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Targets Recommended: c-Fms VEGFR CSF-1R PDGFR c-Kit

890

抑制剂 & 化合物

32

天然产物

1750

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T4315 Ki20227

N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲

c-Fms; VEGFR; CSF-1R; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Ki20227 是一种高效的、口服具有活性的、选择性的CSF1R(c-Fms 酪氨酸激酶)抑制剂,对 CSF1R,VEGFR2,c-Kit 和PDGFRβ的IC50分别为 2 nM,12 nM,451 nM 和 217 nM。它可以阻止破骨细胞分化和溶骨性破坏。
T8312 Derenofylline

Adenosine Receptor GPCR/G Protein; Neuroscience
Derenofylline 是一个有选择性的、具有口服活性的腺苷A1受体的拮抗剂,可抑制心肌纤维化,降低蛋白尿,对腺苷A1、A3和A2A 受体的Ki 值分别为 1、200 和 398 nM。
T7662 α-Demethylnaproxen

COX Immunology/Inflammation; Neuroscience
α-Demethylnaproxen 是一种 COX 的竞争性抑制剂(羊 COX-1 和 -2 的 Ki 值分别为 2119 μM)。
T6366 A-966492

2-[2-氟-4-[(2S)-2-吡咯烷基]苯基]-1H-苯并咪唑-7-甲酰胺

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
A966492 是一种新型有效的抑制剂,对 PARP1 和 PARP2 的 Ki 分别为 1 nM 和 1.5 nM。
T6312 R547

Ro 4584820

Apoptosis; GSK-3; PKA; CDK Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
R547 (Ro 4584820) 是一种口服有效,选择性, ATP 竞争性CDK 抑制剂,对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki 值分别为 2 nM、3 nM、1 nM。
T37042 SCH529074

SCH 529074

p53 Apoptosis
SCH529074 是 p53 的选择性激活剂 (Ki = 1 μM),可用于非小细胞肺癌的研究。 SCH529074 恢复突变 p53 功能并中断 HDM2 介导的野生型 p53 泛素化。
T2101 Navitoclax

ABT-263

BCL Apoptosis
Navitoclax (ABT-263) 是一种 Bcl-2 抑制剂,可与 Bcl-xL、Bcl-2、Bcl-w 等蛋白结合 (Ki<1 nM),具有有效性和口服活性。Navitoclax 具有抗肿瘤活性,可以诱导细胞凋亡。
T6574 Lumiracoxib

Prexige,罗美昔布,COX-189

COX Immunology/Inflammation; Neuroscience
Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂,Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂,具有抗炎和解热活性,可用于骨关节炎和骨癌研究。
T3080 Pyridone 6

Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I

Tyrosine Kinases; JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂,有效抑制 JAK 激酶家族,对JAK2、TYK2、JAK3和JAK1的IC50分别为 11、5 和 15 nM。
T4167 Raf inhibitor 1 dihydrochloride

B-Raf inhibitor 1 dihydrochloride

Raf MAPK
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂,对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 11 和 0.3 nM。
T70407 cemadotin free base

LU103793 free base

Microtubule Associated Cytoskeletal Signaling
Cemadotin free base(LU103793 free base) 是一种新型的抗限定性肽 ,是一种新型的抗有丝分裂肽 ,是Dolastatin 15的类似物 。Dolastatin 15是一种天然存在的细胞毒肽,可阻断有丝分裂并抑制微管(管蛋白),Ki1μM。Cemadotin 用于研究抗癌。
T37696 NOS1-IN-1

nNOS Inhibitor I

NOS Immunology/Inflammation
NOS1-IN-1(nNOS Inhibitor I) 是一种强效、选择性和细胞渗透性 nNOS 抑制剂(Ki120 nM)。NOS1-IN-1 对 eNOS 的 Ki 值为 39 μM,对 iNOS 的 Ki 值为 325 μM。
T1865 S1RA

E-52862,4-(2-((5-甲基-1-(2-萘基)-1H-吡唑-3-基)氧基)乙基)吗啉

Sigma receptor GPCR/G Protein
S1RA (E-52862) 是一种有效且特异性的 sigma-1受体拮抗剂,Ki17nM,对 σ2R 具有良好的选择性,Ki 值大于 1000 nM。
T12912 Sigma-1 receptor antagonist 3

Sigma receptor; HER Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Sigma-1 receptor antagonist 3 是 Sigma-1受体选择性拮抗剂,Ki1.14 nM。它抑制 hERG,IC50为 1.54μM。它在神经性疼痛方面有研究的价值。
T14151 AKR1C1-IN-1

NADPH Metabolism
AKR1C1-IN-1 是高选择性 AKR1C1抑制剂(Ki:4 nM)。
T12911 Sigma-1 receptor antagonist 2

Sigma receptor GPCR/G Protein
Sigma-1 receptor antagonist 2 是有效的sigma 1受体选择性拮抗剂,与 σ1 和 σ2 受体结合的Ki 分别为 3.88 和 1288 nM。
T4229 S1RA hydrochloride

4-[2-[[5-甲基-1-(2-萘基)-1H-吡唑-3-基]氧基]乙基]吗啉盐酸盐(1:1),E-52862 hydrochloride

Sigma receptor GPCR/G Protein
S1RA hydrochloride (E-52862 hydrochloride) 是一种有效且特异性的 sigma-1受体拮抗剂,Ki17nM,对 σ2R 具有良好的选择性,Ki 值大于 1000 nM。
T2493 PD 151746

Cysteine Protease; Proteasome Proteases/Proteasome; Ubiquitination
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
T12306 OMDM-5

Cannabinoid Receptor; Endogenous Metabolite; TRP/TRPV Channel GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
OMDM-5 是有效的、选择性的anandamide 细胞摄取抑制剂,Ki 为 4.8 μM。它是VR1 (TRPV1)激动剂,EC50为 75 nM,显示出对大麻素 1 型受体 (CB1) 的弱配体活性 (Ki=4.9 μM)。
T2074 Raf inhibitor 1

