(4) 545–558. 64. Science Bulletin. 2022. 65. Science Translational Medicine. 2022, 14(656): eabn3231. 66. Science Advances. 2023, 9(9): eade3760. 67. Nature. 2020, 582: 289-293. 68. Nature Communications. 2023, 14(1): 1020.. 69. Nature Communications. 2023, 14(1): 2756.. 70. Nucleic Acids Research. 2021. 71. Nature Communications. 2023, 14(1): 7574. 72. Advanced Science. 2020, 7(16): 2000925. 73. Angewandte Chemie. 2021. 74. Protein & Cell. 2021, 12(11): 877-888. 75. Pharmacology & Therapeutics. (2021): 107930. 76. Nature Communications. 2021, 12(1): 1-12. 77. Li H, Sun Y, Yin H, et al.Virtual screening of natural products targeting ubiquitin-specific protease 7.Journal of Biomolecular Structure and Dynamics.2024: 1-8. 78. Duo L, Chen Y, Liu Q, et al.Discovery of Novel SOS1 Inhibitors Using Machine Learning.RSC Medicinal Chemistry.2024 79. Li X, Xiang C, Zhu S, et al.SNX8 enables lysosome reformation and reverses lysosomal storage disorder.Nature Communications.2024, 15(1): 2553. 80. Zhao L, Zhu Y, Tao H, et al.Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation.Acta Pharmaceutica Sinica B.2024 81. Ma Y, Song Y, Wang J, et al.Discovery of novel covalent inhibitors of DJ-1 through hybrid virtual screening.Future Medicinal Chemistry.2024 (0).
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化合物库组成

Endogenous Metabolite (1044)
Apoptosis (420)
Antibacterial (368)
Autophagy (256)
NF-κB (202)
Antibiotic (161)
Antifungal (152)
Antioxidant (146)
Reactive Oxygen Species (113)
COX (104)
Parasite (97)
TNF (77)
P450 (73)
Influenza Virus (70)
NO Synthase (64)
DNA/RNA Synthesis (63)
AChR (63)
HIV Protease (61)
IL Receptor (58)
AChE (58)
ERK (53)
Anti-infection (53)
Calcium Channel (52)
Caspase (52)
p38 MAPK (51)
PPAR (50)
Akt (50)
GABA Receptor (46)
Tyrosinase (43)
STAT (41)
AMPK (41)
ROS (39)
Virus Protease (37)
Antifection (37)
PI3K (35)
Ferroptosis (34)
5-HT Receptor (34)
Nrf2 (34)
Dehydrogenase (33)
NOS (33)
MMP (33)
BCL (33)
Immunology/Inflammation related (31)
JNK (31)
PKC (31)
Microtubule Associated (30)
Topoisomerase (29)
Lipoxygenase (29)
Mitophagy (27)
Estrogen/progestogen Receptor (27)
ATPase (27)
Potassium Channel (27)
TRP/TRPV Channel (27)
Glucosidase (26)
Estrogen Receptor/ERR (26)
HSV (26)
Adrenergic Receptor (26)
Beta Amyloid (25)
Antiviral (25)
P-gp (25)
Prostaglandin Receptor (24)
PDE (22)
PARP (21)
Sodium Channel (21)
HBV (20)
Phosphatase (20)
Wnt/beta-catenin (20)
Dopamine Receptor (19)
HDAC (19)
EGFR (18)
Nucleoside Antimetabolite/Analog (18)
Drug Metabolite (18)
MAO (17)
Interleukin (16)
Amino Acids and Derivatives (16)
Phospholipase (16)
ribosome (16)
HIF/HIF Prolyl-Hydroxylase (16)
Mitochondrial Metabolism (16)
NMDAR (16)
TLR (15)
SARS-CoV (15)
mTOR (15)
JAK (14)
iGluR (14)
