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173

抑制剂 & 化合物

46

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T8936	Proteinase K proteinase K for tritirachium album,Protease K,蛋白酶 K	Others	Others
	Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶，可用于蛋白消化。它在有 SDS 或尿素存在的情况下，在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。
TQ0056	Cefuracetime SKF81367,头孢呋汀	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuracetime (SKF81367) 是一种头孢菌素抗生素。
T68631	Carbetimer
	Carbetimer is a partially imidized copolymer of ethylene & maleic anhydride with average MW approx 1,200 daltons; capable of specific stimulation of immune response. Carbetimer is a low molecular weight polymer derived from ethylene and maleic anhydride with potent antineoplastic activity. Preclinical studies have shown antitumor effects against many tumor cell lines including B 16 melanoma. Its antitumor actions are felt to include both reduction of uridine and cytidine nucleoside triphosphate ...
T13160	Timegadine 替美加定,SR1368	COX	Immunology/Inflammation; Neuroscience
	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates and in washed rabbit platelets.
T12825	Timepidium bromide SA504,Sesden	AChR	Neuroscience
	Timepidium bromide is an agent of anticholinergic.
T8470	BMS-1001	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1001 是一种有效的 PD-1/PD-L1 相互作用抑制剂（IC50：2.25 nM，在均相时间分辨荧光结合试验中）。
T29955	AMC-01 AMC01,AMC 01	Antiviral; PERK	Apoptosis; Immunology/Inflammation
	AMC-01 具有潜在的抗病毒活，可通过丝氨酸残基 51 的磷酸化诱导 eIF2-α 失活，这种作用具有剂量和时间依赖性。AMC-01 可用来研究动脉粥样硬化和帕金森综合征。
T72030	6,6'-Dimethyl-2,2'-dipyridyl 6,6'-Bi-2-picoline
	6,6'-Dimethyl-2,2'-dipyridyl (6,6'-Bi-2-picoline) 是一种新型的时间分辨荧光免疫分析(TRFIA)螯合物，具有较好的杀菌效果，可用于研究酒渣鼻。
T7315	BAY1125976	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	BAY1125976 是选择性Akt1/Akt2变构抑制剂。在10 μM ATP 时，它抑制 Akt1 和 Akt2 活性的IC50值分别为 5.2 nM 和 18 nM。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T21635	PD184161	MEK	MAPK
	PD 184161 是一种口服有效的，时间和浓度依赖的 MEK 抑制剂，IC50为10-100 nM。它诱导抑郁样行为，抑制细胞增殖并诱导细胞凋亡。
T32668	Leucomalachite green NSC36379,NSC 36379,隐色孔雀绿,NSC-36379	Others	Others
	Leucomalachite green (NSC-36379) 是孔雀石绿的主要代谢物，是潜在的致癌物、致畸物和诱变剂。它是一种三苯甲烷燃料，可用于检测血液。
T9573	GSK3685032	DNA Methyltransferase	Chromatin/Epigenetic
	GSK-3685032 是一种非时间依赖、非共价、选择性的、可逆的DNMT1抑制剂，IC50=0.036 μM。它诱导 DNA 甲基化丧失、转录激活和癌细胞生长抑制。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
TD0082	EDANS sodium EDANS sodium salt,EDANS sodium salt [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid, sodium salt],5-(2-氨乙基氨)-1-萘磺酸钠盐,5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt,N-(Aminoethyl)-5-naphthylamine-1-sulfonic Acid Sodium Salt	Others	Others
	EDANS sodium (5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt) 是开发基于 FRET 的核酸探针的供体，该探针广泛用于实时 PCR 测定。
T1639	Amlexanox 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673	IL Receptor; FGFR; Others; IκB/IKK	Angiogenesis; Immunology/Inflammation; NF-κB; Others; Tyrosine Kinase/Adaptors
	Amlexanox (AA673) 是一种特异性的 IKKε和 TBK1抑制剂，其 IC50=1-2 μM。