B-Raf inhibitor 1

Raf MAPK
Raf inhibitor 1 (B-Raf inhibitor 1)是Raf 激酶抑制剂,对B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 11 和 0.3 nM。
T3101 NQDI-1

NQDI1,NQDI 1

Apoptosis; ASK; MAPK Apoptosis; MAPK
NQDI-1 (NQDI 1) 是一种凋亡信号调节激酶 1 抑制剂,Ki 为 500 nM,IC50为 3 μM。
T15020 CU-CPT22

TLR Immunology/Inflammation
CU-CPT22 是 toll 样受体 1 和 2 蛋白复合物抑制剂,可阻断 Pam3CSK4诱导的 TLR1/2 激活,IC50值为 0.58 µM。 它与 TLR1/2 结合的合成三酰脂蛋白竞争,Ki 值为 0.41 µM。
T11909 LY2444296

FP3FBZ

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
LY2444296 (FP3FBZ) 是 kappa opioid receptor (Ki = 1 nM) 的具有口服活性的和选择性拮抗剂。
T9983 CCR8 antagonist 1

LUN04765

CCR Immunology/Inflammation; Microbiology/Virology
CCR8 antagonist 1 是 C-C Motif 趋化因子受体 8 (CCR8) 的拮抗剂,Ki 值为 1.6 nM。
TP1011L ACTH (1-17) acetate

Melanocortin Receptor GPCR/G Protein; Neuroscience
ACTH (1-17) acetate 是一种有效的人黑皮质素 1 (MC1) 受体激动剂,具有高亲和力 (Ki = 0.21 nM)。
T12010 Aurora B inhibitor 1

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
Aurora B inhibitor 1 是一种 Aurora B (Aurora-1) 抑制剂(Ki <0.010 uM),具有潜在的抗癌活性,可用于研究癌症。
TP1772L Hemokinin 1 (mouse) acetate(208041-90-1 free base)

Neurokinin receptor GPCR/G Protein; Neuroscience
Hemokinin 1 (mouse) acetate(208041-90-1 free base) 是一种选择性兴奋剂 1 受体激动剂,对人 NK1 受体的 Ki 值为 0.175 nM,对人 NK2 受体的 Ki 值为 560 nM。
T10053 5HT6-ligand-1

5-HT Receptor GPCR/G Protein; Neuroscience
5HT6-ligand-1 是一种具有口服活性的 5-HT6 受体配体 (Ki = 1.43 nM)。
T15364 G-1

Estrogen Receptor/ERR; GPR Endocrinology/Hormones; GPCR/G Protein
G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。
T10723 CDC25B-IN-1

ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Phosphatase Metabolism
CDC25B-IN-1 是 CDC25B 的抑制剂,Ki 为 8.5 μM。 CDC25B-IN-1 通过抑制细胞增殖和集落形成来增加 G2/M 期。
T2632 A-1210477

Apoptosis; BCL Apoptosis
A-1210477 是一种选择性的MCL-1有效抑制剂,Ki 值为 0.45 nM。它特异性结合 MCL-1,并以 MCL-1 依赖性方式促进癌细胞凋亡。
T6281 TW-37

TW 37

BCL Apoptosis
TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂,Ki 值分别为 0.26、0.29和1.11μM
T6400 AZD3514

Androgen Receptor Endocrinology/Hormones
AZD3514 是一种口服雄激素受体下调剂(Ki :2.2 μM),能够减少 AR 蛋白表达。
T2375 BX471

BX 471,BX-471,ZK-811752

CCR Immunology/Inflammation; Microbiology/Virology
BX471 (BX 471) 是可口服的非多肽 CCR1选择性拮抗剂,Ki 值为 1 nM,对其选择性是对 CCR2、CCR5 和 CXCR4 的 250 倍。
T4523 TP-3654

Pim Chromatin/Epigenetic; JAK/STAT signaling
TP3654是一种Pim 激酶抑制剂,对Pim-1和Pim-3的Ki 值分别为5和42 nM。
T5169 SGC-GAK-1

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
SGC-GAK-1 是细胞周期蛋白 G 相关激酶 (GAK) 的选择性抑制剂(Ki:3.1 nM),可用作 GAK 的化学探针。
T6034 UMI-77

UMI77,UMI 77

BCL Apoptosis
UMI-77是一种选择性的Mcl-1抑制剂,结合到Mcl-1的 BH3 结合沟,Ki 值为 490 nM,对 Bcl-2 家族的其他成员具有选择性。
T6585 SAR405838

MI773,MI 773,MI-77301,MI-773

Mdm2; E1/E2/E3 Enzyme Apoptosis; Ubiquitination
SAR405838 (MI 773) 是 MI-773 的类似物,具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂,与 MDM2 结合的Ki 值为 0.88 nM。
T10250 ADRA1D receptor antagonist 1 HCl

ADRA1D receptor antagonist 1 HCl(1191908-24-3 free base)

Adrenergic Receptor GPCR/G Protein; Neuroscience
ADRA1D receptor antagonist 1 HCl 是一种具有口服活性、高效性和选择性的 α1D 肾上腺素受体拮抗剂(Ki1.6 nM),具有潜在的抗增殖活性。
T78825 D4R agonist-1

Dopamine Receptor GPCR/G Protein; Neuroscience
D4R agonist-1 是一种具有选择性和有效性的 D4R 部分激动剂(Ki:2.2 nM)。D4R agonist-1 可用于研究神经系统疾病。
T60454 NDM-1 inhibitor-3

Others Others
NDM-1 inhibitor-3 是一种广泛存在于自然界中的 New Delhi Metallo-β-lactamase-1 (NDM-1) 抑制剂(Ki : 4 μM),与抗生素耐药有关。
T8824 CRBN modulator-1

WUN29654

Others; Ligand for E3 Ligase Others; PROTAC
CRBN modulator-1 (WUN29654) 是一种 Thalidomide 类似物。它是一种 CRBN 调节剂,结合 CRBN 的 IC50=3.5 μM,Ki=0.98 μM。
T6905 Netupitant

