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Targets Recommended: Apoptosis FLT JAK Bcr-Abl Aurora Kinase Autophagy

448

抑制剂 & 化合物

83

天然产物

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化合物库

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Cat. No. Product Name
L8800 药物片段库

1119 compounds
1119 种药物片段分子,是FBDD 方法新药筛选的有力工具;
L7110 抗高血压化合物库

678 compounds
678 种高血压相关的小分子,用于高通量和高内涵筛选;

化合物库

药物片段库
Cat.No: L8800
Compounds: 1119
抗高血压化合物库
Cat.No: L7110
Compounds: 678
Cat. No. Product Name Target Signaling Pathways
T3068 AT9283

J-504568

Apoptosis; FLT; JAK; Bcr-Abl; Aurora Kinase; Autophagy Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
AT9283 (J-504568) 是一种多靶点激酶抑制剂,抑制多种实体瘤在体内外的生长和存活,有效抑制Aurora A/B,JAK2/3,Abl (T315I),和Flt3,IC50值范围为 1-30 nM。
T67498 3-Amino-1,2,4-triazole

Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
3-Amino-1,2,4-triazole (Trapidil impurity B) 是一种过氧化氢酶抑制剂,能够诱导过氧化氢解毒的补偿机制。 该机制涉及增加谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。
T22363 Methyl 3-aminopyrazine-2-carboxylate

Others Others
Methyl 3-aminopyrazine-2-carboxylate 是一种吡嗪,在 2 位被甲氧基羰基和 3 位氨基取代。它是吡嗪、甲酯和芳香胺的成员。 3-氨基吡嗪-2-羧酸甲酯可用于化学合成。
T5099 Gefapixant

RO 4926219,AF219,MK-7264

P2X Receptor Membrane transporter/Ion channel; Neuroscience
Gefapixant (AF219) 是一个 P2X3 受体拮抗剂,其对人同源重组 hP2X3 和 hP2X2/3 的 IC50值分别是约 30 和 100-250 nM。
T9596 AP1189 acetate

Melanocortin Receptor GPCR/G Protein; Neuroscience
AP1189 acetate 是黑皮质素 1 和黑皮质素 3 受体的偏向激动剂。
TP1246L ACTH (22-39) acetate

ACTH (22-39) acetate (37548-29-1 Free base)

Others Others
ACTH (22-39) acetate 是促肾上腺皮质激素 (ACTH) 的片段,在 N 末端的第 3 位和第 15 位含有两个脯氨酸残基。
T20163 Acetyltrialanine

Acetyltrialanine 是一种二肽化合物,在 Tb+3-胰腺弹性蛋白酶复合物上的两个位点结合,可做为氮源使用。
T1957 AZD2858

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
AZD2858 是具有口服活性的GSK-3抑制剂,可以抑制 GSK-3α (IC50:0.9 nM) 和 GSK-3β (IC50:5 nM) 的活性,可用于骨折愈合的研究。
T6258 Zibotentan

ZD4054

Apoptosis; Endothelin Receptor Apoptosis; GPCR/G Protein
Zibotentan (ZD4054) 是一种选择性的,具有口服活性的内皮素 A (ETA) 受体拮抗剂,Ki 为 13 nM。它具有抗癌作用,可研究去势抵抗性前列腺癌。
T8959 OS-3-106

Dopamine Receptor GPCR/G Protein; Neuroscience
OS-3-106 是一种新型芳酰胺苯基哌嗪,在腺苷酸环化酶抑制试验中作为 D3R 的部分激动剂。
T16435 PBIT

Histone Demethylase; Histone Methyltransferase Chromatin/Epigenetic
PBIT 是一种特异性 Jumonji/AT 富集互作结构域 1 抑制剂,抑制JARID1A 和JARID1C,IC50分别为 6 和 4.9 μM。它抑制JARID1B(KDM5B 或PLU1) 组蛋白去甲基化酶,IC50值约为 3 μM。
T16392 ONC206

Dopamine Receptor GPCR/G Protein; Neuroscience
ONC206 是一种 ONC201 的类似物,是一种多巴胺 D2- 样受体 (DRD2/3/4) 的选择性拮抗剂,其拮抗作用在纳摩尔级别。它具有广谱抗肿瘤活性。
T20381 Cetyl glycol

NSC-71525,NSC 71525,1,2-十六烷二醇,NSC71525

Others Others
Cetyl glycol (NSC-71525) 有利于金属有机前体的分解、中间体 Co(2+)Fe(3+)-油酸配合物的形成以及纳米颗粒在较低温度下的成核。 Cetyl glycol 是一种可用于化妆品的还原剂。
T50039 3-(2-aminopropyl)phenol hydrochloride

Others Others
3-(2-aminopropyl)phenol hydrochloride 是一种用作分子结构单元的苯乙胺类化合物。它是一种精神活性药物,是5-HT1A、5-HT1B 和5-HT2C 等几种血清素受体的部分激动剂,也是5-HT2A 受体的拮抗剂。
T6598 MPEP

GluR Neuroscience
MPEP 是一种选择性 mGlu5 受体拮抗剂,IC50 为 36 nM,有抗焦虑和抗抑郁活性。
TP1253 Argireline

六胜肽,Acetyl hexapeptide-3,阿基瑞林

Others Others
Argireline (Acetyl hexapeptide-3) 是可渗透皮肤的、无毒的抗皱肽。它对神经肌肉接头处依赖 Ca2+的神经递质释放具有显著的抑制作用。它具有抗皱和抗衰老的活性。
TP1992L M40 acetate(143896-17-7 free base)

Neuropeptide Y Receptor GPCR/G Protein; Neuroscience
M40 acetate(143896-17-7 free base) 是一种有效的、非选择性的甘丙肽受体拮抗剂(GAL1 和 GAL2 的 Ki 值分别为 1.82 和 5.1 nM),在体外抑制大鼠脑中甘丙肽 (1-29) 的结合 (IC50 = 3 - 15 nM)。减弱氟西汀的抗抑郁作用并阻止甘丙肽诱导的体内食物摄入。在剂量 > 100 nM 时,对外周 GAL2 受体也表现出较弱的部分激动剂活性。
T4409 Gilteritinib

吉列替尼,ASP2215

FLT; TAM Receptor; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50:0.29 nM),也是一种 AXL 抑制剂 (IC50:0.73 nM),具有 ATP 竞争性。
T8851 I3MT-3

HMPSNE

Hippo pathway Stem Cells
I3MT-3 (HMPSNE) 是一种有效的、具有细胞膜渗透性的、选择性的 3-巯基丙酮酸硫转移酶 (3MST)的抑制剂,IC50值为2.7 μM,对其他硫化氢/磺胺制硫酶没有活性。它靶向位于 3MST 活性位点的过硫半胱氨酸残基。
T3599 BFH772

BFH-722

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
BFH772 是 VEGFR2抑制剂(IC50:3 nM),具有口服活性。
T0110 Zalcitabine

Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine

HIV Protease; Reverse Transcriptase Microbiology/Virology; Proteases/Proteasome
Zalcitabine (Dideoxycytidine) 是一种核苷类似物逆转录酶抑制剂,用于HIV 感染相关研究。
T10432L AZD-8529 mesylate