T22821	GSK J5 GSK-J5,GSKJ5	Histone Demethylase	Chromatin/Epigenetic
	GSK J5 对血吸虫和蠕虫具有抑制作用，常被当作一种吸血虫杀虫剂。GSK J5 以剂量和时间依赖的方式促进血吸虫死亡。GSK J5 可提高血吸虫死亡率、减低成虫活力。
T77767L1	GLF16 HCl	Others	Others
	GLF16 HCl 是一种荧光团偶联的苏丹黑 B 类似物，可通过通过荧光显微镜和流式细胞术快速检测、分离和实时跟踪衰老细胞。
T9741	INE963	Others	Others
	INE963 是快速有效的血液阶段抗疟剂，EC50为 3-6 nM。INE963 有单纯性疟疾的研究潜力。
T71708	Minamestane	Aromatase	Endocrinology/Hormones
	Minamestane 是一种新型不可逆芳香化酶抑制剂。Minamestane 引起人胎盘芳香化酶的时间依赖性抑制，半衰期为4分钟，K 为59nM。Minamestane 具有抗肿瘤活性。
T39704	KSC-34	Others	Others
	KSC-34 是蛋白二硫异构酶 A1（PDIA1）的共价修饰剂，是一种针对 PDIA1 的 a 位点的选择性抑制剂，以时间依赖的方式抑制PDIA1 还原酶活性，可用于研究淀粉样蛋白异常引起的疾病。
T12425	PF-06424439 methanesulfonate	Acyltransferase; Transferase	Metabolism
	PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
T22986	MK 1903	GPR	Endocrinology/Hormones; GPCR/G Protein
	MK 1903 是一种有效的、具有选择性的羟基羧酸受体2 (HCA2) 的完全激动剂。HCA2也叫做G 蛋白偶联受体109A(GPR109A) 。MK 1903在使用表达人受体(ECso-12.9 nM)的 CHO 细胞进行的均匀时间分辨荧光(htf)测定中，它减少了福斯克林诱导的 cAMP 的产生。
T11824LL	Lanraplenib GS-9876	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Lanraplenib (GS-9876) 是高效的、选择性的、口服具有活力的 SYK 抑制剂 (IC50=9.5 nM) ，能够用于炎症性疾病的研究。它通过糖蛋白 VI (GPVI) 受体抑制血小板中的 SYK 活性，而不会延长猴子或人类的出血时间 (BT)。
T36082	Cysmethynil	Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Cysmethynil 是一种基于吲哚的 Icmt 时间依赖性抑制剂，具有抗肿瘤活性，对 RAS 膜结合和 EGF的信号转导有抑制作用。Cysmethynil 诱导细胞周期阻滞在 G1 期，诱导细胞自噬，可用于研究实体肿瘤。
T21548	PF-4981517 CYP3cide	P450	Metabolism
	PF-4981517 (CYP3cide) 是一种高效，特异性和时间依赖性细胞色素P4503A4 (CYP3A4)抑制剂。对于CYP3A4，CYP3A5 和 CYP3A7，抑制CYP3A 活性的IC50值分别为 0.03 μM，17 μM 和 71μM。PF-4981517 可用于区分CYP3A4和 CYP3A5 对于药物代谢的作用。
T60891	AChE/BChE/MAO-B-IN-1	MAO; AChE	Metabolism; Neuroscience
	AChE/BChE/MAO-B-IN-1是一种可逆的、非时间依赖且可透过血脑屏障的AChE、BChE 和MAO-B 抑制剂，对 hAChE、hBChE 和 hMAO-B 表现出抑制作用，IC50分别为 7.31、0.56 和 26.1 μM。AChE/BChE/MAO-B-IN-1具有神经保护作用且无明显细胞毒性。
T60671	MAO-B-IN-9	Beta Amyloid; Serotonin Transporter; Monoamine Oxidase	Neuroscience
	MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂（IC50：0.18μM），具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用，可以防止Aβ1-42诱导的神经元细胞死亡，这可能与Aβ1-42的抗聚集作用有关。
T76756	Parsatuzumab RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Parsatuzumab (RG 7414) 是一种人源化靶向 EGFL7 的单克隆抗体，也可作为一种免疫调节剂使用。Parsatuzumab 选择性抑制 EGFL7 与内皮细胞之间的相互作用，对内皮生长因子 (VEGF) 有抑制作用。Parsatuzumab 长期其他化合物联合联合使用来研究直肠癌
T34249	Rabeximod ROB-803	TLR	Immunology/Inflammation
	Rabeximod 是一种有效的免疫调节剂，可降低鼠模型中自身免疫性疾病疾病严重程度。Rabeximod 通过刺激TLR2和TLR4下游阻断炎症细胞(可能是巨噬细胞)的激活，以时间依赖性的方式抑制关节炎。Rabeximod 能有效降低创伤性脑损伤抗炎治疗过程中小鼠的脑抗原呈递。
T3536	AZD1283	P2Y Receptor	GPCR/G Protein; Neuroscience
	AZD1283是P2Y12受体拮抗剂，EC50为3.0 ug/kg/min，结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集，抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T31587	DY268 DY 268,DY-268	FXR	Metabolism
	DY268 是一种法尼样X 受体 (FXR)的拮抗剂(在 time-resolved FRET 分析中，IC50=7.5 nM)。在细胞分析中，它能够抑制 FXR 反式激活，IC50=468 nM。
T14884	CBR-5884	Others; Dehydrogenase	Metabolism; Others
	CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂，IC50为 33 μM。它抑制癌细胞中的丝氨酸合成，选择性地抑制黑素瘤和乳腺癌细胞系的增殖，对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。