Ro 67-31898/000,奈妥吡坦,CID 6451149

Neurokinin receptor GPCR/G Protein; Neuroscience
Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1Ki 值为 0.95 nM。
T13453 CGRP antagonist 1

CGRP Receptor GPCR/G Protein; Neuroscience
CGRP antagonist 1是高效 CGRP 受体拮抗剂,Ki 值分别为 35nM,IC50 值为 57 nM。CGRP antagonist 1可用于研究心血管疾病和神经血管疾病。
TP1882L1 Orphanin FQ(1-11) acetate(178249-41-7 free base)

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Orphanin FQ(1-11) acetate(178249-41-7 free base) 含有 Nociceptin 氨基酸 1-11 的肽片段。 ORL1/KOR-3 受体的强效激动剂 (Ki = 55 nM);对阿片受体无亲和力,包括 μ、δ、κ1 和 κ3 受体 (Ki >1000 nM)。在 CD-1 小鼠中显示镇痛特性。
T16118 MLS0315771

Others Others
MLS0315771 是来源于磷酸甘露糖异构酶的竞争性抑制剂, 其 IC50值为~1 μM,Ki=为 1.4 μM。
T12110 MRZ 2-514

8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

NMDAR Neuroscience
MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) 是 NMDA receptor(glycineB) 的拮抗剂,Ki=33 μM。
T2710 TCS 1102

OX Receptor GPCR/G Protein; Neuroscience
TCS 1102 是双食欲素受体拮抗剂,对 OX1和OX2受体的Ki 分别为3和 0.2 nM。
T7488 BD1063 dhydrochloride

BD1063

Sigma receptor GPCR/G Protein
BD1063 dhydrochloride 是有效选择性的 sigma 1受体拮抗剂。
T11997 MELK-IN-1

Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L

MELK PI3K/Akt/mTOR signaling
MELK-IN-1 (MELK inhibitor 17)是一种母体胚胎亮氨酸拉链激酶的有效抑制剂,IC50=3 nM,Ki=0.39 nM。

化合物

Ki20227
Cat.No: T4315
Synonym: N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲
Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit
Derenofylline
Cat.No: T8312
Synonym:
Target: Adenosine Receptor
α-Demethylnaproxen
Cat.No: T7662
Synonym:
Target: COX
A-966492
Cat.No: T6366
Synonym: 2-[2-氟-4-[(2S)-2-吡咯烷基]苯基]-1H-苯并咪唑-7-甲酰胺
Target: PARP
R547
Cat.No: T6312
Synonym: Ro 4584820
Target: Apoptosis, GSK-3, PKA, CDK
SCH529074
Cat.No: T37042
Synonym: SCH 529074
Target: p53
Navitoclax
Cat.No: T2101
Synonym: ABT-263
Target: BCL
Lumiracoxib
Cat.No: T6574
Synonym: Prexige,罗美昔布,COX-189
Target: COX
Pyridone 6
Cat.No: T3080
Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I
Target: Tyrosine Kinases, JAK
Raf inhibitor 1 dihydrochloride
Cat.No: T4167
Synonym: B-Raf inhibitor 1 dihydrochloride
Target: Raf
cemadotin free base
Cat.No: T70407
Synonym: LU103793 free base
Target: Microtubule Associated
NOS1-IN-1
Cat.No: T37696
Synonym: nNOS Inhibitor I
Target: NOS
S1RA
Cat.No: T1865
Synonym: E-52862,4-(2-((5-甲基-1-(2-萘基)-1H-吡唑-3-基)氧基)乙基)吗啉
Target: Sigma receptor
Sigma-1 receptor antagonist 3
Cat.No: T12912
Synonym:
Target: Sigma receptor, HER
AKR1C1-IN-1
Cat.No: T14151
Synonym:
Target: NADPH
Sigma-1 receptor antagonist 2
Cat.No: T12911
Synonym:
Target: Sigma receptor
S1RA hydrochloride
Cat.No: T4229
Synonym: 4-[2-[[5-甲基-1-(2-萘基)-1H-吡唑-3-基]氧基]乙基]吗啉盐酸盐(1:1),E-52862 hydrochloride
Target: Sigma receptor
PD 151746
Cat.No: T2493
Synonym:
Target: Cysteine Protease, Proteasome
OMDM-5
Cat.No: T12306
Synonym:
Target: Cannabinoid Receptor, Endogenous Metabolite, TRP/TRPV Channel
Raf inhibitor 1
Cat.No: T2074
Synonym: B-Raf inhibitor 1
Target: Raf
NQDI-1
Cat.No: T3101
Synonym: NQDI1,NQDI 1
Target: Apoptosis, ASK, MAPK
CU-CPT22
Cat.No: T15020
Synonym:
Target: TLR
LY2444296
Cat.No: T11909
Synonym: FP3FBZ
Target: Opioid Receptor
CCR8 antagonist 1
Cat.No: T9983
Synonym: LUN04765
Target: CCR
ACTH (1-17) acetate
Cat.No: TP1011L
Synonym:
Target: Melanocortin Receptor
Aurora B inhibitor 1
Cat.No: T12010
Synonym:
Target: Aurora Kinase
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
Cat.No: TP1772L
Synonym:
Target: Neurokinin receptor
5HT6-ligand-1
Cat.No: T10053
Synonym:
Target: 5-HT Receptor
G-1
Cat.No: T15364
Synonym:
Target: Estrogen Receptor/ERR, GPR
CDC25B-IN-1
Cat.No: T10723
Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate
Target: Phosphatase
A-1210477
Cat.No: T2632
Synonym:
Target: Apoptosis, BCL
TW-37
Cat.No: T6281
Synonym: TW 37
Target: BCL
AZD3514
Cat.No: T6400
Synonym:
Target: Androgen Receptor
BX471
Cat.No: T2375
Synonym: BX 471,BX-471,ZK-811752
Target: CCR
TP-3654
Cat.No: T4523
Synonym:
Target: Pim
SGC-GAK-1
Cat.No: T5169
Synonym:
Target: Serine/threonin kinase
UMI-77
Cat.No: T6034
Synonym: UMI77,UMI 77
Target: BCL
SAR405838
Cat.No: T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
ADRA1D receptor antagonist 1 HCl
Cat.No: T10250
Synonym: ADRA1D receptor antagonist 1 HCl(1191908-24-3 free base)
Target: Adrenergic Receptor
D4R agonist-1
Cat.No: T78825
Synonym:
Target: Dopamine Receptor
NDM-1 inhibitor-3
Cat.No: T60454
Synonym:
Target: Others
CRBN modulator-1
Cat.No: T8824
Synonym: WUN29654
Target: Others, Ligand for E3 Ligase
Netupitant
Cat.No: T6905
Synonym: Ro 67-31898/000,奈妥吡坦,CID 6451149
Target: Neurokinin receptor
CGRP antagonist 1
Cat.No: T13453
Synonym:
Target: CGRP Receptor
Orphanin FQ(1-11) acetate(178249-41-7 free base)
Cat.No: TP1882L1
Synonym:
Target: Opioid Receptor
MLS0315771
Cat.No: T16118
Synonym:
Target: Others
MRZ 2-514
Cat.No: T12110
Synonym: 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one
Target: NMDAR
TCS 1102
Cat.No: T2710
Synonym:
Target: OX Receptor
BD1063 dhydrochloride
Cat.No: T7488
Synonym: BD1063
Target: Sigma receptor
MELK-IN-1
Cat.No: T11997
Synonym: Nintedanib Impurity L,MELK inhibitor 17,尼达尼布杂质L
Target: MELK
Cat. No. Product Name Target Signaling Pathways
T8260 4',5-Dihydroxyflavone

