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Search Results for " pancreatic "

336

抑制剂 & 化合物

59

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1137L	Pancreatic Polypeptide (human) acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。
TP1044L	Pancreatic Polypeptide, rat acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂，对 NPYR4 具有高亲和力。
TP1137	Pancreatic Polypeptide, human Human pancreatic polypeptide
	Endogenous high affinity agonist for human NPY Y4 receptor (Ki = 0.056 nM). Believed to play an important role in the function of the gastrointestinal tract.
TP1044	Pancreatic Polypeptide, rat Rat pancreatic polypeptide
	Pancreatic Polypeptide, rat is an agonist of NPY receptor, with high affinity at NPYR4. Pancreatic polypeptide (PP) is a 36-amino acid, C-terminally amidated peptide, and is a member of the PP-fold peptide family. It is produced and secreted by the PP cel
T0517	Pancreatin Pancreatic enzymes,pancrelipase,胰酶	Others	Others
	Pancreatin (pancrelipase) 是一种含有胰腺消化酶的猪胰腺提取物。
TP1731	Pancreatic Polypeptide, bovine
	Agonist at Y4 neuropeptide Y receptors.
T3359	Aprotinin 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others; Serine Protease; Influenza Virus; Proteasome	Microbiology/Virology; Others; Proteases/Proteasome; Ubiquitination
	Aprotinin (Traskolan) 是分离自牛肺的一种广谱丝氨酸蛋白酶抑制剂，可抑制多种不同酯酶和蛋白酶的活性。
T76538	Pancreatic polypeptide
	Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽，具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。
T63015	Pancreatic lipase/Carboxylesterase 1-IN-1
	Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂，作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。
T8439	Clobenpropit dihydrobromide	Apoptosis; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clobenpropit dihydrobromide 是一种组胺H3R 拮抗剂/反向激动剂。它与 5-HT3 受体和 α2A/α2C 肾上腺素受体结合，对组胺H4受体起部分激动剂的作用，还能促进凋亡。
T8982	RH01687	Others	Others
	RH01687 是可以保护胰腺 β 细胞免受内质网应激诱导的细胞死亡的化合物。它对糖尿病具有潜在的研究价值。
T9693	TBAP-001	Raf	MAPK
	TBAP-001是RAF 激酶的泛抑制剂，IC50为 62 nM。
T5469	K-Ras-IN-1	Raf; Ras	GPCR/G Protein; MAPK
	K-Ras-IN-1 是K-Ras 抑制剂。K-Ras-IN-1 能与 K-Ras (WT)、K-Ras (G12D)、K-Ras (G12V) 和 H-Ras 结合。它对胰腺癌、结肠癌和肺癌的具潜在的研究价值。
T21773	SP-141 SP 141	Mdm2	Apoptosis
	SP-141 是一种 MDM2 抑制剂，可促进 MDM2 自身泛素化和降解，具有抗癌活性。
T2055	WS3	EGFR; IκB/IKK	Angiogenesis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。
T9050	AG-270	Others; Methionine Adenosyltransferase (MAT)	Chromatin/Epigenetic; Others
	AG-270 是一种可逆的、非竞争性的、具有口服活性的MAT2A 变构抑制剂(IC50:14 nM)。
T9593	Senaparib IMP4297	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Senaparib (IMP4297) 是一种选择性和口服有效的PARP1/2抑制剂，具有强效的抗肿瘤活性。
