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Search Results for " protein-tyrosine "

151

抑制剂 & 化合物

39

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T41099	EGFR Protein Tyrosine Kinase Substrate
	EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T2314	PF-431396	FAK; PYK2	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF 431396 是一种具有口服活性的 FAK (IC50:2 nM) 和 Pyk2 (IC50:11 nM)的抑制剂。
T5480	BI-4464	FAK; Ligands for Target Protein for PROTAC	Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors
	BI-4464 是一种高选择性的 ATP 竞争性 PTK2/FAK 抑制剂，IC50=17 nM。它可用于PROTAC 降解剂的 PTK2 配体。
T6997	SU6656	FAK; Akt; Src	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。
T9576	AMP-945	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	AMP-945 是一种粘着斑激酶抑制剂。
T9973	FAK-IN-7	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-7 有潜在的抗增殖活性，是一种 FAK 抑制剂。
T2001	PF-573228 PF 573228	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-573228是一种选择性的 FAK 抑制剂，对 FAK 纯化重组催化片段的 IC50值为4 nM。
T2465	PF-562271 PF562271,PF 562271	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T6177	PF-562271 besylate PF-00562271 Besylate	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 besylate (PF-00562271 Besylate) 是一种可逆的，有效的，ATP 竞争性的 FAK(IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T1835	Ibrutinib 伊布替尼,依鲁替尼,PCI-32765	Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	Ibrutinib (PCI-32765) 是一种不可逆的、选择性的 Btk 抑制剂，IC50=0.5 nM，它是一种 Btk 配体，用于合成一系列 PROTAC 分子，如 P13I。P13I 作用于人 Burkitt’s 淋巴瘤 RAMOS 细胞，浓度为 10 和 100 nM 时，分别降解 73% 和 89% Btk。
T2655	CEP-37440 CEP37440	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。
T21768	PF-562271 hydrochloride PF-562271 HCl	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 hydrochloride (PF-562271 HCl) 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T4337	PCI 29732 PCI29732,PCI-29732	Others; BCRP; BTK	Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors
	PCI 29732 是一种有效的可逆BTK 抑制剂，对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。
T10285	ALK inhibitor 1	FAK; IGF-1R; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 1 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=31 nM) 和粘着斑激酶 (FAK;IC50=2 nM) 抑制剂。
T1918	NVP-TAE 226 TAE226	Apoptosis; FAK; c-Met/HGFR; PYK2; IGF-1R	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	NVP-TAE 226 (TAE226) 是一种具有 ATP 竞争性的双重FAK 和IGF-1R 抑制剂，IC50分别为 5.5 nM、140 nM。它还抑制Pyk2、胰岛素受体，IC50分为 3.5 nM、40 nM。
T3041	ALK inhibitor 2	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 2 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=37 nM) 和粘着斑激酶 (FAK;IC50=5 nM) 抑制剂。
T2281	GSK2256098 GSK 2256098,GSK-2256098,GTPL7939	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	GSK2256098 (GTPL7939) 是一种选择性FAK 激酶抑制剂，抑制胰腺癌细胞的生长和存活。
T2066	Quizartinib AC220,奎扎替尼	Apoptosis; FLT; Autophagy; Ligands for Target Protein for PROTAC	Angiogenesis; Apoptosis; Autophagy; PROTAC; Tyrosine Kinase/Adaptors
	Quizartinib (AC220) 是一种具有口服活性的高选择性Ⅱ 型 FLT3酪氨酸激酶抑制剂，可诱导细胞凋亡。它抑制 Wt FLT3 和突变型 FLT3-ITD 自磷酸化，IC50分别为 4.1 nM 和 1.1 nM。它可通过优化的 linker 与 VHL 配体连接，从而形成 PROTAC Flt3 降解剂。
T7541	PTP inhibitor 1 PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮	Phosphatase	Metabolism
	PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂，具有抗血管生成作用。
T1996	Defactinib PF-04554878,VS-6063	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Defactinib (VS-6063) 是新型的 FAK 抑制剂，能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。
T0827	Cefsulodin sodium Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。
T0263	Chloropyramine hydrochloride Nilfan,盐酸氯吡胺,Alergosan,Halopyramine hydrochloride	FAK; VEGFR; Histamine Receptor	Angiogenesis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Tyrosine Kinase/Adaptors
	Chloropyramine hydrochloride (Alergosan) 是一种组胺受体 H1 拮抗剂，可抑制VEGFR-3和FAK 的生化功能。
T4636	Protein kinase inhibitors 1	Others; DYRK	Cell Cycle/Checkpoint; Others; Tyrosine Kinase/Adaptors
	Protein kinase inhibitors 1 是新型的 HIPK2 抑制剂，其 IC50=74 nM，Kd=9.5 nM。
