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(Rac)-Shikonin

产品编号 T2897 CAS 54952-43-1

别名: (±)-Shikonin, Alkanet extract, Anchusin, 紫草素, Anchusa acid

(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。

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(Rac)-Shikonin, CAS 54952-43-1

规格	价格/CNY	货期
1 mg	￥ 108	现货
2 mg	￥ 137	现货
5 mg	￥ 198	现货
10 mg	￥ 328	现货
25 mg	￥ 536	现货
50 mg	￥ 783	现货
100 mg	￥ 1,150	现货
1 mL * 10 mM (in DMSO)	￥ 397	现货

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其他形式的 (Rac)-Shikonin:

(-)-Alkannin
现货
Podofilox
现货
Shikonin
现货

选择批次

纯度: 99.73%

纯度: 99.72%

纯度: 98%

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

植物来源	天然产物 > 紫草科 > 紫草属

产品描述	(Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
体外活性	At nanomolar concentrations, shikonin inhibits monocyte chemotaxis and calcium flux in response to a variety of CC chemokines (CCL2 [monocyte chemoattractant protein 1], CCL3 [macrophage inflammatory protein 1α], and CCL5 [regulated upon activation, normal T-cell expressed and secreted protein]), the CXC chemokine (CXCL12 [stromal cell-derived factor 1α]), and classic chemoattractants (formylmethionyl-leucine-phenylalanine and complement fraction C5a). Shikonin down-regulates surface expression of CCR5, a primary HIV-1 coreceptor, on macrophages. The anti-HIV and anti-inflammatory activities of shikonin may be related to its interference with chemokine receptor expression and function[1]. Shikonin inhibits enterocyte calcium-activated chloride channels, the inhibitory effect is partially through inhibition of basolateral K+ channel activity[2].
细胞实验	Freshly isolated human monocytes are plated in a 96-microwell plate (Costar) at 105 cells per well with shikonin at a final concentration of 10, 1, 0.1, 0.01 μM. The numbers of viable cells, as detected by MTS test and the trypan blue exclusion assay, were measured 12 and 24 h after incubation at 37°C in humidified air with 5% CO2. (Only for Reference)

别名	(±)-Shikonin, Alkanet extract, Anchusin, 紫草素, Anchusa acid
分子量	288.3
分子式	C16H16O5
CAS No.	54952-43-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 10 mM

H2O: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4686 mL	17.343 mL	34.6861 mL	86.7152 mL
	5 mM	0.6937 mL	3.4686 mL	6.9372 mL	17.343 mL
	10 mM	0.3469 mL	1.7343 mL	3.4686 mL	8.6715 mL

计算器

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参考文献

1. Chen X, et al. Antimicrob Agents Chemother. 2003, 47(9):2810-6. 2. Yu Jiang, et al. Front. Pharmacol. 2016.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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