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Search Results for " antiproliferative activity "

186

抑制剂 & 化合物

46

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1753	D-64131	Microtubule Associated	Cytoskeletal Signaling
	D64131 是一种微管蛋白聚合抑制剂，IC50 值为 0.53 μM。它具有抗丝分裂活性，可用于癌症研究。
TQ0059	Ilorasertib ABT-348	VEGFR; FLT; c-RET; PDGFR; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Ilorasertib (ABT-348) 是一种 ATP 竞争性多靶点激酶抑制剂，可抑制 Aurora A、Aurora B 和Aurora C，IC50值为120 nM、7 nM 和1 nM。它还抑制 RET 酪氨酸激酶、PDGFRβ 和 Flt1，IC50为7 nM、3 nM 和 32 nM。
T64391	Antiproliferative agent-15	Others	Others
	Antiproliferative agent-15是一种具有抗癌活性的试剂。Antiproliferative agent-15对人结肠癌(HCT116和HCT15)和脑癌(LN-229和GBM-10)具有抗增殖活性。
T64348	Antiproliferative agent-16 Antiproliferative agent-16	Others	Others
	Antiproliferative agent-16 (Antiproliferative agent-16)是一种具有抗癌活性的吲哚酰肼-腙化合物。 Antiproliferative agent-16 对乳腺癌细胞表现出特异性 (对 MCF-7 细胞的 IC50 为 6.94 μM)。
T9974	Antiproliferative agent-13	Dehydrogenase	Metabolism
	Antiproliferative agent-13是一种具有抗增殖活性的化合物。
T70086	EPZ033294	Others	Others
	EPZ033294 具有潜在的抗癌和抗增殖活性。
T60129	MT189 Antiproliferative agent-14	Microtubule Associated	Cytoskeletal Signaling
	MT189 (Antiproliferative agent-14)是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，IC50 为 3.41 μM。MT189 具有优异的抗增殖活性。Antiproliferative agent-14 具有在细胞周期的 G2/M 期阻滞细胞的能力。
T64372	DB722	Others	Others
	DB722是一种具有DNA 结合活性的呋喃脒类似物。DB722显示抗增殖活性。
T9973	FAK-IN-7	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-7 有潜在的抗增殖活性，是一种 FAK 抑制剂。
T11823	LB-60-OF61	NAMPT	Metabolism
	LB-60-OF61 是一种 NAMPT 抑制剂，是一种对对 MYC 癌基因的依赖性癌细胞株显示出抗增殖活性。
T67735	Auristatin23	Others	Others
	Auristatin23是一种抗肿瘤试剂。Auristatin23对肿瘤细胞系具有抗增殖活性。
T10250	ADRA1D receptor antagonist 1 HCl ADRA1D receptor antagonist 1 HCl（1191908-24-3 free base）	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ADRA1D receptor antagonist 1 HCl 是一种具有口服活性、高效性和选择性的 α1D 肾上腺素受体拮抗剂（Ki：1.6 nM），具有潜在的抗增殖活性。
T11337	Fumarate hydratase-IN-1	Others	Others
	Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. Fumarate hydratase-IN-1 is a cell-permeable fumarate hydratase inhibitor.
T77716	Wnt pathway inhibitor 4	Antibacterial	Microbiology/Virology
	Wnt pathway inhibitor 4 是一种小分子抗菌剂，具有抗菌和抗癌细胞增殖活性。
T77558	5,7-Dimethoxy-4-methylcoumarin	Antioxidant	oxidation-reduction
	5,7-Dimethoxy-4-methylcoumarin 具有潜在的抗氧化抗增殖和抗癌或活性。
T35329L	EAD1 TFA(1644388-26-0 Free base) EAD1 HCL(1644388-26-0 Free base)	Apoptosis; Autophagy	Apoptosis; Autophagy
	EAD1 HCL 是一种有效的自噬 (autophagy) 抑制剂，在肺癌和胰腺癌细胞中具有抗增殖活性。EAD1 HCL 还诱导凋亡 (apoptosis)。
T13148	CHK-IN-1	Chk	Cell Cycle/Checkpoint
	CHK-IN-1 是一种具有抗增殖活性的 CHK1 和 CHK2 双重抑制剂。
T35054	Vilaprisan BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670	Progesterone Receptor	Others
	Vilaprisan (BAY 1002670) 是一种新型可口服且具有选择性的黄体酮受体调节剂 (SPRM)，对子宫肌瘤 (UF) 具有抗增殖活性，可用于研究子宫肌瘤。
T77732L	HFY-4A HCL (2094810-82-7 Free base)