GluR Neuroscience
AZD-8529 mesylate 是高度选择性的可口服mGluR2正向调节剂,EC50值为 285 nM。它在 20-25 M 时,对 mGluR1、3、4、5、6、7 和 8 亚型没有显示正变构调节剂反应。
T7055 Bz-RS-ISer(3-Ph)-Ome

Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物,在低细胞毒性下抑制 HSV 复制周期,阻断 Vero 细胞的有丝分裂,影响 M-MSV 诱导的肿瘤大小,并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
T4039 BIBB 515

Others Others
BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂,在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生,从而发挥降脂作用。
T22735 DMAB-anabaseine dihydrochloride

N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride

AChR Neuroscience
DMAB-anabaseine dihydrochloride (N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride) 是一种含有 α7 的神经元烟碱受体部分激动剂和 α4β2 和其他烟碱受体的拮抗剂。
T50089 2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine

Others Others
2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine 是一种吲哚胺类化合物,在结构上与血清素相似。它是5-HT2A 受体的选择性激动剂,在神经科学领域具有潜在的应用。
T5208 BAY-8002

BAY8002,BAY 8002

Monocarboxylate transporter Membrane transporter/Ion channel
BAY-8002 是一种可口服的单羧酸转运蛋白第 1 亚型 MCT1 选择性抑制剂,在表达 MCT1 的 DLD-1 细胞中,IC50值为 85 nM,具有抗肿瘤活性。
T2067 NS11394

NS 11394

GABA Receptor Membrane transporter/Ion channel; Neuroscience
NS11394 是可口服GABAA 的阳性变构调节剂 (PAM),Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体,具有抗炎和抗焦虑活性。
T67747 CB2R/FAAH modulator-3

Cannabinoid Receptor; FAAH GPCR/G Protein; Metabolism; Neuroscience
CB2R/FAAH modulator-3 (compound 27) 是一种双重靶点的调节剂,是 CB2R 的激动剂, 也是FAAH 的抑制剂, 作用于 CB2R 和 CB1R 的 Ki 值分别是 20.1 和 67.6 nM,作用于 FAAH 的IC50值为 3.4 μM。CB2R/FAAH modulator-3 可用于癌症、神经退行性疾病中发生的有害炎症级联反应以及 COVID-19 感染相关研究。
T77505 cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride

Quaternium-15 cis-form

cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride (Quaternium-15 cis-form) 是一种抗菌剂,用于化妆品中作为化妆品防腐剂和抗静电剂。cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride 是一种口服致畸剂,但不是皮肤致畸剂,在大鼠中剂量超过了化妆品的预期累积暴露量。
T11409 GLP-26

HBV Microbiology/Virology
GLP-26 是一种HBV 衣壳组装调节剂,抑制 Hep AD38 系统中的 HBV DNA 复制,IC50值为3 nM。 在 1 μM 时,使 cccDNA 降低> 90%。它破坏前基因组 RNA 的衣壳化,导致核衣壳解体,并减少 cccDNA 库。
T8591 RNase L-IN-2

5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one

Others Others
RNase L-IN-2 是 RNase L 的激活剂,EC50 为 22 uM;对多种类型的 RNA 病毒(包括人类病原体人类副流感病毒 3 型)具有广谱抗病毒活性,在有效浓度下没有细胞毒性。
T4674 SB297006

SB 297006

CCR Immunology/Inflammation; Microbiology/Virology
SB297006 是一种CCR3拮抗剂,IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
T9611 PF-04802367

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
PF-04802367是 GSK-3高选择性抑制剂,对 GSK-3β酶的 IC50为 2.1 nM。它抑制两种 GSK-3 亚型(GSK-3α和GSK-3β)效果差不多,IC50值分别为 10.0 和 9.0 nM。它具有理想的中枢神经系统特性和效力。
T4306 CCG-203971

CCG203971

Rho; Ras Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
CCG-203971 是一种Rho/MRTF/SRF 通路抑制剂,具有潜在的抗转移作用。它有效靶向 RhoA/C 激活的 SRE 荧光素酶,IC50为 6.4 μM。它抑制 PC-3 细胞迁移,IC50为 4.2 μM。
T8630 Baclofen hydrochloride

4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物,是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛,尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作用,通常是减少兴奋性传递。
T28886 Suprafenacine

N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Microtubule Associated Cytoskeletal Signaling
Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂,可在 G2/M 期诱导细胞周期停滞和细胞凋亡。 它 与微管结合并抑制秋水仙碱连接处的聚集。 它对癌细胞有选择性,包​​括耐药癌细胞。
T71857 GTP-14564

FLT; Tyrosine Kinases Angiogenesis; Tyrosine Kinase/Adaptors
GTP-14564是一种新型酪氨酸激酶抑制剂,对 wt-FLT3和ITD-FLT3也具有抑制作用。GTP-14564 在 3μ m 处抑制表达 ITD-FLT3 的白细胞介素-3 非依赖性 Ba/F1 的生长,而需要高 30 倍的 GTP-14564 浓度来抑制表达野生型 FLT3 的 Ba/F3 的 FLT3 配体依赖性生长 (wt-FLT3)。
T14775 Bragsin2

6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2

Others Others
Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) 是非竞争性的核苷酸交换因子 BRAG2选择性抑制剂,其 IC50值为 3 μM。它能够结合到 BRAG2 的 PH 结构域和磷脂双分子层的界面处,使 BRAG2 无法激活磷脂化的 Arf GTPase。它能够影响乳腺癌干细胞。
TP1930L1 Spexin acetate(1370290-58-6 free base)

Neuropeptide Y Receptor GPCR/G Protein; Neuroscience
Spexin acetate(1370290-58-6 free base) 是一种有效的甘丙肽受体 2/3 (GAL2/GAL3) 激动剂(EC50 值分别为 45.7 和 112.2 nM)。对甘丙肽受体 1 没有显着的活性。抑制脂肪细胞对长链脂肪酸的摄取并减少饮食诱导的肥胖小鼠和大鼠的食物消耗。减少金鱼的 LH 分泌。在体内表现出抗焦虑作用。
T4657 WHI-P97

4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
WHI-P97 是一种选择性 JAK-3抑制剂,可用于预防过敏性哮喘的研究。
T14362 AY 9944

Others Others
AY 9944 是特异性的胆固醇生物合成抑制剂。它抑制 7- 脱氢胆固醇 Δ7- 还原酶 (IC50:13 nM),导致胆固醇不足和 7DHC 积累。在高剂量下,它可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶,造成胆固醇 8-en-3β-ol 的积累。
T3980 Su1498

Tyrphostin SU 1498,AG 1498

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Su1498 (Tyrphostin SU 1498) 是一种选择性的 VEGFR2 抑制剂,能够抑制 Flk-1 (IC50:700 nM)。
T1242 Alvimopan

爱维莫潘

Opioid Receptor Endocrinology/Hormones; GPCR/G Protein; Neuroscience
Alvimopan (LY 246736) 是一种选择性和竞争性 μ 阿片受体拮抗剂,IC50值为 1.7 nM。它存在于肌间和黏膜下神经元以及人体肠道固有层的免疫细胞中,可用于术后肠梗阻的研究。
T14767 BP 897 hydrochloride

