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Search Results for " angiogenic "

103

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7057	Methylstat	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药，具有良好的细胞渗透性。在体外试验中，methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3，IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长，GI50 为 5.1 µM，而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化（KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM，MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM）。
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T8616	Fasentin N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter	Metabolism
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂，可抑制GLUT-1/GLUT-4转运蛋白，优先抑制 GLUT4，IC50为 68 μM。它是死亡受体刺激敏化剂，可敏化细胞对 FAS 诱导的细胞死亡，具有抗血管生成活性。
T5194	SPHINX31	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂，其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化，有用于局部新生血管性眼病的研究潜力。
T1939	DMOG Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine,二甲基草酰甘氨酸	HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
	DMOG (Dimethyloxalylglycine) 是 α-酮戊二酸辅因子的拮抗剂，是一种 HIF 脯氨酰羟化酶抑制剂，可导致蛋白HIF-1α的积聚和稳定，诱导细胞自噬。它是一种促血管生成剂，在结肠炎和腹泻动物模型中起保护作用。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) 是一种有效的胸苷磷酸化酶 (thymidine phosphorylase) 抑制剂 (IC50: 39.71 μM)，表现出抗血管生成作用。
T79364	Antiangiogenic agent 4	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Antiangiogenic agent 4（Compound 3b）在HFF和HUVEC细胞中抑制Akt磷酸化，可应用于癌症研究。
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 是一种抗血管生成剂，具有抑制人脐静脉内皮细胞(HUVEC)生长、迁移与趋化运动的作用。此外，该化合物还能降低 Src、cdc42 以及 MAPK 的基因表达。
T24804	SM27 SM-27,NSC-37204,SM 27,NSC37204	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SM27 是一种成纤维细胞生长因子 2（FGF2）抑制剂，具有抗血管生成活性，可用于研究肿瘤。
T28911	Tafetinib SIM-010603,SIM010603,SIM 010603	Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Tafetinib (SIM-010603) 是一种新型有效且可口服的酪氨酸激酶抑制剂，具有抗血管生成和抗肿瘤活性。
T6279L	Givinostat hydrochloride ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Givinostat hydrochloride (ITF2357 hydrochloride) 是一种 HDAC 抑制剂，对 HDAC1 和 HDAC3 的 IC50 分别为 198 和 157 nM。 Givinostat hydrochloride 具有抗炎、抗血管生成和抗肿瘤活性。
T2384	Pomalidomide CC-4047,泊马度胺	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Pomalidomide (CC-4047) 是一种抗血管生成剂和免疫调节剂，以分子胶的方式作用。它与 E3 连接酶 cereblon 相互作用，诱导必需的 Ikaros 转录因子的降解。
T12644L	(S)-Thalidomide (S)-(-)-Thalidomide	Apoptosis	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S 型异构体，具有免疫调节，抗炎，抗癌，抗血管生成活性和促凋亡活性，可用于研究麻风结节性红斑和骨髓瘤。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T2656	Fruquintinib HMPL-013,呋喹替尼	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Fruquintinib (HMPL-013) 是一种选择性的VEGFR 1/2/3抑制剂，它们的IC50值分别为33 nM、0.5 nM、35 nM。
T24997	ABT-510 acetate ABT 510 acetate	Apoptosis	Apoptosis
	ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂，是一种凝血酶原类似物，具有抗炎抗癌和抗血管生成活性，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应，可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。
T0153	Oltipraz 吡噻硫酮,NSC 347901,RP 35972	HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活，IC50为 10 μM，浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。
T68455	AP23846 AP-23846	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	AP23846 是一种新型高效的 Src 家族激酶抑制剂，可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达，并消除下游血管生成过程。
T6091	CP-673451	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	CP673451 是选择性的血小板源生长因子受体 (PDGFR) 抑制剂，能够抑制 PDGFRα (IC50:10 nM) 和 PDGFRβ (IC50:1 nM) 的活性。
T8402	Regorafenib Hydrochloride 瑞戈非尼盐酸盐,BAY73-4506 hydrochloride	Raf; VEGFR; c-RET; PDGFR; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂，可抑制血管生成、基质和致癌受体酪氨酸激酶，具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1，IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。
T79860	TIE-2/VEGFR-2 kinase-IN-5	VEGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂，具有的抗血管生成活性，常用于血管生成相关的生物医学研究领域。
T0213	Thalidomide Thalomid,沙利度胺,Sedoval	Apoptosis; TNF; Autophagy; Ligand for E3 Ligase; Molecular Glues	Apoptosis; Autophagy; PROTAC
	Thalidomide (Thalomid) 能够抑制 cereblon，即 cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分，Kd 值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。它可以作为分子胶来增强底物。