T38164	MnTBAP chloride Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) 是一种具有细胞渗透性的超氧化物歧化酶 (SOD) 模拟物和过氧亚硝酸盐清除剂，能使SOD-大肠杆菌的加倍时间减少了2倍。 MnTBAP chloride 通过上调 BMPR-II 和抑制 NFκB 信号传导展现抗炎作用。MnTBAP chloride 是一种锰卟啉配合物，具有抗氧化性能，具有用于研究慢性肾脏疾病 (CKDs) 纤维化反应的潜力。
TP1369L	[Sar9,Met(O2)11]-Substance P acetate [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide（每只大鼠 10-100 pmol，i.c.v.）在增加平均动脉血压 (MAP) 和心率 (HR)，但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻，而它是一种产生美容效果的化合物。
T37816	SB 243213
	SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders[1]. SB 243213 shows little affinity (pKi<6) for cloned human 5-HT1A, 5-HT1B, 5-HT1E, 5- HT1F and 5-HT7 receptors. It shows...
T37190	L-Allylglycine	Dehydrogenase; GABA Receptor	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Allylglycine 是 GABA 合成酶（谷氨酸脱羧酶）的有效抑制剂。
T26702	AZ12971554 AZ 12971554,AZ-12971554
	AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68µM, Ecarin clotting time (ECT) IC50 = 0.16µM in human plasma.
T19788	Piretanide Eurelix,Tauliz,Arelix
	Piretanide is a time- and voltage-dependent blocker of CFTR Cl(-) currents. Piretanide also acts as a loop diuretic.
T15630	Tilmacoxib RWJ57504,JTP19605,替马考昔,JTE522	COX	Immunology/Inflammation; Neuroscience
	Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).
T70148	CDK8-IN-4k
	CDK8-IN-4k is a potent and highly selective CDK8 inhibitor, with no apparent potential for time-dependent CYP3A4 inhibition.
T12776L	Real Thiol	Others	Others
	Real Thiol, a reversible reaction-based fluorescent probe, can quantitatively monitor the real-time glutathione dynamics in living cells.
T29000	Tralomethrin EPA Pesticide Chemical Code 121501,SAGA,HAG-107,HAG 107,Scout
	Tralomethrin is used as a pyrethroid insecticide. It modifies the gating kinetics of the sodium channels in neurons, increases the length of time the channel remains open after a stimulus, thereby depolarizing the neuron for a longer period of time. This leads to uncontrolled spasms, paralysis, and eventual death.
T68718	103D5R
	103D5R is a novel selective inhibitor of hif-1α, markedly decreasing hif-1α protein levels induced by hypoxia or cobaltous ions in a dose- and time-dependent manner
T27161	DH376 DH-376,DH 376
	DH376 inhibits DAGLα in a time and dose dependent manner in mouse brain. DH376 shows picomolar activity.
T10711	CCR2 antagonist 1	CCR	Immunology/Inflammation; Microbiology/Virology
	CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
T13746	KMG-301AM	Others	Others
	KMG-301AM, the acetoxy methyl esterified form of KMG-301, facilitates the acquisition of time-course and pseudo-colored images depicting the changes in mitochondrial fluorescence when stained with KMG-301.
TD0086	ROX Reference Dye
	ROX Reference Dye was designed to standardize fluorescent reporter gene signals in real-time quantitative PCR or RT-PCR
T41135	Defensin HNP-1 human
	Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development.Defensin HNP-1 human can regulate the growth of atherosclerosis.