Lipoxygenase; Glucosidase Metabolism
4',5-Dihydroxyflavone 是大豆 LOX-1Ki=102.6 μM。它也是一种酵母 α-葡萄糖苷酶抑制剂,IC50=66 μM。
TN1160 1,2,3,6-Tetragalloylglucose

1,2,3,6-Tetra-O-galloyl-β-D-glucose,1,2,3,6-四-O-没食子酰-Β-D-葡萄糖,TeGG

LDL; UGT Metabolism
1,2,3,6-Tetragalloylglucose (TeGG) 是 UDP-葡萄糖醛酸转移酶 1 家族成员,是多肽A1 的抑制剂(Ki:1.68 μM)。
T4429 Rauwolscine hydrochloride

Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride

Adrenergic Receptor GPCR/G Protein; Neuroscience
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂,Ki=12 nM。
T5S0669 Bergamottin

5-Geranoxypsoralen,Bergamotine,Bergaptin,佛手柑素

P450 Metabolism
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。
T4S0145 Corylifol A

Corylinin,补骨脂异黄酮A

hCE; STAT; UGT JAK/STAT signaling; Metabolism; Stem Cells
Corylifol A (Corylinin) 是补骨脂中的一种天然产物,可抑制IL-6 诱导的STAT3激活和磷酸化,IC50值为0.81 μM。
T7472 7-Hydroxyflavone

7-羟基黄酮,7羟基黄酮

P450 Metabolism
7-Hydroxyflavone 是一种黄酮类化合物,从M. indica 中分离得到,具有抗炎活性。它利用 ERK/Nrf2/HO-1 通路保护肾细胞,使其免受尼古丁诱导的细胞毒性。
T4S0051 Coptisine sulfate

Indoleamine 2,3-Dioxygenase (IDO) Metabolism
Coptisine Sulfate 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。
T5S0994 N-Methylcytisine

N-甲基野靛碱,Caulophylline

Others; AChR Neuroscience; Others
N-Methylcytisine (Caulophylline) 是苦参中的一种三环喹啉类生物碱,具有降血糖、缓解疼痛和抗炎活性。它是中枢神经系统中乙酰胆碱烟碱受体的选择性配体,对鱿鱼视神经节中的烟碱乙酰胆碱受体具有很高的亲和力,Kd 为 50 nM。
TN1051 1-Caffeoylquinic acid

金银花,1-咖啡酰奎宁酸

NF-κB NF-κB
1-Caffeoylquinic acid 是一种有效的NF-κB 抑制剂,对 p105 的 RH 结构域显示高结合亲和力,Ki= 0.002 μM,结合能为 1.50 Kcal/mol。它抑制PD-1/PD-L1相互作用。它具有抗氧化应激能力。
T2730 Gossypol (acetic acid)

(±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid

BCL Apoptosis
Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物,分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合,Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。
T5S0056 Coptisine chloride

盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754

Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus; Antibacterial Metabolism; Microbiology/Virology
Coptisine chloride (NSC-119754) 是从黄连中分离到的一种生物碱,是一种非竞争性 IDO 抑制剂,Ki 值为 5.8 μM,IC50值为 6.3 μM。它是一种 H1N1 神经氨酸酶抑制剂,可用于甲型流感病毒感染,IC50为 104.6 μg/mL。
T5S2017 Ingenol

(-)-Ingenol,巨大戟二萜醇,巨大戟醇

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
Ingenol ((-)-Ingenol) 是一种PKC 激活剂,Ki 值为 30 μM,具有抗肿瘤活性。 从 Ingenol 酯中配制新的衍生物可能是开发新的先导化合物以重新激活潜伏 HIV 的创新方法。Ingenol mebutate 是治疗光化性角化病的有效方法。
T5558 Chelidonic acid

Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid

NF-κB; Caspase Apoptosis; NF-κB; Proteases/Proteasome
Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质,用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂,Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。
T5S0053 Coptisine

黄连碱,Coptisin

Indoleamine 2,3-Dioxygenase (IDO) Metabolism
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。
T6323 Oligomycin A

MCH 32,寡霉素A

ATPase; Antibiotic; Antifungal Membrane transporter/Ion channel; Microbiology/Virology
Oligomycin A (MCH 32) 是从链霉菌属中得到的一种线粒体F0F1-ATPase 抑制剂,抑制氧化磷酸化和线粒体偶联膜上发生的所有 ATP 依赖性过程。
T5S1172 Tiliroside