T1792	Regorafenib BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM)，具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。
T10883	CRA-026440 PCI-34051	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CRA-026440(PCI-34051) 是一种高效的 HDAC 抑制剂，对 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 具有抑制作用， Ki 值分别为 4，14，11，15，7 和 20 nM。CRA-026440 具有抗肿瘤和抗血管生成活性，可用于研究结肠癌。
T9127	MYLS22	Others	Others
	MYLS22 是视神经萎缩 1 的选择性抑制剂。它通过影响 NFkB 活性和血管生成基因表达抑制血管生成，靶向作用于内皮细胞 OPA1 ，减少肿瘤的生长。
T14366	AZ10606120 dihydrochloride	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	AZ10606120 dihydrochloride 是一种可选择的、有效的、高亲和力的受体拮抗剂，在人和大鼠 P2X 7 受体上的 K D 值分别为 1.4 和 19 nM。AZ10606120 dihydrochloride 抑制肿瘤生长，具有抗血管生成活性。AZ 10606120在与 ATP 结合位点偶联的位点结合时充当负变构调节剂。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
T4632	NSC 6038 4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide,4-氯-N,N-二-N-丙基苯甲酰胺	Others	Others
	NSC-6038 (4-chloro-N,N-dipropylbenzamide) 是一种苯甲酰胺类生物活性化合物，具有广泛的生物活性，已被证明具有抗炎、抗氧化和抗血管生成的活性，也被证明能有效治疗多种疾病，如癌症、糖尿病和心血管疾病。
T11154L	EG01377 2HCl EG01377 2HCl(2227996-00-9 Free base)	Complement System	Immunology/Inflammation
	EG01377 2HCl 是一种有效的、可生物利用的和选择性的neuropilin-1(NRP1)抑制剂，Kd 值为1.32μM，EG01377 2HCl 对NRP1-a1和NRP1-b1的IC50值均为609nM。EG01377具有抗血管生成，抗迁移及抗肿瘤等活性。
T1185	Rofecoxib MK 966,罗非昔布,罗非考昔,MK-0966	COX	Immunology/Inflammation; Neuroscience
	Rofecoxib (MK 966) 是可口服的 COX-2特异性抑制剂，具有抗炎、解热和镇痛特性以及潜在的抗肿瘤特性。在人骨肉瘤细胞和中国仓鼠卵巢细胞中，对人 COX-2 的 IC50值分别为 26 和 18 nM。
T33701	NM-3 NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	NM-3 是一种可口服的抗血管生成的抑制剂，具有抗肿瘤活性。NM-3在体外和体内可当作辐射调节剂使用。NM-3抑制血管内皮生长因子（VEGF），从而抑制内皮细胞的增殖。NM-3与活性氧的机制诱导细胞凋亡有关。
T70226	Amentoflavone hexaacetate
	Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor. It has anti-angiogenic and anti-metastatic effects.
T36294	D-2-Aminoglutarimide (hydrochloride)
	D-2-Aminoglutarimide is a synthetic intermediate.1It has been used in the synthesis of hydantoins with anti-angiogenic and cancer cell differentiation-inducing activities. 1.Yamaguchi, J., Noguchi-Yachide, T., Sakaguchi, Y., et al.Synthesis of new hydantoins bearing glutarimide or succinimide moiety and their evaluation for cell differentiation-inducing and anti-angiogenic activitiesHeterocycles91(4)764-781(2015)
T28487	Quininib
	Quininib is a regulator of Ocular Angiogenesis. Quininib significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice.
T10182	6-Hydroxybenzbromarone	Others	Others
	6-Hydroxybenzbromarone is the major metabolite of Benzbromarone. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor (IC50: 21.5 μM). It is an angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic
T10635	Burixafor hydrobromide TG-0054 hydrobromide	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in treating choroid neovascularization.
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).
T81549	Papilostatin-2
	Papilostatin-2为抗血管生成肽，适用于抗血管生成研究。
T11519	GW768505A free base	Others	Others
	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.
T11325	Frondoside A	Others	Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T26469	A-176120
	A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth.
T13141	Thalidomide D4	Others	Others
	Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.
T70329	SH-11037
	SH-11037 is a novel potent seh inhibitor, effectively blocking key angiogenic properties of human retinal endothelial cells (hrecs), inhibiting choroidal sprouting and significantly suppressing cnv lesion volume
T83170	Adamtsostatin 4
	Adamtsostatin 4为一种具有抗血管生成特性的肽类化合物，主要应用于抗血管生成相关研究领域。
T72191	Antiproliferative agent-20
	Antiproliferative agent-20，一种具有口服活性的有效抗癌剂，展现出抗增殖及抗血管生成活性。
T64071	Antitumor agent-42
	Antitumor agent-42 能够抑制微管多聚和 NO 释放，表现出抗血管生成、抑制集落形成和诱导凋亡作用。
TP1390	CEP dipeptide 1
	CEP dipeptide 1, a potent angiogenic compound, exhibits robust activity in promoting angiogenesis. This compound is specifically implicated in the pathogenesis of age-related macular degeneration (AMD).
T28392	Pfn1-IN-C1 Pfn1INC1,Pfn1 IN C1,Pfn1 inhibitor C1
	Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ex vivo.

