152
46
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9111 |
8-Azaadenosine
|
Adenosine deaminase | Metabolism |
8-Azaadenosine 是 ADAR1抑制剂和是 A-to-I 编辑抑制剂。它可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。 | |||
T9720 |
T3Inh-1
|
Others | Others |
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 | |||
T2007 |
RQ-00203078
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
RQ00203078是一种口服有效的TRPM8高选择性拮抗剂,对大鼠和人类TRPM8通道的IC50分别为 5.3 nM 和 8.3 nM。它对 TRPV1,TRPA1,TRPV4 或 TRPM2 通道基本没有抑制作用。 | |||
T22115 |
SM-7368
|
NF-κB | NF-κB |
NF-κB Activation Inhibitor III 是一种NF-kB 抑制剂,抑制 TNF-α 诱导的MMP-9上调,靶向抑制下游的MAPK p38,可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。 | |||
T14322 |
ARP-100
MMP-2 Inhibitor III |
MMP | Proteases/Proteasome |
ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1'口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。 | |||
T9102 |
WM-3835
|
Apoptosis; Histone Methyltransferase; Histone Acetyltransferase | Apoptosis; Chromatin/Epigenetic |
WM-3835 是一种高特异性 HBO1(KAT7orMYST2) 抑制剂,可直接与 HBO1 33 的乙酰辅酶 A 结合位点结合 WM-3835 激活细胞凋亡,抑制骨肉瘤细胞的增殖,迁移和侵袭。它抑制小鼠中骨肉瘤异种移植物的生长,有抗肿瘤活性。 | |||
T22136 |
PRL-3 Inhibitor I
PRL-3 Inhibitor,BR-1 |
Phosphatase; Others | Metabolism; Others |
PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂,IC50=0.9 μM。它在细胞检测中显示降低侵袭性。 | |||
T6351 |
MGCD-265 analog
MGCD-265,Glesatinib |
Apoptosis; VEGFR; c-Met/HGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂,具有抗肿瘤活性,对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。 | |||
T6496 |
Vactosertib
TEW-7197,EW-7197 |
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
Vactosertib (EW-7197) 是有效的、具有 ATP 竞争性的、具有口服活性的激活素受体样激酶 5 (ALK5) 抑制剂(IC50:12.9 nM)。它还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50为 17.3 nM),表现出强大的抗转移活性和抗癌作用。 | |||
T0459 |
Sulindac
Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。 | |||
TQ0290 |
ONO-AE3-208
AE 3-208 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
ONO-AE3-208 (AE 3-208) 是一种 EP4 拮抗剂,可抑制前列腺癌的细胞迁移、侵袭和转移。 | |||
T2011 |
RKI1313
RKI 1313,RKI-1313 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
RKI1313 (RKI-1313) 是一种选择性抑制剂,可抑制 ROCK 依赖性信号传导、细胞骨架变化、不依赖锚定的集落形成、迁移和侵袭。 | |||
T28145 |
ND-322 HCl
ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl |
MMP | Proteases/Proteasome |
ND-322 HCl (ND 322 Hydrochloride) 是 MT1-MMP 和 MMP2 的选择性抑制剂,可减少体外黑色素瘤细胞的生长、迁移和侵袭。 | |||
T13050 |
SYP-5
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
SYP-5 是新型HIF-1抑制剂,阻碍肿瘤细胞侵袭和血管生成。 | |||
T25549 |
JCP174
JCP 174,JCP-174 |
Serine Protease | Proteases/Proteasome |
JCP174是一种去棕榈酰化酶抑制剂,可通过靶向 TgPPT1增强弓形虫的宿主细胞侵袭。 | |||
T6011 |
Batimastat
巴马司他,BB94 |
MMP | Proteases/Proteasome |
Batimastat (BB94) 是广谱MMP 抑制剂,能够抑制MMP-1 (IC50:3 nM),MMP-2 (IC50:4 nM),MMP-9 (IC50:4 nM),MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。 | |||
T24088 |
GGTI-2133
GGTI2133,GGTI 2133 |
Transferase | Metabolism |
GGTI-2133 是一种有效的仿肽基香叶基转移酶 I 型抑制剂(GGTase I),IC50值为38 nM。GGTI-2133 可抑制小鼠实验性哮喘中炎症细胞向气道的侵袭。 | |||
T77584 |
Tubulin inhibitor 35
Tubulin IN 35 |
Apoptosis; Microtubule Associated; Topoisomerase | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair |
Tubulin inhibitor 35 (Tubulin IN 35) 是一种有效的拓扑异构酶 I 和微管蛋白聚合 的双重抑制剂,具有抗肿瘤活性,对 MGC-803 和 RKO 细胞株的迁移和侵袭有抑制作用,中断细胞周期,诱导凋亡 (apoptosis)。 | |||
T11854 |
Lipofermata
|
Others; Antibacterial | Microbiology/Virology; Others |