Dopamine Receptor GPCR/G Protein; Neuroscience
BP 897 hydrochloride 是有效的部分多巴胺 D3受体激动剂和弱 D2受体拮抗剂,在多巴胺 D3 受体 (Ki=0.92 nM) 上显示出高亲和力,而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T35900 JAK2-IN-7

JAK2-IN-7

JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
JAK2-IN-7 是一种选择性 JAK2抑制剂,对 JAK2,SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3,FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期,并诱导肿瘤细胞凋亡 (apoptosis),具有抗肿瘤活性。
T9100 BP 897

2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-

Dopamine Receptor GPCR/G Protein; Neuroscience
BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) 是一种有效的部分多巴胺D3受体激动剂和弱D2受体拮抗剂,在多巴胺 D3 受体(Ki=0.92 nM) 上显示出高亲和力,而在 D2 受体上显示出 70 倍的低亲和力 (Ki=61 nM)。它表现出对可卡因寻求行为的选择性抑制。
T3536 AZD1283

P2Y Receptor GPCR/G Protein; Neuroscience
AZD1283是P2Y12受体拮抗剂,EC50为3.0 ug/kg/min,结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集,抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T36520 COR659

Cannabinoid Receptor; GABA Receptor GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。
TP1820L Osteogenic Growth Peptide, OGP acetate

Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)

Others Others
Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽,存在于血清中,浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。

化合物

AT9283
Cat.No: T3068
Synonym: J-504568
Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy
3-Amino-1,2,4-triazole
Cat.No: T67498
Synonym: Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B
Target: Reactive Oxygen Species
Methyl 3-aminopyrazine-2-carboxylate
Cat.No: T22363
Synonym:
Target: Others
Gefapixant
Cat.No: T5099
Synonym: RO 4926219,AF219,MK-7264
Target: P2X Receptor
AP1189 acetate
Cat.No: T9596
Synonym:
Target: Melanocortin Receptor
ACTH (22-39) acetate
Cat.No: TP1246L
Synonym: ACTH (22-39) acetate (37548-29-1 Free base)
Target: Others
Acetyltrialanine
Cat.No: T20163
Synonym:
Target:
AZD2858
Cat.No: T1957
Synonym:
Target: GSK-3
Zibotentan
Cat.No: T6258
Synonym: ZD4054
Target: Apoptosis, Endothelin Receptor
OS-3-106
Cat.No: T8959
Synonym:
Target: Dopamine Receptor
PBIT
Cat.No: T16435
Synonym:
Target: Histone Demethylase, Histone Methyltransferase
ONC206
Cat.No: T16392
Synonym:
Target: Dopamine Receptor
Cetyl glycol
Cat.No: T20381
Synonym: NSC-71525,NSC 71525,1,2-十六烷二醇,NSC71525
Target: Others
3-(2-aminopropyl)phenol hydrochloride
Cat.No: T50039
Synonym:
Target: Others
MPEP
Cat.No: T6598
Synonym:
Target: GluR
Argireline
Cat.No: TP1253
Synonym: 六胜肽,Acetyl hexapeptide-3,阿基瑞林
Target: Others
M40 acetate(143896-17-7 free base)
Cat.No: TP1992L
Synonym:
Target: Neuropeptide Y Receptor
Gilteritinib
Cat.No: T4409
Synonym: 吉列替尼,ASP2215
Target: FLT, TAM Receptor, c-Kit
I3MT-3
Cat.No: T8851
Synonym: HMPSNE
Target: Hippo pathway
BFH772
Cat.No: T3599
Synonym: BFH-722
Target: VEGFR
Zalcitabine
Cat.No: T0110
Synonym: Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine
Target: HIV Protease, Reverse Transcriptase
AZD-8529 mesylate
Cat.No: T10432L
Synonym:
Target: GluR
Bz-RS-ISer(3-Ph)-Ome
Cat.No: T7055
Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate
Target: Others, HIV Protease
BIBB 515
Cat.No: T4039
Synonym:
Target: Others
DMAB-anabaseine dihydrochloride
Cat.No: T22735
Synonym: N,N-dimethyl-4-[(E)-(6-pyridin-3-yl-3,4-dihydro-2H-pyridin-5-ylidene)methyl]aniline;dihydrochloride
Target: AChR
2-(5,7-dichloro-1H-indol-3-yl)ethan-1-amine
Cat.No: T50089
Synonym:
Target: Others
BAY-8002
Cat.No: T5208
Synonym: BAY8002,BAY 8002
Target: Monocarboxylate transporter
NS11394
Cat.No: T2067
Synonym: NS 11394
Target: GABA Receptor
CB2R/FAAH modulator-3
Cat.No: T67747
Synonym:
Target: Cannabinoid Receptor, FAAH
cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride
Cat.No: T77505
Synonym: Quaternium-15 cis-form
Target:
GLP-26
Cat.No: T11409
Synonym:
Target: HBV
RNase L-IN-2
Cat.No: T8591
Synonym: 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one
Target: Others
SB297006
Cat.No: T4674
Synonym: SB 297006
Target: CCR
PF-04802367
Cat.No: T9611
Synonym:
Target: GSK-3
CCG-203971
Cat.No: T4306
Synonym: CCG203971
Target: Rho, Ras
Baclofen hydrochloride
Cat.No: T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Suprafenacine
Cat.No: T28886
Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide
Target: Microtubule Associated
GTP-14564
Cat.No: T71857
Synonym:
Target: FLT, Tyrosine Kinases
Bragsin2
Cat.No: T14775
Synonym: 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2
Target: Others
Spexin acetate(1370290-58-6 free base)
Cat.No: TP1930L1
Synonym:
Target: Neuropeptide Y Receptor
WHI-P97
Cat.No: T4657
Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉
Target: JAK
AY 9944
Cat.No: T14362
Synonym:
Target: Others
Su1498
Cat.No: T3980
Synonym: Tyrphostin SU 1498,AG 1498
Target: VEGFR
Alvimopan
Cat.No: T1242
Synonym: 爱维莫潘
Target: Opioid Receptor
BP 897 hydrochloride
Cat.No: T14767
Synonym:
Target: Dopamine Receptor
JAK2-IN-7
Cat.No: T35900
Synonym: JAK2-IN-7
Target: JAK
BP 897
Cat.No: T9100
Synonym: 2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-
Target: Dopamine Receptor
AZD1283
Cat.No: T3536
Synonym:
Target: P2Y Receptor
COR659
Cat.No: T36520
Synonym:
Target: Cannabinoid Receptor, GABA Receptor
Osteogenic Growth Peptide, OGP acetate
Cat.No: TP1820L
Synonym: Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)
Target: Others
Cat. No. Product Name Target Signaling Pathways
T21344 1-Deoxynojirimycin hydrochloride

Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

PI3K; Antibacterial; Antibiotic; Glucosidase Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂,具有降血糖、减肥和抗病毒的作用,可抑制餐后血糖,预防糖尿病。
T4760 KSD 2405