化合物

Cat.No: T7057

Target: Histone Demethylase, Others

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

Cat.No: T8616

Synonym: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Target: transporter

Cat.No: T5194

Target: Serine/threonin kinase

Cat.No: T1939

Synonym: Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine,二甲基草酰甘氨酸

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Antiangiogenic agent 2

Cat.No: T62931

Antiangiogenic agent 4

Cat.No: T79364

Target: Akt

Antiangiogenic agent 3

Cat.No: T72363

Cat.No: T24804

Synonym: SM-27,NSC-37204,SM 27,NSC37204

Target: FGFR

Cat.No: T28911

Synonym: SIM-010603,SIM010603,SIM 010603

Target: Tyrosine Kinases

Givinostat hydrochloride

Cat.No: T6279L

Synonym: ITF2357 hydrochloride,Givinostat HCl,ITF2357,ITF 2357,ITF-2357,ITF2357 HCl

Target: HDAC

Cat.No: T2384

Synonym: CC-4047,泊马度胺

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

(S)-Thalidomide

Cat.No: T12644L

Synonym: (S)-(-)-Thalidomide

Target: Apoptosis

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Cat.No: T2656

Synonym: HMPL-013,呋喹替尼

Target: VEGFR

ABT-510 acetate

Cat.No: T24997

Synonym: ABT 510 acetate

Target: Apoptosis

Cat.No: T0153

Synonym: 吡噻硫酮,NSC 347901,RP 35972

Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF

Cat.No: T68455

Synonym: AP-23846

Target: Src

Cat.No: T6091

Target: VEGFR, PDGFR, c-Kit

Regorafenib Hydrochloride

Cat.No: T8402

Synonym: 瑞戈非尼盐酸盐,BAY73-4506 hydrochloride

Target: Raf, VEGFR, c-RET, PDGFR, Autophagy

TIE-2/VEGFR-2 kinase-IN-5

Cat.No: T79860

Target: VEGFR, Tie-2

Cat.No: T0213

Synonym: Thalomid,沙利度胺,Sedoval

Target: Apoptosis, TNF, Autophagy, Ligand for E3 Ligase, Molecular Glues

Cat.No: T1792

Synonym: BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cat.No: T10883

Synonym: PCI-34051

Target: HDAC

Cat.No: T9127

Target: Others

AZ10606120 dihydrochloride

Cat.No: T14366

Target: P2X Receptor

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Cat.No: T4632

Synonym: 4-chloro-N,N-dipropylbenzamide,4-Chloro-N,N-di-n-propylbenzaMide,4-氯-N,N-二-N-丙基苯甲酰胺

Target: Others

Cat.No: T11154L

Synonym: EG01377 2HCl(2227996-00-9 Free base)

Target: Complement System

Cat.No: T1185

Synonym: MK 966,罗非昔布,罗非考昔,MK-0966

Target: COX

Cat.No: T33701

Synonym: NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3

Target: Apoptosis, Reactive Oxygen Species

Amentoflavone hexaacetate

Cat.No: T70226

D-2-Aminoglutarimide (hydrochloride)

