Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Givinostat hydrochloride (ITF2357 hydrochloride) 是一种 HDAC 抑制剂,对 HDAC1 和 HDAC3 的 IC50 分别为 198 和 157 nM。 Givinostat hydrochloride 具有抗炎、抗血管生成和抗肿瘤活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 463 | 现货 | ||
2 mg | ¥ 669 | 现货 | ||
5 mg | ¥ 957 | 现货 | ||
10 mg | ¥ 1,670 | 现货 | ||
25 mg | ¥ 3,520 | 现货 | ||
50 mg | ¥ 4,970 | 现货 | ||
100 mg | ¥ 7,230 | 现货 | ||
500 mg | ¥ 14,470 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,460 | 现货 |
产品描述 | Givinostat hydrochloride (ITF2357 hydrochloride) is an inhibitor of HDAC with IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride exhibits anti-inflammatory, anti-angiogenic, and antineoplastic activities. |
靶点活性 | HD1-B:7.5 nM (IC50), HDAC10 (human):340 nM (IC50), HDAC6 (human):315 nM (IC50), HDAC3 (human):157 nM (IC50), HD2:10 nM (IC50), HDAC9 (human):541 nM (IC50), HDAC4 (human):1059 nM (IC50), HD1-A:16 nM (IC50), HDAC11 (human):292 nM (IC50), HDAC7 (human):524 nM (IC50), HDAC2 (human):325 nM (IC50), HDAC8 (human):854 nM (IC50), HDAC1 (human):198 nM (IC50), HDAC5 (human):532 nM (IC50) |
体外活性 | Givinostat hydrochloride inhibits JS-1 cell proliferation in a concentration-dependent manner. Givinostat hydrochloride (≥500 nM) is associated with significant inhibition of JS-1 cell proliferation. Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat hydrochloride ≥250 nM plus LPS and the group without LPS treatment[3]. Givinostat hydrochloride (25, 50, and 100 nM) reduces IL-1β secretion more than 70%. Givinostat hydrochloride suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM, but at 100 and 200 nM, there is no reduction[4]. |
体内活性 | Givinostat hydrochloride (10 mg/kg) reduces serum TNFα by 60%. Pretreatment of Givinostat hydrochloride (0.1 mg/kg) significantly reduces the circulating TNFα by nearly 90%[4]. |
别名 | ITF2357 hydrochloride, Givinostat HCl, ITF2357, ITF 2357, ITF-2357, ITF2357 HCl |
分子量 | 457.95 |
分子式 | C24H28ClN3O4 |
CAS No. | 199657-29-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (60.05 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1836 mL | 10.9182 mL | 21.8364 mL | 54.5911 mL |
5 mM | 0.4367 mL | 2.1836 mL | 4.3673 mL | 10.9182 mL | |
10 mM | 0.2184 mL | 1.0918 mL | 2.1836 mL | 5.4591 mL | |
20 mM | 0.1092 mL | 0.5459 mL | 1.0918 mL | 2.7296 mL | |
50 mM | 0.0437 mL | 0.2184 mL | 0.4367 mL | 1.0918 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Givinostat hydrochloride 199657-29-9 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC ITF2357 hydrochloride inhibit Givinostat HCl Givinostat Hydrochloride ITF-2357 Hydrochloride Histone deacetylases ITF2357 ITF 2357 Hydrochloride Givinostat ITF 2357 ITF-2357 Inhibitor ITF2357 Hydrochloride ITF2357 HCl inhibitor