GluR (13)
TGF-beta/Smad (13)
Reductase (13)
Adenosine Receptor (13)
HCV Protease (13)
Opioid Receptor (12)
VEGFR (12)
MAPK (11)
NOD (11)
Cannabinoid Receptor (11)
Androgen Receptor (11)
Sirtuin (11)
GPR (11)
Histamine Receptor (11)
CDK (11)
Platelet aggregation (10)
transporter (10)
LDL (9)
Fatty Acid Synthase (9)
Glucocorticoid Receptor (9)
Monoamine Oxidase (9)
IκB/IKK (9)
PKA (9)
Chloride channel (9)
p53 (9)
HMG-CoA Reductase (9)
BACE (9)
RAAS (9)
Xanthine Oxidase (8)
HSP (8)
FXR (8)
MEK (8)
UGT (8)
HIF (8)
Proteasome (7)
Transferase (7)
Aryl Hydrocarbon Receptor (7)
PAFR (7)
Beta-Secretase (6)
Free radical scavengers (6)
Liver X Receptor (6)
Carbonic Anhydrase (6)
Tyrosine Kinases (6)
FAAH (6)
NADPH (6)
IGF-1R (6)
Indoleamine 2,3-Dioxygenase (IDO) (6)
NOD-like Receptor (NLR) (6)
GSK-3 (6)
Lipid (6)
Reverse Transcriptase (6)
HER (6)
MRP (6)
Gamma-secretase (6)
FAK (6)
Epigenetic Reader Domain (5)
cAMP (5)
CaMK (5)
AhR (5)
DNA (5)
PTEN (5)
Integrin (5)
Cysteine Protease (5)
Arginase (5)
Amylase (5)
Serine Protease (5)
Aromatase (5)
ABC (5)
GST (5)
GPCR19 (4)
Syk (4)
FGFR (4)
Acyltransferase (4)
Histone Acetyltransferase (4)
Aminopeptidase (4)
ATP Citrate Lyase (4)
PGE Synthase (4)
PDK (4)
Thyroid hormone receptor(THR) (4)
CCR (4)
Serine/threonin kinase (4)
cell cycle arrest (4)
Src (4)
E1/E2/E3 Enzyme (4)
IAP (4)
CXCR (4)
ROR (4)
c-Met/HGFR (4)
DNA Alkylator/Crosslinker (3)
Phosphorylase (3)
Serotonin Transporter (3)
Bombesin Receptor (3)
P2Y Receptor (3)
Trk receptor (3)
LTR (3)
P2X Receptor (3)
Bcr-Abl (3)
c-Myc (3)
Glutathione Peroxidase (3)
SGLT (3)
Progesterone Receptor (3)
Telomerase (3)
S6 Kinase (3)
Retinoid Receptor (3)
Monoamine Transporter (3)
NADPH-oxidase (3)
Smo (3)
Imidazoline Receptor (3)
DNA Methyltransferase (3)
Hedgehog/Smoothened (3)
DNA gyrase (3)
Ras (3)
Proton pump (3)
CAT (3)
Pyroptosis (2)
PAI-1 (2)
ATM/ATR (2)
Antifolate (2)
Casein Kinase (2)
RSV (2)
Neurokinin receptor (2)
OCT (2)
gp120/CD4 (2)
Lipase (2)
Histone Demethylase (2)
DYRK (2)
PLK (2)
Histone Methyltransferase (2)
DHFR (2)
IRAK (2)
Thrombin (2)
PKM (2)
S1P Receptor (2)
hCE (2)
Pim (2)
OAT (2)
RANKL/RANK (2)
PAK (2)
PDGFR (2)
DPP-4 (2)
Aurora Kinase (2)
Leukotriene Receptor (2)
Glucokinase (2)
Decarboxylase (2)
Adiponectin receptor (2)
Arp2/3 Complex (1)
NMU2R (1)
FLT (1)
GlyT (1)
TAM Receptor (1)
CYP19A1 (1)
Hexokinase (1)
Glucagon Receptor (1)
Norepinephrine (1)
CD38 (1)
Stearoyl-CoA Desaturase (SCD) (1)
Bradykinin Receptor (1)
cGAS (1)
Hydrogenase (1)
CFTR (1)
PAD (1)
advanced glycation end products (1)
Angiotensin-converting Enzyme (ACE) (1)
Mdm2 (1)
PD-1/PD-L1 (1)
Epoxide Hydrolase (1)
Adenylyl cyclase (1)
stilbene oxidase (1)
ROS Kinase (1)
Endothelin Receptor (1)
Transaminase (1)
NPC1L1 (1)