3-羟基苯甲醇,3-Hydroxybenzyl alcohol

Others; Endogenous Metabolite Metabolism; Others
KSD 2405 (3-Hydroxybenzyl alcohol) 是内源性代谢产物的一种。
Fr12596 3-Acetylcoumarin

Others Others
3-Acetylcoumarin 作为室温下铜催化 CN 偶联反应的实用配体。它具有神经保护和杀螨特性。
T3807 (-)-Gallocatechin gallate

(-)-gallocatechin-3-O-gallate,(-)-Gallocatechol gallate,没食子儿茶素没食子酸酯,Gallocatechin gallate

Others Others
(-)-Gallocatechin gallate ((-)-gallocatechin-3-O-gallate) 是一种从茶中分离出来的多酚,具有防癌活性。 它在 20 microM 时降低破骨细胞生成。
T33492 Methyl pyropheophorbide-a

MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052

Pyropheophorbide-a methyl ester (MPPa) is a PDT photosensitizer, and is also a semisynthetic natural product derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazo
T37152 3-Methyl-2-cyclopenten-1-one

Endogenous Metabolite Metabolism
3-Methyl-2-cyclopenten-1-one 可作为食品添加剂,在 2-5 ppm 下可改善肉类和肉制品的风味。添加3-Methyl-2-cyclopenten-1-one 在对雄性Wistar 大鼠口服给药时显示出胃细胞保护活性。
T5569 3-Amino-4-methylpentanoic acid

DL-Homovaline,3-氨基-4-甲基戊酸,DL-beta-leucine,beta-Aminoisocaproic acid,beta-Leucine

Endogenous Metabolite Metabolism
3-Amino-4-methylpentanoic acid (DL-Homovaline) 是 L-亮氨酸的异构体,是 β 氨基酸,通过亮氨酸 2,3-氨基变位酶在人体中由 L-亮氨酸代谢天然产生。
T19083 1-Methylinosine

N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷

Nucleoside Antimetabolite/Analog; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
1-Methylinosine (N1-Methylinosine) 是在真核生物 tRNA 反密码子 3' 位 tRNA 的 37 位上发现的修饰核苷酸,具有代谢物的作用。
T6S2023 Harpagoside

Others; COX; NO Synthase Immunology/Inflammation; Neuroscience; Others
Harpagoside 是从爪钩草中分离出来的一种天然产物,可抑制COX-1和COX-2活性,并抑制 NO 的产生。
TN1266 3-O-Methylquercetin

IL Receptor; cAMP; PDE GPCR/G Protein; Immunology/Inflammation; Metabolism
3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物,可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。
T3731 Hydrocinnamic acid

3-Phenylpropanoic acid,氢化肉桂酸,3-Phenylpropionic acid,3-Phenyl-n-propionic acid

Others; Endogenous Metabolite Metabolism; Others
Hydrocinnamic acid (3-Phenylpropanoic acid) 是一种根际化合物,具有生长调控活性。
T4S1876 3-Deoxyaconitine

Sodium Channel Membrane transporter/Ion channel
3-Deoxyaconitine 是一种二萜类生物碱,对钠离子通道有激活作用。
T8011 1,2-dioleoyl-sn-glycero-3-phosphocholine

二油酰磷脂酰胆碱,DOPC

Others Others
1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 是磷脂的一种,在胶束,脂质体和其他类型的人工膜的生成中通常单独使用或与其他组分一起使用。
T3S2072 3-Butylidenephthalide

Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞;丁烯基酞内酯

Parasite; Glucosidase Metabolism; Microbiology/Virology
3-Butylidenephthalide (Butylidene phthalide) 是从 Ligusticum chuanxiongHort 鉴定出的一种邻苯二甲酸酐衍生物,有杀虫活性。
T9143 D-Isoleucine

(2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine

Others Others
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸,提高海马 CA1-CA3 的长期增效作用。
T3S1967 (S)-Indoximod

N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Others; Indoleamine 2,3-Dioxygenase (IDO) Metabolism; Others
(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂,可用于研究癌症。
T1688 Pregnanediol

5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇

Estrogen/progestogen Receptor; Endogenous Metabolite Endocrinology/Hormones; Metabolism
Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) 是一种黄体酮的主要代谢物 (metabolite),能够通过尿液排出。它提供了一种间接测定体内孕激素水平的方法。
T3377 L-Phenylalanine

L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Calcium Channel; Endogenous Metabolite; iGluR Membrane transporter/Ion channel; Metabolism; Neuroscience
L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸,是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂,用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂,Ki 为 980 nM。
T3S1960 Kakuol

Antifungal Microbiology/Virology
Kakuol 是一种有抗真菌活性的天然产物。
T2S1907 Coniferaldehyde

Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,松柏醛,Coniferyl aldehyde,松柏醛;4-羟基-3-甲氧基肉桂醛

Apoptosis; Antioxidant Apoptosis; oxidation-reduction
Coniferaldehyde (Ferulaldehyde) 是一种血红素加氧酶-1 的有效诱导剂,具有抗炎作用。在 RAW264.7 巨噬细胞中,它通过 PKCα/βII/Nrf-2/HO-1 依赖性途径来抑制 LPS 诱导的细胞凋亡。
T13555 Ascr#2

Ascaroside C6

Others Others
Ascr#2 (asc-C6-MK)是秀丽隐杆线虫中的糖苷类化合物,促进 dauer 形成。Ascr#2 在低浓度下与 ascr#3 的混合物可作为雄性引诱剂,可用于检测种群密度。
T4429 Rauwolscine hydrochloride

Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride

Adrenergic Receptor GPCR/G Protein; Neuroscience
Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂,Ki=12 nM。
T8105 Indole-3-carboxaldehyde

3-Formylindole,3-吲哚甲醛

Endogenous Metabolite Metabolism
Indole-3-carboxaldehyde (3-Formylindole) 是由黄化豌豆幼苗的粗酶制剂氧化降解IAA 的产物,是一种卷心菜提取物。它可用于制备吲哚类植物抗毒素环芸香素类似物。
T8274 3-Methyl-L-histidine

Endogenous Metabolite Metabolism
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T3794 Pentagalloylglucose

Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Influenza Virus Microbiology/Virology
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T5554 1,3,5-Trimethoxybenzene

Phloroglucinol trimethyl ether,Sym-trimethoxybenzene,1,3,5-三甲氧基苯

Others Others
1,3,5-Trimethoxybenzene (Phloroglucinol trimethyl ether) 是一种中国玫瑰品种中的主要芳香化合物。它在三个连续的甲基化步骤中由间苯三酚(初始前体) 合成。它能够用于缓解紧张等。
T5083 L-Cysteic acid monohydrate

L-磺基丙氨酸 一水合物,3-Sulfo-L-alanine Monohydrate

Endogenous Metabolite; GluR Metabolism; Neuroscience
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) 是内源性代谢产物的一种。
TL0007 Bisdemethoxycurcumin

双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin

Epigenetic Reader Domain; Wnt/beta-catenin Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。
T5243 (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate

DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE

Others; Endogenous Metabolite Metabolism; Others
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) 是内源性代谢产物的一种。
T3S0364 L-Arginine