T24730	Roslin 2 bromide Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2	FAK; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种 p53 再激活剂，可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。
T2609	Masitinib AB1010,马赛替尼	Apoptosis; FAK; c-Fms; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Hck	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。它有抗增殖，促凋亡活性，且毒性低。
T4185	lavendustin C HDBA,NSC 666251,N-(2,5-二羟基苄基)-5-氨基水杨酸	CaMK; EGFR; Tyrosinase; Src	Angiogenesis; JAK/STAT signaling; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	lavendustin C (NSC 666251) 是 Ca2+钙调蛋白依赖性激酶 II 抑制剂，IC50为 0.2 µM。它抑制 EGFR 相关酪氨酸激酶和 pp60c-src(+)激酶，IC50分别为 0.012 和 0.5 µM。
T1950	PND-1186 PND1186,PND 1186,VS-4718,SR-2516	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PND-1186 (VS-4718) 是一种高特异性的FAK 可逆抑制剂，IC50为 1.5 nM。它选择性促进肿瘤细胞凋亡。
T7119	Y15 1,2,4,5-苯四胺四盐酸盐,1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂，能够降低其自身磷酸化活性，抑制癌细胞的活力，阻断肿瘤生长。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T31458	DiFMUP
	DiFMUP is the fluorescent substrate of protein tyrosine phosphatase.
T21761	HNMPA	IGF-1R	Tyrosine Kinase/Adaptors
	HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。
T7381	TCS 401	Phosphatase	Metabolism
	TCS 401 是一种选择性的蛋白酪氨酸磷酸酶 1B 抑制剂。
T12578	(E,E)-RAMB4 PTP1B-IN-8	Phosphatase	Metabolism
	PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T4256	PTP1B-IN-2	Phosphatase	Metabolism
	PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂，IC50=50 nM。
T4511	ST271 ST 271	Phospholipase; Tyrosine Kinases	Metabolism; Tyrosine Kinase/Adaptors
	ST271 是蛋白质酪氨酸激酶 (PTK) 抑制剂，抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化的IC50值分别为 6.7 和 9 μM。
T7900	BAY-474	c-Met/HGFR	Tyrosine Kinase/Adaptors
	BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂，能够用于表观遗传学探针。
T7356	PTP1B-IN-1 PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物	Phosphatase	Metabolism
	PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM)
TP1051L	Protein Kinase C Peptide Substrate acetate Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others	Others
	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) 以依赖于第二信使和特定衔接蛋白的方式靶向特定细胞间隔物，以响应激活 g 蛋白偶联受体、酪氨酸激酶受体或酪氨酸激酶偶联受体的细胞外信号。
T50088	N-phenylthiophene-2-carboximidamide	Others	Others
	N-phenylthiophene-2-carboximidamide 是一种噻吩衍生物，可以作为蛋白酪氨酸激酶（PTKs）的抑制剂和 G 蛋白偶联受体（GPCR）的配体发挥作用。
T7101	Tyrphostin AG30 Tyrphostin AG30(AG30),酪氨酸磷酸化抑制剂 AG 30	EGFR; Tyrosine Kinases	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG30 (AG30) 是一种有效的蛋白质酪氨酸激酶 (PTK) 抑制剂，选择性地抑制 c-ErbB 的自我更新诱导，并能抑制原发性红细胞 c-ErbB 激活 STAT5。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T19498	p-Cresyl sulfate potassium p-Tolyl sulfate potassium salt,p-Cresol sulfate potassium,p-Methylphenyl potassium sulfate,对甲基硫酸钾,Potassium p-tolyl sulfate	Endogenous Metabolite	Metabolism
	p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) 是一种尿毒症毒素，能够与原型蛋白质结合。
T14841	BVT948	Phosphatase; P450; Histone Methyltransferase	Chromatin/Epigenetic; Metabolism
	BVT948 是一种蛋白酪氨酸磷酸酶抑制剂，还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。
T13013	Sodium stibogluconate Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠	Phosphatase	Metabolism
	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 是一种有效的蛋白酪氨酸磷酸酶 (phosphatase) 抑制剂。它在10，100 和 100 μg/mL 时分别抑制 99% 的 SHP-1，SHP-2 和 PTP1B 活性。
T10190	7-BIA	Phosphatase	Metabolism
	7-BIA 是一种受体型蛋白酪氨酸磷酸酶 D (PTPRD) 抑制剂，具有抗抗成瘾作用，可用于研究神经性疼痛。
T67893	PTP1B-IN-22	Phosphatase	Metabolism
	PTP1B-IN-22是一种蛋白酪氨酸磷酸酶1B (PTP1B)抑制剂，可抑制骨骼肌 L6肌管的葡萄糖摄取。
T6217	LFM-A13	PLK; JAK; BTK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	LFM-A13 是一种 BTK，JAK2，PLK 有效抑制剂，可抑制 BTK、Plx1 和 PLK3 的活性，IC50分别为 2.5、10 和 61 μM。
T37184	CX08005 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase	Metabolism
	CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂，可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。
T4491	LMPTP INHIBITOR 1 hydrochloride LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))	Phosphatase	Metabolism
	LMPTP INHIBITOR 1 hydrochloride 是一种高选择性的低分子量蛋白酪氨酸磷酸酶 (LMPTP) 抑制剂。LMPTP INHIBITOR 1 (hydrochloride) 能够抑制 LMPTP-A 的活性，IC50值为 0.8 μM。