Cat.No: T36294

Cat.No: T28487

6-Hydroxybenzbromarone

Cat.No: T10182

Target: Others

Burixafor hydrobromide

Cat.No: T10635

Synonym: TG-0054 hydrobromide

Target: CXCR

Cat.No: T69599

Cat.No: T81549

GW768505A free base

Cat.No: T11519

Target: Others

Cat.No: T11325

Target: Others

Cat.No: T26469

Cat.No: T13141

Target: Others

Cat.No: T70329

Adamtsostatin 4

Cat.No: T83170

Antiproliferative agent-20

Cat.No: T72191

Antitumor agent-42

Cat.No: T64071

CEP dipeptide 1

Cat.No: TP1390

Cat.No: T28392

Synonym: Pfn1INC1,Pfn1 IN C1,Pfn1 inhibitor C1

Cat. No.	Product Name	Target	Signaling Pathways
T3803	Specnuezhenide 特女贞苷,Nuzhenide,Nuezhenide	Others; NF-κB; Wnt/beta-catenin	Cytoskeletal Signaling; NF-κB; Others; Stem Cells
	Specnuezhenide (Nuezhenide) 是分离自女贞子的果实中。它可抑制 NF-κB 和 wnt/β-catenin 信号传导，进而抑制 IL-1β 诱导的软骨细胞炎症。它可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。
T0724	Formononetin Biochanin B,Flavosil,刺芒柄花素,Formononetol	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Formononetin (Flavosil) 是一种 FGFR2抑制剂，IC50约为4.31 μM。它是一种 O-甲基化的异黄酮，是来自黄芪根的植物雌激素，可有效抑制血管生成和肿瘤生长。
T8846	beta-Escin B-escin,AESCINE,beta-七叶素	Immunology/Inflammation related	Immunology/Inflammation
	beta-Escin 是七叶树种子的主要活性成分。它可抑制碱性成纤维细胞生长因子所诱导的增殖、迁移、管形成以及体内 CAM 血管生成。它具有研究抗血管生成作用的分子机制的潜力。
T2S1200	Sinapine	Antioxidant; P-gp; AChE	Membrane transporter/Ion channel; Neuroscience; oxidation-reduction
	Sinapine 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T3392	Sinapine thiocyanate	P-gp; AChE	Membrane transporter/Ion channel; Neuroscience
	Sinapine thiocyanate 是萝卜中分离出来的一种生物碱，具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂，可用于研究阿尔茨海默症，共济失调，重症肌无力和帕金森氏病。
T2961	Notoginsenoside R1 Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1	Apoptosis; ERK; Beta Amyloid	Apoptosis; MAPK; Neuroscience
	Notoginsenoside R1 (Sanchinoside R1) 是一种从三七中分离出来的皂苷，具有抗氧化、抗炎、抗血管生成和抗凋亡的活性。它有神经保护和抗缺血/再灌注损伤的心脏保护作用。
T3056	Bavachinin 补骨脂二氢黄酮加醚,补骨脂二氢黄酮甲醚,Bavachinin A,7-O-Methylbavachin	PPAR	DNA Damage/DNA Repair; Metabolism
	Bavachinin (Bavachinin A) 是一种具有抗炎症和抗血管生成作用的天然化合物。
TN1916	Matairesinol 罗汉松树脂酚	ATPase; p38 MAPK; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel
	Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
TN1421	Bacopaside II	Apoptosis	Apoptosis
	Bacopaside II 是药用植物Bacopa monnieri 的提取物，可阻断Aquaporin-1 (AQP1)水通道并阻碍表达 AQP1 的细胞迁移，还诱导细胞周期停滞和细胞凋亡。
T5648	Purpurin 吡啉,1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO; Antibacterial; Antibiotic; Antifungal	Metabolism; Microbiology/Virology; Neuroscience
	Purpurin (Verantin) 是来自Rubia tinctorumL. 的天然蒽醌，具有抗抑郁样作用。
T5726	Specneuzhenide Nuezhenide,特女贞苷	Others	Others
	Specneuzhenide (Nuezhenide) 是一种酚糖苷，分离自 Ligustrum sinense 中。它具有抗肿瘤作用。
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
T67708	Thiolutin Acetopyrrothin	Antibacterial; Antibiotic	Microbiology/Virology
	Thiolutin (Acetopyrrothin) 是一种内皮细胞粘附抑制剂，由链霉菌产生。 Thiolutin 具有抗生素和抗血管生成特性。 Thiolutin 可快速诱导 Hsp27 的磷酸化。
T3843	Pinosylvin 银松素,3,5-stilbenediol,5-Styrylresorcinol	Apoptosis; Others; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Others
	Pinosylvin (5-Styrylresorcinol) 是从Pinus spp 的心材中分离出来的一种白藜芦醇类似物，可诱导白血病细胞凋亡和自噬。它是一种感染前的类苯乙烯类毒素，具有抗菌活性。
T2883	Syringic acid 3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,丁香酸,NSC 2129	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	Syringic acid (3,5-dimethoxy-4-hydroxy Benzoic Acid) 能抑制低密度脂蛋白的氧化。