化合物

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Cat.No: T8936

Synonym: proteinase K for tritirachium album,Protease K,蛋白酶 K

Target: Others

Cat.No: TQ0056

Synonym: SKF81367,头孢呋汀

Target: Antibacterial, Antibiotic

Cat.No: T68631

Cat.No: T13160

Synonym: 替美加定,SR1368

Target: COX

Timepidium bromide

Cat.No: T12825

Synonym: SA504,Sesden

Target: AChR

Cat.No: T8470

Target: PD-1/PD-L1

Cat.No: T29955

Synonym: AMC01,AMC 01

Target: Antiviral, PERK

6,6'-Dimethyl-2,2'-dipyridyl

Cat.No: T72030

Synonym: 6,6'-Bi-2-picoline

Cat.No: T7315

Target: Akt

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Cat.No: T21635

Target: MEK

Leucomalachite green

Cat.No: T32668

Synonym: NSC36379,NSC 36379,隐色孔雀绿,NSC-36379

Target: Others

Cat.No: T9573

Target: DNA Methyltransferase

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Cat.No: TD0082

Synonym: EDANS sodium salt,EDANS sodium salt [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid, sodium salt],5-(2-氨乙基氨)-1-萘磺酸钠盐,5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt,N-(Aminoethyl)-5-naphthylamine-1-sulfonic Acid Sodium Salt

Target: Others

Cat.No: T1639

Synonym: 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Cat.No: T22821

Synonym: GSK-J5,GSKJ5

Target: Histone Demethylase

Cat.No: T77767L1

Target: Others

Cat.No: T9741

Target: Others

Cat.No: T71708

Target: Aromatase

Cat.No: T39704

Target: Others

PF-06424439 methanesulfonate

Cat.No: T12425

Target: Acyltransferase, Transferase

Cat.No: T22986

Target: GPR

Cat.No: T11824LL

Synonym: GS-9876

Target: Syk

Cat.No: T36082

Target: Autophagy, Ras

Cat.No: T21548

Synonym: CYP3cide

Target: P450

AChE/BChE/MAO-B-IN-1

Cat.No: T60891

Target: MAO, AChE

Cat.No: T60671

Target: Beta Amyloid, Serotonin Transporter, Monoamine Oxidase

Cat.No: T76756

Synonym: RG 7414,Anti-EGFL7,MEGF0444A,MEGF-0444A,RO-5490248,M0444A

Target: VEGFR

Cat.No: T34249

Synonym: ROB-803

Target: TLR

Cat.No: T3536

Target: P2Y Receptor

Cat.No: T31587

Synonym: DY 268,DY-268

Target: FXR

Cat.No: T14884

Target: Others, Dehydrogenase

MnTBAP chloride

Cat.No: T38164

Synonym: Mn(III)TBAP

[Sar9,Met(O2)11]-Substance P acetate

Cat.No: TP1369L

Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)