化合物

EGFR Protein Tyrosine Kinase Substrate

Cat.No: T41099

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

Cat.No: TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Cat.No: T2314

Target: FAK, PYK2

Cat.No: T5480

Target: FAK, Ligands for Target Protein for PROTAC

Cat.No: T6997

Target: FAK, Akt, Src

Cat.No: T9576

Target: FAK

Cat.No: T9973

Target: FAK

Cat.No: T2001

Synonym: PF 573228

Target: Apoptosis, FAK

Cat.No: T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

PF-562271 besylate

Cat.No: T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Cat.No: T1835

Synonym: 伊布替尼,依鲁替尼,PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

Cat.No: T2655

Synonym: CEP37440

Target: FAK, ALK

PF-562271 hydrochloride

Cat.No: T21768

Synonym: PF-562271 HCl

Target: FAK, PYK2, CDK

Cat.No: T4337

Synonym: PCI29732,PCI-29732

Target: Others, BCRP, BTK

ALK inhibitor 1

Cat.No: T10285

Target: FAK, IGF-1R, ALK

Cat.No: T1918

Synonym: TAE226

Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R

ALK inhibitor 2

Cat.No: T3041

Target: FAK, ALK

Cat.No: T2281

Synonym: GSK 2256098,GSK-2256098,GTPL7939

Target: Apoptosis, FAK

Cat.No: T2066

Synonym: AC220,奎扎替尼

Target: Apoptosis, FLT, Autophagy, Ligands for Target Protein for PROTAC

PTP inhibitor 1

Cat.No: T7541

Synonym: PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮

Target: Phosphatase

Cat.No: T1996

Synonym: PF-04554878,VS-6063

Target: FAK

Cefsulodin sodium

Cat.No: T0827

Synonym: Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠

Target: Antibacterial, Antibiotic

Chloropyramine hydrochloride

Cat.No: T0263

Synonym: Nilfan,盐酸氯吡胺,Alergosan,Halopyramine hydrochloride

Target: FAK, VEGFR, Histamine Receptor

Protein kinase inhibitors 1

Cat.No: T4636

Target: Others, DYRK

Roslin 2 bromide

Cat.No: T24730

Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2

Target: FAK, p53

Cat.No: T2609

Synonym: AB1010,马赛替尼

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

Cat.No: T4185

Synonym: HDBA,NSC 666251,N-(2,5-二羟基苄基)-5-氨基水杨酸

Target: CaMK, EGFR, Tyrosinase, Src

Cat.No: T1950

Synonym: PND1186,PND 1186,VS-4718,SR-2516

Target: Apoptosis, FAK

Cat.No: T7119

Synonym: 1,2,4,5-苯四胺四盐酸盐,1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14

Target: FAK

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Cat.No: T31458

Cat.No: T21761

Target: IGF-1R

Cat.No: T7381

Target: Phosphatase

Cat.No: T12578

Synonym: PTP1B-IN-8

Target: Phosphatase

Cat.No: T4256

Target: Phosphatase

Cat.No: T4511

Synonym: ST 271

Target: Phospholipase, Tyrosine Kinases

Cat.No: T7900

Target: c-Met/HGFR

Cat.No: T7356

Synonym: PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物

Target: Phosphatase

Protein Kinase C Peptide Substrate acetate

Cat.No: TP1051L

Synonym: Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)