T10255	AES-135	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AES-135 是一种基于羟肟酸的泛HDAC 抑制剂，抑制 HDAC3、HDAC6和 HDAC11，IC50为 654、190 和 636 nM，具有抗肿瘤活性。
T60028	MM41	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	MM41 是一种人类端粒和基因启动子 DNA 四链体稳定剂，对 MIA PaCa-2 胰腺癌细胞系的 IC50 <10 nM。
T14779	BRD7389	SGK; FLT; Pim; CDK; S6 Kinase; DAPK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	BRD7389 是一种 RSK 家族激酶抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 1.5 μM、2.4 μM 和 1.2 μM。
T2058	Palosuran ACT-058362	GPR	Endocrinology/Hormones; GPCR/G Protein
	Palosuran (ACT-058362) 是人类 UT 受体的新型强效特异性拮抗剂，对表达人重组受体的 CHO 细胞膜的IC50值为 3.6 nM。它可改善糖尿病大鼠的胰腺和肾脏功能。
T2613	Almorexant 阿莫伦特,ACT 078573	OX Receptor	GPCR/G Protein; Neuroscience
	Almorexant (ACT 078573) 是一种有效的竞争性食欲素 1 受体 (OX1)/食欲素 2 受体 (OX2) 双重拮抗剂，OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T4367	Mycro 3 Mycro-3	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Mycro 3 在全细胞分析中对 c-Myc 具有强效选择性，可用于胰腺癌的研究。
T8901	YUM70	Apoptosis; GPR; HSP	Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
	YUM70 是一种选择性葡萄糖调节蛋白 78 抑制剂，抑制全长蛋白的 GRP78 ATPase 活性的IC50值为 1.5 μM。它在胰腺癌中诱导内质网应激介导的细胞凋亡。
T11282	FGTI-2734	Transferase	Metabolism
	FGTI-2734 是有效的RAS C-末端法尼基转移酶 (FT) 和香叶烯基转移酶-1 (GGT-1) 抑制剂，IC50s 分别为 250 nM 和 520 nM。它可以阻断 KRAS 的膜定位，从而解决 KRAS 耐药性问题，并抑制突变的 KRAS 胰腺肿瘤。
T15159	Dorzagliatin HMS5552	Glucokinase	Metabolism
	Dorzagliatin (HMS5552) 是双重作用的葡萄糖激酶 (glucokinase;GK) 激活剂，可改善 2 型糖尿病的血糖控制，提高胰腺 β 细胞功能。
T12006	Metarrestin ML246	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。
T3283	Cetilistat 新利司他,ATL-962	Lipid	Metabolism
	Cetilistat (ATL-962) 是胰腺脂肪酶 (pancreatic lipase) 抑制剂，能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性，可用作有效的抗肥胖药。
T9465	ZZW-115 hydrochloride	Apoptosis; Others	Apoptosis; Others
	ZZW-115 hydrochloride 是一种 NUPR1抑制剂，Kd 为 2.1 μM。它通过坏死和凋亡诱导肿瘤细胞死亡，具有抗癌活性。
T2667	PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK75 是一种可逆的DNA-PK 和p110α-选择性的抑制剂，抑制 DNA-PK、p110α 和 p110γ，IC50分别为 2、5.8 和 76 nM。它诱导凋亡，抑制 p110α 效果比抑制 p110β 高 200 多倍，p110β的IC50为 1.3 μM。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T7539	O6-Benzylguanine O-6-苄基鸟嘌呤	Apoptosis; DNA Alkylation; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	O6-Benzylguanine 是鸟嘌呤类似物，是 DNA 修复酶 O6 烷基鸟嘌呤DNA 烷基转移酶(MGMT/AGT)抑制剂，可诱导肿瘤细胞凋亡，具有抗肿瘤活性。它作为 AGT 底物，将其苄基转移到 AGT 半胱氨酸残基上，从而不可逆地灭活 AGT 并阻止 DNA 修复。
T6916	OICR-9429 OICR 9429	Histone Methyltransferase; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	OICR-9429 是一个新颖的相互作用的小分子Wdr5-MLL 拮抗剂，IC50是 5 uM，在体外抑制急性髓性白血病细胞。