银椴甙,Tribuloside,银椴苷;椴树苷

Antioxidant oxidation-reduction
Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。
T21504 γ-Linolenic Acid methyl ester

Methyl gamma-linolenate,γ-亚麻酸甲酯

LTR Immunology/Inflammation
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) 是一种弱白三烯 B4 (LTB4) 受体拮抗剂。
T4861 trans-Aconitic acid

ATPase; Endogenous Metabolite Membrane transporter/Ion channel; Metabolism
trans-Aconitic acid 是反式丙酮酸2-甲基转移酶的底物,存在于正常人尿液中,大量存在于 Reye 综合征和有机酸尿症。
T0683 Mevastatin

Compactin,ML236B,美伐他汀

Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid Apoptosis; Autophagy; Metabolism; Microbiology/Virology
Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药,可诱导细胞凋亡,将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性,用于心血管疾病的研究。
T16896 SL 0101-1

SL0101

S6 Kinase MAPK; PI3K/Akt/mTOR signaling
SL 0101-1 (SL0101) 是一种可透过细胞膜且具有选择性、高效性、可逆性、ATP竞争性的 p90核糖体S6激酶(RSK) 的抑制剂,对 RSK 的 IC50 值为 89 nM。SL 0101-1 (SL0101) 也是一种有效的 RSK1/2 抑制剂,其 Ki 值为 1 μM。
T71833 Acetylaszonalenin

Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM.
T14121 Actinonin

(-)-Actinonin

Aminopeptidase Metabolism
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
T74198 Beauverolide Ja

Beauverolide Ja 是一种环四缩酚肽,是一种有效的钙调蛋白 (CaM) 抑制剂,对 Ca2+-CaM 的Kd 为 0.078 μM,Ki 为 0.39 μM。Beauverolide Ja 是Isaria fumosorosea 的次级代谢产物。
T72172 4,6-O-Ethylidene-α-D-glucose

Ethylidene-glucose

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物,是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂,对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。
T38241 2-Aminoimidazole

2-Aminoimidazole is a potent antibiofilm agent and adjuvant to antimicrobial treatments, which effectively disrupts bacterial self-protection mechanisms by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. Additionally, 2-Aminoimidazole acts as a weak noncompetitive inhibitor of human arginase I, with a Ki value of 3.6 mM[1][2][3].
TN4613 (-)-N-methylcoclaurine

N-Methylcoclaurine

Others Others
N-Methylcoclaurine shows binding affinities for the &#312; opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 1
T35770 Cylindrospermopsin

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...
T75644 Lupanine hydrochloride

Lupanine (D-Lupanine) hydrochloride 是 Sparteine ((+)-Sparteine ) 的天然酮衍生物,具有神经节麻痹活性。Lupanine hydrochloride 对烟碱受体 (nicotinic receptor) (nAChR) 具有结合亲和力,Ki 值为 500 nM。
T75541 Tanshinone IIA anhydride

Tanshinone IIA anhydride 是一种有效且不可逆的人羧酸酯酶 (CE) 抑制剂,对人 CE1 和人肠道 CE (hiCE) 的Ki 值分别为 1.9 nM 和 1.4 nM。
T73857 Mesembrine

Mesembrine ((+)-Mesembrine) 一种主要的生物碱,具有芳基八氢吲哚骨架。Mesembrine 是一种5-HT 转运蛋白抑制剂,Ki1.4 nM。Mesembrine 还抑制磷酸二酯酶 4B (PDE4B),IC50为 7.8 μM。
T83915 Norbixin hydrate

Norbixin是一种在B. orellana中发现的类胡萝卜素,具有多样的生物活性。在无细胞测试中,它与过氧化物酶体增殖物激活受体γ (PPARγ)结合(Ki = 1.15 µM)。在心脑血管代谢综合征大鼠模型中,Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性,降低血清脂质水平及心脏中硫代巴比妥酸反应性物质(TBARS)和谷胱甘肽(GSH)的水平。在胆固醇诱导的动脉粥样硬化兔模型中,它降低氧化型LDL和主动脉蛋白氧化水平,并减少动脉粥样硬化面积。Norbixin(每天0.11 mg/kg)减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外,它还能预防与年龄相关的黄斑变性(AMD)Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。
T35624 Ajoene

Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

4',5-Dihydroxyflavone
Cat.No: T8260
Synonym:
Target: Lipoxygenase, Glucosidase
1,2,3,6-Tetragalloylglucose
Cat.No: TN1160
Synonym: 1,2,3,6-Tetra-O-galloyl-β-D-glucose,1,2,3,6-四-O-没食子酰-Β-D-葡萄糖,TeGG
Target: LDL, UGT
Rauwolscine hydrochloride
Cat.No: T4429
Synonym: Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride
Target: Adrenergic Receptor
Bergamottin
Cat.No: T5S0669
Synonym: 5-Geranoxypsoralen,Bergamotine,Bergaptin,佛手柑素
Target: P450
Corylifol A
Cat.No: T4S0145
Synonym: Corylinin,补骨脂异黄酮A
Target: hCE, STAT, UGT
7-Hydroxyflavone
Cat.No: T7472
Synonym: 7-羟基黄酮,7羟基黄酮
Target: P450
Coptisine sulfate
Cat.No: T4S0051
Synonym:
Target: Indoleamine 2,3-Dioxygenase (IDO)
N-Methylcytisine
Cat.No: T5S0994
Synonym: N-甲基野靛碱,Caulophylline
Target: Others, AChR
1-Caffeoylquinic acid
Cat.No: TN1051
Synonym: 金银花,1-咖啡酰奎宁酸
Target: NF-κB
Gossypol (acetic acid)
Cat.No: T2730
Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid
Target: BCL
Coptisine chloride
Cat.No: T5S0056
Synonym: 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754
Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial
Ingenol
Cat.No: T5S2017
Synonym: (-)-Ingenol,巨大戟二萜醇,巨大戟醇
Target: PKC
Chelidonic acid
Cat.No: T5558
Synonym: Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid
Target: NF-κB, Caspase
Coptisine
Cat.No: T5S0053
Synonym: 黄连碱,Coptisin
Target: Indoleamine 2,3-Dioxygenase (IDO)
Oligomycin A
Cat.No: T6323
Synonym: MCH 32,寡霉素A
Target: ATPase, Antibiotic, Antifungal
Tiliroside
Cat.No: T5S1172
Synonym: 银椴甙,Tribuloside,银椴苷;椴树苷
Target: Antioxidant
γ-Linolenic Acid methyl ester
Cat.No: T21504
Synonym: Methyl gamma-linolenate,γ-亚麻酸甲酯
Target: LTR
trans-Aconitic acid
Cat.No: T4861
Synonym:
Target: ATPase, Endogenous Metabolite
Mevastatin
Cat.No: T0683
Synonym: Compactin,ML236B,美伐他汀
Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid
SL 0101-1
Cat.No: T16896
Synonym: SL0101
Target: S6 Kinase
Acetylaszonalenin
Cat.No: T71833
Synonym:
Target:
Actinonin
Cat.No: T14121
Synonym: (-)-Actinonin
Target: Aminopeptidase
Beauverolide Ja
Cat.No: T74198
Synonym:
Target:
4,6-O-Ethylidene-α-D-glucose
Cat.No: T72172
Synonym: Ethylidene-glucose
Target:
2-Aminoimidazole
Cat.No: T38241
Synonym:
Target:
(-)-N-methylcoclaurine
Cat.No: TN4613
Synonym: N-Methylcoclaurine
Target: Others
Cylindrospermopsin
Cat.No: T35770
Synonym:
Target:
Lupanine hydrochloride
Cat.No: T75644
Synonym:
Target:
Tanshinone IIA anhydride
Cat.No: T75541
Synonym:
Target:
Mesembrine
Cat.No: T73857
Synonym:
Target:
Norbixin hydrate
Cat.No: T83915
Synonym:
Target:
Ajoene
Cat.No: T35624
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-01827 CD30/TNFRSF8 Protein, Human, Recombinant (His)

D1S166E,tumor necrosis factor receptor sup...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P28908-1.
TMPY-05443 CD30/TNFRSF8 Protein, Mouse, Recombinant (His)

Ki-1,Ki,D1S166E...

Mouse HEK293 Cells
CD30/TNFRSF8 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is Q60846.
TMPY-05737 CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc)

Cd30,Ki,tumor necrosis factor receptor superfamily,...

Mouse HEK293 Cells
CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.92 kDa and the accession number is Q60846.
TMPY-01888 KRAS Protein,Human, Recombinant (Q61H, His)

KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho...

Human E. coli
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2.
TMPY-04116 KRAS Protein,Human,Recombinant(G12C & Q61H, His)

NS,CFC2,K-RAS4B,C-K-RAS,KRAS2,K-RAS2B,K-RAS,Kirsten...

Human E. coli
KRAS Protein,Human,Recombinant(G12C & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPY-06056 KRAS Protein, Human, Recombinant (G12D, His)

KRAS1,K-RAS4B,Kirsten rat sarcoma viral on...

Human E. coli
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2.
TMPY-04113 KRAS Protein,Human,Recombinant(G12D & Q61H, His)

Kirsten rat sarcoma viral oncogene homolog,KRAS2,

Human E. coli
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2.
TMPJ-01436 MKI67 Protein, Human, Recombinant (GST)

Ki-67,Antigen Ki67,MKI67,KI

Human E. coli
MKI67 also also known as Ki67, is a 350-400 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. MKI67 contains 1 FHA domain and plays a key role in cell proliferation. MKI67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, MKI67 qualifies as a cell proliferation marker. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition...
TMPY-06282 CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated

tumor necrosis factor receptor superfamily, member 8,Ki<...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 67.02 kDa and the accession number is P28908-1.
TMPY-05471 CD30/TNFRSF8 Protein, Human, Recombinant (hFc)

Ki-1,tumor necrosis factor receptor superf...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.2 kDa and the accession number is P28908-1.
TMPY-03105 Ki67/MKI67 Protein, Human, Recombinant (GST)

MIB-1,PPP1R105,marker of prolifer...

Human E. coli
MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tu...
TMPY-05118 CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated

D1S166E,Ki-1,tumor necro...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.9 kDa and the accession number is P28908-1.
TMPY-06430 CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated

Ki-1,CD30,D1S166E,tumor ...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 41.74 kDa and the accession number is P28908-1.
TMPJ-00342 CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His)

Lymphocyte activation antigen CD30,TNFRSF8,Tumor necrosis fa...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 60-95 KDa and the accession number is P28908.
TMPJ-00240 CAMK1 Protein, Human, Recombinant (His)

CaM Kinase I Alpha,CaMKI-α,CaM Ki...

Human HEK293 Cells
Calcium/Calmodulin-Dependent Protein Kinase Type 1 (CAMK1) belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, and CaMK subfamily. CAMK1 contains one protein kinase domain and widely expressed. CAMK1 is phosphorylated by CaMKK1 and CaMKK2 on Thr-177. CAMK1 regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization, and neurite outgrowth. CAMK1 plays a role in K+ and ANG2-mediated regulation of the aldo...
TMPJ-00341 CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc)

TNFRSF8,Ki-1 antigen,CD30,CD30L receptor,T...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P28908.
TMPJ-00340 CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated

Lymphocyte activation antigen CD30,TNFRSF8,CD30,Ki-...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 60-90 KDa and the accession number is P28908.
TMPJ-00343 CD30/TNFRSF8 Protein, Human, Recombinant (mFc)

TNFRSF8,Tumor necrosis factor receptor superfamily member 8,...

Human HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 90-120 KDa and the accession number is P28908.
TMPY-06345 KRAS Protein, Human, Recombinant (His & Avi), Biotinylated

RASK2,K-RAS2A,RALD,C-K-RAS,NS3,Kirsten rat sarcoma ...