Lipofermata 是一种脂肪酸转运蛋白 2抑制剂,可阻止脂质转运至黑色素瘤细胞并减少黑色素瘤的生长和侵袭。 | |||
T15574 |
Incyclinide
COL-3,CMT-3 |
MMP | Proteases/Proteasome |
Incyclinide (COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂,能够诱导细胞外基质降解,抑制血管生成,肿瘤生长和侵袭以及转移。 | |||
T61448 |
AZA1
Rac1/Cdc42-IN-1 |
Apoptosis; Rho; CDK | Apoptosis; Cell Cycle/Checkpoint |
AZA1 (Rac1/Cdc42-IN-1) 是一种有效的Rac1和Cdc42双重抑制剂。AZA1 诱导前列腺癌细胞凋亡,抑制癌细胞增殖,迁移和侵袭。 | |||
T15646 |
KBU2046
|
Others | Others |
KBU2046 是口服有效的,体外细胞运动和侵袭的高选择性抑制剂。它结合伴侣异源复合物,选择性地改变调节运动性的侣伴蛋白的结合,并且缺乏经典 HSP90抑制剂的所有标志。它抑制癌症转移并延长寿命。 | |||
T41094 |
Wnt/β-catenin agonist 2
|
GSK-3; Wnt/beta-catenin | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
Wnt/β-catenin agonist 2激活 Wnt/β-catenin 信号传导,是一种有效的 Wnt 激动剂。 Wnt/β-catenin agonist 2可用于与信号转导相关的疾病研究,与癌症侵袭转移密切相关。 | |||
T26629 |
Angstrom6
A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide |
PAI-1 | Metabolism |
Angstrom6 (A-6 peptide) 是一种从单链尿激酶纤溶酶原激活剂(scuPA)中提取的 8 肽,它能干扰 uPA/uPAR 级联反应并抑制下游效应。Angstrom6 具有抗肿瘤活性,能通过与 CD44 结合并调节 CD44 介导的细胞信号传导,抑制肿瘤细胞的迁移、侵袭和转移。 | |||
T3691 |
(Rac)-SAR131675
SAR131675 |
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(Rac)-SAR131675 是一种有效的、选择性的VEGFR3抑制剂,其IC50=23 nM。 | |||
T61722 |
ZDLD20
|
Apoptosis | Apoptosis |
ZDLD20 是一种具有口服活性和选择性的CDK4抑制剂,是一种 β-咔啉类化合物,具有抗 HCT116 和抗癌活性,抑制集落形成、抑制侵袭和迁移、诱导细胞凋亡和阻止细胞周期的 G1 期。 | |||
T3708 |
BP-1-102
|
STAT | JAK/STAT signaling; Stem Cells |
BP-1-102 是可口服的转录因子Stat3小分子抑制剂,IC50值为 6.8 μM。 | |||
T60197 |
UNC 1025
|
Others | Others |
UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 ... | |||
T77701 |
FL118
FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin |
Survivin | Apoptosis |
FL118是一种新型存活素抑制剂,可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物,具有抗癌活性,通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化,从而抑制人乳腺癌细胞的迁移和侵袭。 | |||
T14091 |
AC-73
|
Autophagy | Autophagy |
AC-73 是一种可口服的 Cluster of Differentiation 147 (CD147) 抑制剂,具有很高的生物利用,可选择性破坏 CD147 的二聚化 (结合位点在 CD147 的 N 端 IgC2 域中包括 Glu64 和 Glu73),从而对 CD147/ERK1/2/STAT3/MMP-2 途径产生抑制,并抑制肝癌细胞的运动和侵袭。AC-73 具有抗增殖活性,诱导白血病细胞自噬。 | |||
T73300 |
AXL-IN-13
|
FLT; TAM Receptor; PDGFR; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
AXL-IN-13 是一种有效且具有口服活性的 AXL 抑制剂 ,其IC50值为 1.6 nM,Kd 值为0.26 nM。AXL-IN-13 具有抗癌活性,可逆转 TGF-β1 诱导的上皮间质转化 (EMT),并抑制癌细胞迁移和侵袭。 | |||
T21872 |
CCT018159
|
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
CCT018159 是一种 3,4-二芳基吡唑间苯二酚,是一种 ATP 竞争性HSP90ATPase 抑制剂,对人 Hsp90β 和酵母 Hsp90 具有抑制作用,IC50分别为 3.2 和 6.6 μM。CCT018159 抑制与侵袭和血管生成有关的关键内皮细胞和肿瘤细胞功能。CCT018159 引起与 G1 期阻滞相关的细胞抑制并诱导细胞凋亡。 | |||
T67836 |
AT-533
|
HSP; HSV | Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
AT-533 是有效的 HSV 和 Hsp90 抑制剂。AT-533 可以阻断 HIF-1α/VEGF/VEGFR-2 信号通路,从而抑制血管生成和肿瘤生长。AT-533 也抑制下游通路的激活,包括 Erk1/2, FAK, Akt/mTOR/p70S6K。AT-533 抑制人脐静脉内皮细胞 (HUVEC) 的细胞迁移、侵袭和管形成。 | |||
TP1565L1 |
Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt(881188-51-8 Free base) |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Foxy-5 Ammonium Salt是 WNT5A 激动剂,是 WNT5A 的一个模拟肽,是 Wnt 家族的非经典成员。Foxy-5 Ammonium Salt可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导,并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 Ammonium Salt在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。 | |||
T25765 |
LY52
LY-52,LY 52 |
||
LY52 is a matrix metalloproteinase-2 inhibitor. It acts by suppressing tumor invasion and metastasis. | |||
T70821 |
FC11409B
|
||