T9240	sulfopin Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-	Others	Others
	Sulfopin 是高选择性共价Pin1抑制剂(Ki:17 nM)，在体内能够阻断 Myc 驱动的肿瘤。其中肽基脯氨酰异构酶 Pin1 在癌症中被用来激活癌基因和灭活肿瘤抑制因子。
T2148	Carbidopa monohydrate Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa monohydrate (S(-)-Carbidopa) 是一种外周型脱羧酶抑制剂，可用于帕金森病的研究。它是一种选择性芳香烃受体 (AhR) 调节剂。它抑制胰腺癌细胞和肿瘤生长。
T0686	Orlistat Ro-18-0647,奥利司他,Tetrahydrolipstatin	Apoptosis; Others; Fatty Acid Synthase	Apoptosis; Metabolism; Others
	Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂，也是一种脂肪酸合成酶抑制剂，可研究肥胖症，具有抗动脉粥样硬化作用。
T8766	GOT1 inhibitor-1 GOT1 inhibitor 2c	Others	Others
	GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM)，是一种戊酸衍生物。它可用于以及胰腺导管腺癌 (PDAC) 。
T9831	MKC-1 Ro-31-7453	Apoptosis; Akt; Microtubule Associated; mTOR	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MKC-1 (Ro-31-7453) 是一种口服生物可利用的小分子双吲哚基马来酰亚胺细胞周期抑制剂，具有潜在的抗肿瘤活性。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
T1603	Glipizide CP 28720,K 4024,格列吡嗪	Potassium Channel; PPAR; ABC	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性。
T2275	YK-4-279 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂，能抑制ESFT 细胞增长，诱导凋亡。
T28475	Pyrazoloacridine PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	Pyrazoloacridine (PD 115934) 是一种核酸结合剂，在 K562 细胞中抑制 topo I 和 II 的活性，IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。
T15389L	Glucagon (1-29), bovine, human, porcine hydrochloride 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride	Glucocorticoid Receptor; Glucagon Receptor	Endocrinology/Hormones; GPCR/G Protein
	Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化，促进糖异生。
TQ0157	EIPA L593754,MH 12-43	Sodium Channel; TRP/TRPV Channel	Membrane transporter/Ion channel
	EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂，IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T6155	Almorexant hydrochloride ACT-078573 hydrochloride,Almorexant HCl	OX Receptor	GPCR/G Protein; Neuroscience
	Almorexant hydrochloride (ACT-078573 hydrochloride) 是一种有效的竞争性食欲素 1 受体(OX1)/食欲素 2 受体 (OX2) 双重拮抗剂，OX1 和 OX2 的 Ki 值分别为 1.3 和 0.17 nM。
T2287	PIK-75 hydrochloride PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂，抑制 DNA-PK，p110α和 p110γ，可诱导凋亡。
TP1963	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide
	Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.
T75913	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
	[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 为高效且选择性的神经肽 YY5 受体激动剂，其与 hY5 受体的结合 IC50 值为 0.24 nM，已知可促进饮食摄入。
T77668	hPL-IN-1	Others	Others
	hPL-IN-1 是一种有效的可逆胰脂肪酶 (PL) 抑制剂 (IC50=1.86 μM)，可用于研究与肥胖相关的疾病。