Target: Others

N-phenylthiophene-2-carboximidamide

Cat.No: T50088

Target: Others

Tyrphostin AG30

Cat.No: T7101

Synonym: Tyrphostin AG30(AG30),酪氨酸磷酸化抑制剂 AG 30

Target: EGFR, Tyrosine Kinases

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

p-Cresyl sulfate potassium

Cat.No: T19498

Synonym: p-Tolyl sulfate potassium salt,p-Cresol sulfate potassium,p-Methylphenyl potassium sulfate,对甲基硫酸钾,Potassium p-tolyl sulfate

Target: Endogenous Metabolite

Cat.No: T14841

Target: Phosphatase, P450, Histone Methyltransferase

Sodium stibogluconate

Cat.No: T13013

Synonym: Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠

Target: Phosphatase

Cat.No: T10190

Target: Phosphatase

Cat.No: T67893

Target: Phosphatase

Cat.No: T6217

Target: PLK, JAK, BTK

Cat.No: T37184

Synonym: 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid

Target: Phosphatase

LMPTP INHIBITOR 1 hydrochloride

Cat.No: T4491

Synonym: LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base))

Target: Phosphatase

Cat. No.	Product Name	Target	Signaling Pathways
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T3122	Fangchinoline Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline	Apoptosis; FAK; HIV Protease; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Fangchinoline (Tetrandrine B) 是从Stephaniatetrandra 中分离出来的，一种具有广泛生物学活性的天然产物。它是新型HIV-1抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。它靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。
T1695	DL-O-Tyrosine	Amino Acids and Derivatives	Metabolism
	DL-O-Tyrosine 是苯丙氨酸的代谢物，是形成儿茶酚胺的前体。它被用作β-地中海贫血中蛋白质氧化损伤的生物标志物。
TN1096	Ginsenoside Ra1 人参皂苷 Ra1,人参皂苷Ra1	Others; Tyrosine Kinases	Others; Tyrosine Kinase/Adaptors
	Ginsenoside Ra1 是来自人参的成分。 Ginsenoside Ra1 对缺氧/复氧诱导的蛋白酪氨酸激酶 (PTK) 活化具有显着抑制作用。
TN1053	Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷	Phosphatase	Metabolism
	Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) 是一种分离自Saussrurea lappa 中的化合物，是一种温和的人类蛋白酪氨酸磷酸酶 1B 抑制剂，其IC50=26.6 μM。
T1737	Genistein NPI 031L,三叶草,染料木素,金雀异黄酮	Apoptosis; EGFR; Endogenous Metabolite; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Genistein (NPI 031L) 是一种大豆异黄酮，是一种多重的酪氨酸激酶抑制剂，通过改变细胞凋亡，细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
TN1470	Cassiaside B2 决明子苷B2	Phosphatase; MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂，具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物（NRE）的有效成分之一。
TN2019	Orobol 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮	BCL; Caspase; PI3K	Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K，对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。
T0610	Piceatannol 白皮杉醇,trans-Piceatannol,Astringenin	Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	Piceatannol (Astringenin) 是一种Syk 抑制剂，可降低由 TNF 诱导的 iNOS 表达，可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯，可诱导细胞自噬和凋亡，具有抗癌和抗炎特性。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5400	Aerugidiol
	Aerugidiol inhibits protein tyrosine phosphatase 1B (PTP1B).
T20555	Glycyltyrosine NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine
	Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion.
T19885	Methyllucidone
	Methyllucidone is an inhibitor of STAT3 that acts by regulating the expression of the protein tyrosine phosphatase MEG2.
TN3042	4-Hydroxycinnamamide	ATPase; EGFR; Potassium Channel; p38 MAPK; Calcium Channel; Sodium Channel; AMPK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
TN3335	Abyssinone V	Phosphatase	Metabolism
	Abyssinone V 是一种从刺桐茎皮中分离的天然化合物，是蛋白质酪氨酸磷酸酶 1B (PTP1B) 的抑制剂。
T13740	Isotanshinone IIA	Others	Others
	Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.
TN3505	Beta-Peltoboykinolic acid	Phosphatase	Metabolism
	Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity.
TN2887	3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Phosphatase	Metabolism
	(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T73073	PTP1B-IN-21
	PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50>100 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T73072	PTP1B-IN-20
	PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50=78.0 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T38587	Chrysophanol triglucoside
	Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia , inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC 50 s of 80.17 and 197.06 μM, respectively. Chrysophanol triglucoside has the potential for diabetes research.
TN2913	3-Acetoxy-11-ursen-28,13-olide	Phosphatase	Metabolism
	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.
TN1775	Isocryptotanshinone	ERK; JNK; STAT	JAK/STAT signaling; MAPK; Stem Cells
	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
T3827	Rhein-8-glucoside calcium 大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt	Phosphatase; Antibacterial	Metabolism; Microbiology/Virology
	Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中，分离得到的蒽醌类 hPTP1B 抑制剂，IC50值为11.5 μM，具有抗菌作用。
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....
T75495	Rubrofusarin 6-O-β-D-glucopyranoside
	Rubrofusarin 6-O-β-D-glucopyranoside为Rubrofusarin的糖苷形式，具有抑制蛋白酪氨酸磷酸酶 1B (PTP1B) 的活性，IC50值为87.36 μM，适用于糖尿病和抑郁症研究。
TN3525	Boehmenan	ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell
T79985	Cryptosporioptide A	Phosphatase	Metabolism
	Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂，针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用，其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。
TN4279	Isoderrone	Tyrosinase	Proteases/Proteasome
	Isoderrone 在体外对α-葡萄糖苷酶(α-glucosidase)有抑制作用；它是一种蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂，IC50值为22.7±1.7μM，表明它可能是一种治疗2型糖尿病的新药。
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
TN2928	Pygenic acid A 3-Epicorosolic acid,脓毒酸A
	3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro
T80007	Stevisalioside A	Phosphatase	Metabolism
	Stevisalioside A (Compound 2)，一种从甜叶菊根提取的化合物，展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B，IC50为526.8 μM，并能降低Stevisalioside A引起的高血糖小鼠血糖水平，改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。
T36950	Rubrofusarin triglucoside
	Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM[1]. [1]. Pradeep Paudel, et al. Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. ACS Omega. 2019 Jul 3;4(7):11621-11630.

