keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂,是一种凝血酶原类似物,具有抗炎抗癌和抗血管生成活性,能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应,可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 539 | 现货 | ||
5 mg | ¥ 1,330 | 现货 | ||
10 mg | ¥ 2,160 | 现货 | ||
25 mg | ¥ 3,660 | 现货 | ||
50 mg | ¥ 5,270 | 现货 | ||
100 mg | ¥ 7,430 | 现货 |
产品描述 | ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.ABT-510 acetate reduces angiogenesis and inflammatory responses in a mouse model of inflammatory bowel disease. ABT-510 acetate reduces angiogenesis and inflammation in mouse models of inflammatory bowel disease (IBD) and can be used in cancer research, particularly in epithelial ovarian cancer, as well as in inflammatory bowel disease (IBD). |
体外活性 |
ABT-510 acetate (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID 8 cells and increases the incidence of apoptosis in human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3.[1] ABT-510 acetate (0-10 μM; 7 days) inhibits NO-stimulated growth and invasion of vascular cells into the extracellular matrix. ABT-510 acetate blocks tumor-driven vascular cell growth, NO-driven cGMP flux, and CD36-mediated fatty acid uptake.[3] |
体内活性 |
ABT-510 acetate (100 mg/kg; i.p.; once daily for 90 days) induces apoptosis in vivo and significantly reduces epithelial ovarian tumor size, ascites volume, and secondary lesion spread in mice.[1] ABT-510 acetate (60 mg/kg; subcutaneous osmotic minipump; once daily for 7 days) reduces angiogenesis and inflammation in a mouse model of inflammatory bowel disease.[2] |
别名 | ABT 510 acetate |
分子量 | 1054.28 |
分子式 | C48H87N13O13 |
CAS No. | 442526-87-6 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90.0 mg/mL (85.4 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 0.9485 mL | 4.7426 mL | 9.4851 mL | 23.7129 mL |
5 mM | 0.1897 mL | 0.9485 mL | 1.897 mL | 4.7426 mL | |
10 mM | 0.0949 mL | 0.4743 mL | 0.9485 mL | 2.3713 mL | |
20 mM | 0.0474 mL | 0.2371 mL | 0.4743 mL | 1.1856 mL | |
50 mM | 0.019 mL | 0.0949 mL | 0.1897 mL | 0.4743 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ABT-510 acetate 442526-87-6 Apoptosis ABT-510 Acetate ABT510 Acetate ABT 510 acetate ABT 510 Acetate Inhibitor inhibitor inhibit