TMA2474	δ-Tocotrienol Delta-Tocotrienol,δ-生育三烯酚	ERK; BCL; VEGFR; Akt; PI3K; PDK; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E，存在于蔬菜，水果，种子，坚果，谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂，可以降低胆固醇和其他脂质，保护心血管疾病。
T3391	Corosolic acid Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid	FAK; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Corosolic acid (Colosic acid) 是从大花紫薇中提取的一种天然产物，具有抗肿瘤活性。
TN1087	Deoxypodophyllotoxin 脱氧鬼臼毒素,去氧鬼臼毒素	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素，是鬼臼毒素衍生物，具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂，作为靶向微管药物，在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加，诱导细胞自噬和凋亡。
TN2429	Capsiate	Antioxidant; TRP/TRPV Channel	Membrane transporter/Ion channel; oxidation-reduction
	Capsiate 是一种具有口服活性的 TRPV1 激动剂，是非刺激性辣椒素类似物，可作为抗过敏剂，具有抗炎、抗氧、降糖和抑制血管生成活性。
TN1828	Kahweol	Apoptosis; NF-κB; AMPK	Apoptosis; Chromatin/Epigenetic; NF-κB; PI3K/Akt/mTOR signaling
	Kahweol 是小果咖啡的成分之一，可诱导细胞凋亡，具有抗炎、抗血管生成和抗癌活性。它通过激酶的活化抑制的脂肪生成和增加葡萄糖摄取。
T1082	Benzyl isothiocyanate Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester	Apoptosis; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology
	Benzyl isothiocyanate (Benzoylthiocarbimide) 是一种具有杀菌活性的天然异硫氰酸酯，最初存在于十字花科蔬菜中。它显示出免疫调节、抗寄生虫、抗生素、抗氧化、抗动脉粥样硬化、抗血管生成、抗转移、抗癌化疗和化学预防活性。
T10619	Bromelain	Apoptosis; Others	Apoptosis; Others
	Bromelain 是来源于菠萝茎的一种抗炎药，可诱导细胞凋亡，具有纤维蛋白溶解、抗癌、抗水肿和抗血栓形成活性。它通过下调血浆激肽原，抑制前列腺素 E2 表达，降解晚期糖基化终产物受体，在COX 途径上游发生抗氧化作用以及调节血管生成生物标志物而发挥作用。
TN1804	Isosilybin A 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2	Apoptosis; Tyrosinase; PPAR; ABC	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素，可抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制，具有抗前列腺癌活性。
T36715	Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tetrac (Tetraiodothyroacetic acid)是L-甲状腺素(T4)的衍生物，是一种甲状腺整合素受体拮抗剂。Tetrac通过阻断EGFR介导的结直肠癌细胞信号传导来诱导抗增殖。Tetrac 可阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3)在细胞表面甲状腺素整合素 αvβ3 受体上的作用。Tetra 具有抗血管生成、抗肿瘤活性和促凋亡活性。
T2860	Vanillyl Alcohol 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol	Apoptosis; Others	Apoptosis; Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇，具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来，在食品和饮料中用作调味剂。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN4101	Ganoderenic acid H	Others	Others
	Ganoderenic acid H is one compound of triterpenoids isolated from Ganoderma lucidum, triterpenoids exhibit a broad spectrum of anti-cancer properties, including anti-proliferative, anti-metastatic and anti-angiogenic activities.
TN2972	3-O-(E)-p-Coumaroylbetulin	Others	Others
	3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM.
T70778	Depudecin
	Depudecin is a polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity.
TN3139	5α-Hydroxycostic acid 5alpha-Hydroxycostic acid	ERK; FAK; Phospholipase; NOS; Akt; Src	Angiogenesis; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TQ0112	Tubulysin A TubA	Microtubule Associated	Cytoskeletal Signaling
	Tubulysin A is a natural product from myxobacterial. It has many function in vitro assays, including anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, and anti-angiogenic.
T38606	Sinapine hydroxide
	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].
TN5096	Tanshindiol B	Histone Methyltransferase	Chromatin/Epigenetic
	Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors. It also possesses the anti-angiogenic act
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Cat.No: T3803