L-精氨酸,L-Arg,(S)-(+)-Arginine

IL Receptor; Endogenous Metabolite; NO Synthase Immunology/Inflammation; Metabolism
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。
T5088 3-Indoleacetic acid sodium

Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt

Others; Endogenous Metabolite Metabolism; Others
3-Indoleacetic acid sodium (Heteroauxin sodium salt) 是一种天然存在的植物生长素类激素。能刺激细胞伸长和分裂,促进植物生长发育。然而,高浓度时,它表现出生长抑制作用,包括生长和阻止茎和根的生长。后一种效应形成了合成生长素被开发为农业除草剂和生物调节剂的基础。
T5S0890 Oleandrin

Neriostene,Folinerin,Foliandrin,欧夹竹桃苷

Apoptosis; ATPase; Potassium Channel; Sodium Channel Apoptosis; Membrane transporter/Ion channel
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。
T5S1889 Yunaconitine

Guayewuanine B,滇乌头碱

Others Others
Yunaconitine (Guayewuanine B) 是一种乌头类生物碱,具有剧毒。
T5S1981 alpha-Cyperone

(+)-α-Cyperone,α-香附酮,α-Cyperone

Others; Endogenous Metabolite Metabolism; Others
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
T4938 Potassium 1H-indol-3-yl sulfate

硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate

AhR; Endogenous Metabolite Immunology/Inflammation; Metabolism
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) 是人芳烃受体(AhR)的激动剂。芳烃受体(AhR)最近被发现是免疫炎症条件的病理生理调节剂,Potassium 1H-indol-3-yl sulfate 已被证明是AhR的配体。Potassium 1H-indol-3-yl sulfate 也是膳食蛋白质中色氨酸的代谢物。色氨酸被肠道细菌代谢为吲哚,吲哚被吸收到血液中,然后在肝脏中进一步代谢为硫酸吲哚,通常通过尿液排出体外。在肾功能受损的慢性肾病患者中,Potassium 1H-indol-3-yl sulfate 可作为尿毒症毒素在血清中积累,诱导氧化应激并加速疾病进展。250 μM Potassium 1H-indol-3-yl sulfate 可诱导NF-Κb活化,促进大鼠近端小管细胞TGF-β1和Smad3的表达,与促纤维化活性相关。
T38373 2-heptyl-3-hydroxy-4(1H)-Quinolone

2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Others Others
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。
T5S1172 Tiliroside

银椴甙,Tribuloside,银椴苷;椴树苷

Antioxidant oxidation-reduction
Tiliroside (Tribuloside) 是糖苷类黄酮,是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收,具有抗糖尿病作用。
T2S2215 Crebanine

Apoptosis; Others; Akt Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
T6S1487 Ginsenoside Rg5

人参皂苷Rg5,人参皂甙 Rg5

NF-κB; COX; IGF-1R Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。
T4881 Phosphorylethanolamine

O-Phosphorylethanolamine,乙醇胺磷酸酯

Others; Endogenous Metabolite Metabolism; Others
Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体,也是磷脂分解的产物。与其他器官相比,大脑中磷酸单酯的含量要高得多。在大脑发育过程中,磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯,在阿尔茨海默病患者的大脑中减少。
TN1245 3-Deoxysappanchalcone

Others; Akt; mTOR Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.
T40705 m-Tolualdehyde

m-Tolualdehyde, also known as 3-Methylbenzaldehyde, is a chemical compound in the tolualdehyde family featuring a methyl substituent positioned at the 3-position. It finds application as a food additive.
TN4011 Erythrodiol 3-palmitate

Others Others
Erythrodiol 3-palmitate has antitumor activity, it inhibited the proliferation of K562 cells with the inhibition rate of 47% at 100 ug/mL.
T13556 Ascr#3

Others Others
Ascr#3, an ascaroside isolated from Caenorhabditis elegans, acts as a potent male attractant, and also promotes dauer formation combined with ascr#2 at low concentration.
T37884 1,3-Linolein-2-Olein

1,3-Dilinoleoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains linoleic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position. It has been found in grape seed, pumpkin seed, soybean, sunflower, and wheat germ oils, with the highest content in grape seed oil.
TN2972 3-O-(E)-p-Coumaroylbetulin

Others Others
3-β-O-trans-p-coumaroylbetulinol has anti-angiogenic effect, it possesses significant anti-proliferative activity with 66.7% inhibition at 100uM.
TMA0918 Neochamaejasmine A

Caspase Apoptosis; Proteases/Proteasome
Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro
TN2763 2-Hydroxy-3-methoxybenzoic acid glucose ester

PAFR GPCR/G Protein
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
TN2529 1-Decarboxy-3-oxo-ceanothic acid

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
1-Decarboxy-3-oxo-ceanothic acid shows in vitro cytotoxic activity in a human ovarian adenocarcinoma cell line, the cytotoxic effect is mediated, at least in part, by the induction of apoptosis. It shows cytotoxic against OVCAR-3 and HeLa cancer cell line
TN2501 1,5,6-Trihydroxy-3-methoxyxanthone

芒果

ROS Immunology/Inflammation
1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
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天然产物