化合物

Pancreatic Polypeptide (human) acetate

Cat.No: TP1137L

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide, rat acetate

Cat.No: TP1044L

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide, human

Cat.No: TP1137

Synonym: Human pancreatic polypeptide

Pancreatic Polypeptide, rat

Cat.No: TP1044

Synonym: Rat pancreatic polypeptide

Cat.No: T0517

Synonym: Pancreatic enzymes,pancrelipase,胰酶

Target: Others

Pancreatic Polypeptide, bovine

Cat.No: TP1731

Cat.No: T3359

Synonym: 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

Pancreatic polypeptide

Cat.No: T76538

Pancreatic lipase/Carboxylesterase 1-IN-1

Cat.No: T63015

Clobenpropit dihydrobromide

Cat.No: T8439

Target: Apoptosis, Histamine Receptor

Cat.No: T8982

Target: Others

Cat.No: T9693

Target: Raf

Cat.No: T5469

Target: Raf, Ras

Cat.No: T21773

Synonym: SP 141

Target: Mdm2

Cat.No: T2055

Target: EGFR, IκB/IKK

Cat.No: T9050

Target: Others, Methionine Adenosyltransferase (MAT)

Cat.No: T9593

Synonym: IMP4297

Target: PARP

Cat.No: T10255

Target: HDAC

Cat.No: T60028

Target: DNA/RNA Synthesis

Cat.No: T14779

Target: SGK, FLT, Pim, CDK, S6 Kinase, DAPK

Cat.No: T2058

Synonym: ACT-058362

Target: GPR

Cat.No: T2613

Synonym: 阿莫伦特,ACT 078573

Target: OX Receptor

Cat.No: T4367

Synonym: Mycro-3

Target: c-Myc, Autophagy

Cat.No: T8901

Target: Apoptosis, GPR, HSP

Cat.No: T11282

Target: Transferase

Cat.No: T15159

Synonym: HMS5552

Target: Glucokinase

Cat.No: T12006

Synonym: ML246

Target: DNA/RNA Synthesis

Cat.No: T3283

Synonym: 新利司他,ATL-962

Target: Lipid

ZZW-115 hydrochloride

Cat.No: T9465

Target: Apoptosis, Others

Cat.No: T2667

Target: Apoptosis, DNA-PK, PI3K

Cat.No: T15017

Target: TLR

O6-Benzylguanine

Cat.No: T7539

Synonym: O-6-苄基鸟嘌呤

Target: Apoptosis, DNA Alkylation, DNA/RNA Synthesis

Cat.No: T6916

Synonym: OICR 9429

Target: Histone Methyltransferase, JAK

Cat.No: T9240

Synonym: Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-

Target: Others

Carbidopa monohydrate

Cat.No: T2148

Synonym: Carbidopa Hydrate,S(-)-Carbidopa,卡比多巴水合物

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T0686

Synonym: Ro-18-0647,奥利司他,Tetrahydrolipstatin

Target: Apoptosis, Others, Fatty Acid Synthase

GOT1 inhibitor-1

Cat.No: T8766

Synonym: GOT1 inhibitor 2c

Target: Others

Cat.No: T9831

Synonym: Ro-31-7453

Target: Apoptosis, Akt, Microtubule Associated, mTOR

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

Cat.No: T1603

Synonym: CP 28720,K 4024,格列吡嗪

Target: Potassium Channel, PPAR, ABC

Cat.No: T2275

Synonym: 4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮

Target: Apoptosis, DNA/RNA Synthesis

Pyrazoloacridine

Cat.No: T28475

Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Target: Apoptosis, Topoisomerase

Glucagon (1-29), bovine, human, porcine hydrochloride

Cat.No: T15389L

Synonym: 盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride

Target: Glucocorticoid Receptor, Glucagon Receptor

Cat.No: TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Almorexant hydrochloride