	HFY-4A HCL是一种新型 HDAC 抑制剂。HFY-4A HCL具有抗肿瘤活性，在乳腺癌细胞中显示出抗增殖活性。(apoptosis)。HFY-4A 诱导细胞凋亡，抑制乳腺癌异种移植小鼠模型中的肿瘤生长。
T21804	GW 610	Others	Others
	GW 610 是一种抗肿瘤剂，能够选择性作用于肺癌、结肠癌和乳腺癌细胞系，具有抗癌活性。
T72062	BI-2865	Ras	GPCR/G Protein; MAPK
	BI-2865 是一种非共价的泛-KRAS 抑制剂。BI-2865 可与 KRAS WT、G12C、G12D、G12V 和 G13D 突变体结合，KD 值分别为 6.9、4.5、32、26、4.3 nM。BI-2865在对表达 KRAS G12C、G12D 或 G12V 突变体的 BaF3 细胞实验的过程中显示出抗增殖活性，平均 IC50值大约为 140 nM。
T77631	Enpp/Carbonic anhydrase-IN-2	Apoptosis; PDE; Carbonic Anhydrase	Apoptosis; Metabolism
	Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.Enpp/Carbonic anhydrase-IN-2 induced apoptosis.Enpp/Carbonic anhydrase-IN-2 has antiproliferative activity against cancer cells and low cytotoxicity against normal cells.
T19812	Propentofylline HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE	Metabolism
	Propentofylline (Hextol) 是一种甲基黄嘌呤衍生物，具有神经保护、抗增殖和抗炎活性，可增强的突触腺苷信号传导，可用于研究阿尔茨海默病、血管性痴呆、认知障碍、痴呆和慢性疼痛。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T27582	iCRT-5 iCRT 5,iCRT5	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	iCRT-5 是一种有效的 Wnt 通路抑制剂。iCRT-5 具有抗增殖活性，可以阻断 Wnt/β-catenin 表达，诱导细胞凋亡。iCRT-5 可用于研究多发性骨髓瘤。
T77667	PI3Kδ-IN-16	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	PI3Kδ-IN-16 是一种具有选择性和有效的 PI3Kδ 抑制剂，具有抗癌抗增殖活性，诱导细胞周期停滞和细胞凋亡。
T14125	Adarotene ST1926	Apoptosis	Apoptosis
	Adarotene (ST1926) 是一种细胞凋亡诱导剂，通过产生 DNA 损伤，来阻止人类肿瘤细胞的增殖。
T63429	SMO-IN-2	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	SMO-IN-2 是一种有效的 smoothened (SMO) 抑制剂，对 hedgehog (Hh) 信号传导有抑制作用。SMO-IN-2 对人髓母细胞瘤细胞系显示出抗增殖活性和抗癌活性。SMO-IN-2 可用于研究癌症。
T3521	γ-Secretase-IN-1 Compound E	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	γ-Secretase-IN-1 是一种高效的 γ-secretase 抑制剂，对T-47D 细胞显示部分抗增殖活性且抑制 β-amyloid(40)，β-amyloid(42)，和Notch γ-分泌酶裂解。
T77731	ERK5-IN-6	ERK	MAPK
	ERK5-IN-6 是一种有效的 ERK5 激酶抑制剂。ERK5-IN-6 具有抗增殖活性、抗惊厥活性和抗肿瘤活性，可用于研究中枢神经系统相关疾病。
T9150	SCR130 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-	Apoptosis; Others; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	SCR130 (1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-) 是基于 SCR7 的 DNA 非同源末端连接抑制剂，可诱导细胞凋亡并，具有抗癌活性。它特异性依赖连接酶 IV，抑制 DNA 的末端连接。
T5152	MKT-077 MKT 077,FJ-776,MKT077	HSP	Cytoskeletal Signaling; Metabolism
	MKT-077 (FJ-776) 是一种阳离子红花青染料，通过抑制 Hsp70 分子伴侣家族成员的能力，显示出对癌细胞系的抗增殖活性。
T15789	LTURM34	DNA-PK; PI3K; PI4K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	LTURM34 是一种 DNA-PK 抑制剂，IC50 为 34 nM。它在广泛的肿瘤细胞系中显示出有效的抗增殖活性，对 DNA-PK 的选择性比 PI3K 高 170 倍。
T77685	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile	PDK	PI3K/Akt/mTOR signaling
	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 是一种 PDK1 抑制剂，具有抗癌和抗增殖活性，可用来研究血管肉瘤、腺癌、多骨髓瘤、牛皮癣、前列腺癌和和阿尔茨海默病。
T77502	Wnt pathway inhibitor 3	Wnt/beta-catenin; Adenylyl cyclase	Cytoskeletal Signaling; Neuroscience; Stem Cells
	Wnt pathway inhibitor 3 是一种有效的 AC1 抑制剂，IC50 值为 45 nM。Wnt pathway inhibitor 3 具有抗增殖活性，可用于研究改善实验性骨关节炎小鼠模型中的骨关节炎。