Human E. coli
KRAS Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with His and Avi tag. The predicted molecular weight is 23.78 kDa and the accession number is P01116-2.
TMPU-00001 KRAS Protein, Human, Recombinant (G12S, GST)

NS,C-K-RAS,K-RAS2A,KRAS1,K-RAS2B,KRAS2,K-RAS4A,CFC2...

Human E. coli
KRAS Protein, Human, Recombinant (G12S, GST) is expressed in E. coli expression system with GST tag. The accession number is P01116.
TMPY-06138 KRAS Protein, Human, Recombinant (61Q, His)

Kirsten rat sarcoma viral oncogene homolog,K-RAS2B,...

Human E. coli
KRAS Protein, Human, Recombinant (61Q, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 21.9 kDa and the accession number is P01116-2.
TMPY-03754 SCLY Protein, Human, Recombinant (His)

selenocysteine lyase,hSCL,SCL

Human Baculovirus Insect Cells
SCLY, also known as selenocysteine lyase, belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. It is a novel enzyme that exclusively decomposes L-selenocysteine into L-alanine and H2Se in various mammalian tissues. SCLY contains pyridoxal 5'-phosphate and weighs approximately 85,000. SCLY participates in selenoamino acid metabolism. It employs one cofactor, pyridoxal phosphate. Its maximum reactivity is at about pH 9.0. It was shown that 1 mol of selenocysteine is conver...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

AMPK, AMPK(α1, β1, γ1)

Human Baculovirus Insect Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619-1&Q9Y478-1&Q13131-1.
TMPY-03878 Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

Integrin alpha V β6,ITGAV & ITGB6,integrin, alpha 5 (fibrone...

Human HEK293 Cells
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
TMPY-02501 CD3D & CD3E Heterodimer Protein, Human, Recombinant

CD3d molecule, δ (CD3-TCR complex),CD3-δ,CD3d molecule, delt...

Human HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 77.5 kDa and the accession number is P04234-1&P07766-1.
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

CD3-DELTA,CD3d molecule, delta (CD3-TCR complex),CD3d molecu...

Human HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 31.05 kDa and the accession number is P04234-1&P07766-1.
TMPY-02245 SNAP-25 Protein, Human, Recombinant (His)

synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ

Human E. coli
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp...
TMPK-00383 ACE2/ACEH Protein, Human, Recombinant (His & Avi)

ACE2,ACE-2,ACEH

Human HEK293 Cells
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension.The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. A...
TMPY-01147 R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)

RSPO,CRISTIN3,R-spondin 1

Human HEK293 Cells
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.2 kDa and the accession number is Q2MKA7-1.
TMPY-01850 CEACAM3 Protein, Human, Recombinant (His)

W282,W264,CEA,CD66D,CGM1,MGC11987...

Human HEK293 Cells
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp...
TMPY-01938 CD98 Protein, Human, Recombinant (His)

4T2HC,4F2,CD98HC,NACAE,MDU1,4F2HC,CD98,solute carri...

Human HEK293 Cells
CD98 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P08195-1.
TMPY-01894 SIGIRR Protein, Human, Recombinant (His)

TIR8,single immunoglobulin and toll-interleukin

Human HEK293 Cells
SIGIRR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14 kDa and the accession number is Q6IA17-1.
TMPY-01281 ACVR2B Protein, Mouse, Recombinant (His)

ActRIIB,activin A receptor, type IIB,4930516B21...

Mouse HEK293 Cells
ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1.
TMPY-01258 IL-13RA1 Protein, Human, Recombinant (His)

NR4,interleukin 13 receptor, alpha 1

Human HEK293 Cells
IL-13RA1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.3 kDa and the accession number is P78552-1.
TMPY-04346 PD-L2 Protein, Human, Recombinant (His)

PD-L2,B7-DC,CD273,Btdc,PDCD1L2,B7DC,PDL2,programmed...

Human HEK293 Cells
PD-L2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9BQ51-1.
TMPY-02525 RGMA Protein, Human, Recombinant (His)

repulsive guidance molecule family member a,RGM

Human HEK293 Cells
RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form...
TMPY-00861 IL-33 Protein, Human, Recombinant

IL1F11,C9orf26,NFEHEV,NF-HEV,DVS2...

Human E. coli
IL-33 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is O95760-1.
TMPY-01247 FLT3 Protein, Human, Recombinant (T227M, His)

FLK2,FLK-2,CD135,STK1,fms-related tyrosine...

Human HEK293 Cells
FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
TMPY-01185 DR5/TRAIL R2 Protein, Human, Recombinant (His)

KILLER,TRICK2A,TRICK2,DR5,TRICKB,tumor necrosis fac...

Human HEK293 Cells
DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.
TMPY-05220 TSLP Protein, Human, Recombinant (R127A & R130S, His)

thymic stromal lymphopoietin

Human HEK293 Cells
TSLP Protein, Human, Recombinant (R127A & R130S, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.2 kDa and the accession number is Q969D9-1.
TMPY-06418 R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)

R-spondin 2,CRISTIN2

Human HEK293 Cells
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.01 kDa and the accession number is Q6UXX9-1.
TMPY-02813 ErbB4 Protein, Human, Rhesus, Recombinant (His)

erb-b2 receptor tyrosine kinase 4

Human,Rhesus HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1.
TMPY-06873 FLT3 Ligand Protein, Human, Recombinant

FLT3LG,fms related tyrosine kinase 3 ligand,FLT3L,F...

Human E. coli
FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-01883 EPOR Protein, Human, Recombinant (His)

erythropoietin receptor,EPO-R

Human HEK293 Cells
EPOR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.3 kDa and the accession number is P19235-1.
TMPY-04970 TIGIT Protein, Human, Recombinant (hFc)

WUCAM,VSTM3,VSIG9,T cell immunoreceptor with Ig and ITIM dom...

Human HEK293 Cells
TIGIT Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is Q495A1-1.
TMPY-04939 LAG-3 Protein, Human, Recombinant

LAG-3,lymphocyte-activation gene 3,CD223

Human HEK293 Cells
LAG-3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 45.3 kDa and the accession number is P18627-1.
TMPY-04348 CTLA-4 Protein, Human, Recombinant (His)

ALPS5,CD152,GRD4,cytotoxic T-lymphocyte-associated ...