Target: Neurokinin receptor

Cat.No: T37816

Cat.No: T37190

Target: Dehydrogenase, GABA Receptor

Cat.No: T26702

Synonym: AZ 12971554,AZ-12971554

Cat.No: T19788

Synonym: Eurelix,Tauliz,Arelix

Cat.No: T15630

Synonym: RWJ57504,JTP19605,替马考昔,JTE522

Target: COX

Cat.No: T70148

Cat.No: T12776L

Target: Others

Cat.No: T29000

Synonym: EPA Pesticide Chemical Code 121501,SAGA,HAG-107,HAG 107,Scout

Cat.No: T68718

Cat.No: T27161

Synonym: DH-376,DH 376

CCR2 antagonist 1

Cat.No: T10711

Target: CCR

Cat.No: T13746

Target: Others

ROX Reference Dye

Cat.No: TD0086

Defensin HNP-1 human

Cat.No: T41135

Cat. No.	Product Name	Target	Signaling Pathways
T7907	7-Methoxyflavone	Others	Others
	7-Methoxyflavone 是一种分离自 Zornia brasiliensis 的化合物。它能够抑制福尔马林疼痛反应神经源期的舔爪时间 (65.6%)，有外周镇痛活性，但不影响炎症期的伤害性反映。
T4S1050	Pristimerin 扁塑藤素,Celastrol methyl ester	NF-κB; Antibacterial	Microbiology/Virology; NF-κB
	Pristimerin (Celastrol methyl ester) 是一种可逆的单酰基甘油脂肪酶高效抑制剂，IC50值为93 nM。
T3501	Colistimethate Sodium Colistin-1,3,5,9-tetramethanesulfonic A acid,多粘菌素E甲磺酸钠	Others	Others
	Colistin-1,3,5,9-tetramethanesulfonic A acid 用于治疗选择有限的患者因选定的需氧革兰氏阴性病原体引起的严重感染。
T83396	23-Nor-6-oxopristimerol
	23-Nor-6-oxopristimerol 为酚类二萜三萜化合物。
TN4498	Maritimein	Others	Others
	Maritimein 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4498，CAS号为 490-54-0。
T75547	Maritimetin
	Maritimein，一种可从雪菊提取的橙酮，具有显著的对diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) 自由基清除能力，IC50值仅为4.12 μM。该化合物因此被广泛应用于心血管疾病的研究领域。
T3S0601	Buddlejasaponin IVb 醉鱼草皂苷IVb,Saikosaponin 1b	Others	Others
	Buddlejasaponin IVb (Saikosaponin 1b) 是一种三萜皂苷，从Clinopodium chinense (Benth.) O. Kuntze 中分离得到，能够缩短凝血时间，具有止血作用。
T2S0842	Scutellarin methyl ester Scutellarin methylester,野黄芩苷甲酯	Others	Others
	Scutellarin methyl ester (3-Oxotirucallenoic Acid) 是一种灯盏花素的成分, 其中灯盏花素是灯盏花中几种黄酮类化合物的粗提物。
T6S1843	Tenacissoside I 通关藤苷I,Tenacissimoside B	Others	Others
	Tenacissoside I (Tenacissimoside B) 是一种 C21 甾体，来自于Marsdenia tenacissima 中，在M. tenacissima 含量较高。
T19538	(R)-(-)-1,3-Butanediol	Endogenous Metabolite	Metabolism
	(R)-(-)-1,3-Butanediol 是一种新型生酮酯，可在短时间内快速增加健康成人循环中 r- 和 s-ß-羟基丁酸浓度，可用于研究代谢系统相关疾病。
T1400	Demeclocycline hydrochloride 地美环素,Declomycin,Clortetrin,盐酸地美环素,Detravis,Demeclocycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Demeclocycline hydrochloride (Declomycin) 是四环素类抗生素，可治疗粉刺，莱姆病和支气管炎。
T7520	Deoxycytidine triphosphate	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Deoxycytidine triphosphate 是一种核苷三磷酸，是合成 DNA 的原料，可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。
T4S0790	Diosbulbin B 山药	Others	Others
	Diosbulbin B 是一种二萜内酯，从D. bulbifera L.中分离得到，具有抗肿瘤活性，但可引起肝损伤。
T3S2105	N-Benzylpalmitamide Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide	Others; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience; Others
	N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱，可以时间依赖性方式抑制脂肪酸酰胺水解酶，有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。
T5773	Moslosooflavone 5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone	NF-κB; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) 是一种从雪莲中分离出来的类黄酮，具有抗缺氧和抗炎作用。
T3S0006	(E)-Ferulic acid methyl ester Methyl ferulate,Methyl (E)-ferulate,(E)-阿魏酸甲酯	IL Receptor; p38 MAPK; TNF; COX; NO Synthase; JNK; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience
	(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) 具有较强 DPPH 和 ABTS+自由基清除特性。
T4S1540	Myrislignan	Apoptosis; NF-κB	Apoptosis; NF-κB
	Myrislignan 是一种木酚素，从Myristica fragransHoutt 分离得到，具有抗炎作用。它通过抑制NF-kB 信号通路的激活，减轻LPS 诱导的小鼠巨噬细胞炎症反应。
T0978	Pantethine LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine	Endogenous Metabolite	Metabolism
	D-Pantethine (Pantomin) 是泛酸的二聚体形式, 是生产辅酶 A 的中间体。D-Pantethine 能够作为膳食补充剂，用于改善血液胆固醇和研究痤疮。
TJS2216	Aurantiamide acetate 金色酰胺醇酯,Asperglaucide	Cysteine Protease	Proteases/Proteasome
	Aurantiamide acetate (Asperglaucide) 是抑制口服有活性的 cathepsin 选择性抑制剂，分离自 Portulaca oleracea L。它具有抗炎作用，可用于研究炎性相关疾病。