T61318	BRD4 Inhibitor-20	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4 Inhibitor-20是一种有效的溴结构域蛋白4(BRD4)抑制剂，具有口服活性。BRD4 Inhibitor-20在癌细胞系中具有抗增殖活性，并被用于各种癌症的研究，如结肠癌。
T12660L	BAY1238097	Epigenetic Reader Domain	Chromatin/Epigenetic
	BAY1238097 是一种具有有效性和选择性的溴结构域和末端外基序(BET)抑制剂，具有抗癌活性，在AML (急性髓性白血病) 和MM (多发性骨髓瘤) 模型中表现出较强的抗增殖活性。BAY1238097 可用于研究晚期难治性恶性肿瘤。
T73350	BAY-3827	Acyltransferase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	BAY-3827 是一种具有强效性和选择性的 AMPK 抑制剂，具有潜在的抗肿瘤活性，在雄激素依赖性前列腺癌模型中显示出抗增殖活性。 BAY-3827 抑制乙酰 CoA 羧化酶 1 的磷酸化。
T64167L	Ifebemtinib FA BI-853520 FA（1227948-82-4 Free base)	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Ifebemtinib FA (BI-853520 FA) 是一种具有口服活性和高效性的粘附斑激酶 (FAK) 抑制剂，具有抗癌抗增殖活性，可用于研究卵巢癌和肺癌。
T77525	EN450	NF-κB	NF-κB
	EN450 是一种针对的 NF-κB 的半胱氨酸反应性共价分子胶降解剂，具有抗增殖活性和潜在的抗癌活性，通过依赖Cullin E3 连接酶和蛋白酶发挥作用，可用于研究白血病。
T78701	Tubulin inhibitor 32	Apoptosis	Apoptosis
	Tubulin inhibitor 32是一种口服活性的新型微管抑制剂，具有抗增殖和抗肿瘤活性，可抑制微管聚合，可诱导细胞凋亡及在G2/M期引起细胞周期停滞。
T23897	CLK1/2-IN-3 CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3	CDK	Cell Cycle/Checkpoint
	CLK1/2-IN-3(Cpd-3) 是一种具有高效性和选择性的 CLK1 和 CLK2 抑制剂，抗增殖活性，抑制 CLK1、CLK2、SRPK1、SRPK2、SRPK3 的的活性。CLK1/2-IN-3 可诱导核斑点扩大，可诱导S6K pre-mRNA选择性剪接和随后抑制多种癌细胞类型细胞生长。
T72084	(R)-BI-2852	Ras	GPCR/G Protein; MAPK
	(R)-BI-2852 可用作RAS 家族蛋白的抑制剂，是治疗和预防肿瘤的化合物。 (R)-BI-2852 具有抗增殖和抗肿瘤剂活性。
T63351L	MS8511 HCl MS8511 HCl(2866408-21-9 Free base)	Histone Methyltransferase	Chromatin/Epigenetic
	MS8511 HCl 是一种具有选择性和有效性的 G9a/GLP 共价抑制剂，通过靶向底物结合位点的半胱氨酸残基发挥作用。 MS8511 具有抗癌活性和抗增殖活性，可降低细胞内 H3K9me2 水平。MS8511 可用于研究包括脑癌、乳腺癌、卵巢癌在内的多种癌症。
T67775	Enpp/Carbonic anhydrase-IN-1	PDE; Carbonic Anhydrase	Metabolism
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) 是有效的 Enpp 和 carbonic anhydrase 抑制剂。Enpp/Carbonic anhydrase-IN-1抑制 NPP1、NPP2、NPP3、CA-II、CA-IX 的 IC50 值分别 1.36、1.35、3.00、0.88、1.02 µM。Enpp/Carbonic anhydrase-IN-1 选择性抑制癌细胞的增殖，对正常细胞毒性较低。
T50056	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide	Others	Others
	4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide 是一种磺酰胺衍生物，用于合成各种超分子结构的构建块，如金属有机骨架和配位聚合物。它对多种肿瘤细胞系具有抗增殖活性。
T11157L	EGFR-IN-1 hydrochloride	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-1 hydrochloride 是 L858R/T790M 突变体 EGFR 的不可逆特异性抑制剂，选择性是野生型 EGFR 的 100 倍。 EGFR-IN-1 hydrochloride 在 H1975 细胞和突变体 HCC827 细胞中表现出有效的抗肿瘤和抗增殖活性，IC50 分别为 4 和 28 nM。
T15181	DuP-697	COX	Immunology/Inflammation; Neuroscience
	DuP-697 是一种不可逆的特异性 COX-2 抑制剂，对人 COX-2 和 COX-1 的 IC50 值为 10 nM 和 800 nM。 DuP-697 具有抗增殖活性，IC50 为 42.8 nM。 DuP-697 具有抗血管生成、抗炎、解热和凋亡作用。
T61575	USP15-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP15-IN-1 是一种有效的 USP15 抑制剂（IC50 为 3.76 μM）。USP15-IN-1对非小细胞肺癌和白血病细胞具有高度的抗增殖活性。USP15是 cGAS 的互作蛋白，并且 USP15可以促进 cGAS 识别DNA 激活下游信号通路。
T62281	PARP-1-IN-2	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-2 是一种有效且可透过血脑屏障的 PARP1 抑制剂（IC50： 149 nM）。PARP-1-IN-2 在细胞实验中对人肺腺癌上皮细胞系 A549 显示出显著的抗增殖活性。PARP-1-IN-2 可诱导 A549 细胞凋亡。