1-Deoxynojirimycin hydrochloride
Cat.No: T21344
Synonym: Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin
Target: PI3K, Antibacterial, Antibiotic, Glucosidase
KSD 2405
Cat.No: T4760
Synonym: 3-羟基苯甲醇,3-Hydroxybenzyl alcohol
Target: Others, Endogenous Metabolite
3-Acetylcoumarin
Cat.No: Fr12596
Synonym:
Target: Others
(-)-Gallocatechin gallate
Cat.No: T3807
Synonym: (-)-gallocatechin-3-O-gallate,(-)-Gallocatechol gallate,没食子儿茶素没食子酸酯,Gallocatechin gallate
Target: Others
Methyl pyropheophorbide-a
Cat.No: T33492
Synonym: MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052
Target:
3-Methyl-2-cyclopenten-1-one
Cat.No: T37152
Synonym:
Target: Endogenous Metabolite
3-Amino-4-methylpentanoic acid
Cat.No: T5569
Synonym: DL-Homovaline,3-氨基-4-甲基戊酸,DL-beta-leucine,beta-Aminoisocaproic acid,beta-Leucine
Target: Endogenous Metabolite
1-Methylinosine
Cat.No: T19083
Synonym: N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷
Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite
Harpagoside
Cat.No: T6S2023
Synonym:
Target: Others, COX, NO Synthase
3-O-Methylquercetin
Cat.No: TN1266
Synonym:
Target: IL Receptor, cAMP, PDE
Hydrocinnamic acid
Cat.No: T3731
Synonym: 3-Phenylpropanoic acid,氢化肉桂酸,3-Phenylpropionic acid,3-Phenyl-n-propionic acid
Target: Others, Endogenous Metabolite
3-Deoxyaconitine
Cat.No: T4S1876
Synonym:
Target: Sodium Channel
1,2-dioleoyl-sn-glycero-3-phosphocholine
Cat.No: T8011
Synonym: 二油酰磷脂酰胆碱,DOPC
Target: Others
3-Butylidenephthalide
Cat.No: T3S2072
Synonym: Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞;丁烯基酞内酯
Target: Parasite, Glucosidase
D-Isoleucine
Cat.No: T9143
Synonym: (2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine
Target: Others
(S)-Indoximod
Cat.No: T3S1967
Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine
Target: Others, Indoleamine 2,3-Dioxygenase (IDO)
Pregnanediol
Cat.No: T1688
Synonym: 5Beta-Pregnane-3Alpha,20alpha-Diol,孕甾二醇,Pregnandiol,孕二醇
Target: Estrogen/progestogen Receptor, Endogenous Metabolite
L-Phenylalanine
Cat.No: T3377
Synonym: L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine
Target: Calcium Channel, Endogenous Metabolite, iGluR
Kakuol
Cat.No: T3S1960
Synonym:
Target: Antifungal
Coniferaldehyde
Cat.No: T2S1907
Synonym: Ferulaldehyde,Ferulyl aldehyde,4-HYDROXY-3-METHOXYCINNAMALDEHYDE,松柏醛,Coniferyl aldehyde,松柏醛;4-羟基-3-甲氧基肉桂醛
Target: Apoptosis, Antioxidant
Ascr#2
Cat.No: T13555
Synonym: Ascaroside C6
Target: Others
Rauwolscine hydrochloride
Cat.No: T4429
Synonym: Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride
Target: Adrenergic Receptor
Indole-3-carboxaldehyde
Cat.No: T8105
Synonym: 3-Formylindole,3-吲哚甲醛
Target: Endogenous Metabolite
3-Methyl-L-histidine
Cat.No: T8274
Synonym:
Target: Endogenous Metabolite
Pentagalloylglucose
Cat.No: T3794
Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖
Target: Influenza Virus
1,3,5-Trimethoxybenzene
Cat.No: T5554
Synonym: Phloroglucinol trimethyl ether,Sym-trimethoxybenzene,1,3,5-三甲氧基苯
Target: Others
L-Cysteic acid monohydrate
Cat.No: T5083
Synonym: L-磺基丙氨酸 一水合物,3-Sulfo-L-alanine Monohydrate
Target: Endogenous Metabolite, GluR
Bisdemethoxycurcumin
Cat.No: TL0007
Synonym: 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin
Target: Epigenetic Reader Domain, Wnt/beta-catenin
(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate
Cat.No: T5243
Synonym: DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE
Target: Others, Endogenous Metabolite
L-Arginine
Cat.No: T3S0364
Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine
Target: IL Receptor, Endogenous Metabolite, NO Synthase
3-Indoleacetic acid sodium
Cat.No: T5088
Synonym: Indole-3-Acetic Acid sodium salt,Sodium 2-(1H-indol-3-yl)acetate,IAA sodium salt,吲哚乙酸钠,Heteroauxin sodium salt
Target: Others, Endogenous Metabolite
Oleandrin
Cat.No: T5S0890
Synonym: Neriostene,Folinerin,Foliandrin,欧夹竹桃苷
Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel
Yunaconitine
Cat.No: T5S1889
Synonym: Guayewuanine B,滇乌头碱
Target: Others
alpha-Cyperone
Cat.No: T5S1981
Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone
Target: Others, Endogenous Metabolite
Potassium 1H-indol-3-yl sulfate
Cat.No: T4938
Synonym: 硫酸吲哚钾盐,Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate
Target: AhR, Endogenous Metabolite
2-heptyl-3-hydroxy-4(1H)-Quinolone
Cat.No: T38373
Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal
Target: Others
Tiliroside
Cat.No: T5S1172
Synonym: 银椴甙,Tribuloside,银椴苷;椴树苷
Target: Antioxidant
Crebanine
Cat.No: T2S2215
Synonym:
Target: Apoptosis, Others, Akt
Ginsenoside Rg5
Cat.No: T6S1487
Synonym: 人参皂苷Rg5,人参皂甙 Rg5
Target: NF-κB, COX, IGF-1R
Phosphorylethanolamine
Cat.No: T4881
Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯
Target: Others, Endogenous Metabolite
3-Deoxysappanchalcone
Cat.No: TN1245
Synonym:
Target: Others, Akt, mTOR
m-Tolualdehyde
Cat.No: T40705
Synonym:
Target:
Erythrodiol 3-palmitate
Cat.No: TN4011
Synonym:
Target: Others
Ascr#3
Cat.No: T13556
Synonym:
Target: Others
1,3-Linolein-2-Olein
Cat.No: T37884
Synonym:
Target:
3-O-(E)-p-Coumaroylbetulin
Cat.No: TN2972
Synonym:
Target: Others
Neochamaejasmine A
Cat.No: TMA0918
Synonym:
Target: Caspase
2-Hydroxy-3-methoxybenzoic acid glucose ester
Cat.No: TN2763
Synonym:
Target: PAFR
1-Decarboxy-3-oxo-ceanothic acid
Cat.No: TN2529
Synonym:
Target: DNA/RNA Synthesis
1,5,6-Trihydroxy-3-methoxyxanthone
Cat.No: TN2501
Synonym: 芒果
Target: ROS
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Cat. No. Product Name Species Expression System
TMPY-00916 Antithrombin III Protein, Human, Recombinant (His)

AT3D,THPH7,ATIII,AT3...

Human HEK293 Cells
Antithrombin III Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.5 kDa and the accession number is A0A024R944.
TMPH-00857 ABAT Protein, Human, Recombinant (His & Myc & SUMO)

L-AIBAT,GABA aminotransferase,GABA transaminase,GAB...

Human E. coli
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. ABAT Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 73.3 kDa and the accession number is P80404.
TMPY-00672 Azurocidin/CAP37 Protein, Human, Recombinant (His)

AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,...

Human HEK293 Cells
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n...
TMPJ-00135 BDNF Protein, Human/Murine/Rat, Recombinant

BDNF,Abrineurin,Brain-Derived Neurotrophic Factor

Human,Mouse,Rat E. coli
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPJ-01469 NGF Protein, Human, Recombinant (E. colli)

NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt...

Mouse E. coli
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo...
TMPY-03855 DNase I Protein, Human, Recombinant (His)

DRNI,DNL1,deoxyribonuclease I

Human HEK293 Cells
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i...
TMPJ-00387 IL-4R alpha Protein, Mouse, Recombinant (hFc)

Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol...

Mouse HEK293 Cells
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ...
TMPJ-01011 FGF-9 Protein, Mouse, Recombinant (His)

heparin-binding growth factor-9,GAF,HBGF-9,Glia-activat<...

Mouse E. coli
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v...
TMPY-06986 FGF-8b Protein, Human, Recombinant

NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8...

Human E. coli
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-00132 Mesothelin Protein, Human, Recombinant

MPF,SMRP,Mesothelin

Human HEK293 Cells
Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3.
TMPY-04935 CD47 Protein, Human, Recombinant (aa 1-139, His)

MER6,CD47 molecule,IAP,OA3

Human HEK293 Cells
CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3.
TMPY-03763 Neuropilin-2 Protein, Human, Recombinant (hFc)

Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP2

Human HEK293 Cells
Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3.
TMPY-05191 CD47 Protein, Human, Recombinant, Biotinylated

CD47 molecule,MER6,OA3,IAP

Human HEK293 Cells
CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-04683 CD47 Protein, Human, Recombinant

MER6,CD47 molecule,OA3,IAP

Human HEK293 Cells
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
TMPY-00072 GITR/TNFRSF18 Protein, Human, Recombinant (His)

AITR,GITR-D,tumor necrosis factor receptor superfamily, memb...