天然产物

Cat.No: TN1433

Target: FAK, Others, Akt

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T3122

Synonym: Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

DL-O-Tyrosine

Cat.No: T1695

Target: Amino Acids and Derivatives

Ginsenoside Ra1

Cat.No: TN1096

Synonym: 人参皂苷 Ra1,人参皂苷Ra1

Target: Others, Tyrosine Kinases

Aloe-emodin-8-O-β-D-glucopyranoside

Cat.No: TN1053

Synonym: Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷

Target: Phosphatase

Cat.No: T1737

Synonym: NPI 031L,三叶草,染料木素,金雀异黄酮

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Cat.No: TN1470

Synonym: 决明子苷B2

Target: Phosphatase, MAO, 5-HT Receptor

Cat.No: TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮

Target: BCL, Caspase, PI3K

Cat.No: T0610

Synonym: 白皮杉醇,trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: TN5400

Cat.No: T20555

Synonym: NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine

Cat.No: T19885

4-Hydroxycinnamamide

Cat.No: TN3042

Target: ATPase, EGFR, Potassium Channel, p38 MAPK, Calcium Channel, Sodium Channel, AMPK

Cat.No: T39219

Cat.No: TN3335

Target: Phosphatase

Isotanshinone IIA

Cat.No: T13740

Target: Others

Beta-Peltoboykinolic acid

Cat.No: TN3505

Target: Phosphatase

3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid

Cat.No: TN2887

Target: Phosphatase

Cat.No: T73073

Cat.No: T73072

Chrysophanol triglucoside

Cat.No: T38587

3-Acetoxy-11-ursen-28,13-olide

Cat.No: TN2913

Target: Phosphatase

Isocryptotanshinone

Cat.No: TN1775

Target: ERK, JNK, STAT

Rhein-8-glucoside calcium

Cat.No: T3827

Synonym: 大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt

Target: Phosphatase, Antibacterial

Cat.No: T38069

Rubrofusarin 6-O-β-D-glucopyranoside

Cat.No: T75495

Cat.No: TN3525

Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53

Cryptosporioptide A

Cat.No: T79985

Target: Phosphatase

Cat.No: TN4279

Target: Tyrosinase

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Cat.No: TN2928

Synonym: 3-Epicorosolic acid,脓毒酸A

Stevisalioside A

Cat.No: T80007

Target: Phosphatase

Rubrofusarin triglucoside

Cat.No: T36950

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