化合物

Cat.No: T1753

Target: Microtubule Associated

Cat.No: TQ0059

Synonym: ABT-348

Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase

Antiproliferative agent-15

Cat.No: T64391

Target: Others

Antiproliferative agent-16

Cat.No: T64348

Synonym: Antiproliferative agent-16

Target: Others

Antiproliferative agent-13

Cat.No: T9974

Target: Dehydrogenase

Cat.No: T70086

Target: Others

Cat.No: T60129

Synonym: Antiproliferative agent-14

Target: Microtubule Associated

Cat.No: T64372

Target: Others

Cat.No: T9973

Target: FAK

Cat.No: T11823

Target: NAMPT

Cat.No: T67735

Target: Others

ADRA1D receptor antagonist 1 HCl

Cat.No: T10250

Synonym: ADRA1D receptor antagonist 1 HCl（1191908-24-3 free base）

Target: Adrenergic Receptor

Fumarate hydratase-IN-1

Cat.No: T11337

Target: Others

Wnt pathway inhibitor 4

Cat.No: T77716

Target: Antibacterial

5,7-Dimethoxy-4-methylcoumarin

Cat.No: T77558

Target: Antioxidant

EAD1 TFA(1644388-26-0 Free base)

Cat.No: T35329L

Synonym: EAD1 HCL(1644388-26-0 Free base)

Target: Apoptosis, Autophagy

Cat.No: T13148

Target: Chk

Cat.No: T35054

Synonym: BAY 1002670,BAY10-02670,BAY-1002670,BAY1002670,BAY-10-02670,BAY 10-02670

Target: Progesterone Receptor

HFY-4A HCL (2094810-82-7 Free base)