Human HEK293 Cells
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3.
TMPY-01897 PRSS3 Protein, Human, Recombinant (His)

PRSS4,TRY4,TRY3,RP11-176F3.3,T9,M...

Human HEK293 Cells
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ...
TMPY-01020 Periostin/OSF-2 Protein, Human, Recombinant (His)

PN,OSF-2,OSF2,periostin,periostin, osteoblast specific facto...

Human HEK293 Cells
Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3.
TMPY-00892 Neuropilin-2 Protein, Human, Recombinant (His)

NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-2

Human HEK293 Cells
Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3.
TMPY-01180 CD86 Protein, Human, Recombinant (His)

CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72

Human HEK293 Cells
CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3.
TMPY-05748 CD45 Protein, Human, Recombinant (aa 26-577, His)

L-CA,T200,LCA,B220,protein tyrosine phosphatase, re...

Human HEK293 Cells
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3.
TMPY-04142 RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re...

Human HEK293 Cells
RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
TMPJ-01099 IL-15RA Protein, Human, Recombinant (hFc, Human Cells)

interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...

Human HEK293 Cells
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun...
TMPY-04298 CDCP1 Protein, Human, Recombinant (His)

TRASK,CD318,CUB domain containing protein 1,SIMA1

Human HEK293 Cells
CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3.
TMPY-00357 HNT/NTM Protein, Human, Recombinant (His)

HNT,NTRI,IGLON2,neurotrimin

Human HEK293 Cells
HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3.
TMPY-00480 NCAM1 Protein, Human, Recombinant (His)

neural cell adhesion molecule 1,CD56,MSK39,NCAM

Human HEK293 Cells
NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3.
TMPJ-00054 PLGF-2 Protein, Human, Recombinant (His)

PlGF-2,PlGF2,PlGF,PGF,PGFL

Human HEK293 Cells
Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF‑1), 152 (PlGF‑2), and 203 (PlGF‑3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 ‑ 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key ...
TMPH-02649 FAN1 Protein, Mouse, Recombinant (His & Myc)

Mouse E. coli
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...
TMPH-03460 ERG26 Protein, S. cerevisiae, Recombinant (His & Myc)

SVG-Saccharomyces cerevisiae E. coli
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group. ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The pre...
TMPH-00600 RuvC Protein, E. coli, Recombinant (His & SUMO)

E. coli E. coli
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
TMPH-03469 3-dehydroquinase Protein, Salmonella typhi, Recombinant (His)

aroD,DHQ1,3-dehydroquinase,Type I DHQase,3...

Salmonella typhi P. pastoris (Yeast)
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site. 3-dehydroquinase Protein, Salmonella typhi, Recombinant (His) is expressed in yeast...
TMPH-00044 RuvC Protein, Akkermansia muciniphila, Recombinant (His & Myc)

Akkermansia muciniphila E. coli
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. RuvC Protein, Akkermansia muciniphila, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.2 kDa and the...
TMPH-00583 Rep Protein, E. coli, Recombinant (GST)

E. coli E. coli
Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.
TMPH-02464 AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO)

AHL-lactonase,N-acyl homoserine lactonase

Microbacterium testaceum E. coli
Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3. Has slight activity towards L-homoserine lactone, and no activity towards gamma-butyrolactone. AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.3 kDa and the accession number is C6L862.
TMPH-00837 BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc)

Alpha-insect toxin BjaIT,Bj-alpha-IT

Hottentotta judaicus E. coli
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is Q56TT9.
TMPY-01960 Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)

syntaxin binding protein 3,MUNC18C,UNC-18C,MUNC18-<...

Human Baculovirus Insect Cells
Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesic...
TMPJ-00902 Kell Protein, Human, Recombinant (His)

CD238,KEL,Kell blood group glycoprotein

Human HEK293 Cells
Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that car...
TMPY-01479 SPG3A Protein, Human, Recombinant (GST)

HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP...

Human Baculovirus Insect Cells
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and...
TMPH-03182 DTE Protein, Pseudomonas cichorii, Recombinant (His & Myc)

Ketose 3-epimerase,D-ribulose 3-epimerase,...

Pseudomonas cichorii E. coli
Catalyzes the epimerization of various ketoses at the C(3) position. It is able to interconvert D-tagatose and D-ribulose to D-sorbose and D-xylulose, respectively. The enzyme is also able to accept other ketopentoses such as D-psicose with lower efficiency. DTE Protein, Pseudomonas cichorii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 40.1 kDa and the accession number is O50580.
TMPH-00178 AiiA Protein, Bacillus thuringiensis subsp., Recombinant (His & Myc)

N-acyl homoserine lactonase AiiA,AHL-lactonase AiiA

Bacillus thuringiensis subsp. kurstaki E. coli
Catalyzes hydrolysis of N-hexanoyl-(S)-homoserine lactone, but not the R-enantiomer. Hydrolyzes short- and long-chain N-acyl homoserine lactones with or without 3-oxo substitution at C3, has maximum activity on C10-AHL. AiiA Protein, Bacillus thuringiensis subsp., Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.7 kDa and the accession number is P0CJ63.
TMPY-03266 COL4A3BP Protein, Human, Recombinant (His & GST)

CERTL,GPBP,collagen, type IV, alpha 3 (Goodpasture ...

Human Baculovirus Insect Cells
COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. One isoform of COL4A3BP is also involved in ceramide intracellular transport. COL4A3BP specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as t...
TMPH-01774 OGG1 Protein, Human, Recombinant (His)

Human E. coli
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. OGG1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.8 kDa and the accession number is O15527.
TMPH-02822 PNLIP Protein, Mouse, Recombinant (His & SUMO)

Mouse E. coli
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones. PNLIP Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.8 kDa and the accession number is Q6P8U6.
TMPH-02285 USP6 Protein, Human, Recombinant (His & KSI)

Human E. coli
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
TMPJ-01185 SULT1C4 Protein, Human, Recombinant (His)

SULT1C4,Sulfotransferase,hCG_27301,SULT1C2

Human E. coli
Human Sulfotransferase (SULT1C4) is an enzyme that in humans is encoded by the SULT1C4 gene, belongs to the sulfotransferase 1 family. SULT1C4 is expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. Sulfotransferase utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. It shows activity towards p-nitrophenol and N-hy...
TMPY-03981 CPLX3 Protein, Human, Recombinant (His)

CPXIII,Nbla11589,CPX-III,complexin 3

Human HEK293 Cells
CPLX3, also known as complexin 3, belongs to the complexin/synaphin family. As a SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma. CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state. Specifically, the central helix of CPX allows SNAREs to ...
TMPK-01328 Apolipoprotein H/APOH Protein, Cynomolgus, Recombinant (His)