Synonym: 特女贞苷,Nuzhenide,Nuezhenide

Target: Others, NF-κB, Wnt/beta-catenin

Cat.No: T0724

Synonym: Biochanin B,Flavosil,刺芒柄花素,Formononetol

Target: Apoptosis, FGFR

Cat.No: T8846

Synonym: B-escin,AESCINE,beta-七叶素

Target: Immunology/Inflammation related

Cat.No: T2S1200

Target: Antioxidant, P-gp, AChE

Sinapine thiocyanate

Cat.No: T3392

Target: P-gp, AChE

Notoginsenoside R1

Cat.No: T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1

Target: Apoptosis, ERK, Beta Amyloid

Cat.No: T3056

Synonym: 补骨脂二氢黄酮加醚,补骨脂二氢黄酮甲醚,Bavachinin A,7-O-Methylbavachin

Target: PPAR

Cat.No: TN1916

Synonym: 罗汉松树脂酚

Target: ATPase, p38 MAPK, ROS

Cat.No: TN1421

Target: Apoptosis

Cat.No: T5648

Synonym: 吡啉,1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin

Target: MAO, Antibacterial, Antibiotic, Antifungal

Cat.No: T5726

Synonym: Nuezhenide,特女贞苷

Target: Others

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

Cat.No: T67708

Synonym: Acetopyrrothin

Target: Antibacterial, Antibiotic

Cat.No: T3843

Synonym: 银松素,3,5-stilbenediol,5-Styrylresorcinol

Target: Apoptosis, Others, Antibacterial, Autophagy

Cat.No: T2883

Synonym: 3,5-dimethyl ether Gallic Acid,SYRA,3,5-dimethoxy-4-hydroxy Benzoic Acid,丁香酸,NSC 2129

Target: Others, Endogenous Metabolite, Antibacterial

Cat.No: TMA2474

Synonym: Delta-Tocotrienol,δ-生育三烯酚

Target: ERK, BCL, VEGFR, Akt, PI3K, PDK, p53

Cat.No: T3391

Synonym: Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid

Target: FAK, Autophagy

Deoxypodophyllotoxin

Cat.No: TN1087

Synonym: 脱氧鬼臼毒素,去氧鬼臼毒素

Target: Apoptosis, Microtubule Associated, Autophagy

Cat.No: TN2429

Target: Antioxidant, TRP/TRPV Channel

Cat.No: TN1828

Target: Apoptosis, NF-κB, AMPK

Benzyl isothiocyanate

Cat.No: T1082

Synonym: Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester

Target: Apoptosis, Antibacterial, Antibiotic

Cat.No: T10619

Target: Apoptosis, Others

Cat.No: TN1804

Synonym: 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2

Target: Apoptosis, Tyrosinase, PPAR, ABC

Cat.No: T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

Vanillyl Alcohol

Cat.No: T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Ganoderenic acid H

Cat.No: TN4101

Target: Others

3-O-(E)-p-Coumaroylbetulin

Cat.No: TN2972

Target: Others

Cat.No: T70778

5α-Hydroxycostic acid

Cat.No: TN3139

Synonym: 5alpha-Hydroxycostic acid

Target: ERK, FAK, Phospholipase, NOS, Akt, Src

Cat.No: TQ0112

Synonym: TubA

Target: Microtubule Associated

Sinapine hydroxide

Cat.No: T38606

Cat.No: TN5096

Target: Histone Methyltransferase

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

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