FC11409B is a CAIX inhibitor, inhibiting breast cancer invasion and metastasis. | |||
T24848 |
TachypleginA
Tachyplegin A,Tachyplegin-A |
||
TachypleginA is a parasite motility and invasion inhibitor. | |||
T10588 |
BPI-9016M
|
Others | Others |
BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma. | |||
T24531 |
NIC
|
||
NIC is an inhibitor of host invasion. It is also an inhibitor of VEGF binding to immobilized heparin. | |||
T68823 |
SPU-106
|
||
SPU-106 is a novel specific PAK4 inhibitor, effectively inhibiting the invasion of SGC7901 cells without cytotoxicity, regulating the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. | |||
T24849 |
TachypleginA-2
tA 2,tA-2,tA2 |
||
TachypleginA-2 is a parasite motility and invasion inhibitor. | |||
T70841 |
Osteosarcoma-IN-D14
|
||
Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes. | |||
T36651 |
Anti-MERS-2E6 mAb
Anti-MERS-2E6 mAb |
||
Anti-MERS-2E6 mAb (MERS-2E6), a human IgG1 neutralizing antibody, is expressed in CHO cells. It effectively competes with the virus Spike protein for binding to the CD26 receptor, consequently inhibiting viral invasion into host cells. | |||
T26394 |
6-Alkynyl-fucose
6-Alk-Fuc |
||
6-Alkynyl-fucose, a widely used fucosylation probe, acts by strongly inhibiting fucosylation and GDP-fucose synthetase FX and halting hepatoma invasion. | |||
T11846 | LHVS | Cysteine Protease | Proteases/Proteasome |
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor. | |||
T71508 | TCSA | ||
TCSA is an inhibitor of fungal morphogenesis, biofilm formation, and host cell invasion. | |||
T34695 |
Spiclomazine HCl
APY-606,Diceplon,Disepron,APY606,Spiclomazine Hydrochloride |
||
Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion. | |||
T25925 |
p-DDAP
pDDAP,p-Dodecylaminophenol |
||
p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9). | |||
T25228 |
CG-707
CG 707 |
||
CG-707 is an inhibitor of PRL-3 that acts by blocking the migration and invasion of metastatic cancer cells. | |||
T68876 | BXL0124 | ||
BXL0124 is a gemini vitamin D analog which targets CD44-STAT3 signaling and inhibits breast cancer invasion. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13229 |
Tunicamycin
|
Influenza Virus; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Tunicamycin 是一种抗生素的混合物,通过阻断 GlcNAc 磷酸转移酶 (GPT),抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性,还具有抗细菌、抗真菌和抗病毒活性。 | |||
TN1019 |
Beta-mangostin
β-Mangostin,beta-倒捻子素 |
Apoptosis; Antibacterial; Parasite | Apoptosis; Microbiology/Virology |
Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物,有抗癌和抗菌活性,对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性,对恶性疟原虫的 IC50值为 3.00 μg/mL。 | |||
T5S0045 |
Isofraxidin
6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶 |
MMP; ERK; p38 MAPK; TLR; COX | Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。 | |||
T4S1796 |
Heterophyllin B
|
PI3K | PI3K/Akt/mTOR signaling |
Heterophyllin B 是一种活性环肽,从 Pseudostellaria heterophylla 中分离得到,可用于研究食管癌。 | |||
TQ0214 |
Dimethylcurcumin
ASC-J9,二甲基姜黄素,GO-Y025 |
Androgen Receptor | Endocrinology/Hormones |
Dimethylcurcumin (ASC-J9) 是雄激素受体降解增强剂,能够有效抑制耐药性前列腺癌细胞增殖和侵袭。 | |||
TN1198 |
19-Hydroxybufalin
|
Others | Others |
19-Hydroxybufalin 是蟾二烯羟酸内酯,能够阻碍上皮间质转化,抑制 PC3 细胞的迁移和侵袭。 | |||
T6S0325 |
Glycitein
黄豆黄素,Glycetein |
Apoptosis; Others | Apoptosis; Others |