Cat.No: T77732L

Cat.No: T21804

Target: Others

Cat.No: T72062

Target: Ras

Enpp/Carbonic anhydrase-IN-2

Cat.No: T77631

Target: Apoptosis, PDE, Carbonic Anhydrase

Propentofylline

Cat.No: T19812

Synonym: HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285

Target: PDE

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Cat.No: T27582

Synonym: iCRT 5,iCRT5

Target: Apoptosis, Wnt/beta-catenin

Cat.No: T77667

Target: Apoptosis, PI3K

Cat.No: T14125

Synonym: ST1926

Target: Apoptosis

Cat.No: T63429

Target: Hedgehog/Smoothened

γ-Secretase-IN-1

Cat.No: T3521

Synonym: Compound E

Target: Beta Amyloid, Gamma-secretase

Cat.No: T77731

Target: ERK

Cat.No: T9150

Synonym: 1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

Target: Apoptosis, Others, DNA/RNA Synthesis

Cat.No: T5152

Synonym: MKT 077,FJ-776,MKT077

Target: HSP

Cat.No: T15789

Target: DNA-PK, PI3K, PI4K

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile

Cat.No: T77685

Target: PDK

Wnt pathway inhibitor 3

Cat.No: T77502

Target: Wnt/beta-catenin, Adenylyl cyclase

BRD4 Inhibitor-20

Cat.No: T61318

Target: Epigenetic Reader Domain

Cat.No: T12660L

Target: Epigenetic Reader Domain

Cat.No: T73350

Target: Acyltransferase, AMPK

Cat.No: T64167L

Synonym: BI-853520 FA（1227948-82-4 Free base)

Target: FAK

Cat.No: T77525

Target: NF-κB

Tubulin inhibitor 32

Cat.No: T78701

Target: Apoptosis

Cat.No: T23897

Synonym: CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3

Target: CDK

Cat.No: T72084

Target: Ras

Cat.No: T63351L

Synonym: MS8511 HCl(2866408-21-9 Free base)