Monocarboxylate transporter (1)
Thrombopoietin Receptor (1)
Dynamin (1)
ATTECs (1)
MT Receptor (1)
MyD88 (1)
CaSR (1)
Factor Xa (1)
Annexin A (1)
Melatonin Receptor (1)
IRE1 (1)
Prolyl Endopeptidase (PREP) (1)
IDO (1)
ROCK (1)
CRISPR/Cas9 (1)
Somatostatin (1)
STING (1)
Glutaminase (1)
ALK (1)
CPT (1)
GluCls (1)
Protease (1)
Survivin (1)
Complement System (1)
Fas/FasL (1)
YAP (1)
LPL Receptor (1)
BCRP (1)
OXPHOS (1)
Adenosine deaminase (1)
Raf (1)
IFNAR (1)
PERK (1)
aconitase (1)
RAR/RXR  (1)
Glutathione reductase (1)
Oxytocin Receptor (1)
Cell wall (1)
MTH1 (1)
Chk (1)

化合物库信息示例

Empty 1000025-07-9 1000413-72-8 229005-80-5 1000787-75-6 946387-07-1 1000998-59-3 1175526-27-8 1001288-58-9 1001350-96-4 1001404-83-6 Empty
Vadadustat TAK875 TAK-779 Tegobuvir RN-1734 BMS-687453 AM211 FT011 BMS754807 AAI101
Empty 1001625-82-6 1001645-58-4 1001753-24-7 1001908-89-9 1002304-34-8 1002-84-2 100291-86-9 100299-08-9 10030-52-1 10040-45-6 Empty
RPW-24 SRT1720 hydrochloride INH6 SRT 2183 AMG208 Pentadecanoic acid Apiopaeonoside Pemirolast potassium L-Anserine nitrate salt Sodium Picosulfate
Empty 100427-26-7 1004316-88-4 10045-45-1 100462-37-1 1004990-28-6 100-51-6 1005-24-9 1005264-47-0 1005334-57-5 1005342-46-0 Empty
Lercanidipine Cobicistat 1-Ethyl-2-benzimidazolinone ROSIRIDIN PF-AKT400 Benzyl alcohol 1-Methylnicotinamide chloride MX69 CVT-10216 LCL161
Empty 1005491-05-3 100-55-0 1005504-62-0 1005883-72-6 100643-71-8 1007207-67-1 10075-50-0 1007647-73-5 100784-20-1 10083-24-6 Empty
Tirasemtiv Roniacol Rg3039 Z433927330 Desloratadine CH5132799 5-Bromoindole Smurf1-IN-A01 Halosulfuron-methyl Piceatannol
Empty 100872-83-1 100874-08-6 1009119-64-5 1009119-65-6 100929-71-3 1009298-09-2 1009298-59-2 100929-99-5 1009734-33-1 10097-84-4 Empty
ML346 SB 4 Daclatasvir Daclatasvir dihydrochloride NADPH (tetracyclohexanamine) AZD8055 Vistusertib PAβN dihydrochloride HZ1157 Rotundine
Empty 1009816-48-1 1009817-63-3 1009820-21-6 100986-85-4 101001-34-7 1010411-21-8 1010-60-2 1011244-68-0 1011301-27-1 1011529-10-4 Empty
Thiamet G B-AP15 Silmitasertib Levofloxacin Pamicogrel GSK369796 Dihydrochloride 2-Chloronaphthoquinone TFAP Tenovin3 Azvudine
Empty 101152-94-7 101155-02-6 1011557-82-6 1011-74-1 101-20-2 1012054-59-9 101-21-3 101-26-8 101303-98-4 1013101-36-4 Empty
Milnacipran hydrochloride BW-A78U Tenovin-6 DL-Normetanephrine hydrochloride Triclocarban CUDC101 Chlorpropham Mestinon Zacopride hydrochloride PF04691502
Empty 101-31-5 1013-69-0 1013750-77-0 1013753-99-5 10138-52-0 1013920-15-4 1013937-63-7 1014691-61-2 101477-54-7 101494-95-5 Empty
L-Hyoscyamine Noreugenin ML-030 BC-1382 Gadolinium chloride Vorolanib VTP-27999 TFA GSK0660 Lomerizine hydrochloride 8-CHLOROQUINAZOLIN-4(1H)-ONE
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