Cat.No: T6155

Synonym: ACT-078573 hydrochloride,Almorexant HCl

Target: OX Receptor

PIK-75 hydrochloride

Cat.No: T2287

Synonym: PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75

Target: Apoptosis, DNA-PK, PI3K

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide

Cat.No: TP1963

Synonym: cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA

Cat.No: T75913

Cat.No: T77668

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S0777	Phellodendrine chloride	Others	Others
	Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收，进而抑制 KRAS 突变的胰腺癌细胞的增殖。
TN2269	Tetramethylcurcumin	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	Tetramethylcurcumin 是一种新型姜黄素类似物，是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。
T4964	steviolbioside CCRIS-6025,菊双糖甙,甜菊双糖苷	Others	Others
	Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用，对乳腺癌具有潜在的研究价值。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
TN1620	Eriocalyxin B 毛萼乙素	Apoptosis; cAMP; NF-κB; STAT	Apoptosis; GPCR/G Protein; JAK/STAT signaling; NF-κB; Stem Cells
	Eriocalyxin B 是从中草药枇杷素中分离得到的一种二萜类天然产物，可诱导细胞凋亡，具有抗癌和抗炎作用。
T14840	Butyrylcarnitine	Endogenous Metabolite	Metabolism
	Butyrylcarnitine 是血浆中的代谢物，是疾病引起异常代谢的指标，可用于诊断心力衰竭和胰腺囊肿。
T6942	Picolinamide 2-Pyridinecarboxamide,2-Carbamoylpyridine,2-吡啶甲酰胺,2-Picolinamide,Picolinoylamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Picolinamide (Picolinoylamide) 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。
T4S1312	Gypsogenin-3-O-glucuronide 丝石竹皂苷元3-O-Β-D-葡萄糖醛酸甲酯,Methyl gypsogenin 3-O-beta-D-glucuronopy,丝石竹皂苷元-3-O-β-D-葡萄糖醛酸甲酯	Others	Others
	Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) 是一种皂角苷前体，普遍存在于满天星属植物中。
T36115	Colchicoside 3-Demethylcolchicine glucoside	Others	Others
	Colchicoside (3-Demethylcolchicine glucoside) 提取自嘉兰，在胰腺癌小鼠模型中显示出疗效。
T20604L	Litorin acetate(55749-97-8 Free base)	Bombesin Receptor	GPCR/G Protein
	Litorin acetate 是一种两栖类铃蟾肽衍生物，是一种铃蟾肽受体激动剂。它刺激平滑肌收缩，刺激胃泌素、胃酸和胰腺分泌，抑制体内营养。
T0743	DL-Carnitine Carnitina,Carnitine,卡尼丁	Others	Others
	DL-Carnitine (Carnitina) 是肝脏和横纹肌的成分。在治疗上它用于刺激胰腺和胃的分泌并治疗高脂蛋白血症。
T5668	Triacetylresveratrol 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol	BCL; NF-κB; STAT	Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells
	Triacetylresveratrol (Acetyl-trans-resveratrol) 是 Resveratrol 的乙酰化类似物，可降低 STAT3和 NF-κB 磷酸化，具有抗癌作用。
T5707	3-O-Methylgalangin 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚	Antibacterial	Microbiology/Virology
	3-O-Methylgalangin (GALANGIN-3-METHYLETHER) 是一种来源于高良姜根茎的天然黄酮，具有抗菌活性，抑制胰腺脂肪酶。
T2840	Phloracetophenone 2,4,6-三羟基苯乙酮,2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone	Others; P450; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Others
	Phloracetophenone (1-(2,4,6-Trihydroxyphenyl)ethanone) 是多叶姜黄中苯乙酮糖苷的糖苷配基部分，具有抗肥胖，降血脂和降低胆固醇作用，能够增强胆固醇 7α-羟化酶的活性。
T2203	D-Carnitine hydrochloride (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride) 已被用于研究麦角硫因素转运蛋白 SLC22A4 和肉毒碱转运蛋白 SLC22A5，也被用于使棕榈酸进入线粒体。
T3028	Tripterin Celastrol,Tripterine,雷公藤红素	Apoptosis; Mitophagy; Proteasome; Autophagy	Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination
	Tripterin (Celastrol) 属于天然产物，是一种蛋白酶体抑制剂，抑制 20S 蛋白酶体的胰凝乳蛋白酶样活性 (IC50=2.5 μM)。Tripterin 具有抗炎、抗感染和免疫调节的作用。
T10086	24-Hydroxycholesterol Cholest-5-ene-3beta,24-diol	Liver X Receptor; NMDAR	Metabolism; Neuroscience
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物，是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂，可用于研究心血管生成和胰腺癌。
T2P2919	(2S,3R,4S)-4-Hydroxyisoleucine (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine	PI3K	PI3K/Akt/mTOR signaling
	(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分，具有抗糖尿病、抗糖尿病肾病的作用。
T3404	Cucurbitacin B Cuc B,葫芦素B,DATISCACIN,葫芦素 B,Amarine	Apoptosis; PTEN; Integrin; Endogenous Metabolite; HIF; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	Cucurbitacin B (Cuc B) 是一具有抗癌活性的天然产物。
T1507	Streptozocin STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889	DNA Alkylator/Crosslinker; DNA Alkylation; DNA/RNA Synthesis; Antibacterial; Antibiotic; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Streptozocin (NSC-85998) 是一种抗生素，可诱导 DNA 甲基化。Streptozocin 对产生胰岛素的胰岛 B 细胞具有毒性，常用于构建 1 型糖尿病的动物模型。该产品在溶液中不稳定，建议现配现用。