Glycitein (Glycetein) 是一种大豆异黄酮,可研究抗氧化和细胞凋亡。 | |||
TN1068 |
Tricin
|
Others; CDK | Cell Cycle/Checkpoint; Others |
Tricin 是米糠中大量存在的一种天然类黄酮。它通过抑制 CDK9 来抑制HCMV 的复制。它通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。 | |||
TN2269 |
Tetramethylcurcumin
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
Tetramethylcurcumin 是一种新型姜黄素类似物,是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。 | |||
T2897 |
(Rac)-Shikonin
(±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid |
Others | Others |
(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。 | |||
T7979 |
2-Hydroxychalcone
2-(2-Hydroxybenzal)Acetophenone,2-羟基查酮 |
Apoptosis; BCL; Others; NF-κB | Apoptosis; NF-κB; Others |
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) 是一种天然黄酮,可通过下调 Bcl-2 诱导凋亡,也可抑制NF-kB 的激活。它是抗氧化剂,抑制脂质过氧化,还可抑制三阴性乳腺癌细胞的侵袭。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
TN1433 | Batatasin III | FAK; Others; Akt | Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭,并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用,显示出抑制萌发活性。 | |||
TN3628 |
Chamaejasmenin B
|
Others | Others |
Chamaejasmenin B 是一种从 Stellera chamaejasme L 中分离得到的化合物。Chamaejasmenin B 具有抗癌和抗肿瘤活性,可抑制癌细胞迁移和侵袭,抑制肿瘤转移。Chamaejasmenin B 可用于研究如乳腺癌类的癌症。 | |||
T3418 |
Demethylzeylasteral
去甲泽拉木醛,Demethylzeylasteral (T-96) |
Apoptosis; UGT | Apoptosis; Metabolism |
Demethylzeylasteral (Demethylzeylasteral (T-96)) 分离自雷公藤,具有抗炎、免疫抑制和抗肿瘤活性。它通过阻断 TGF-β 信号通路,抑制三阴性乳腺癌的侵袭,它能显著减轻动脉粥样硬化。 | |||
TMA2474 |
δ-Tocotrienol
Delta-Tocotrienol,δ-生育三烯酚 |
ERK; BCL; VEGFR; Akt; PI3K; PDK; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E,存在于蔬菜,水果,种子,坚果,谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂,可以降低胆固醇和其他脂质,保护心血管疾病。 | |||
TN1854 |
Lasiodin
毛栲利素,Lasiokaurin |
P450; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Proteases/Proteasome |
Lasiodin (Lasiokaurin) 是一种来自植物香茶菜的二帖化合物,可抑制 NPC 细胞增殖。 Lasiodin 具有抗氧化、抗肿瘤活性和抗菌活性,可诱导细胞周期组长和凋亡,诱导细胞迁移和侵袭,可用于研究鼻咽癌 | |||
TN1557 |
Decursinol angelate
|
ERK; VEGFR; PKC; JNK | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors |
Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物,是 PKC 激酶的激活剂,有细胞毒性,抗肿瘤和抗炎活性。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T3402 |
20(S)-Ginsenoside Rg3
20(S)-人参皂苷 Rg3,人参皂苷 Rg3,20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3 |
EGFR; Beta Amyloid; Potassium Channel; NF-κB; COX; Sodium Channel; Endogenous Metabolite | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
20(S)-Ginsenoside Rg3 (Rg3) 是红参的主要成分,通过抑制肿瘤细胞的粘附和侵袭来抑制肿瘤细胞肺转移。它抑制Na+和hKv1.4通道,IC50分别为 32.2±4.5 和 32.6±2.2 μM。它还抑制Aβ,NF-κB 活性和COX-2表达,抑制人脐静脉内皮细胞的增殖并具有抗血管生成活性。 | |||
T4S21320 |
ISOGINKGETIN
异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮 |
MMP; Others | Others; Proteases/Proteasome |
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。 | |||
T4958 |
(-)-Alkannin
Alkannin,左旋紫草素,紫草素,Shikonin |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物,具有抗癌活性,可抑制细胞周期,诱导细胞凋亡,用作食品着色剂,在 Rho 激酶途径中可改善肝脏炎症。 | |||
T3403 |
Glabridin
光甘草定,Q-100692,KB-289522,LS-176045 |
Reactive Oxygen Species; Tyrosinase; GABA Receptor; Antibacterial; PPAR | DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Glabridin (KB-289522) 能够结合并激活PPARγ,EC50值为 6115 nM,是一种从Glycyrrhiza glabra 中分到的异黄烷类天然产物。它具有抗炎、抗菌、抗肾炎、抗氧化、抗肿瘤、抗糖尿病、抗骨质疏松、保护神经、保护心血管、清除自由基等作用。 | |||
T75643 |
Isoxanthohumol
|
HSV | Microbiology/Virology |
Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物,对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性,对疱疹病毒(HSV1和HSV2)和牛病毒性腹泻病毒(BVDV)具有抑制作用。 | |||
T6S1141 |
Ganoderic acid A
灵芝酸 A,灵芝酸A |
Apoptosis; NF-κB; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; NF-κB |
Ganoderic acid A 能够抑制 JAK-STAT3信号通路,也能抑制细胞增殖,存活率和 ROS。 它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T6S0119 |
Dauricine
蝙蝠葛碱 |
Apoptosis; Others; NF-κB | Apoptosis; NF-κB; Others |
Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱,具有抗炎活性。它通过抑制NF-κB 激活,剂量依赖性地抑制结肠癌细胞的增值和侵袭,并诱导凋亡。 | |||
TN1880 |
Lucidenic acid B
Lucidenicacid B |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物,可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解,可通过线粒体介导诱导人白血病细胞凋亡 。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
TN1141 |
Isodeoxyelephantopin
异去氧苦地胆素,异去氧苦地胆苦素 |
NF-κB; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Isodeoxyelephantopin 是从地胆草中分离得到的一种倍半萜烯内酯,能调节 LncRNA 的表达,有抗乳腺癌的作用。它可诱导活性氧的生成,抑制 NF-κB 的激活。 | |||
T26358 |
(-)-Agelastatin A
|
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(-)-Agelastatin A inhibits osteopontin-mediated adhesion, invasion, and colony formation. | |||
TN6547 |
Angustifoline
鲁冰花 |
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Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest. | |||
TN1881 |
Lucidenic acid C
赤芝酸 C,赤芝酸C |
MMP | Proteases/Proteasome |
Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells. | |||
TN3709 | Coronarin D ethyl ether | NF-κB | NF-κB |
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro. | |||
T75678 |
Tomentosin
|
Apoptosis | Apoptosis |
Tomentosin 是一种从里海旋覆花中提取出来倍半萜内酯,具有潜在的抗炎和抗癌活性,可促进胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。 | |||
TN1953 |
Morusinol
桑根皮醇,桑树醇 |
ERK; MEK; Autophagy; Ras | Autophagy; GPCR/G Protein; MAPK |
Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性,在体内抑制动脉血栓形成,通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。 | |||
TN4046 | Excisanin A | MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ... | |||
TN3708 | Coronarin D | BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i | |||
T72803 | Norartocarpetin | ||
Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性,其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性,其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。 | |||
T36749 |
Herboxidiene
|
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Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo... | |||
TN3364 |
Agrimonolide
|
Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells |
Agrimonolide 是一种来自异香豆素的化合物,主要存在于草药Agrimonia pilosa Ledeb 中,具有显著的生物活性。Agrimonolide 通过抑制脂多糖(LPS)诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平,可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1,对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是,Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制,同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡,同时增加活性氧(ROS)和总铁的水平。Agrimonolide 很容易穿过血脑屏障,表明其在神经系统疾病的治疗应用方面具有潜力。 | |||
TN5153 |
Torilin
|
MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome |
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症,它可以减轻关节炎的严重程度,改变 dLN 或关节中的白细胞活化,并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成,IC(50)值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性,它可能通过抑制肿瘤侵袭来抑制肿瘤发生,逆转癌细胞的多药耐药性,它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。 |