T75636	(E/Z)-Squalene (E/Z)-Super Squalene,(E/Z)-AddaVax
	(E/Z)-Squalen 调节细胞内活性氧化物质 (ROS) 的产生，并呈浓度和时间依赖性引起细胞凋亡和坏死。(E/Z)-Squalene ((E/Z)-AddaVax) 在肝脏中积累并降低肝脏胆固醇和甘油三酯。
T3S1955	7-Ethylcamptothecin	Others	Others
	7-Ethylcamptothecin 是一种喜树碱类似物。其中喜树碱是一种细胞毒性生物碱，从喜树中分离出得到，对 L1210 白血病和 Walker 256 癌肉瘤模型具有很强的抗肿瘤活性。
T4A2462	Telocinobufagin Telobufotoxin,远华蟾蜍精,Telocinobufogenin	Others	Others
	Telocinobufagin (Telobufotoxin) 是一种从蟾酥中分离提取获得的组份。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T3893	Forsythoside B 连翘酯苷 B,连翘脂苷B	TNF; NF-κB	Apoptosis; NF-κB
	Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB，调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T2S1837	Steviol 甜菊醇,NSC 226902,Hydroxydehydrostevic acid	Others	Others
	Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。
TMA2386	4,4'-Methylenediphenol	Others	Others
	4,4'-Methylenediphenol 首次从 Galeola Faberi 的根茎中分离出来，具有抗氧化活性。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T5S2347	Deoxyshikonin 去氧紫草素,Arnebin 7	Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others
	Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物，具有抗肿瘤活性，在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
TN1476	Cauloside A	Others	Others
	Cauloside A exhibits concentration- and time-dependent mitochondriotoxic activities.
TN4906	Rengynic acid	Antifection	Microbiology/Virology
	Rengynic acid has potent antiviral effect on RSV for the first time in vitro.
TN5013	Shizukaol D	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Shizukaol D exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway. Shizukaol D may be used to treat metabolic syndrome, it induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation.
TN3973	Epinodosin	Others	Others
	Epinodosin induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner.Epinodosin has a biphasic, dose-dependent effect on root growth and a strong inhibitory effect on root hair development in Lactuca sativa L. seedlings.
TN2830	26-Nor-8-oxo-alpha-onocerin	Others	Others
	26-Nor-8-oxo-alpha-onocerin can promote the osteoblast proliferation rate, the effect is time-dependent,concentration-dependent and differentiation state-dependent.
TN4151	Glyurallin A	Others	Others
	Glyurallin A possesses an antigenotoxic effect against carcinogenic N-methyl-N-nitrosourea (MNU) for the first time, it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention.
TN7037	(Z)-9-nonadecene 9-Nonadecene	Others	Others
	(Z)-9-nonadecene (9-Nonadecene) 首次在 T. melanocephalum 中被发现。它是下颌腺中的主要成分，而虹膜在尾腺中产生。
TN4166	Griffipavixanthone	ERK; Raf; ROS; MEK; Caspase	Apoptosis; Immunology/Inflammation; MAPK; Proteases/Proteasome
	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
TN4637	Neogrifolin	PARP; GSK-3; Akt; Caspase	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS and MG63 osteosarcoma cell lines; it exhibits inhibitory activity against nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells with the IC50value of 23.3 microM. Neogrifolin possesses antimicrobial activities against Bacillus cereus and Enterococcus faecalis, the MIC values of 20 and 0.5 microg/mL, respe...
TN4890	Rabdosin B	Others	Others
	Rabdosin B shows cytotoxic activity against three human tumour HepG2, GLC-82 and HL-60 cell lines, it induces significant DNA damage to HepG2 cells in a time- and dose-dependent manner. Rabdosin B at higher concentrations inhibits root growth by affecting
TN4519	Mesuaxanthone A 胡桐，海棠木	Others	Others
	Mesuaxanthone A and mesuaxanthone B are two yellow pigments.They produce varying degrees of C.N.S. depression characterised by ptosis, sedation, decreased spontaneous motor activity, loss of muscle tone, potentiation of pentobarbitone sleeping time and et
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...
TN4291	Isofuranodiene	IL Receptor; NOS	Immunology/Inflammation
	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo

天然产物

7-Methoxyflavone

Cat.No: T7907

Target: Others

Cat.No: T4S1050

Synonym: 扁塑藤素,Celastrol methyl ester

Target: NF-κB, Antibacterial

Colistimethate Sodium

Cat.No: T3501

Synonym: Colistin-1,3,5,9-tetramethanesulfonic A acid,多粘菌素E甲磺酸钠

Target: Others

23-Nor-6-oxopristimerol

Cat.No: T83396

Cat.No: TN4498

Target: Others

Cat.No: T75547

Buddlejasaponin IVb

Cat.No: T3S0601

Synonym: 醉鱼草皂苷IVb,Saikosaponin 1b

Target: Others

Scutellarin methyl ester

Cat.No: T2S0842

Synonym: Scutellarin methylester,野黄芩苷甲酯

Target: Others

Tenacissoside I

Cat.No: T6S1843

Synonym: 通关藤苷I,Tenacissimoside B

Target: Others

(R)-(-)-1,3-Butanediol

Cat.No: T19538

Target: Endogenous Metabolite

Demeclocycline hydrochloride

Cat.No: T1400

Synonym: 地美环素,Declomycin,Clortetrin,盐酸地美环素,Detravis,Demeclocycline HCl

Target: ribosome, Antibacterial, Antibiotic

Deoxycytidine triphosphate

Cat.No: T7520

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: T4S0790

Synonym: 山药

Target: Others

N-Benzylpalmitamide

Cat.No: T3S2105

Synonym: Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide

Target: Others, FAAH, Autophagy

Moslosooflavone

Cat.No: T5773

Synonym: 5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone

Target: NF-κB, Reactive Oxygen Species

(E)-Ferulic acid methyl ester

Cat.No: T3S0006

Synonym: Methyl ferulate,Methyl (E)-ferulate,(E)-阿魏酸甲酯

Target: IL Receptor, p38 MAPK, TNF, COX, NO Synthase, JNK, Antifection

Cat.No: T4S1540

Target: Apoptosis, NF-κB

Cat.No: T0978

Synonym: LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine

Target: Endogenous Metabolite

Aurantiamide acetate

Cat.No: TJS2216

Synonym: 金色酰胺醇酯,Asperglaucide

Target: Cysteine Protease

Cat.No: T75636

Synonym: (E/Z)-Super Squalene,(E/Z)-AddaVax

7-Ethylcamptothecin

Cat.No: T3S1955

Target: Others

Telocinobufagin

Cat.No: T4A2462

Synonym: Telobufotoxin,远华蟾蜍精,Telocinobufogenin

Target: Others

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

Cat.No: T3893

Synonym: 连翘酯苷 B,连翘脂苷B

Target: TNF, NF-κB

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T2S1837

Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Target: Others

4,4'-Methylenediphenol

Cat.No: TMA2386

Target: Others

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cat.No: T5S2347

Synonym: 去氧紫草素,Arnebin 7

Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T38108

Target: Antioxidant, PDE

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: TN1476

Target: Others

Cat.No: TN4906

Target: Antifection

Cat.No: TN5013

Target: AMPK

Cat.No: TN3973

Target: Others

26-Nor-8-oxo-alpha-onocerin

Cat.No: TN2830

Target: Others

Cat.No: TN4151

Target: Others

(Z)-9-nonadecene

Cat.No: TN7037

Synonym: 9-Nonadecene

Target: Others

Griffipavixanthone

Cat.No: TN4166

Target: ERK, Raf, ROS, MEK, Caspase

Cat.No: TN4637

Target: PARP, GSK-3, Akt, Caspase

Cat.No: TN4890

Target: Others

Mesuaxanthone A

Cat.No: TN4519

Synonym: 胡桐，海棠木

Target: Others

Cat.No: T36348

Cat.No: TN4291

Target: IL Receptor, NOS

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