Human HEK293 Cells
CTLA-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is P16410-1.
TMPY-00947 VCAM-1 Protein, Human, Recombinant (hFc)

INCAM-100,CD106,VCAM-1,vascular c...

Human HEK293 Cells
VCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 100.8 kDa and the accession number is P19320-1.
TMPY-04165 FGFR3 Protein, Human, Recombinant (His)

JTK4,CEK2,fibroblast growth factor receptor 3,HSFGFR3EX,CD33...

Human HEK293 Cells
FGFR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.6 kDa and the accession number is P22607-1.
TMPY-01137 HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)

erb-b2 receptor tyrosine kinase 2,NEU,ENVW,HERV-7q,...

Human HEK293 Cells
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71 kDa and the accession number is P04626-1.
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重组蛋白

CD30/TNFRSF8 Protein, Human, Recombinant (His)
Cat.No: TMPY-01827
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-05443
Species: Mouse
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-05737
Species: Mouse
Expression System: HEK293 Cells
KRAS Protein,Human, Recombinant (Q61H, His)
Cat.No: TMPY-01888
Species: Human
Expression System: E. coli
KRAS Protein,Human,Recombinant(G12C & Q61H, His)
Cat.No: TMPY-04116
Species: Human
Expression System: E. coli
KRAS Protein, Human, Recombinant (G12D, His)
Cat.No: TMPY-06056
Species: Human
Expression System: E. coli
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Cat.No: TMPY-04113
Species: Human
Expression System: E. coli
MKI67 Protein, Human, Recombinant (GST)
Cat.No: TMPJ-01436
Species: Human
Expression System: E. coli
CD30/TNFRSF8 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06282
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05471
Species: Human
Expression System: HEK293 Cells
Ki67/MKI67 Protein, Human, Recombinant (GST)
Cat.No: TMPY-03105
Species: Human
Expression System: E. coli
CD30/TNFRSF8 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05118
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06430
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His)
Cat.No: TMPJ-00342
Species: Human
Expression System: HEK293 Cells
CAMK1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00240
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, hFc)
Cat.No: TMPJ-00341
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (aa 19-379, His & Avi), Biotinylated
Cat.No: TMPJ-00340
Species: Human
Expression System: HEK293 Cells
CD30/TNFRSF8 Protein, Human, Recombinant (mFc)
Cat.No: TMPJ-00343
Species: Human
Expression System: HEK293 Cells
KRAS Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06345
Species: Human
Expression System: E. coli
KRAS Protein, Human, Recombinant (G12S, GST)
Cat.No: TMPU-00001
Species: Human
Expression System: E. coli
KRAS Protein, Human, Recombinant (61Q, His)
Cat.No: TMPY-06138
Species: Human
Expression System: E. coli
SCLY Protein, Human, Recombinant (His)
Cat.No: TMPY-03754
Species: Human
Expression System: Baculovirus Insect Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04451
Species: Human
Expression System: Baculovirus Insect Cells
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
Cat.No: TMPY-03878
Species: Human
Expression System: HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant
Cat.No: TMPY-02501
Species: Human
Expression System: HEK293 Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
Cat.No: TMPY-03745
Species: Human
Expression System: HEK293 Cells
SNAP-25 Protein, Human, Recombinant (His)
Cat.No: TMPY-02245
Species: Human
Expression System: E. coli
ACE2/ACEH Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00383
Species: Human
Expression System: HEK293 Cells
R-Spondin 1/RSPO1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01147
Species: Human
Expression System: HEK293 Cells
CEACAM3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01850
Species: Human
Expression System: HEK293 Cells
CD98 Protein, Human, Recombinant (His)
Cat.No: TMPY-01938
Species: Human
Expression System: HEK293 Cells
SIGIRR Protein, Human, Recombinant (His)
Cat.No: TMPY-01894
Species: Human
Expression System: HEK293 Cells
ACVR2B Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01281
Species: Mouse
Expression System: HEK293 Cells
IL-13RA1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01258
Species: Human
Expression System: HEK293 Cells
PD-L2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04346
Species: Human
Expression System: HEK293 Cells
RGMA Protein, Human, Recombinant (His)
Cat.No: TMPY-02525
Species: Human
Expression System: HEK293 Cells
IL-33 Protein, Human, Recombinant
Cat.No: TMPY-00861
Species: Human
Expression System: E. coli
FLT3 Protein, Human, Recombinant (T227M, His)
Cat.No: TMPY-01247
Species: Human
Expression System: HEK293 Cells
DR5/TRAIL R2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01185
Species: Human
Expression System: HEK293 Cells
TSLP Protein, Human, Recombinant (R127A & R130S, His)
Cat.No: TMPY-05220
Species: Human
Expression System: HEK293 Cells
R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-06418
Species: Human
Expression System: HEK293 Cells
ErbB4 Protein, Human, Rhesus, Recombinant (His)
Cat.No: TMPY-02813
Species: Human,Rhesus
Expression System: HEK293 Cells
FLT3 Ligand Protein, Human, Recombinant
Cat.No: TMPY-06873
Species: Human
Expression System: E. coli
EPOR Protein, Human, Recombinant (His)
Cat.No: TMPY-01883
Species: Human
Expression System: HEK293 Cells
TIGIT Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04970
Species: Human
Expression System: HEK293 Cells
LAG-3 Protein, Human, Recombinant
Cat.No: TMPY-04939
Species: Human
Expression System: HEK293 Cells
CTLA-4 Protein, Human, Recombinant (His)
Cat.No: TMPY-04348
Species: Human
Expression System: HEK293 Cells
VCAM-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00947
Species: Human
Expression System: HEK293 Cells
FGFR3 Protein, Human, Recombinant (His)
Cat.No: TMPY-04165
Species: Human
Expression System: HEK293 Cells
HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
Cat.No: TMPY-01137
Species: Human
Expression System: HEK293 Cells
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