B2GPI,B2G1,BG,B2GP1,APOH,beta(2)GPI,β(2)GPI,Apo-H

Cynomolgus HEK293 Cells
Apolipoprotein (apo)H (also known as beta 2 glycoprotein-I) is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipoproteins. APOH displays a genetically determined structural polymorphism: three alleles (APOH*1, APOH*2, APOH*3) at a single locus on chromosome 17 code for different isoforms, and population studies have shown that APOH*2 is the most frequent allele.
TMPY-03866 Syntaxin 3 Protein, Human, Recombinant (His)

syntaxin 3,STX3A

Human E. coli
STX3, also known as syntaxin 3, belongs to the syntaxin family. STX3 is a target membrane protein (t-SNARE) that is needed for membrane fusion. Membrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and t-SNAREs. STX3, together with syntaxin 2, are predominantly localized at the plasma membrane. Syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network. It is pos...
TMPH-00426 DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)

dinB,DNA polymerase IV,Pol IV

Colwellia psychrerythraea E. coli
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression...
TMPH-02404 LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)

Yellow scorpion E. coli
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ...
TMPH-00427 DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant

DNA polymerase IV,dinB,Pol IV

Colwellia psychrerythraea E. coli
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression syste...
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重组蛋白

Antithrombin III Protein, Human, Recombinant (His)
Cat.No: TMPY-00916
Species: Human
Expression System: HEK293 Cells
ABAT Protein, Human, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-00857
Species: Human
Expression System: E. coli
Azurocidin/CAP37 Protein, Human, Recombinant (His)
Cat.No: TMPY-00672
Species: Human
Expression System: HEK293 Cells
BDNF Protein, Human/Murine/Rat, Recombinant
Cat.No: TMPJ-00135
Species: Human,Mouse,Rat
Expression System: E. coli
NGF Protein, Human, Recombinant (E. colli)
Cat.No: TMPJ-01469
Species: Mouse
Expression System: E. coli
DNase I Protein, Human, Recombinant (His)
Cat.No: TMPY-03855
Species: Human
Expression System: HEK293 Cells
IL-4R alpha Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00387
Species: Mouse
Expression System: HEK293 Cells
FGF-9 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01011
Species: Mouse
Expression System: E. coli
FGF-8b Protein, Human, Recombinant
Cat.No: TMPY-06986
Species: Human
Expression System: E. coli
Mesothelin Protein, Human, Recombinant
Cat.No: TMPY-00132
Species: Human
Expression System: HEK293 Cells
CD47 Protein, Human, Recombinant (aa 1-139, His)
Cat.No: TMPY-04935
Species: Human
Expression System: HEK293 Cells
Neuropilin-2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-03763
Species: Human
Expression System: HEK293 Cells
CD47 Protein, Human, Recombinant, Biotinylated
Cat.No: TMPY-05191
Species: Human
Expression System: HEK293 Cells
CD47 Protein, Human, Recombinant
Cat.No: TMPY-04683
Species: Human
Expression System: HEK293 Cells
GITR/TNFRSF18 Protein, Human, Recombinant (His)
Cat.No: TMPY-00072
Species: Human
Expression System: HEK293 Cells
PRSS3 Protein, Human, Recombinant (His)
Cat.No: TMPY-01897
Species: Human
Expression System: HEK293 Cells
Periostin/OSF-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01020
Species: Human
Expression System: HEK293 Cells
Neuropilin-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00892
Species: Human
Expression System: HEK293 Cells
CD86 Protein, Human, Recombinant (His)
Cat.No: TMPY-01180
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (aa 26-577, His)
Cat.No: TMPY-05748
Species: Human
Expression System: HEK293 Cells
RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
Cat.No: TMPY-04142
Species: Human
Expression System: HEK293 Cells
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
Cat.No: TMPJ-01099
Species: Human
Expression System: HEK293 Cells
CDCP1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04298
Species: Human
Expression System: HEK293 Cells
HNT/NTM Protein, Human, Recombinant (His)
Cat.No: TMPY-00357
Species: Human
Expression System: HEK293 Cells
NCAM1 Protein, Human, Recombinant (His)
Cat.No: TMPY-00480
Species: Human
Expression System: HEK293 Cells
PLGF-2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00054
Species: Human
Expression System: HEK293 Cells
FAN1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02649
Species: Mouse
Expression System: E. coli
ERG26 Protein, S. cerevisiae, Recombinant (His & Myc)
Cat.No: TMPH-03460
Species: SVG-Saccharomyces cerevisiae
Expression System: E. coli
RuvC Protein, E. coli, Recombinant (His & SUMO)
Cat.No: TMPH-00600
Species: E. coli
Expression System: E. coli
3-dehydroquinase Protein, Salmonella typhi, Recombinant (His)
Cat.No: TMPH-03469
Species: Salmonella typhi
Expression System: P. pastoris (Yeast)
RuvC Protein, Akkermansia muciniphila, Recombinant (His & Myc)
Cat.No: TMPH-00044
Species: Akkermansia muciniphila
Expression System: E. coli
Rep Protein, E. coli, Recombinant (GST)
Cat.No: TMPH-00583
Species: E. coli
Expression System: E. coli
AIIM Protein, Microbacterium testaceum, Recombinant (His & SUMO)
Cat.No: TMPH-02464
Species: Microbacterium testaceum
Expression System: E. coli
BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc)
Cat.No: TMPH-00837
Species: Hottentotta judaicus
Expression System: E. coli
Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01960
Species: Human
Expression System: Baculovirus Insect Cells
Kell Protein, Human, Recombinant (His)
Cat.No: TMPJ-00902
Species: Human
Expression System: HEK293 Cells
SPG3A Protein, Human, Recombinant (GST)
Cat.No: TMPY-01479
Species: Human
Expression System: Baculovirus Insect Cells
DTE Protein, Pseudomonas cichorii, Recombinant (His & Myc)
Cat.No: TMPH-03182
Species: Pseudomonas cichorii
Expression System: E. coli
AiiA Protein, Bacillus thuringiensis subsp., Recombinant (His & Myc)
Cat.No: TMPH-00178
Species: Bacillus thuringiensis subsp. kurstaki
Expression System: E. coli
COL4A3BP Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-03266
Species: Human
Expression System: Baculovirus Insect Cells
OGG1 Protein, Human, Recombinant (His)
Cat.No: TMPH-01774
Species: Human
Expression System: E. coli
PNLIP Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02822
Species: Mouse
Expression System: E. coli
USP6 Protein, Human, Recombinant (His & KSI)
Cat.No: TMPH-02285
Species: Human
Expression System: E. coli
SULT1C4 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01185
Species: Human
Expression System: E. coli
CPLX3 Protein, Human, Recombinant (His)
Cat.No: TMPY-03981
Species: Human
Expression System: HEK293 Cells
Apolipoprotein H/APOH Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01328
Species: Cynomolgus
Expression System: HEK293 Cells
Syntaxin 3 Protein, Human, Recombinant (His)
Cat.No: TMPY-03866
Species: Human
Expression System: E. coli
DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)
Cat.No: TMPH-00426
Species: Colwellia psychrerythraea
Expression System: E. coli
LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)
Cat.No: TMPH-02404
Species: Yellow scorpion
Expression System: E. coli
DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant
Cat.No: TMPH-00427
Species: Colwellia psychrerythraea
Expression System: E. coli
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