Target: Histone Methyltransferase

Enpp/Carbonic anhydrase-IN-1

Cat.No: T67775

Target: PDE, Carbonic Anhydrase

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide

Cat.No: T50056

Target: Others

EGFR-IN-1 hydrochloride

Cat.No: T11157L

Target: EGFR

Cat.No: T15181

Target: COX

Cat.No: T61575

Target: DUB

Cat.No: T62281

Target: PARP

Cat. No.	Product Name	Target	Signaling Pathways
TN4569	Minimolide F	Others	Others
	Minimolide F 是从 Centipeda minima 中分离得到的，对人鼻咽癌细胞具有抗增殖活性，IC50 为 17.4 μM。
TC0039	Vasicinone	Others	Others
	Vasicinone 是一种喹唑啉类生物碱，分离自凡士林植物中。它是具有研究帕金森病和其他氧化应激相关神经退行性疾病的潜力。
T9605	Sangivamycin BA-90912,桑霉素,NSC 65346	Nucleoside Antimetabolite/Analog; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Sangivamycin (NSC-65346) 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。
TN1933	Mitraphylline 帽柱木菲碱,帽柱叶碱	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Mitraphylline 是一种绒毛钩藤中主要的五环吲哚类生物碱，可阻碍脂多糖介导的原代人中性粒细胞活化。
TN1675	Gardenin B 栀子黄素B	Apoptosis; ROS; Caspase; NO Synthase	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Gardenin B 是从Baccharis scandens 中分离出的一种黄酮类天然产物。它对肺、乳腺、结肠、肝和白血病细胞系以及角质形成细胞具有优异的抗增殖活性。
T2212	Geniposide 栀子苷,京尼平甙	Beta Amyloid; Influenza Virus	Microbiology/Virology; Neuroscience
	Geniposide 是从栀子花中提取的一种环烯醚萜甙，具有如神经保护、抗糖尿病、抗增殖和抗氧化多种生物活性。它可调节 Nrf2 易位。
T3916	Ginsenoside F2 人参皂苷F2	Apoptosis; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism
	Ginsenoside F2 是 Ginsenoside Rb1 的代谢物，通过激活内在的凋亡途径和线粒体功能障碍来诱导乳腺的凋亡，对乳腺癌干细胞具有抗增殖活性。
T6102	2'-acetylacteoside	Antioxidant; Reductase	Endocrinology/Hormones; Metabolism; oxidation-reduction
	2'-Acetylacteoside 是一种苯乙醇苷类化合物，分离自来江藤中，可抑制自由基诱导的红细胞溶血，具有清除自由基的作用。
T14305	Apicidin OSI 2040	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Apicidin (OSI 2040) 是组蛋白去乙酰化酶（HDAC）抑制剂，具有抗寄生虫活性和抗增殖活性。Apicidin 通过减少 APP/PS1 小鼠中的 Abeta 负荷来减轻记忆缺陷，抑制细胞生长增殖，诱导细胞凋亡和自噬，可用于研究白血病。
T6S0052	Chelerythrine Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine	Apoptosis; BCL; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T3404	Cucurbitacin B Cuc B,葫芦素B,DATISCACIN,葫芦素 B,Amarine	Apoptosis; PTEN; Integrin; Endogenous Metabolite; HIF; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Cucurbitacin B (Cuc B) 是一具有抗癌活性的天然产物。
T75643	Isoxanthohumol	HSV	Microbiology/Virology
	Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物，对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性，对疱疹病毒（HSV1和HSV2）和牛病毒性腹泻病毒（BVDV）具有抑制作用。
T2P2806	Hederacolchiside A1 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13	Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。
T4S1637	gamma-Mangostin Normangostin,γ-倒捻子素	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	gamma-Mangostin (Normangostin) 是从药用植物山竹的果壳中提纯的一种天然产物，是一种竞争性5-HT2A 受体拮抗剂。它是运甲状腺素蛋白原纤维化抑制剂，与甲状腺素结合位点结合并稳定了 TTR 四聚体，具有抗高血压、预防结肠癌等作用。
T81794	Micromonosporamide A
	Micromonosporamide A exhibits glutamine-dependent antiproliferative activity. Micromonosporamide A体现了以谷氨酰胺为依赖的抗增殖活性。
TN1810	Jatropholone B	Others	Others
	Jatropholone B shows antiproliferative activity against cancer cell lines. It also has gastroprotective activity in preventing the gastric lesions in mice.
TN4629	Nemoralisin C	Others	Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN3605	Casegravol	Others	Others
	Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells.
T17270	Yatein	Others	Others
	Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.
TN3447	Arjunglucoside I
	Arjunglucoside I has anti-inflammatory activity, it exhibits significant activity against carrageenan-induced paw edema in rat. It also shows antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM.
TN3429	Aphagranin A	Others	Others
	Aphagranin A exhibits strong antiproliferative activity against the growth of six lines of human cancer cells (MCF-7, A549, HepG2, Bel-7402, SGC-7901, and BGC-823.
T81996	Kadsuphilin A
	Kadsuphilin A, 提取自Kadsura coccinea (Lem.), 展现出较弱的抗增殖活性。
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR pathway and S phase cell cycle arre
TN1988	Nephthenol	Others	Others
	Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.
TN3660	Cinnamyl caffeate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell apoptosis; it possesses potent antiproliferative activity with the EC(50) value of 0.114 microM, toward colon 26-L5 carcinoma. Cinnamyl caffeate possesses potent NO inhibitory activity with the IC(50) value of 9.53 microM.
TN6204	Santin 5,7-Dihydroxy-3,6,4'-trimethoxyflavone	Influenza Virus	Microbiology/Virology
	Santin (5,7-Dihydroxy-3,6,4'-trimethoxyflavone) 是从桦树芽中提取的黄酮类化合物，具有抗增殖、抗流感和抗癌活性。 Santin 可用于有关抗 IAV 药物的研究。
TN2913	3-Acetoxy-11-ursen-28,13-olide	Phosphatase	Metabolism
	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.
T36430	Pheophorbide a
	Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 μg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells. It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 μg/ml.
TN4303	Isokaempferide	ATPase; Potassium Channel; Calcium Channel; TNF; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.
T75609	7-epi-Isogarcinol
	7-epi-Isogarcinol 是一种PPAP（多环聚异戊二烯酰基间苯三酚），显示出适度的抗增殖活性。它通过阻断STAT3信号通路，诱导apoptosis（细胞凋亡）并抑制细胞迁移作用。
T72964	Dictyostatin Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin
	Dictyostatin ((-)-Dictyostatin ; Dictyostatin 1) 是一种有效的微管稳定剂。 Dictyostatin 也是一种抗癌剂。 Dictyostatin 具有抗增殖活性。Dictyostatin 具有研究 tauopathies 的潜力。
TN4623	Nagilactone C	Antifection	Microbiology/Virology
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectivel...
TN2936	3-Hydroxy-11-ursen-28,13-olide	Others	Others
	3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag
TN4142	Glochidonol	Others	Others
	Glochidonol exhibits strong inhibitory effects against three human tumor cell lines, MCF-7, NCI-H-460 and SF-268, the GI(50) values of 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, respectively; it also exerts its antiproliferative activity through the involv
T82692	Comosone II
	Comosone II (化合物4)，一种从姜黄(Curcuma zedoaria)分离的化合物，展现中度抗增殖活性。对于Ca Ski癌细胞，其IC50值为76 μg/mL，显示其对癌细胞生长的抑制作用。
TN4140	Glochidiol	Others	Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor
TN2328	Zeylenone	Apoptosis; ERK; MAPK; Akt; PI3K; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物，具有抗肿瘤和抗癌细胞增殖活性，通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖，诱导细胞凋亡 (apoptosis)。
T37008	Reveromycin A
	Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 μg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 μg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 μg/ml at pH 3). Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in oste...
TN3348	(+)-Acuminatin Acuminatin	PAFR	GPCR/G Protein
	(+)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. (+)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the huma...
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
T72742	(-)-Pinocembrin (-)-乔松素
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。
T72803	Norartocarpetin
	Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
T37911	cis-Resveratrol 顺式白藜芦醇,(Z)-Resveratrol
	Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the &#181M range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: TN4569