T2978	Mogroside V	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Mogroside V 是三萜糖苷，是非糖类甜味剂，甜度比蔗糖甜高300倍。它具有抗氧化，抗糖尿病和抗癌作用。
T3849	Kinsenoside 金线莲苷,(+)-Kinsenoside	Apoptosis; Nrf2	Apoptosis; Immunology/Inflammation
	Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分，以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力，防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。
T3867	Alpinetin 山姜素,(-)-alpinetin	BCL; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物，能够活化PPAR-γ，具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。
TWS2045	Bruceine D 鸦胆子素D,鸦胆子苦素D	Apoptosis; Antiviral; Gamma-secretase; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Bruceine D 是Notch 抑制剂，有抗癌活性，诱导几种人癌细胞调亡。它是一种有效的植物性昆虫拒食剂，有显著的系统特性和抑制害虫生长的作用。它具有较强的驱虫活性，抑制D. intermedius 的 EC50值为 0.57 mg/L。
T5S1389	Escin IB 七叶皂苷B,七叶皂苷 IB	5-HT Receptor; NO Synthase	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Escin IB 是一种皂苷，分离自马栗子种子的皮和胚乳中，能够抑制 pancreatic lipase 的活性。
T3779	Crocin II Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B	Caspase; COX; NO Synthase	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。
T3S0013	Ethyl trans-caffeate 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester	Others	Others
	Ethyl trans-caffeate (Caffeic Acid Ethyl Ester) 具有抗炎作用。它是一种有前途的天然化合物，未来在慢性肝病中的应用。它是一种有效的化学预防化合物，可防止因太阳紫外线照射引起的皮肤癌变。它是与人胰腺α-淀粉酶复合的代表性抑制剂的高分辨率结构。它强烈抑制 JB6 Cl41细胞的肿瘤转化，无毒性。 PI3K、ERK1/2 和 p38 激酶活性在体外通过与 HOEC 直接结合而受到抑制。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T37512	cis-4-Hydroxy-L-proline	Endogenous Metabolite	Metabolism
	cis-4-Hydroxy-L-proline 是脯氨酸的一种类似物，抑制胶原蛋白的产生。它通过阻止三层螺旋胶原在细胞层上的沉积从而抑制成纤维细胞的生长。它还可抑制原发性N-亚硝基甲基脲诱导的大鼠乳腺肿瘤的生长。
T13624	Conophylline	Others	Others
	Conophylline is a natural alkaloid extracted from a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells and suppresses HSC and induces apoptosis.
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
T40464	Neotheaflavin
	Neotheaflavin, from black tea, inhibits pancreatic lipase.
TMA0805	Lupanine	ATPase; Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells.
T83206	Acanthopanaxoside A
	Acanthopanaxoside A 为三萜类皂苷化合物，能够抑制胰腺脂肪酶 (lipase) 活性。
TN5789	Royleanone
	Royleanone possesses cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2.
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.
T40584	Corymbiferin
	Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of histopathology in both the liver and pancreatic β cells.
T82712	Ciwujianoside C4
	Ciwujianoside C4，一种皂苷类化合物，在体外能够增强胰腺脂肪酶活性。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
T7711	Uridine triphosphate 尿苷5'-三磷酸酯,UTP,Uridine 5'-triphosphate,三磷酸尿苷	Others; Endogenous Metabolite	Metabolism; Others
	Uridine triphosphate (Uridine 5'-triphosphate) 是一种核苷酸，调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。
TN3118	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)	Others	Others
	5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.
TN5463	Leachianone G
	Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Leachianone G shows potent antiviral
T75678	Tomentosin	Apoptosis	Apoptosis
	Tomentosin 是一种从里海旋覆花中提取出来倍半萜内酯，具有潜在的抗炎和抗癌活性，可促进胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。
T81701	Nardoguaianone K 10-epi-Nardoguaianone J
	Nardoguaianone K，一种从Nardostachys chinensis根中分离得到的愈创木脂类化合物，用于胰腺癌研究。
T82713	Ciwujianoside C1
	Ciwujianoside C1, 一种从Acanthopanax senticosus叶中分离得到的皂苷，具有抑制体外胰腺脂肪酶活性的功能。
T80702	α-Thevetin B
	α-Thevetin B（Compound 24）, 一种从Thevetia peruviana分离得到的心脏苷，用于肺癌、胃癌和胰腺癌的研究。
T75645	Echitamine chloride
	Echitamine chloride 是存在于 Alstonia scholaris 中的主要单萜吲哚生物碱，具有有效的抗肿瘤活性。Echitamine chloride 会诱导 DNA 片段化和细胞凋亡 (apoptosis)。Echitamine chloride 抑制胰腺脂肪酶 (pancreatic lipase)，IC50为 10.92 µM。
TN4580	Morachalcone A	Tyrosinase	Proteases/Proteasome
	Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells agai
T83308	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl
	5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) 是从漏斗石斛 (D. infundibulum) 中分离出的化合物。该化合物不具有对 α-葡萄糖苷酶和胰脂肪酶的抑制活性。
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天然产物