Target: Others

Cat.No: TC0039

Target: Others

Cat.No: T9605

Synonym: BA-90912,桑霉素,NSC 65346

Target: Nucleoside Antimetabolite/Analog, PKC

Cat.No: TN1933

Synonym: 帽柱木菲碱,帽柱叶碱

Target: IL Receptor, TNF, NF-κB

Cat.No: TN1675

Synonym: 栀子黄素B

Target: Apoptosis, ROS, Caspase, NO Synthase

Cat.No: T2212

Synonym: 栀子苷,京尼平甙

Target: Beta Amyloid, Influenza Virus

Cat.No: T3916

Synonym: 人参皂苷F2

Target: Apoptosis, Endogenous Metabolite, Autophagy

2'-acetylacteoside

Cat.No: T6102

Target: Antioxidant, Reductase

Cat.No: T14305

Synonym: OSI 2040

Target: Apoptosis, HDAC, Autophagy

Cat.No: T6S0052

Synonym: Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3404

Synonym: Cuc B,葫芦素B,DATISCACIN,葫芦素 B,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Cat.No: T75643

Target: HSV

Hederacolchiside A1

Cat.No: T2P2806

Synonym: 黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13

Target: Apoptosis, ERK, MEK, Akt, PI3K, Parasite, mTOR

gamma-Mangostin

Cat.No: T4S1637

Synonym: Normangostin,γ-倒捻子素

Target: Others, 5-HT Receptor

Micromonosporamide A

Cat.No: T81794

Cat.No: TN1810

Target: Others

Cat.No: TN4629

Target: Others

Cat.No: TN3605

Target: Others

Cat.No: T17270

Target: Others

Arjunglucoside I

Cat.No: TN3447

Cat.No: TN3429

Target: Others

Cat.No: T81996

Cat.No: TN6591

Cat.No: TN1988

Target: Others

Cinnamyl caffeate

Cat.No: TN3660

Target: Calcium Channel

Cat.No: TN6204

Synonym: 5,7-Dihydroxy-3,6,4'-trimethoxyflavone

Target: Influenza Virus

3-Acetoxy-11-ursen-28,13-olide

Cat.No: TN2913

Target: Phosphatase

Cat.No: T36430

Cat.No: TN4303

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

7-epi-Isogarcinol

Cat.No: T75609

Cat.No: T72964

Synonym: Dictyostatin 1,(-)-Dictyostatin ; Dictyostatin 1,(-)-Dictyostatin

Cat.No: TN4623

Target: Antifection

3-Hydroxy-11-ursen-28,13-olide

Cat.No: TN2936

Target: Others

Cat.No: TN4142

Target: Others

Cat.No: T82692

Cat.No: TN4140

Target: Others

Cat.No: TN2328

Target: Apoptosis, ERK, MAPK, Akt, PI3K, mTOR

Cat.No: T37008

Cat.No: TN3348

Synonym: Acuminatin

Target: PAFR

Cat.No: TN5474

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

Norartocarpetin

Cat.No: T72803

cis-Resveratrol

Cat.No: T37911

Synonym: 顺式白藜芦醇,(Z)-Resveratrol

3-Hydroxyterphenyllin

Cat.No: T36000

Cat.No: T36954

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