Phellodendrine chloride

Cat.No: T5S0777

Target: Others

Tetramethylcurcumin

Cat.No: TN2269

Target: Apoptosis, STAT

Cat.No: T4964

Synonym: CCRIS-6025,菊双糖甙,甜菊双糖苷

Target: Others

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: TN1620

Synonym: 毛萼乙素

Target: Apoptosis, cAMP, NF-κB, STAT

Butyrylcarnitine

Cat.No: T14840

Target: Endogenous Metabolite

Cat.No: T6942

Synonym: 2-Pyridinecarboxamide,2-Carbamoylpyridine,2-吡啶甲酰胺,2-Picolinamide,Picolinoylamide

Target: PARP

Gypsogenin-3-O-glucuronide

Cat.No: T4S1312

Synonym: 丝石竹皂苷元3-O-Β-D-葡萄糖醛酸甲酯,Methyl gypsogenin 3-O-beta-D-glucuronopy,丝石竹皂苷元-3-O-β-D-葡萄糖醛酸甲酯

Target: Others

Cat.No: T36115

Synonym: 3-Demethylcolchicine glucoside

Target: Others

Litorin acetate(55749-97-8 Free base)

Cat.No: T20604L

Target: Bombesin Receptor

Cat.No: T0743

Synonym: Carnitina,Carnitine,卡尼丁

Target: Others

Triacetylresveratrol

Cat.No: T5668

Synonym: 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol

Target: BCL, NF-κB, STAT

3-O-Methylgalangin

Cat.No: T5707

Synonym: 3-Methylgalangin,GALANGIN-3-METHYLETHER,高良姜素 3-O-甲醚,高良姜素-3-甲醚

Target: Antibacterial

Phloracetophenone

Cat.No: T2840

Synonym: 2,4,6-三羟基苯乙酮,2,4,6-trihydroxyacetophenone,1-(2,4,6-Trihydroxyphenyl)ethanone

Target: Others, P450, Antibacterial, Antibiotic

D-Carnitine hydrochloride

Cat.No: T2203

Synonym: (S)-Carnitine Hydrochloride,L-Carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T3028

Synonym: Celastrol,Tripterine,雷公藤红素

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

24-Hydroxycholesterol

Cat.No: T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

(2S,3R,4S)-4-Hydroxyisoleucine

Cat.No: T2P2919

Synonym: (4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine

Target: PI3K

Cat.No: T3404

Synonym: Cuc B,葫芦素B,DATISCACIN,葫芦素 B,Amarine

Target: Apoptosis, PTEN, Integrin, Endogenous Metabolite, HIF, STAT, Autophagy

Cat.No: T1507

Synonym: STZ,Streptozotocin,链脲佐菌素,NSC-85998,链脲菌素,U 9889

Target: DNA Alkylator/Crosslinker, DNA Alkylation, DNA/RNA Synthesis, Antibacterial, Antibiotic, Autophagy

Cat.No: T2978

Target: AMPK

Cat.No: T3849

Synonym: 金线莲苷,(+)-Kinsenoside

Target: Apoptosis, Nrf2

Cat.No: T3867

Synonym: 山姜素,(-)-alpinetin

Target: BCL, PPAR

Cat.No: TWS2045

Synonym: 鸦胆子素D,鸦胆子苦素D

Target: Apoptosis, Antiviral, Gamma-secretase, Parasite

Cat.No: T5S1389

Synonym: 七叶皂苷B,七叶皂苷 IB

Target: 5-HT Receptor, NO Synthase

Cat.No: T3779

Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Ethyl trans-caffeate

Cat.No: T3S0013

Synonym: 咖啡酸乙酯,Ethyl caffeate,Caffeic Acid Ethyl Ester

Target: Others

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

cis-4-Hydroxy-L-proline

Cat.No: T37512

Target: Endogenous Metabolite

Cat.No: T13624

Target: Others

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Cat.No: T40464

Cat.No: TMA0805

Target: ATPase, Potassium Channel, Calcium Channel

Acanthopanaxoside A

Cat.No: T83206

Cat.No: TN5789

Cat.No: T20604

Cat.No: T40584

Ciwujianoside C4

Cat.No: T82712

Cat.No: T36954

Uridine triphosphate

Cat.No: T7711

Synonym: 尿苷5'-三磷酸酯,UTP,Uridine 5'-triphosphate,三磷酸尿苷

Target: Others, Endogenous Metabolite

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)

Cat.No: TN3118

Target: Others

Cat.No: TN5463

Cat.No: T75678

Target: Apoptosis

Nardoguaianone K

Cat.No: T81701

Synonym: 10-epi-Nardoguaianone J

Ciwujianoside C1

Cat.No: T82713

Cat.No: T80702

Echitamine chloride

Cat.No: T75645

Cat.No: TN4580

Target: Tyrosinase

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl

Cat.No: T83308

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